KEGG   PATHWAY: pvp05146
Entry
pvp05146                    Pathway                                
Name
Amoebiasis - Pteropus vampyrus (large flying fox)
Description
Entamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis of amoebiasis begins with parasite attachment and disruption of the intestinal mucus layer, followed by apoptosis of host epithelial cells. Intestinal tissue destruction causes severe dysentery and ulcerations in amoebic colitis. Several amoebic proteins such as lectins, cysteine proteineases, and amoebapores are associated with the invasion process. The parasite can cause extraintestinal infection like amoebic liver abscess by evading immune response.
Class
Human Diseases; Infectious disease: parasitic
Pathway map
pvp05146  Amoebiasis
pvp05146

Disease
H00360  Amoebiasis
Organism
Pteropus vampyrus (large flying fox) [GN:pvp]
Gene
105288781  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
105288870  VCL; vinculin isoform X1 [KO:K05700]
105289063  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105289298  RAB5A; ras-related protein Rab-5A [KO:K07887]
105289568  COL3A1; collagen alpha-1(III) chain [KO:K19720]
105289903  IL12B; interleukin-12 subunit beta [KO:K05425]
105291123  FN1; fibronectin [KO:K05717]
105291132  ARG1; arginase-1 [KO:K01476] [EC:3.5.3.1]
105291179  LAMA2; laminin subunit alpha-2 [KO:K05637]
105291526  TLR2; toll-like receptor 2 [KO:K10159]
105291934  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
105292271  LAMA3; laminin subunit alpha-3 isoform X2 [KO:K06240]
105292339  CXCL8; interleukin-8 [KO:K10030]
105292342  [KO:K05505]
105292652  TLR4; toll-like receptor 4 [KO:K10160]
105292710  SERPINB10; serpin B10 [KO:K13963]
105292713  [KO:K13963]
105292827  LAMC1; laminin subunit gamma-1 isoform X1 [KO:K05635]
105292869  LAMC2; laminin subunit gamma-2 [KO:K06246]
105293029  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105293152  IL6; interleukin-6 isoform X2 [KO:K05405]
105293539  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
105294361  COL1A2; collagen alpha-2(I) chain [KO:K06236]
105294710  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105294764  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
105294766  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
105295219  LAMA4; laminin subunit alpha-4 [KO:K06241]
105295430  COL1A1; collagen alpha-1(I) chain [KO:K06236]
105296083  [KO:K04632]
105296119  [KO:K06237]
105296151  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
105296163  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
105296207  LAMA1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
105296605  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105297129  PRDX1; peroxiredoxin-1 [KO:K13279] [EC:1.11.1.24]
105297140  [KO:K02649]
105297702  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105297846  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
105297999  RELA; transcription factor p65 [KO:K04735]
105298571  C8G; complement component C8 gamma chain isoform X3 [KO:K03999]
105298668  LAMC3; laminin subunit gamma-3 [KO:K06247]
105298726  IL1R2; interleukin-1 receptor type 2 isoform X1 [KO:K04387]
105298727  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
105298737  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
105298945  C8A; complement component C8 alpha chain [KO:K03997]
105298995  C8B; complement component C8 beta chain [KO:K03998]
105299112  C9; complement component C9 [KO:K04000]
105299206  TGFB3; transforming growth factor beta-3 [KO:K13377]
105299371  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
105299444  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
105299697  HSPB1; heat shock protein beta-1 [KO:K04455]
105300184  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
105300311  [KO:K06244]
105300342  LAMB4; laminin subunit beta-4 [KO:K06245]
105300344  LAMB1; laminin subunit beta-1 [KO:K05636]
