KEGG   PATHWAY: ptr04666
Entry
ptr04666                    Pathway                                
Name
Fc gamma R-mediated phagocytosis - Pan troglodytes (chimpanzee)
Description
Phagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes take part in this process in higher organisms. After opsonization with antibodies (IgG), foreign extracellular materials are recognized by Fc gamma receptors. Cross-linking of Fc gamma receptors initiates a variety of signals mediated by tyrosine phosphorylation of multiple proteins, which lead through the actin cytoskeleton rearrangements and membrane remodeling to the formation of phagosomes. Nascent phagosomes undergo a process of maturation that involves fusion with lysosomes. The acquisition of lysosomal proteases and release of reactive oxygen species are crucial for digestion of engulfed materials in phagosomes.
Class
Organismal Systems; Immune system
Pathway map
ptr04666  Fc gamma R-mediated phagocytosis
ptr04666

Other DBs
GO: 0006909
Organism
Pan troglodytes (chimpanzee) [GN:ptr]
Gene
457259  FCGR1A; high affinity immunoglobulin gamma Fc receptor I isoform X2 [KO:K06498]
450194  FCGR2A; low affinity immunoglobulin gamma Fc region receptor II-a precursor [KO:K06472]
457457  FCGR3A; low affinity immunoglobulin gamma Fc region receptor III-A isoform X1 [KO:K06463]
745350  low affinity immunoglobulin gamma Fc region receptor III-B isoform X1 [KO:K06463]
457607  PTPRC; receptor-type tyrosine-protein phosphatase C isoform X1 [KO:K06478] [EC:3.1.3.48]
458163  HCK; tyrosine-protein kinase HCK isoform X1 [KO:K08893] [EC:2.7.10.2]
472771  LYN; tyrosine-protein kinase Lyn isoform X3 [KO:K05854] [EC:2.7.10.2]
464586  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
460858  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
457922  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
471079  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
456565  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
461836  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
456035  AKT2; RAC-beta serine/threonine-protein kinase isoform X6 [KO:K04456] [EC:2.7.11.1]
740898  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100609583  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
468426  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
746903  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
458253  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X3 [KO:K01116] [EC:3.1.4.11]
454268  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
460442  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
459203  PRKCE; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
460182  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
450188  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
454037  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
458680  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
467664  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
469617  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
468935  PLA2G4C; cytosolic phospholipase A2 gamma isoform X1 [KO:K16342] [EC:3.1.1.4]
100610135  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
104004422  cytosolic phospholipase A2 beta isoform X2 [KO:K16342] [EC:3.1.1.4]
107973006  cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
129135285  cytosolic phospholipase A2 beta-like isoform X1 [KO:K16342] [EC:3.1.1.4]
129144382  cytosolic phospholipase A2 beta-like isoform X1 [KO:K16342] [EC:3.1.1.4]
749464  PLA2G4B; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
453356  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
748548  LOW QUALITY PROTEIN: cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
470208  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
742020  MARCKS; myristoylated alanine-rich C-kinase substrate [KO:K12561]
745609  MARCKSL1; MARCKS-related protein [KO:K13536]
470996  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
454454  PLD2; phospholipase D2 isoform X2 [KO:K01115] [EC:3.1.4.4]
461869  PLPP1; phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
456884  PLPP3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
455525  PLPP2; phospholipid phosphatase 2 isoform X1 [KO:K01080] [EC:3.1.3.4]
738821  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
468943  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
454832  PRKCA; protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
453993  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
456276  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
743307  NCF1; neutrophil cytosol factor 1 [KO:K08011]
464706  GSN; gelsolin isoform X1 [KO:K05768]
472296  SCIN; scinderin isoform X2 [KO:K05768]
455647  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
473114  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
