KEGG   PATHWAY: schu04115
Entry
schu04115                   Pathway                                
Name
p53 signaling pathway - Siniperca chuatsi (mandarin fish)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
schu04115  p53 signaling pathway
schu04115

Organism
Siniperca chuatsi (mandarin fish) [GN:schu]
Gene
122861351  siva1; apoptosis regulatory protein Siva [KO:K22744]
122861455  [KO:K16857]
122861465  cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
122861629  atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
122861818  tp53i3; quinone oxidoreductase PIG3 isoform X1 [KO:K10133] [EC:1.-.-.-]
122861943  [KO:K04402]
122862664  [KO:K10808] [EC:1.17.4.1]
122862665  [KO:K10808] [EC:1.17.4.1]
122862792  sesn1; sestrin-1 isoform X1 [KO:K10141]
122862992  [KO:K02159]
122863142  thbs1b; thrombospondin-1 [KO:K16857]
122863866  rrm2b; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
122863907  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
122864018  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
122864667  [KO:K04596]
122864847  sesn2; sestrin-2 isoform X1 [KO:K20394]
122864976  ccne2; G1/S-specific cyclin-E2 [KO:K06626]
122865210  ccng2; cyclin-G2 [KO:K10146]
122865550  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
122865551  [KO:K04402]
122865611  [KO:K04722]
122865794  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
122866503  [KO:K02161]
122867151  [KO:K26543]
122867304  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
122867936  mdm4; protein Mdm4 isoform X1 [KO:K10127]
122868367  [KO:K02159]
122868680  rprml; reprimo-like protein [KO:K10128]
122868879  ccndx; cyclin Dx [KO:K10151]
122869351  cdk21; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
122870059  tp53; cellular tumor antigen p53 [KO:K04451]
122870527  serpine1; plasminogen activator inhibitor 1 isoform X1 [KO:K03982]
122871065  cdkn1d; cyclin-dependent kinase inhibitor 1D isoform X1 [KO:K06625]
122871227  ccne1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
122871393  [KO:K10151]
122871400  apaf1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
122871522  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
122871542  mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
122872360  [KO:K10142] [EC:1.16.1.-]
122873522  tsc2; tuberin isoform X1 [KO:K07207]
122873701  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
122874314  siah1; E3 ubiquitin-protein ligase Siah1 isoform X1 [KO:K04506] [EC:2.3.2.27]
122874557  cd82b; CD82 molecule b [KO:K06509]
122874664  gtse1; G2 and S phase-expressed protein 1 [KO:K10129]
122874759  ccnd2a; G1/S-specific cyclin-D2a isoform X1 [KO:K10151]
122874918  bida; BH3 interacting domain death agonist [KO:K04726]
122875207  [KO:K04503]
122875423  pidd1; p53-induced death domain-containing protein 1 isoform X1 [KO:K10130]
122875443  ddb2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
122875838  [KO:K10146]
122876018  chek2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
122876144  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
122876352  hdr; hematopoietic death receptor isoform X1 [KO:K04722]
122876431  zgc:153993; apoptosis regulator BAX [KO:K02159]
122876462  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
122876603  [KO:K06509]
122877074  rchy1; RING finger and CHY zinc finger domain-containing protein 1 isoform X1 [KO:K10144] [EC:2.3.2.27]
122877489  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
122877856  [KO:K04402]
122878185  zmat3; zinc finger matrin-type protein 3 isoform X1 [KO:K10137]
122878295  gorab; RAB6-interacting golgin [KO:K19748]
122878309  igfbp3; insulin-like growth factor-binding protein 3 [KO:K10138]
122878436  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
122878692  ppm1da; protein phosphatase, Mg2+/Mn2+ dependent, 1Da isoform X1 [KO:K10147] [EC:3.1.3.16]
122879039  [KO:K21770]
122879076  ppp1r13l; relA-associated inhibitor isoform X1 [KO:K27356]
122879777  [KO:K02187] [EC:3.4.22.56]
122879975  ccng1; cyclin-G1 [KO:K10145]
122880086  sesn4; sestrin-3 isoform X1 [KO:K10141]
122881068  si:ch73-139j3.4; tetraspanin-19 isoform X1 [KO:K06509]
122881921  adgrb1a; adhesion G protein-coupled receptor B1 isoform X1 [KO:K04596]
122881991  [KO:K21770]
122882773  tp73; tumor protein p73 isoform X1 [KO:K10148]
122882972  casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
122883132  znf385a; LOW QUALITY PROTEIN: zinc finger protein 385A [KO:K26543]
122883232  [KO:K10135]
122883257  bcl2l1; bcl-2-like protein 1 [KO:K04570]
122883752  igf3; insulin-like growth factor 3 [KO:K05459]
122883924  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
122884033  ptena; phosphatase and tensin homolog A [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
122884034  fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
122884042  [KO:K10136]
122884087  [KO:K08738]
122884088  [KO:K08738]
122884260  aifm2; apoptosis-inducing factor 2 isoform X1 [KO:K22745]
122884401  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
122885212  [KO:K08738]
122885554  rprma; protein reprimo A [KO:K10128]
122885921  casp10; caspase-8 [KO:K04398] [EC:3.4.22.61]
122886611  casp8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
122886613  [KO:K04398] [EC:3.4.22.61]
122887038  cop1; E3 ubiquitin-protein ligase COP1 [KO:K10143] [EC:2.3.2.27]
122887137  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
122887265  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a isoform X1 [KO:K04402]
122887336  [KO:K04570]
122887422  [KO:K10138]
122888418  [KO:K10147] [EC:3.1.3.16]
122888471  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
122888619  ei24; etoposide-induced protein 2.4 homolog isoform X1 [KO:K10134]
122888650  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
schu04110  Cell cycle
schu04210  Apoptosis
schu04218  Cellular senescence
KO pathway
ko04115   

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