KEGG   PATHWAY: pvp04726
Entry
pvp04726                    Pathway                                
Name
Serotonergic synapse - Pteropus vampyrus (large flying fox)
Description
Serotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endocrine secretion, as well as in pathological states including abnormal mood and cognition. Once released from presynaptic axonal terminals, 5-HT binds to receptors, which have been divided into 7 subfamilies on the basis of conserved structures and signaling mechanisms. These families include the ionotropic 5-HT3 receptors and G-protein-coupled 5-HT receptors, the 5-HT1 (Gi /Go -coupled), 5-HT2(Gq-coupled), 5-HT4/6/7 (Gs-coupled) and 5-HT5 receptors. Presynaptically localized 5-HT1B receptors are thought to be the autoreceptors that suppress excess 5-HT release. 5-HT's actions are terminated by transporter- mediated reuptake into neurons, leading to catabolism by monoamine oxidase.
Class
Organismal Systems; Nervous system
Pathway map
pvp04726  Serotonergic synapse
pvp04726

Other DBs
GO: 0007210
Organism
Pteropus vampyrus (large flying fox) [GN:pvp]
Gene
105288668  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
105288669  PLA2G4F; cytosolic phospholipase A2 zeta isoform X2 [KO:K16342] [EC:3.1.1.4]
105288758  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
105288781  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
105288785  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
105288787  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
105288850  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
105288958  ALOX5; arachidonate 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
105289063  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105289068  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
105289326  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
105289647  HTR1F; 5-hydroxytryptamine receptor 1F [KO:K04153]
105289947  GABRB2; gamma-aminobutyric acid receptor subunit beta-2 [KO:K05181]
105290153  KCND2; potassium voltage-gated channel subfamily D member 2 [KO:K04892]
105290410  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
105290444  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
105290808  APP; amyloid-beta A4 protein isoform X1 [KO:K04520]
105291239  ALOX12B; arachidonate 12-lipoxygenase, 12R-type isoform X1 [KO:K08021] [EC:1.13.11.-]
105291464  KCNJ3; G protein-activated inward rectifier potassium channel 1 isoform X1 [KO:K04997]
105291491  SLC18A2; synaptic vesicular amine transporter [KO:K08155]
105291659  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
105291746  ALOX15; arachidonate 15-lipoxygenase [KO:K00460] [EC:1.13.11.33]
105291886  SLC6A4; sodium-dependent serotonin transporter [KO:K05037]
105291977  ALOX12; arachidonate 12-lipoxygenase, 12S-type [KO:K00458] [EC:1.13.11.31]
105292074  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha [KO:K04534]
105292679  PTGS1; prostaglandin G/H synthase 1 [KO:K00509] [EC:1.14.99.1]
105293094  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
105293898  GABRB1; gamma-aminobutyric acid receptor subunit beta-1 isoform X1 [KO:K05181]
105294059  KRAS; GTPase KRas isoform X2 [KO:K07827]
105294112  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
105294373  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
105294383  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
105294710  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105294972  TRPC1; short transient receptor potential channel 1 isoform X2 [KO:K04964]
105295029  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
105295052  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
105295155  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
105295171  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
105295302  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
105295517  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
105295621  HTR3A; 5-hydroxytryptamine receptor 3A isoform X2 [KO:K04819]
105295661  HTR3B; LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 3B [KO:K04819]
105295807  KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000]
105295886  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
105295952  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
105296083  [KO:K04632]
105296125  [KO:K04161]
105296550  NRAS; GTPase NRas isoform X1 [KO:K07828]
105296664  SLC18A1; chromaffin granule amine transporter [KO:K08155]
105296936  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
105296997  HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153]
105297195  [KO:K07428] [EC:1.14.14.1]
105297202  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
105297298  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
105297498  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X2 [KO:K08014]
105297702  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105297807  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 isoform X2 [KO:K04540]
105297846  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
105298024  [KO:K07414] [EC:1.14.14.1]
105298593  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
105298737  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
105298918  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
105299021  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105299303  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
105299387  HTR1A; 5-hydroxytryptamine receptor 1A [KO:K04153]
105299420  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
105299444  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
105299738  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
105300015  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
105300718  KCNJ9; G protein-activated inward rectifier potassium channel 3 [KO:K05002]
105301042  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
105301394  [KO:K07413] [EC:1.14.14.1]
105301608  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
105301629  TPH2; tryptophan 5-hydroxylase 2 [KO:K00502] [EC:1.14.16.4]
105302452  [KO:K04634]
105302718  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 isoform X1 [KO:K04541]
105303281  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 isoform X4 [KO:K04547]
105303444  [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
105303559  DDC; aromatic-L-amino-acid decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
105303584  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
105304216  TPH1; tryptophan 5-hydroxylase 1 [KO:K00502] [EC:1.14.16.4]
105304363  CACNA1D; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
105304566  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
105305432  MAOA; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
105305433  MAOB; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
105305459  ARAF; serine/threonine-protein kinase A-Raf isoform X8 [KO:K08845] [EC:2.7.11.1]
105305933  HRAS; GTPase HRas isoform X1 [KO:K02833]
105306042  KCNJ5; G protein-activated inward rectifier potassium channel 4 isoform X2 [KO:K04999]
105306132  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
105306170  [KO:K05181]
105307158  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
105307169  [KO:K04819]
105307179  [KO:K04819]
105307194  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
105307274  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
105307521  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
105307968  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
105308501  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
105308549  KCNN2; small conductance calcium-activated potassium channel protein 2 isoform X1 [KO:K04943]
105308818  [KO:K19662] [EC:2.7.11.13]
105309056  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
105309385  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
105309462  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105309827  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
105310026  [KO:K05181]
105310269  [KO:K04543]
111744611  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
Compound
C00076  Calcium cation
C00078  L-Tryptophan
C00165  Diacylglycerol
C00219  Arachidonate
C00238  Potassium cation
C00427  Prostaglandin H2
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00643  5-Hydroxy-L-tryptophan
C00696  Prostaglandin D2
C00780  Serotonin
C00909  Leukotriene A4
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C04822  8(R)-HPETE
C05356  5(S)-HPETE
C05635  5-Hydroxyindoleacetate
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14812  12(R)-HPETE
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14823  8(S)-HPETE
Reference
PMID:18676031
  Authors
Millan MJ, Marin P, Bockaert J, Mannoury la Cour C
  Title
Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions.
