KEGG   PATHWAY: schu04218
Entry
schu04218                   Pathway                                
Name
Cellular senescence - Siniperca chuatsi (mandarin fish)
Description
Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of factors, such as telomere shortening, oncogene activation, irradiation, DNA damage and oxidative stress. It is characterized by enlarged flattened morphology, senescence-associated beta-galactosidase (SA-b-gal) activity, secretion of inflammatory cytokines, growth factors and matrix metalloproteinases, as part of the senescence-associated secretory phenotype (SASP). Cellular senescence is functionally associated with many biological processes including aging, tumor suppression, placental biology, embryonic development, and wound healing.
Class
Cellular Processes; Cell growth and death
Pathway map
schu04218  Cellular senescence
schu04218

Other DBs
GO: 0090398
Organism
Siniperca chuatsi (mandarin fish) [GN:schu]
Gene
122861346  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122861438  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
122861461  lin52; protein lin-52 homolog [KO:K21775]
122861465  cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
122861589  calm1a; calmodulin-1a [KO:K02183]
122861629  atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
122861757  [KO:K01367] [EC:3.4.22.52]
122861809  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
122861906  e2f2; transcription factor E2F2 isoform X1 [KO:K09389]
122861943  [KO:K04402]
122862044  [KO:K06269] [EC:3.1.3.16]
122862054  [KO:K21124]
122862259  smad3a; mothers against decapentaplegic homolog 3a isoform X1 [KO:K23605]
122862370  zfp36l1a; mRNA decay activator protein ZFP36L1a [KO:K18753]
122862797  foxo3b; forkhead box protein O3B [KO:K09408]
122862804  traf3ip2a; E3 ubiquitin ligase TRAF3IP2 [KO:K21124]
122862891  zfp36l1b; mRNA decay activator protein ZFP36L1b isoform X1 [KO:K18753]
122863128  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
122863261  [KO:K13377]
122863336  gata4; transcription factor GATA-4 [KO:K09183]
122863352  calm1b; calmodulin-1b [KO:K02183]
122863362  lin9; protein lin-9 homolog isoform X1 [KO:K21773]
122863654  mybl2b; v-myb avian myeloblastosis viral oncogene homolog-like 2b [KO:K21769]
122863717  [KO:K06269] [EC:3.1.3.16]
122863907  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
122863992  foxo6b; forkhead box protein O6b [KO:K09408]
122864018  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
122864162  rbbp4; histone-binding protein RBBP4 isoform X1 [KO:K10752]
122864240  [KO:K06751]
122864285  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
122864399  [KO:K06751]
122864401  [KO:K06751]
122864402  [KO:K06751]
122864418  [KO:K06751]
122864421  [KO:K06751]
122864473  [KO:K04388] [EC:2.7.11.30]
122864664  [KO:K05405]
122864698  [KO:K06751]
122864719  [KO:K06751]
122864819  e2f3; transcription factor E2F3 isoform X1 [KO:K06620]
122864976  ccne2; G1/S-specific cyclin-E2 [KO:K06626]
122865188  tsc1b; TSC complex subunit 1b isoform X1 [KO:K07206]
122865263  rad1; cell cycle checkpoint protein RAD1 [KO:K02830] [EC:3.1.11.2]
122865318  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1 [KO:K04348] [EC:3.1.3.16]
122865334  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
122865456  [KO:K07205]
122865465  smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
122865550  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
122865551  [KO:K04402]
122865794  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
122865894  lin54; protein lin-54 homolog [KO:K21776]
122866108  zgc:56235; voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15041]
122866331  myca; transcriptional regulator Myc-A isoform X1 [KO:K04377]
122866484  hus1; checkpoint protein HUS1 isoform X1 [KO:K10903]
122866506  [KO:K07208]
122866616  tgfbr1b; TGF-beta receptor type-1b isoform X1 [KO:K04674] [EC:2.7.11.30]
122867099  rhebl1; ras homolog, mTORC1 binding like 1 isoform X1 [KO:K07208]
122867304  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
122867463  [KO:K15040]
122867604  map2k6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
122867750  mapkapk2a; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
122867784  rassf5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
122867951  ppp1cab; protein phosphatase 1, catalytic subunit, alpha isozyme b [KO:K06269] [EC:3.1.3.16]
122868217  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
122868355  hipk1b; homeodomain-interacting protein kinase 1 isoform X1 [KO:K08826] [EC:2.7.11.1]
122868775  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
