KEGG   PATHWAY: ptr04810
Entry
ptr04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Pan troglodytes (chimpanzee)
Class
Cellular Processes; Cell motility
Pathway map
ptr04810  Regulation of actin cytoskeleton
ptr04810

Other DBs
GO: 0030036
Organism
Pan troglodytes (chimpanzee) [GN:ptr]
Gene
464655  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
455878  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
465729  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
747759  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
741624  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
450130  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
451158  F2; prothrombin isoform X1 [KO:K01313] [EC:3.4.21.5]
471510  F2R; proteinase-activated receptor 1 [KO:K03914]
449570  INS; insulin preproprotein [KO:K04526]
461435  EGF; pro-epidermal growth factor isoform X5 [KO:K04357]
462158  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
641462  FGF2; fibroblast growth factor 2 [KO:K18497]
747181  FGF6; fibroblast growth factor 6 [KO:K04358]
472708  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
471553  FGF10; fibroblast growth factor 10 [KO:K04358]
468631  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
744975  FGF7; fibroblast growth factor 7 [KO:K04358]
473676  FGF16; fibroblast growth factor 16 [KO:K04358]
739611  FGF18; fibroblast growth factor 18 [KO:K04358]
747727  FGF4; fibroblast growth factor 4 [KO:K04358]
466693  FGF3; fibroblast growth factor 3 [KO:K04358]
739665  FGF20; fibroblast growth factor 20 [KO:K04358]
744731  FGF9; fibroblast growth factor 9 [KO:K04358]
101056934  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
747710  FGF19; fibroblast growth factor 19 [KO:K22603]
468948  FGF21; fibroblast growth factor 21 [KO:K22429]
747164  FGF23; fibroblast growth factor 23 [KO:K22428]
740202  PDGFA; platelet-derived growth factor subunit A isoform X2 [KO:K04359]
458844  PDGFB; platelet-derived growth factor subunit B isoform X2 [KO:K17386]
466765  PDGFD; platelet-derived growth factor D isoform X2 [KO:K05450]
736477  PDGFC; platelet-derived growth factor C isoform X3 [KO:K05450]
457407  INSRR; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
463415  EGFR; epidermal growth factor receptor isoform X3 [KO:K04361] [EC:2.7.10.1]
464122  FGFR1; fibroblast growth factor receptor 1 isoform X3 [KO:K04362] [EC:2.7.10.1]
466220  FGFR2; fibroblast growth factor receptor 2 isoform X12 [KO:K05093] [EC:2.7.10.1]
461067  FGFR3; fibroblast growth factor receptor 3 isoform X9 [KO:K05094] [EC:2.7.10.1]
462301  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
461318  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
462188  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
459926  FN1; fibronectin isoform X14 [KO:K05717]
461880  ITGA1; integrin alpha-1 [KO:K06480]
471550  ITGA2; integrin alpha-2 isoform X3 [KO:K06481]
454730  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
455111  ITGA3; integrin alpha-3 isoform X3 [KO:K06482]
470596  ITGA4; integrin alpha-4 isoform X4 [KO:K06483]
451958  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
459742  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
451967  ITGA7; integrin alpha-7 isoform X4 [KO:K06583]
450323  ITGA8; integrin alpha-8 isoform X3 [KO:K06584]
470789  ITGA9; integrin alpha-9 isoform X2 [KO:K06585]
457982  ITGA10; integrin alpha-10 [KO:K06586]
453537  ITGA11; integrin alpha-11 [KO:K06587]
459807  ITGAV; integrin alpha-V isoform X2 [KO:K06487]
454045  ITGAL; integrin alpha-L [KO:K05718]
454069  ITGAM; integrin alpha-M precursor [KO:K06461]
454070  ITGAX; integrin alpha-X isoform X1 [KO:K06462]
468103  ITGAD; integrin alpha-D [KO:K06594]
454435  ITGAE; integrin alpha-E [KO:K06524]
450396  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
458607  ITGB2; integrin beta-2 isoform X2 [KO:K06464]
468295  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
454887  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
460646  ITGB5; integrin beta-5 [KO:K06588]
459683  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
451934  ITGB7; integrin beta-7 [KO:K06590]
463282  ITGB8; integrin beta-8 isoform X2 [KO:K06591]
460916  KNG1; kininogen-1 [KO:K03898]
100612769  BDKRB1; B1 bradykinin receptor [KO:K03915]
467547  BDKRB2; B2 bradykinin receptor isoform X2 [KO:K03916]
451272  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
463758  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
469725  CHRM3; muscarinic acetylcholine receptor M3 isoform X1 [KO:K04131]
466504  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
503515  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
464703  C5; complement C5 isoform X7 [KO:K03994]
449612  C6; complement component C6 isoform X1 [KO:K03995]
738238  C7; complement component C7 isoform X1 [KO:K03996]
456886  C8A; complement component C8 alpha chain [KO:K03997]
456887  C8B; complement component C8 beta chain isoform X1 [KO:K03998]
