KEGG   PATHWAY: schu04110
Entry
schu04110                   Pathway                                
Name
Cell cycle - Siniperca chuatsi (mandarin fish)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
schu04110  Cell cycle
schu04110

Other DBs
GO: 0000278
Organism
Siniperca chuatsi (mandarin fish) [GN:schu]
Gene
122861338  bub1bb; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
122861417  ywhaqb; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b [KO:K16197]
122861438  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
122861465  cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
122861536  orc3; origin recognition complex subunit 3 isoform X1 [KO:K02605]
122861543  ppp2r5eb; protein phosphatase 2, regulatory subunit B', epsilon isoform X1 [KO:K11584]
122861622  ppp2r5ca; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
122861629  atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
122861769  stag1a; cohesin subunit SA-1a isoform X1 [KO:K06671]
122861834  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
122861906  e2f2; transcription factor E2F2 isoform X1 [KO:K09389]
122861943  [KO:K04402]
122862259  smad3a; mothers against decapentaplegic homolog 3a isoform X1 [KO:K23605]
122862440  [KO:K06067] [EC:3.5.1.98]
122862706  esco2; N-acetyltransferase ESCO2 [KO:K11268] [EC:2.3.1.-]
122862912  [KO:K06067] [EC:3.5.1.98]
122863237  knl1; kinetochore scaffold 1 isoform X1 [KO:K11542]
122863261  [KO:K13377]
122863329  bub1; LOW QUALITY PROTEIN: mitotic checkpoint serine/threonine-protein kinase BUB1 [KO:K02178] [EC:2.7.11.1]
122863476  ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
122863644  ppp2r5cb; protein phosphatase 2, regulatory subunit B', gamma b isoform X1 [KO:K11584]
122863669  mcm3; DNA replication licensing factor MCM3 [KO:K02541] [EC:5.6.2.3]
122863799  [KO:K04501]
122863838  [KO:K06670]
122863907  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
122864018  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
122864119  [KO:K16197]
122864420  mcm2; DNA replication licensing factor MCM2 [KO:K02540] [EC:5.6.2.3]
122864819  e2f3; transcription factor E2F3 isoform X1 [KO:K06620]
122864823  sgo1; shugoshin 1 isoform X1 [KO:K11580]
122864976  ccne2; G1/S-specific cyclin-E2 [KO:K06626]
122865044  cdca5; sororin [KO:K17390]
122865060  [KO:K06067] [EC:3.5.1.98]
122865161  abl1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
122865389  skp2; S-phase kinase-associated protein 2 [KO:K03875]
122865465  smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
122865483  [KO:K06672]
122865489  smad4a; mothers against decapentaplegic homolog 4a [KO:K04501]
122865550  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
122865551  [KO:K04402]
122865794  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
122866111  cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
122866331  myca; transcriptional regulator Myc-A isoform X1 [KO:K04377]
122866431  [KO:K03347]
122866791  prkdc; DNA-dependent protein kinase catalytic subunit isoform X1 [KO:K06642] [EC:2.7.11.1]
122867184  dbf4b; uncharacterized protein dbf4b [KO:K06629]
122867223  espl1; separin isoform X1 [KO:K02365] [EC:3.4.22.49]
122867362  anapc16; anaphase-promoting complex subunit 16 [KO:K25229]
122867407  ep300a; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
122867556  waplb; wings apart-like protein homolog isoform X1 [KO:K25163]
122867837  bub3; mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
122868145  pkmyt1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
122868808  [KO:K04498] [EC:2.3.1.48]
122868879  ccndx; cyclin Dx [KO:K10151]
122868958  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
122868960  cdc27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
122869060  anapc2; LOW QUALITY PROTEIN: anaphase-promoting complex subunit 2 [KO:K03349]
122869351  cdk21; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
122869422  mcm5; DNA replication licensing factor MCM5 [KO:K02209] [EC:5.6.2.3]
122869593  ep300b; LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
122869654  mad2l1; mitotic spindle assembly checkpoint protein MAD2A isoform X1 [KO:K02537]
122869664  ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
122869943  rbl1; retinoblastoma-like protein 1 [KO:K04681]
122870059  tp53; cellular tumor antigen p53 [KO:K04451]
122870308  anapc10; anaphase-promoting complex subunit 10 [KO:K03357]
122870448  hdac8; histone deacetylase 8 isoform X1 [KO:K11405] [EC:3.5.1.98]
122870508  ccnb3; G2/mitotic-specific cyclin-B3 isoform X1 [KO:K21771]
122871065  cdkn1d; cyclin-dependent kinase inhibitor 1D isoform X1 [KO:K06625]