122868879  ccndx; cyclin Dx [KO:K10151]
122868911  [KO:K04433] [EC:2.7.12.2]
122869241  [KO:K04958]
122869351  cdk21; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
122869588  rras; ras-related protein R-Ras [KO:K07830]
122869590  hipk3b; homeodomain-interacting protein kinase 3 isoform X1 [KO:K08826] [EC:2.7.11.1]
122869720  capn1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
122869868  [KO:K04348] [EC:3.1.3.16]
122869943  rbl1; retinoblastoma-like protein 1 [KO:K04681]
122870059  tp53; cellular tumor antigen p53 [KO:K04451]
122870088  [KO:K00922] [EC:2.7.1.153]
122870413  cxcl19; C-X-C motif chemokine 19 [KO:K10030]
122870508  ccnb3; G2/mitotic-specific cyclin-B3 isoform X1 [KO:K21771]
122870527  serpine1; plasminogen activator inhibitor 1 isoform X1 [KO:K03982]
122870615  rela; transcription factor p65 isoform X1 [KO:K04735]
122870617  [KO:K06269] [EC:3.1.3.16]
122871065  cdkn1d; cyclin-dependent kinase inhibitor 1D isoform X1 [KO:K06625]
122871133  foxm1; forkhead box protein M1 isoform X1 [KO:K09406]
122871227  ccne1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
122871338  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
122871339  [KO:K04441] [EC:2.7.11.24]
122871393  [KO:K10151]
122871542  mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
122872723  [KO:K06751]
122872739  [KO:K07208]
122872848  capn8; calpain-8 isoform X1 [KO:K03853] [EC:3.4.22.53]
122872850  [KO:K03853] [EC:3.4.22.53]
122872851  [KO:K01367] [EC:3.4.22.52]
122872953  cdkn2a/b; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
122872977  slc25a4; ADP/ATP translocase 1 [KO:K05863]
122873103  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
122873144  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122873522  tsc2; tuberin isoform X1 [KO:K07207]
122873658  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
122873767  [KO:K10030]
122873955  calml4a; calmodulin-like protein 4a [KO:K02183]
122874243  hipk3a; homeodomain-interacting protein kinase 3a [KO:K08826] [EC:2.7.11.1]
122874303  mapk12a; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
122874402  rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
122874443  nfatc3b; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
122874568  calml4b; calmodulin-like protein 4 isoform X1 [KO:K02183]
122874759  ccnd2a; G1/S-specific cyclin-D2a isoform X1 [KO:K10151]
122874765  e2f4; transcription factor E2F4 isoform X1 [KO:K04682]
122874834  kras; GTPase KRas isoform X1 [KO:K07827]
122875107  [KO:K02833]
122875137  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
122875138  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
122875207  [KO:K04503]
122875289  tesmin; spexin prohormone 2 isoform X1 [KO:K21776]
122875314  hipk2; homeodomain-interacting protein kinase 2 isoform X1 [KO:K08826] [EC:2.7.11.1]
122875567  itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
122875695  vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
122876018  chek2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
122876093  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122876144  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
122876153  tsc1a; TSC complex subunit 1a [KO:K07206]
122876462  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
122876487  trpv4; transient receptor potential cation channel subfamily V member 4 [KO:K04973]
122876592  eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
122876770  [KO:K02649]
122877020  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1 [KO:K04348] [EC:3.1.3.16]
122877022  rras2; ras-related protein R-Ras2 [KO:K07830]
122877053  rad9b; cell cycle checkpoint control protein RAD9B isoform X1 [KO:K10995]
122877056  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
122877070  [KO:K04500]
122877320  traf3ip2l; E3 ubiquitin ligase TRAF3IP2 [KO:K21124]
122877476  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
122877489  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
122877580  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
122877856  [KO:K04402]
122878127  [KO:K02649]
122878181  [KO:K00922] [EC:2.7.1.153]
122878309  igfbp3; insulin-like growth factor-binding protein 3 [KO:K10138]
122878436  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
122878451  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122878453  [KO:K21770]
122878474  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
122878567  foxo1a; forkhead box protein O1-A [KO:K07201]
122878574  trpm7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
122878875  [KO:K18753]
122879039  [KO:K21770]
122879475  [KO:K04682]