100610119  C8G; complement component C8 gamma chain [KO:K03999]
100610175  C9; complement component C9 isoform X3 [KO:K04000]
463234  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
454827  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
100609242  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 isoform X1 [KO:K04347]
107969673  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
465655  FGD1; FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
100615555  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
464422  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
454246  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
747142  CRK; adapter molecule crk isoform X1 [KO:K04438]
107970369  CRKL; crk-like protein [KO:K04438]
104001055  DOCK1; dedicator of cytokinesis protein 1 isoform X6 [KO:K13708]
458229  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
459171  SOS1; son of sevenless homolog 1 isoform X2 [KO:K03099]
452897  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
466302  HRAS; GTPase HRas isoform X1 [KO:K02833]
473387  KRAS; GTPase KRas isoform X1 [KO:K07827]
742713  NRAS; GTPase NRas [KO:K07828]
468955  RRAS; ras-related protein R-Ras [KO:K07829]
451038  RRAS2; ras-related protein R-Ras2 isoform X2 [KO:K07830]
470938  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
473803  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
460858  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
457922  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
471079  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
456565  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
461836  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
455647  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
473114  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
457076  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
473949  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
100614256  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
463781  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
460182  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
472772  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
450188  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
456390  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
454037  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
458680  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
456035  AKT2; RAC-beta serine/threonine-protein kinase isoform X6 [KO:K04456] [EC:2.7.11.1]
740898  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100609583  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
749634  RGCC; regulator of cell cycle RGCC isoform X1 [KO:K26108]
456067  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X4 [KO:K12330]
451618  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
456157  ARHGAP35; rho GTPase-activating protein 35 isoform X1 [KO:K05732]
461014  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
741907  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
465884  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
742575  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
747131  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
456609  CDC42; cell division control protein 42 homolog isoform X2 [KO:K04393]
451439  PAK1; serine/threonine-protein kinase PAK 1 isoform X2 [KO:K04409] [EC:2.7.11.1]
460965  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
450118  PAK3; serine/threonine-protein kinase PAK 3 isoform X2 [KO:K05733] [EC:2.7.11.1]
100609406  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
469876  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
453327  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
452673  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X22 [KO:K13710]
454549  GIT1; ARF GTPase-activating protein GIT1 isoform X3 [KO:K05737]
455326  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
470307  ROCK2; rho-associated protein kinase 2 isoform X2 [KO:K17388] [EC:2.7.11.1]
742591  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
465143  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
471840  MYLK4; myosin light chain kinase family member 4 isoform X2 [KO:K00907] [EC:2.7.11.18]
101057233  MYLK; myosin light chain kinase, smooth muscle isoform X2 [KO:K00907] [EC:2.7.11.18]
462795  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
745709  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
743656  serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
459118  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
452095  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
456295  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
452243  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
750383  myosin light chain 5 isoform X1 [KO:K12753]
463920  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