457076  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
456609  CDC42; cell division control protein 42 homolog isoform X2 [KO:K04393]
743187  WAS; actin nucleation-promoting factor WAS [KO:K05747]
107969760  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
746973  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
736054  ACTR3C; actin-related protein 3C isoform X2 [KO:K18584]
459563  ACTR3; actin-related protein 3 [KO:K18584]
738748  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
463568  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
737235  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
459938  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
737048  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
129138215  actin-related protein 2/3 complex subunit 3-like [KO:K05756]
100614809  ARPC4; actin-related protein 2/3 complex subunit 4 isoform X2 [KO:K05755]
464728  ARPC5L; actin related protein 2/3 complex subunit 5 like [KO:K05754]
457574  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
741907  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
465884  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
742575  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
462935  WASF1; actin-binding protein WASF1 isoform X2 [KO:K05753]
456675  WASF2; actin-binding protein WASF2 [KO:K05748]
473870  actin-binding protein WASF2-like [KO:K05748]
452502  WASF3; actin-binding protein WASF3 [KO:K06083]
451439  PAK1; serine/threonine-protein kinase PAK 1 isoform X2 [KO:K04409] [EC:2.7.11.1]
463466  LIMK1; LIM domain kinase 1 isoform X2 [KO:K05743] [EC:2.7.11.1]
458970  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
452853  CFL2; cofilin-2 isoform X2 [KO:K05765]
745772  CFL1; cofilin-1 isoform X1 [KO:K05765]
455590  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
464513  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X4 [KO:K00889] [EC:2.7.1.68]
457288  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
452892  ARF6; ADP-ribosylation factor 6 [KO:K07941]
747142  CRK; adapter molecule crk isoform X1 [KO:K04438]
107970369  CRKL; crk-like protein [KO:K04438]
104001055  DOCK1; dedicator of cytokinesis protein 1 isoform X6 [KO:K13708]
456617  ASAP3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X5 [KO:K12488]
459014  ASAP2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
464399  ASAP1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X3 [KO:K12488]
748765  low affinity immunoglobulin gamma Fc region receptor II-b isoform X1 [KO:K12560]
470683  INPP5D; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X1 [KO:K03084] [EC:3.1.3.86]
451403  INPPL1; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X4 [KO:K15909] [EC:3.1.3.86]
748918  GAB2; GRB2-associated-binding protein 2 isoform X1 [KO:K08091]
743259  SPNS1; protein spinster homolog 1 isoform X6 [KO:K07362]
455718  DNM2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
735972  BIN1; myc box-dependent-interacting protein 1 isoform X48 [KO:K12562]
463363  AMPH; amphiphysin isoform X1 [KO:K12562]
471462  MYO10; unconventional myosin-X [KO:K12559]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00416  Phosphatidate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06124  Sphingosine 1-phosphate
Reference
PMID:12488490
  Authors
Garcia-Garcia E, Rosales C
  Title
Signal transduction during Fc receptor-mediated phagocytosis.
  Journal
J Leukoc Biol 72:1092-108 (2002)
DOI:10.1189/jlb.72.6.1092
Reference
PMID:11708889
  Authors
Cox D, Greenberg S
  Title
Phagocytic signaling strategies: Fc(gamma)receptor-mediated phagocytosis as a model system.
  Journal
Semin Immunol 13:339-45 (2001)
DOI:10.1006/smim.2001.0330
Reference
PMID:15466916
  Authors
Swanson JA, Hoppe AD
  Title
The coordination of signaling during Fc receptor-mediated phagocytosis.
  Journal
J Leukoc Biol 76:1093-103 (2004)
DOI:10.1189/jlb.0804439
Reference
PMID:11244038
  Authors
Ravetch JV, Bolland S
  Title
IgG Fc receptors.
  Journal
Annu Rev Immunol 19:275-90 (2001)
DOI:10.1146/annurev.immunol.19.1.275
Reference
PMID:18322649
  Authors
Groves E, Dart AE, Covarelli V, Caron E
  Title
Molecular mechanisms of phagocytic uptake in mammalian cells.
  Journal
Cell Mol Life Sci 65:1957-76 (2008)
DOI:10.1007/s00018-008-7578-4
Reference
PMID:10376013
  Authors
Kwiatkowska K, Sobota A
  Title
Signaling pathways in phagocytosis.
  Journal
Bioessays 21:422-31 (1999)
DOI:10.1002/(SICI)1521-1878(199905)21:5<422::AID-BIES9>3.0.CO;2-#
Reference
PMID:10577498
  Authors
Greenberg S
  Title
Modular components of phagocytosis.
  Journal
J Leukoc Biol 66:712-7 (1999)
DOI:10.1002/jlb.66.5.712
Reference
PMID:10224668
  Authors
Lennartz MR
  Title
Phospholipases and phagocytosis: the role of phospholipid-derived second messengers in phagocytosis.