122879483  zgc:114130; mRNA decay activator protein ZFP36 isoform X1 [KO:K18753]
122879501  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
122879603  ets1; protein C-ets-1 isoform X1 [KO:K02678]
122879636  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
122879689  mre11a; double-strand break repair protein MRE11 [KO:K10865]
122879818  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
122880046  fbxw11a; F-box and WD repeat domain-containing 11-A isoform X1 [KO:K03362]
122880172  rbb4l; histone-binding protein RBBP7 [KO:K10752]
122880178  sqstm1; sequestosome-1 isoform X1 [KO:K14381]
122880192  ppid; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
122880230  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
122880302  rad9a; cell cycle checkpoint control protein RAD9A isoform X1 [KO:K10994] [EC:3.1.11.2]
122880440  [KO:K04681]
122880599  slc25a5; ADP/ATP translocase 2 [KO:K05863]
122880688  ccna2; cyclin-A2 [KO:K06627]
122880708  nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
122880976  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
122881213  tgfbr2b; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
122881463  lin37; protein lin-37 homolog [KO:K21774]
122881863  [KO:K04446]
122881867  [KO:K06620]
122881991  [KO:K21770]
122882212  nbn; nibrin isoform X1 [KO:K10867]
122882679  zgc:171775; STKc_p38 domain-containing protein isoform X1 [KO:K04441] [EC:2.7.11.24]
122882690  hipk1a; homeodomain-interacting protein kinase 1 isoform X1 [KO:K08826] [EC:2.7.11.1]
122882704  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
122883134  nfatc2a; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
122883224  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
122883274  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
122883280  mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
122883345  mapkapk2b; MAP kinase-activated protein kinase 2b isoform X1 [KO:K04443] [EC:2.7.11.1]
122883528  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
122883572  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
122883769  e2f1; transcription factor E2F1 [KO:K17454]
122883924  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
122884012  [KO:K01367] [EC:3.4.22.52]
122884013  [KO:K03853] [EC:3.4.22.53]
122884033  ptena; phosphatase and tensin homolog A [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
122884142  [KO:K06268]
122884289  vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
122884401  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
122884608  zfp36l2; mRNA decay activator protein ZFP36L2 [KO:K18753]
122884853  [KO:K17332]
122884868  sirt1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
122884935  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122884948  mcu; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
122884956  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
122885136  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
122885265  mrasa; ras-related protein M-Ras [KO:K07831]
122885282  [KO:K02183]
122886281  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
122886563  rheb; GTP-binding protein Rheb isoform X1 [KO:K07208]
122886592  [KO:K00922] [EC:2.7.1.153]
122886971  [KO:K04377]
122887224  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
122887265  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a isoform X1 [KO:K04402]
122887422  [KO:K10138]
122887472  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
122887535  [KO:K02649]
122887627  e2f5; transcription factor E2F5 isoform X1 [KO:K04682]
122887900  si:dkey-251i10.1; ADP/ATP translocase 2 [KO:K05863]
122888423  [KO:K04456] [EC:2.7.11.1]
122888471  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
122888506  rad50; DNA repair protein RAD50 [KO:K10866] [EC:3.6.-.-]
122888510  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
122888640  ccna1; cyclin-A1 isoform X1 [KO:K06627]
122888650  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
122888786  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
122888821  rb1; retinoblastoma-associated protein [KO:K06618]
122888851  [KO:K07201]
122889002  [KO:K10752]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07909  Sirolimus
C16844  Hydroxyl radical
Reference
PMID:24954210
  Authors
Munoz-Espin D, Serrano M
  Title
Cellular senescence: from physiology to pathology.
  Journal
Nat Rev Mol Cell Biol 15:482-96 (2014)
DOI:10.1038/nrm3823
Reference
PMID:26646499
  Authors
Childs BG, Durik M, Baker DJ, van Deursen JM
  Title
Cellular senescence in aging and age-related disease: from mechanisms to therapy.