105300436  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
105300437  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
105300653  RAB7B; ras-related protein Rab-7b [KO:K07898]
105301262  IFNG; interferon gamma [KO:K04687]
105301330  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
105301331  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
105301444  LAMA5; laminin subunit alpha-5 [KO:K06240]
105302419  LAMB2; laminin subunit beta-2 [KO:K06243]
105302420  [KO:K06243]
105302451  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
105302452  [KO:K04634]
105302599  RAB5B; ras-related protein Rab-5B [KO:K07888]
105303028  ITGB2; integrin beta-2 [KO:K06464]
105303982  IL1B; interleukin-1 beta [KO:K04519]
105304501  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
105305325  TNF; tumor necrosis factor [KO:K03156]
105305876  IL12A; interleukin-12 subunit alpha [KO:K05406]
105305964  MUC2; mucin-2 [KO:K10955]
105306300  RAB5C; ras-related protein Rab-5C isoform X1 [KO:K07889]
105306348  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
105306878  [KO:K06448]
105306881  [KO:K06448]
105306974  CD14; monocyte differentiation antigen CD14 [KO:K04391]
105307215  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105307575  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105307748  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
105307945  TGFB1; transforming growth factor beta-1 [KO:K13375]
105308049  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
105308144  ARG2; arginase-2, mitochondrial isoform X1 [KO:K01476] [EC:3.5.3.1]
105308299  [KO:K08041] [EC:4.6.1.1]
105308501  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
105308818  [KO:K19662] [EC:2.7.11.13]
105308926  IL10; interleukin-10 [KO:K05443]
105308956  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
105309299  [KO:K06448]
105309300  [KO:K06448]
105309409  [KO:K01319] [EC:3.4.21.20]
105309413  [KO:K01319] [EC:3.4.21.20]
105309462  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105309539  SERPINB9; serpin B9 isoform X1 [KO:K13963]
105309691  RAB7A; ras-related protein Rab-7a [KO:K07897]
105311366  SERPINB6; serpin B6 [KO:K13963]
Compound
C00027  Hydrogen peroxide
C00062  L-Arginine
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C01074  N-Acetylgalactosamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01498  Gelatine
C02737  Phosphatidylserine
C18287  Monocyte locomotion inhibitory factor
Reference
PMID:11378035
  Authors
Stanley SL
  Title
Pathophysiology of amoebiasis.
  Journal
Trends Parasitol 17:280-5 (2001)
DOI:10.1016/S1471-4922(01)01903-1
Reference
PMID:10756002
  Authors
Espinosa-Cantellano M, Martinez-Palomo A
  Title
Pathogenesis of intestinal amebiasis: from molecules to disease.
  Journal
Clin Microbiol Rev 13:318-31 (2000)
DOI:10.1128/CMR.13.2.318-331.2000
Reference
PMID:9832261
  Authors
Huston CD, Petri WA Jr
  Title
Host-pathogen interaction in amebiasis and progress in vaccine development.
  Journal
Eur J Clin Microbiol Infect Dis 17:601-14 (1998)
DOI:10.1007/BF01708342
Reference
PMID:14700586
  Authors
Huston CD
  Title
Parasite and host contributions to the pathogenesis of amebic colitis.
  Journal
Trends Parasitol 20:23-6 (2004)
DOI:10.1016/j.pt.2003.10.013
Reference
PMID:15813717
  Authors
Campos-Rodriguezp R, Jarillo-Luna A
  Title
The pathogenicity of Entamoeba histolytica is related to the capacity of evading innate immunity.
  Journal
Parasite Immunol 27:1-8 (2005)
DOI:10.1111/j.1365-3024.2005.00743.x
Reference
PMID:19207103
  Authors
Lejeune M, Rybicka JM, Chadee K
  Title
Recent discoveries in the pathogenesis and immune response toward Entamoeba histolytica.
  Journal
Future Microbiol 4:105-18 (2009)
DOI:10.2217/17460913.4.1.105
Reference
PMID:17576362
  Authors
Carrero JC, Cervantes-Rebolledo C, Aguilar-Diaz H, Diaz-Gallardo MY, Laclette JP, Morales-Montor J
  Title
The role of the secretory immune response in the infection by Entamoeba histolytica.