  Journal
Int J Biochem Cell Biol 31:415-30 (1999)
DOI:10.1016/S1357-2725(98)00108-3
Reference
PMID:11228151
  Authors
May RC, Machesky LM
  Title
Phagocytosis and the actin cytoskeleton.
  Journal
J Cell Sci 114:1061-77 (2001)
Reference
PMID:17050193
  Authors
Joshi T, Butchar JP, Tridandapani S
  Title
Fcgamma receptor signaling in phagocytes.
  Journal
Int J Hematol 84:210-6 (2006)
DOI:10.1532/IJH97.06140
Reference
PMID:17308335
  Authors
Lee WL, Cosio G, Ireton K, Grinstein S
  Title
Role of CrkII in Fcgamma receptor-mediated phagocytosis.
  Journal
J Biol Chem 282:11135-43 (2007)
DOI:10.1074/jbc.M700823200
Reference
PMID:11304556
  Authors
Uchida H, Kondo A, Yoshimura Y, Mazaki Y, Sabe H
  Title
PAG3/Papalpha/KIAA0400, a GTPase-activating protein for ADP-ribosylation factor (ARF), regulates ARF6 in Fcgamma receptor-mediated phagocytosis of macrophages.
  Journal
J Exp Med 193:955-66 (2001)
DOI:10.1084/jem.193.8.955
Reference
PMID:15485887
  Authors
Ganesan LP, Wei G, Pengal RA, Moldovan L, Moldovan N, Ostrowski MC, Tridandapani S
  Title
The serine/threonine kinase Akt Promotes Fc gamma receptor-mediated phagocytosis in murine macrophages through the activation of p70S6 kinase.
  Journal
J Biol Chem 279:54416-25 (2004)
DOI:10.1074/jbc.M408188200
Reference
PMID:9545263
  Authors
Melendez A, Floto RA, Gillooly DJ, Harnett MM, Allen JM
  Title
FcgammaRI coupling to phospholipase D initiates sphingosine kinase-mediated calcium mobilization and vesicular trafficking.
  Journal
J Biol Chem 273:9393-402 (1998)
DOI:10.1074/jbc.273.16.9393
Reference
PMID:12821647
  Authors
Gu H, Botelho RJ, Yu M, Grinstein S, Neel BG
  Title
Critical role for scaffolding adapter Gab2 in Fc gamma R-mediated phagocytosis.
  Journal
J Cell Biol 161:1151-61 (2003)
DOI:10.1083/jcb.200212158
Reference
PMID:9417101
  Authors
Dana R, Leto TL, Malech HL, Levy R
  Title
Essential requirement of cytosolic phospholipase A2 for activation of the phagocyte NADPH oxidase.
  Journal
J Biol Chem 273:441-5 (1998)
DOI:10.1074/jbc.273.1.441
Reference
PMID:10601359
  Authors
Gold ES, Underhill DM, Morrissette NS, Guo J, McNiven MA, Aderem A
  Title
Dynamin 2 is required for phagocytosis in macrophages.
  Journal
J Exp Med 190:1849-56 (1999)
DOI:10.1084/jem.190.12.1849
Reference
PMID:10755615
  Authors
Gold ES, Morrissette NS, Underhill DM, Guo J, Bassetti M, Aderem A
  Title
Amphiphysin IIm, a novel amphiphysin II isoform, is required for macrophage phagocytosis.
  Journal
Immunity 12:285-92 (2000)
DOI:10.1016/S1074-7613(00)80181-8
Reference
PMID:10586078
  Authors
Raeder EM, Mansfield PJ, Hinkovska-Galcheva V, Shayman JA, Boxer LA
  Title
Syk activation initiates downstream signaling events during human polymorphonuclear leukocyte phagocytosis.
  Journal
J Immunol 163:6785-93 (1999)
Reference
PMID:9581795
  Authors
Sanchez-Mejorada G, Rosales C
  Title
Signal transduction by immunoglobulin Fc receptors.
  Journal
J Leukoc Biol 63:521-33 (1998)
DOI:10.1002/jlb.63.5.521
Reference
  Authors
Rosales C (ed).
  Title
Molecular Mechanisms of Phagocytosis
  Journal
Springer (2005)
Related
pathway
ptr04020  Calcium signaling pathway
ptr04142  Lysosome
ptr04144  Endocytosis
ptr04810  Regulation of actin cytoskeleton
KO pathway
ko04666   
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