  Journal
Nat Med 21:1424-35 (2015)
DOI:10.1038/nm.4000
Reference
PMID:26105537
  Authors
Sharpless NE, Sherr CJ
  Title
Forging a signature of in vivo senescence.
  Journal
Nat Rev Cancer 15:397-408 (2015)
DOI:10.1038/nrc3960
Reference
PMID:26435346
  Authors
Fridlyanskaya I, Alekseenko L, Nikolsky N
  Title
Senescence as a general cellular response to stress: A mini-review.
  Journal
Exp Gerontol 72:124-8 (2015)
DOI:10.1016/j.exger.2015.09.021
Reference
PMID:27417123
  Authors
Lujambio A
  Title
To clear, or not to clear (senescent cells)? That is the question.
  Journal
Bioessays 38 Suppl 1:S56-64 (2016)
DOI:10.1002/bies.201670910
Reference
PMID:26564316
  Authors
Di Mitri D, Alimonti A
  Title
Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer.
  Journal
Trends Cell Biol 26:215-26 (2016)
DOI:10.1016/j.tcb.2015.10.005
Reference
PMID:27574725
  Authors
Francica P, Aebersold DM, Medova M
  Title
Senescence as biologic endpoint following pharmacological targeting of receptor tyrosine kinases in cancer.
  Journal
Biochem Pharmacol 126:1-12 (2017)
DOI:10.1016/j.bcp.2016.08.022
Reference
PMID:23982440
  Authors
Bartling B
  Title
Cellular senescence in normal and premature lung aging.
  Journal
Z Gerontol Geriatr 46:613-22 (2013)
DOI:10.1007/s00391-013-0543-3
Reference
PMID:24238962
  Authors
Munoz-Espin D, Canamero M, Maraver A, Gomez-Lopez G, Contreras J, Murillo-Cuesta S, Rodriguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M, Serrano M
  Title
Programmed cell senescence during mammalian embryonic development.
  Journal
Cell 155:1104-18 (2013)
DOI:10.1016/j.cell.2013.10.019
Reference
PMID:26697828
  Authors
Herranz N, Gallage S, Gil J
  Title
TORn about SASP regulation.
  Journal
Cell Cycle 14:3771-2 (2015)
DOI:10.1080/15384101.2015.1105694
Reference
PMID:28410770
  Authors
Martin N, Bernard D
  Title
Calcium signaling and cellular senescence.
  Journal
Cell Calcium S0143-4160(17)30049-0 (2017)
DOI:10.1016/j.ceca.2017.04.001
Reference
PMID:25764980
  Authors
Farfariello V, Iamshanova O, Germain E, Fliniaux I, Prevarskaya N
  Title
Calcium homeostasis in cancer: A focus on senescence.
  Journal
Biochim Biophys Acta 1853:1974-9 (2015)
DOI:10.1016/j.bbamcr.2015.03.005
Reference
PMID:24062309
  Authors
McCarthy DA, Clark RR, Bartling TR, Trebak M, Melendez JA
  Title
Redox control of the senescence regulator interleukin-1alpha and the secretory phenotype.
  Journal
J Biol Chem 288:32149-59 (2013)
DOI:10.1074/jbc.M113.493841
Reference
PMID:27288568
  Authors
Donninger H, Schmidt ML, Mezzanotte J, Barnoud T, Clark GJ
  Title
Ras signaling through RASSF proteins.
  Journal
Semin Cell Dev Biol 58:86-95 (2016)
DOI:10.1016/j.semcdb.2016.06.007
Reference
PMID:28455242
  Authors
Barnoud T, Schmidt ML, Donninger H, Clark GJ
  Title
The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence.
  Journal
Cancer Lett 400:30-36 (2017)
DOI:10.1016/j.canlet.2017.04.030
Reference
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Science 349:aaa5612 (2015)
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A New Pathway for Senescence Regulation.
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Aging Cell 13:773-9 (2014)
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SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.
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Related
pathway
schu04020  Calcium signaling pathway
schu04068  FoxO signaling pathway
schu04110  Cell cycle
schu04115  p53 signaling pathway
schu04150  mTOR signaling pathway
KO pathway
ko04218   

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