122871143  cdkn1ca; cyclin-dependent kinase inhibitor 1Ca [KO:K09993]
122871227  ccne1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
122871313  orc5; origin recognition complex subunit 5 isoform X1 [KO:K02607]
122871393  [KO:K10151]
122871542  mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
122872372  orc4; origin recognition complex subunit 4 [KO:K02606]
122872827  anapc11; anaphase-promoting complex subunit 11 [KO:K03358]
122872953  cdkn2a/b; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
122873157  cdc6; cell division control protein 6 homolog [KO:K02213]
122873285  mad1l1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
122873457  smc3; structural maintenance of chromosomes protein 3 isoform X1 [KO:K06669]
122873527  plk1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
122873541  cdkn2d; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
122873857  pds5a; sister chromatid cohesion protein PDS5 homolog A isoform X1 [KO:K11267]
122873931  crebbpa; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
122874341  anapc13; anaphase-promoting complex subunit 13 [KO:K12456]
122874402  rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
122874484  wee1; wee1-like protein kinase [KO:K06632] [EC:2.7.11.1]
122874495  smc1b; structural maintenance of chromosomes protein 1B [KO:K06636]
122874595  ticrr; treslin isoform X1 [KO:K26117]
122874759  ccnd2a; G1/S-specific cyclin-D2a isoform X1 [KO:K10151]
122874765  e2f4; transcription factor E2F4 isoform X1 [KO:K04682]
122874911  wee2; wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
122875137  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
122875207  [KO:K04503]
122875268  [KO:K09993]
122875381  cdkn1bb; cyclin-dependent kinase inhibitor 1Bb [KO:K06624]
122875495  ddx11; ATP-dependent DNA helicase DDX11 [KO:K11273] [EC:5.6.2.7]
122875678  cdc45; cell division control protein 45 homolog [KO:K06628]
122875861  nipbla; nipped-B-like protein A isoform X1 [KO:K06672]
122875862  ndc80; kinetochore protein NDC80 homolog [KO:K11547]
122875867  [KO:K03363]
122876018  chek2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
122876047  ccnh; cyclin-H isoform X1 [KO:K06634]
122876144  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
122876423  cdk7; cyclin-dependent kinase 7 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
122876462  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
122876532  pcna; proliferating cell nuclear antigen [KO:K04802]
122876541  anapc5; anaphase-promoting complex subunit 5 [KO:K03352]
122876696  [KO:K04501]
122876785  [KO:K04382] [EC:3.1.3.16]
122876895  cdc14b; dual specificity protein phosphatase CDC14B isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
122877049  anapc7; anaphase-promoting complex subunit 7 [KO:K03354]
122877070  [KO:K04500]
122877489  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
122877506  cdkn2c; cyclin-dependent kinase 4 inhibitor C isoform X1 [KO:K06622]
122877685  [KO:K11266]
122877701  orc1; origin recognition complex subunit 1 isoform X1 [KO:K02603]
122877737  cdc14ab; LOW QUALITY PROTEIN: dual specificity protein phosphatase CDC14AB [KO:K06639] [EC:3.1.3.16 3.1.3.48]
122877758  anapc4; anaphase-promoting complex subunit 4 [KO:K03351]
122877856  [KO:K04402]
122877968  [KO:K03364]
122878436  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
122878453  [KO:K21770]
122878708  ywhae1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 isoform X1 [KO:K06630]
122879039  [KO:K21770]
122879190  ywhag2; 14-3-3 protein gamma-B [KO:K16198]
122879195  anapc15; anaphase-promoting complex subunit 15 [KO:K25228]
122879475  [KO:K04682]
122879501  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
122879564  ppp2r1bb; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
122879916  atrx; transcriptional regulator ATRX isoform X1 [KO:K10779]
122879960  [KO:K04382] [EC:3.1.3.16]
122880110  pttg1; securin isoform X1 [KO:K06635]
122880230  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
122880440  [KO:K04681]
122880688  ccna2; cyclin-A2 [KO:K06627]
122880704  stag2b; cohesin subunit SA-2 [KO:K06671]
122880880  [KO:K06671]
122880883  mcm7; DNA replication licensing factor MCM7 isoform X1 [KO:K02210] [EC:5.6.2.3]
122880890  aurkb; aurora kinase B isoform X1 [KO:K11479] [EC:2.7.11.1]
122880976  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
122881238  [KO:K16197]
122881341  trip13; pachytene checkpoint protein 2 homolog [KO:K22399]
122881539  ttk; dual specificity protein kinase Ttk isoform X1 [KO:K08866] [EC:2.7.12.1]
122881561  [KO:K26116]
122881628  [KO:K06670]
122881867  [KO:K06620]