  Journal
Trends Pharmacol Sci 29:454-64 (2008)
DOI:10.1016/j.tips.2008.06.007
Reference
PMID:16896947
  Authors
Bockaert J, Claeysen S, Becamel C, Dumuis A, Marin P
  Title
Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation.
  Journal
Cell Tissue Res 326:553-72 (2006)
DOI:10.1007/s00441-006-0286-1
Reference
PMID:11916537
  Authors
Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS, Garnovskaya MN
  Title
Multiplicity of mechanisms of serotonin receptor signal transduction.
  Journal
Pharmacol Ther 92:179-212 (2001)
DOI:10.1016/S0163-7258(01)00169-3
Reference
PMID:15034221
  Authors
Noda M, Higashida H, Aoki S, Wada K
  Title
Multiple signal transduction pathways mediated by 5-HT receptors.
  Journal
Mol Neurobiol 29:31-9 (2004)
DOI:10.1385/MN:29:1:31
Reference
PMID:20561690
  Authors
Daubert EA, Condron BG
  Title
Serotonin: a regulator of neuronal morphology and circuitry.
  Journal
Trends Neurosci 33:424-34 (2010)
DOI:10.1016/j.tins.2010.05.005
Reference
PMID:16826372
  Authors
Chameau P, van Hooft JA
  Title
Serotonin 5-HT(3) receptors in the central nervous system.
  Journal
Cell Tissue Res 326:573-81 (2006)
DOI:10.1007/s00441-006-0255-8
Reference
PMID:9651340
  Authors
Tournois C, Mutel V, Manivet P, Launay JM, Kellermann O
  Title
Cross-talk between 5-hydroxytryptamine receptors in a serotonergic cell line. Involvement of arachidonic acid metabolism.
  Journal
J Biol Chem 273:17498-503 (1998)
DOI:10.1074/jbc.273.28.17498
Reference
PMID:19545642
  Authors
Iliff JJ, Jia J, Nelson J, Goyagi T, Klaus J, Alkayed NJ
  Title
Epoxyeicosanoid signaling in CNS function and disease.
  Journal
Prostaglandins Other Lipid Mediat 91:68-84 (2010)
DOI:10.1016/j.prostaglandins.2009.06.004
Reference
PMID:12676358
  Authors
Adayev T, Ray I, Sondhi R, Sobocki T, Banerjee P
  Title
The G protein-coupled 5-HT1A receptor causes suppression of caspase-3 through MAPK and protein kinase Calpha.
  Journal
Biochim Biophys Acta 1640:85-96 (2003)
DOI:10.1016/S0167-4889(03)00023-5
Reference
PMID:11701344
  Authors
Albert PR, Tiberi M
  Title
Receptor signaling and structure: insights from serotonin-1 receptors.
  Journal
Trends Endocrinol Metab 12:453-60 (2001)
DOI:10.1016/S1043-2760(01)00498-2
Reference
PMID:9658404
  Authors
Durham PL, Russo AF
  Title
Serotonergic repression of mitogen-activated protein kinase control of the calcitonin gene-related peptide enhancer.
  Journal
Mol Endocrinol 12:1002-9 (1998)
DOI:10.1210/mend.12.7.0135
Reference
PMID:15710402
  Authors
Robert S, Maillet M, Morel E, Launay JM, Fischmeister R, Mercken L, Lezoualc'h F
  Title
Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac.
  Journal
FEBS Lett 579:1136-42 (2005)
DOI:10.1016/j.febslet.2005.01.010
Reference
PMID:12543273
  Authors
Lezoualc'h F, Robert SJ
  Title
The serotonin 5-HT4 receptor and the amyloid precursor protein processing.
  Journal
Exp Gerontol 38:159-66 (2003)
DOI:10.1016/S0531-5565(02)00157-2
Reference
PMID:11043573
  Authors
Durham PL, Russo AF
  Title
Differential regulation of mitogen-activated protein kinase-responsive genes by the duration of a calcium signal.
  Journal
Mol Endocrinol 14:1570-82 (2000)
DOI:10.1210/mend.14.10.0529
Reference
PMID:9542727
  Authors
Hagberg GB, Blomstrand F, Nilsson M, Tamir H, Hansson E
  Title
Stimulation of 5-HT2A receptors on astrocytes in primary culture opens voltage-independent Ca2+ channels.
  Journal
Neurochem Int 32:153-62 (1998)
DOI:10.1016/S0197-0186(97)00087-9
Reference
  Authors
Nestler EJ, Hyman SE, Malenka RC.
  Title
Molecular neuropharmacology: A foundation for clinical neuroscience
  Journal
The McGraw-Hill Companies, Inc. (2001)
Related
pathway
pvp00380  Tryptophan metabolism
pvp00590  Arachidonic acid metabolism
pvp04020  Calcium signaling pathway
pvp04721  Synaptic vesicle cycle
pvp04976  Bile secretion
KO pathway
ko04726   

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