458216  MYL9; myosin regulatory light polypeptide 9 isoform X2 [KO:K12755]
472470  MYL10; myosin regulatory light chain 10 isoform X2 [KO:K12756]
455313  MYL12B; myosin regulatory light chain 12B [KO:K12757]
455314  MYL12A; myosin regulatory light chain 12A isoform X3 [KO:K12757]
471369  myosin regulatory light chain 12B [KO:K12757]
107968677  MYL11; myosin regulatory light chain 11 [KO:K12758]
468959  MYH14; myosin-14 isoform X3 [KO:K10352]
470200  MYH9; myosin-9 [KO:K10352]
455090  MYH10; myosin-10 isoform X1 [KO:K10352]
462144  DIAPH1; protein diaphanous homolog 1 [KO:K05740]
473694  DIAPH2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
456669  SLC9A1; sodium/hydrogen exchanger 1 isoform X1 [KO:K05742]
455590  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
464513  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X4 [KO:K00889] [EC:2.7.1.68]
457288  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
467044  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1 [KO:K00920] [EC:2.7.1.149]
742458  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
746830  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
459908  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
463466  LIMK1; LIM domain kinase 1 isoform X2 [KO:K05743] [EC:2.7.11.1]
458970  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
452752  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
454951  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X3 [KO:K05627]
737268  ENAH; protein enabled homolog [KO:K05746]
463688  WASL; actin nucleation-promoting factor WASL [KO:K23612]
456675  WASF2; actin-binding protein WASF2 [KO:K05748]
473870  actin-binding protein WASF2-like [KO:K05748]
462221  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
453278  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
451961  NCKAP1L; nck-associated protein 1-like isoform X1 [KO:K05750]
459801  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
459892  ABI2; abl interactor 2 isoform X8 [KO:K05751]
100608101  BRK1; protein BRICK1 [KO:K05752]
462935  WASF1; actin-binding protein WASF1 isoform X2 [KO:K05753]
746973  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
736054  ACTR3C; actin-related protein 3C isoform X2 [KO:K18584]
459563  ACTR3; actin-related protein 3 [KO:K18584]
738748  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
463568  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
737235  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
459938  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
737048  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
129138215  actin-related protein 2/3 complex subunit 3-like [KO:K05756]
100614809  ARPC4; actin-related protein 2/3 complex subunit 4 isoform X2 [KO:K05755]
464728  ARPC5L; actin related protein 2/3 complex subunit 5 like [KO:K05754]
457574  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
746570  ACTG1; actin, cytoplasmic 2 [KO:K05692]
450133  ACTB; actin, cytoplasmic 1 [KO:K05692]
471759  PFN3; profilin-3 [KO:K05759]
460989  PFN2; profilin-2 isoform X2 [KO:K05759]
748477  PFN1; profilin-1 isoform X2 [KO:K05759]
100611207  PFN4; profilin-4 [KO:K05759]
452303  PXN; paxillin isoform X14 [KO:K05760]
463100  EZR; ezrin [KO:K08007]
747081  MSN; moesin isoform X1 [KO:K05763]
465493  TMSB4X; thymosin beta-4 [KO:K05764]
104007609  thymosin beta-4 [KO:K05764]
101059399  thymosin beta-4 [KO:K05764]
101058899  thymosin beta-4 [KO:K05764]
107975747  thymosin beta-4-like [KO:K05764]
134807627  thymosin beta-4-like [KO:K05764]
104004853  thymosin beta-4-like [KO:K05764]
452853  CFL2; cofilin-2 isoform X2 [KO:K05765]
745772  CFL1; cofilin-1 isoform X1 [KO:K05765]
454551  SSH2; protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
467124  SSH1; protein phosphatase Slingshot homolog 1 isoform X2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
451365  SSH3; protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
450531  VCL; vinculin isoform X1 [KO:K05700]
467762  IQGAP1; ras GTPase-activating-like protein IQGAP1 isoform X2 [KO:K16848]
461801  IQGAP2; ras GTPase-activating-like protein IQGAP2 isoform X1 [KO:K05767]
457397  IQGAP3; ras GTPase-activating-like protein IQGAP3 isoform X1 [KO:K05767]
464706  GSN; gelsolin isoform X1 [KO:K05768]
472296  SCIN; scinderin isoform X2 [KO:K05768]
456010  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
452993  ACTN1; alpha-actinin-1 isoform X2 [KO:K05699]
461999  APC; adenomatous polyposis coli protein isoform X5 [KO:K02085]
455551  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
470538  ARHGEF4; rho guanine nucleotide exchange factor 4 isoform X1 [KO:K05769]
745230  SPATA13; spermatogenesis-associated protein 13 isoform X4 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
ptr04010  MAPK signaling pathway
ptr04510  Focal adhesion
ptr04520  Adherens junction
KO pathway
ko04810   
LinkDB

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