KEGG   PATHWAY: rno00280
Entry
rno00280                    Pathway                                
Name
Valine, leucine and isoleucine degradation - Rattus norvegicus (rat)
Class
Metabolism; Amino acid metabolism
Pathway map
rno00280  Valine, leucine and isoleucine degradation
rno00280

Module
rno_M00036  Leucine degradation, leucine => acetoacetate + acetyl-CoA [PATH:rno00280]
rno_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:rno00280]
Other DBs
GO: 0006550 0006552 0006574
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
100360621  Il4i1; L-amino-acid oxidase isoform X1 [KO:K03334] [EC:1.4.3.2]
100361036  Oxct2a; uncharacterized protein LOC100361036 [KO:K01027] [EC:2.8.3.5]
113965  Hadh; hydroxyacyl-coenzyme A dehydrogenase, mitochondrial precursor [KO:K00022] [EC:1.1.1.35]
140547  Echs1; enoyl-CoA hydratase, mitochondrial precursor [KO:K07511] [EC:4.2.1.17]
170465  Acaa2; 3-ketoacyl-CoA thiolase, mitochondrial [KO:K07508] [EC:2.3.1.16]
170670  Hadha; trifunctional enzyme subunit alpha, mitochondrial precursor [KO:K07515] [EC:4.2.1.17 1.1.1.211]
171142  Ehhadh; peroxisomal bifunctional enzyme [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
171155  Hadhb; trifunctional enzyme subunit beta, mitochondrial precursor [KO:K07509] [EC:2.3.1.16]
24157  Acaa1a; 3-ketoacyl-CoA thiolase A, peroxisomal isoform 1 [KO:K07513] [EC:2.3.1.16]
24158  Acadm; medium-chain specific acyl-CoA dehydrogenase, mitochondrial precursor [KO:K00249] [EC:1.3.8.7]
24450  Hmgcs2; hydroxymethylglutaryl-CoA synthase, mitochondrial precursor [KO:K01641] [EC:2.3.3.10]
24513  Ivd; isovaleryl-CoA dehydrogenase, mitochondrial precursor [KO:K00253] [EC:1.3.8.4]
24624  Pccb; propionyl-CoA carboxylase beta chain, mitochondrial precursor [KO:K01966] [EC:6.4.1.3 2.1.3.15]
25014  Acat1; acetyl-CoA acetyltransferase, mitochondrial precursor [KO:K00626] [EC:2.3.1.9]
25244  Bckdha; 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial [KO:K00166] [EC:1.2.4.4]
25618  Acadsb; short/branched chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K09478] [EC:1.3.8.5]
287305  4930438A08Rikl; L-amino-acid oxidase [KO:K03334] [EC:1.4.3.2]
291450  Aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
293829  Mcee; methylmalonyl-CoA epimerase, mitochondrial [KO:K05606] [EC:5.1.99.1]
294972  Mccc1; methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial [KO:K01968] [EC:6.4.1.4]
29539  Aldh2; aldehyde dehydrogenase, mitochondrial precursor [KO:K00128] [EC:1.2.1.3]
29592  Bcat1; branched-chain-amino-acid aminotransferase, cytosolic isoform 1 [KO:K00826] [EC:2.6.1.42]
29611  Dbt; lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial [KO:K09699] [EC:2.3.1.168]
29637  Hmgcs1; hydroxymethylglutaryl-CoA synthase, cytoplasmic [KO:K01641] [EC:2.3.3.10]
29711  Bckdhb; 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial precursor [KO:K00167] [EC:1.2.4.4]
298079  Aldh1b1; aldehyde dehydrogenase X, mitochondrial precursor [KO:K00128] [EC:1.2.1.3]
298483  Lao1; L-amino acid oxidase 1 precursor [KO:K03334] [EC:1.4.3.2]
298942  Dld; dihydrolipoyl dehydrogenase, mitochondrial precursor [KO:K00382] [EC:1.8.1.4]
301384  Hibch; 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial isoform 2 [KO:K05605] [EC:3.1.2.4]
308100  Acat2; acetyl-CoA acetyltransferase, cytosolic [KO:K00626] [EC:2.3.1.9]
316421  Aox2; aldehyde oxidase 2 [KO:K00157] [EC:1.2.3.1]
316424  Aox4; aldehyde oxidase 4 [KO:K00157] [EC:1.2.3.1]
361215  Auh; methylglutaconyl-CoA hydratase, mitochondrial [KO:K05607] [EC:4.2.1.18]
361884  Mccc2; methylcrotonoyl-CoA carboxylase beta chain, mitochondrial [KO:K01969] [EC:6.4.1.4]
