KEGG   PATHWAY: schu04210
Entry
schu04210                   Pathway                                
Name
Apoptosis - Siniperca chuatsi (mandarin fish)
Description
Apoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled by numerous interrelating processes. The 'extrinsic' pathway involves stimulation of members of the tumor necrosis factor (TNF) receptor subfamily, such as TNFRI, CD95/Fas or TRAILR (death receptors), located at the cell surface, by their specific ligands, such as TNF-alpha, FasL or TRAIL, respectively. The 'intrinsic' pathway is activated mainly by non-receptor stimuli, such as DNA damage, ER stress, metabolic stress, UV radiation or growth-factor deprivation. The central event in the 'intrinsic' pathway is the mitochondrial outer membrane permeabilization (MOMP), which leads to the release of cytochrome c. These two pathways converge at the level of effector caspases, such as caspase-3 and caspase-7. The third major pathway is initiated by the constituents of cytotoxic granules (e.g. Perforin and Granzyme B) that are released by CTLs (cytotoxic T-cells) and NK (natural killer) cells. Granzyme B, similarly to the caspases, cleaves its substrates after aspartic acid residues, suggesting that this protease has the ability to activate members of the caspase family directly. It is the balance between the pro-apoptotic and anti-apoptotic signals that eventually determines whether cells will undergo apoptosis, survive or proliferate. TNF family of ligands activates anti-apoptotic or cell-survival signals as well as apoptotic signals. NGF and Interleukin-3 promotes the survival, proliferation and differentiation of neurons or hematopoietic cells, respectively. Withdrawal of these growth factors leads to cell death, as described above.
Class
Cellular Processes; Cell growth and death
Pathway map
schu04210  Apoptosis
schu04210

Other DBs
GO: 0006915
Organism
Siniperca chuatsi (mandarin fish) [GN:schu]
Gene
122861346  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122861507  [KO:K08669] [EC:3.4.21.108]
122861600  eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
122861757  [KO:K01367] [EC:3.4.22.52]
122861809  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
122861907  ctsl.1; cathepsin L.1 [KO:K01365] [EC:3.4.22.15]
122861943  [KO:K04402]
122861996  [KO:K04721]
122862269  nfkbiab; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b [KO:K04734]
122862302  fosaa; proto-oncogene c-Fos isoform X1 [KO:K04379]
122862735  map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
122862755  fosab; v-fos FBJ murine osteosarcoma viral oncogene homolog Ab [KO:K04379]
122862756  si:ch211-153j24.3; proto-oncogene c-Fos [KO:K04379]
122862820  [KO:K07374]
122862992  [KO:K02159]
122863303  eif2s1b; eukaryotic translation initiation factor 2 subunit 1b [KO:K03237]
122863309  parp1; poly [ADP-ribose] polymerase 1 isoform X1 [KO:K24070]
122863348  nfkbiaa; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a [KO:K04734]
122863530  ctsbb; LOW QUALITY PROTEIN: cathepsin Bb [KO:K01363] [EC:3.4.22.1]
122864206  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
122864416  daxx; death domain-associated protein 6 isoform X1 [KO:K02308]
122864987  [KO:K01368] [EC:3.4.22.27]
122864988  [KO:K01371] [EC:3.4.22.38]
122864990  [KO:K12641]
122865138  [KO:K04397] [EC:3.4.22.60]
122865197  sptan1; spectrin alpha chain, non-erythrocytic 1 isoform X1 [KO:K06114]
122865199  traf2b; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
122865241  lmnb1; lamin-B1 [KO:K07611]
122865334  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
122865433  ptpn13; tyrosine-protein phosphatase non-receptor type 13 isoform X1 [KO:K02374]
122865510  [KO:K04397] [EC:3.4.22.60]
122865536  [KO:K03173] [EC:2.3.2.27]
122865550  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
122865551  [KO:K04402]
122865611  [KO:K04722]
122865666  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
122865896  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
122866149  [KO:K19901]
122866216  tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
122866503  [KO:K02161]
122867206  casp7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
122867420  ctsz; cathepsin Z [KO:K08568] [EC:3.4.18.1]