  Journal
Parasite Immunol 29:331-8 (2007)
DOI:10.1111/j.1365-3024.2007.00955.x
Reference
PMID:12660071
  Authors
Stanley SL Jr
  Title
Amoebiasis.
  Journal
Lancet 361:1025-34 (2003)
DOI:10.1016/S0140-6736(03)12830-9
Reference
PMID:14502002
  Authors
Stauffer W, Ravdin JI
  Title
Entamoeba histolytica: an update.
  Journal
Curr Opin Infect Dis 16:479-85 (2003)
DOI:10.1097/01.qco.0000092821.42392.ca
Reference
PMID:12142490
  Authors
Petri WA Jr, Haque R, Mann BJ
  Title
The bittersweet interface of parasite and host: lectin-carbohydrate interactions during human invasion by the parasite Entamoeba histolytica.
  Journal
Annu Rev Microbiol 56:39-64 (2002)
DOI:10.1146/annurev.micro.56.012302.160959
Reference
PMID:18725798
  Authors
Baxt LA, Singh U
  Title
New insights into Entamoeba histolytica pathogenesis.
  Journal
Curr Opin Infect Dis 21:489-94 (2008)
DOI:10.1097/QCO.0b013e32830ce75f
Reference
PMID:12160867
  Authors
Petri WA Jr
  Title
Pathogenesis of amebiasis.
  Journal
Curr Opin Microbiol 5:443-7 (2002)
DOI:10.1016/S1369-5274(02)00335-1
Reference
PMID:17702556
  Authors
Guo X, Houpt E, Petri WA Jr
  Title
Crosstalk at the initial encounter: interplay between host defense and ameba survival strategies.
  Journal
Curr Opin Immunol 19:376-84 (2007)
DOI:10.1016/j.coi.2007.07.005
Reference
PMID:20303955
  Authors
Mortimer L, Chadee K
  Title
The immunopathogenesis of Entamoeba histolytica.
  Journal
Exp Parasitol 126:366-80 (2010)
DOI:10.1016/j.exppara.2010.03.005
Reference
PMID:16380324
  Authors
Meza I, Talamas-Rohana P, Vargas MA
  Title
The cytoskeleton of Entamoeba histolytica: structure, function, and regulation by signaling pathways.
  Journal
Arch Med Res 37:234-43 (2006)
DOI:10.1016/j.arcmed.2005.09.008
Reference
PMID:10637584
  Authors
Meza I
  Title
Extracellular matrix-induced signaling in Entamoeba histolytica: its role in invasiveness.
  Journal
Parasitol Today 16:23-8 (2000)
DOI:10.1016/S0169-4758(99)01586-0
Reference
PMID:11352795
  Authors
Stanley SL Jr, Reed SL
  Title
Microbes and microbial toxins: paradigms for microbial-mucosal interactions. VI. Entamoeba histolytica: parasite-host interactions.
  Journal
Am J Physiol Gastrointest Liver Physiol 280:G1049-54 (2001)
DOI:10.1152/ajpgi.2001.280.6.G1049
Reference
PMID:20145703
  Authors
Wong-Baeza I, Alcantara-Hernandez M, Mancilla-Herrera I, Ramirez-Saldivar I, Arriaga-Pizano L, Ferat-Osorio E, Lopez-Macias C, Isibasi A
  Title
The role of lipopeptidophosphoglycan in the immune response to Entamoeba histolytica.
  Journal
J Biomed Biotechnol 2010:254521 (2010)
DOI:10.1155/2010/254521
Related
pathway
pvp00330  Arginine and proline metabolism
pvp00590  Arachidonic acid metabolism
pvp04144  Endocytosis
pvp04210  Apoptosis
pvp04510  Focal adhesion
pvp04610  Complement and coagulation cascades
pvp04612  Antigen processing and presentation
pvp04620  Toll-like receptor signaling pathway
pvp04672  Intestinal immune network for IgA production
pvp04810  Regulation of actin cytoskeleton
KO pathway
ko05146   

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