365096  Acat2l1; acetyl-CoA acetyltransferase, cytosolic-like isoform X1 [KO:K00626] [EC:2.3.1.9]
366463  Oxct2b; succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial precursor [KO:K01027] [EC:2.8.3.5]
367112  Hmgcll1; 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic [KO:K01640] [EC:4.1.3.4]
367196  Acad8; isobutyryl-CoA dehydrogenase, mitochondrial [KO:K11538] [EC:1.3.99.-]
493909  Aox3; aldehyde oxidase 3 [KO:K00157] [EC:1.2.3.1]
498962  Acsf3; malonate--CoA ligase ACSF3, mitochondrial isoform X2 [KO:K18660] [EC:6.2.1.76 6.2.1.-]
501072  Acaa1b; 3-ketoacyl-CoA thiolase B, peroxisomal precursor [KO:K07513] [EC:2.3.1.16]
54349  Aox1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
63864  Hsd17b10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
63938  Hibadh; 3-hydroxyisobutyrate dehydrogenase, mitochondrial precursor [KO:K00020] [EC:1.1.1.31]
64040  Aldh9a1; 4-trimethylaminobutyraldehyde dehydrogenase [KO:K00149] [EC:1.2.1.47 1.2.1.3]
64203  Bcat2; branched-chain-amino-acid aminotransferase, mitochondrial precursor [KO:K00826] [EC:2.6.1.42]
64304  Acads; short-chain specific acyl-CoA dehydrogenase, mitochondrial precursor [KO:K00248] [EC:1.3.8.1]
65183  Aldh3a2; aldehyde dehydrogenase family 3 member A2 [KO:K00128] [EC:1.2.1.3]
65984  Aacs; acetoacetyl-CoA synthetase [KO:K01907] [EC:6.2.1.16]
687008  Pcca; propionyl-CoA carboxylase alpha chain, mitochondrial [KO:K01965] [EC:6.4.1.3]
688517  Mmut; methylmalonyl-CoA mutase, mitochondrial [KO:K01847] [EC:5.4.99.2]
690163  Oxct1; succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial precursor [KO:K01027] [EC:2.8.3.5]
79238  Hmgcl; hydroxymethylglutaryl-CoA lyase, mitochondrial precursor [KO:K01640] [EC:4.1.3.4]
81632  Abat; 4-aminobutyrate aminotransferase, mitochondrial [KO:K13524] [EC:2.6.1.19 2.6.1.22]
81708  Aldh6a1; methylmalonate-semialdehyde/malonate- semialdehyde dehydrogenase [acylating], mitochondrial precursor [KO:K00140] [EC:1.2.1.18 1.2.1.27]
83784  Agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
Compound
C00024  Acetyl-CoA
C00068  Thiamin diphosphate
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00164  Acetoacetate
C00183  L-Valine
C00233  4-Methyl-2-oxopentanoate
C00332  Acetoacetyl-CoA
C00349  2-Methyl-3-oxopropanoate
C00356  (S)-3-Hydroxy-3-methylglutaryl-CoA
C00407  L-Isoleucine
C00630  2-Methylpropanoyl-CoA
C00671  (S)-3-Methyl-2-oxopentanoic acid
C00683  (S)-Methylmalonyl-CoA
C01205  (R)-3-Amino-2-methylpropanoate
C01213  (R)-Methylmalonyl-CoA
C02170  Methylmalonate
C02939  3-Methylbutanoyl-CoA
C03069  3-Methylcrotonyl-CoA
C03231  3-Methylglutaconyl-CoA
C03284  L-3-Aminoisobutanoate
C03344  2-Methylacetoacetyl-CoA
C03345  2-Methylbut-2-enoyl-CoA
C03460  2-Methylprop-2-enoyl-CoA
C04405  (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA
C05996  Branched chain fatty acid
C05998  3-Hydroxyisovaleryl-CoA
C06000  (S)-3-Hydroxyisobutyryl-CoA
C06001  (S)-3-Hydroxyisobutyrate
C06002  (S)-Methylmalonate semialdehyde
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C15974  3-Methyl-1-hydroxybutyl-ThPP
C15975  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine
C15976  2-Methyl-1-hydroxypropyl-ThPP
C15977  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine
C15978  2-Methyl-1-hydroxybutyl-ThPP
C15979  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine
C15980  (S)-2-Methylbutanoyl-CoA
C20827  3-Hydroxyisovalerate
Related
pathway
rno00020  Citrate cycle (TCA cycle)
rno00240  Pyrimidine metabolism
rno00290  Valine, leucine and isoleucine biosynthesis
rno00640  Propanoate metabolism
rno00900  Terpenoid backbone biosynthesis
KO pathway
ko00280   

DBGET integrated database retrieval system