122881991  [KO:K21770]
122882213  dbf4; protein DBF4 homolog A [KO:K06629]
122882922  smc1a; structural maintenance of chromosomes protein 1A [KO:K06636]
122883188  rad21l1; double-strand-break repair protein rad21-like protein 1 isoform X1 [KO:K06670]
122883237  zbtb17; zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500]
122883339  [KO:K16197]
122883420  mad2l2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
122883769  e2f1; transcription factor E2F1 [KO:K17454]
122883905  cdt1; DNA replication factor Cdt1 isoform X1 [KO:K10727]
122883924  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
122884003  [KO:K26093]
122884112  ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
122884401  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
122884454  wapla; wings apart-like protein homolog [KO:K25163]
122884974  fbxo5; F-box only protein 5 [KO:K10292]
122884977  anapc1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
122885228  cdc16; cell division cycle protein 16 homolog [KO:K03353]
122885407  [KO:K04683]
122885418  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
122885719  si:ch211-269e2.1; cohesin subunit SA-2 isoform X1 [KO:K06671]
122886279  [KO:K03364]
122886360  mau2; MAU2 chromatid cohesion factor homolog [KO:K11266]
122886363  cdc20; cell division cycle protein 20 homolog [KO:K03363]
122886607  mcm6; DNA replication licensing factor MCM6 [KO:K02542] [EC:5.6.2.3]
122886608  orc2; origin recognition complex subunit 2 isoform X1 [KO:K02604]
122886971  [KO:K04377]
122887148  [KO:K06639] [EC:3.1.3.16 3.1.3.48]
122887265  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a isoform X1 [KO:K04402]
122887277  cdc7; cell division cycle 7-related protein kinase isoform X1 [KO:K02214] [EC:2.7.11.1]
122887374  mcm4; DNA replication licensing factor MCM4 [KO:K02212] [EC:5.6.2.3]
122887558  fzr1b; fizzy-related protein homolog isoform X1 [KO:K03364]
122887627  e2f5; transcription factor E2F5 isoform X1 [KO:K04682]
122887818  [KO:K06630]
122887906  cdc23; cell division cycle protein 23 homolog [KO:K03355]
122887922  ywhaba; 14-3-3 protein beta/alpha-A [KO:K16197]
122888120  pds5b; sister chromatid cohesion protein PDS5 homolog B [KO:K11267]
122888262  ywhag1; 14-3-3 protein gamma-1 [KO:K16198]
122888471  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
122888512  ppp2cab; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
122888513  skp1; S-phase kinase-associated protein 1 [KO:K03094]
122888640  ccna1; cyclin-A1 isoform X1 [KO:K06627]
122888650  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
122888664  [KO:K10779]
122888805  stag2a; cohesin subunit SA-2a isoform X1 [KO:K06671]
122888821  rb1; retinoblastoma-associated protein [KO:K06618]
Reference
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Oncogene 24:2899-908 (2005)
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Surfing the p53 network.
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Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.
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Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression.
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Mol Cell 24:101-13 (2006)
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Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.
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CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?
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The spindle-assembly checkpoint in space and time.
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Curr Biol 13:R104-14 (2003)
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Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.
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Annu Rev Genet 38:203-32 (2004)
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Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.
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Proc Natl Acad Sci U S A 95:6733-8 (1998)
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Reference
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  Title
Controlling the response to DNA damage by the APC/C-Cdh1.
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Qiao X, Zhang L, Gamper AM, Fujita T, Wan Y
  Title
APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.
  Journal
Cell Cycle 9:3904-12 (2010)
DOI:10.4161/cc.9.19.13585
Related
pathway
schu03030  DNA replication
schu04010  MAPK signaling pathway
schu04120  Ubiquitin mediated proteolysis
schu04210  Apoptosis
KO pathway
ko04110   

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