122867451  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
122867699  birc5a; baculoviral IAP repeat-containing protein 5a [KO:K08731]
122867963  [KO:K04466] [EC:2.7.11.25]
122868056  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
122868207  [KO:K04467] [EC:2.7.11.10]
122868362  map3k14a; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
122868367  [KO:K02159]
122868696  ctsba; cathepsin B isoform X1 [KO:K01363] [EC:3.4.22.1]
122868707  ern1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
122868779  [KO:K07818]
122868780  [KO:K07818]
122868986  prf1.3; perforin-1.3 [KO:K07818]
122869241  [KO:K04958]
122869670  badb; BCL2 associated agonist of cell death b [KO:K02158]
122869720  capn1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
122870059  tp53; cellular tumor antigen p53 [KO:K04451]
122870088  [KO:K00922] [EC:2.7.1.153]
122870615  rela; transcription factor p65 isoform X1 [KO:K04735]
122871400  apaf1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
122871634  atf4a; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
122871760  [KO:K07374]
122871820  [KO:K07374]
122871822  [KO:K07374]
122872438  [KO:K07818]
122872823  lmnl3; lamin L3 isoform X1 [KO:K07611]
122872848  capn8; calpain-8 isoform X1 [KO:K03853] [EC:3.4.22.53]
122872850  [KO:K03853] [EC:3.4.22.53]
122872851  [KO:K01367] [EC:3.4.22.52]
122873144  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122873225  [KO:K04396] [EC:3.4.22.59]
122873363  [KO:K07818]
122873364  [KO:K07818]
122873701  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
122874053  ern2; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
122874135  actb1; actin, cytoplasmic 1 isoform X1 [KO:K05692]
122874366  ctsh; pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
122874834  kras; GTPase KRas isoform X1 [KO:K07827]
122874918  bida; BH3 interacting domain death agonist [KO:K04726]
122875107  [KO:K02833]
122875138  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
122875423  pidd1; p53-induced death domain-containing protein 1 isoform X1 [KO:K10130]
122875567  itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
122875669  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
122875692  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
122875992  [KO:K19901]
122876028  endog; endonuclease G, mitochondrial [KO:K01173]
122876093  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122876100  ctsla; cathepsin La [KO:K01365] [EC:3.4.22.15]
122876112  prf1.5; perforin 1.5 isoform X1 [KO:K07818]
122876144  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
122876306  traf2a; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
122876352  hdr; hematopoietic death receptor isoform X1 [KO:K04722]
122876412  fadd; protein FADD [KO:K02373]
122876431  zgc:153993; apoptosis regulator BAX [KO:K02159]
122876586  ctsd; cathepsin D [KO:K01379] [EC:3.4.23.5]
122876770  [KO:K02649]
122876781  [KO:K05692]
122877172  cts12; procathepsin L isoform X1 [KO:K01365] [EC:3.4.22.15]
122877446  lmnb2; lamin-B2 isoform X1 [KO:K07611]
122877476  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
122877489  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
122877551  [KO:K01366] [EC:3.4.22.16]
122877580  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
122877856  [KO:K04402]
122877958  [KO:K01353] [EC:3.4.21.79]
122877959  [KO:K01353] [EC:3.4.21.79]
122877960  [KO:K01353] [EC:3.4.21.79]
122878127  [KO:K02649]
122878181  [KO:K00922] [EC:2.7.1.153]
122878277  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
122878280  jun; transcription factor AP-1 [KO:K04448]
122878436  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
122878451  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122878474  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
122878813  sept4b; septin 4b isoform X1 [KO:K16943]
122879046  [KO:K10522]
122879315  diabloa; diablo, IAP-binding mitochondrial protein a isoform X1 [KO:K10522]
122879444  ctsc; dipeptidyl peptidase 1 [KO:K01275] [EC:3.4.14.1]
122879777  [KO:K02187] [EC:3.4.22.56]
122879830  ctsf; cathepsin F [KO:K01373] [EC:3.4.22.41]
122879886  cd40lg; CD40 ligand [KO:K04389]
122880393  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
122880623  ctso; cathepsin O [KO:K01374] [EC:3.4.22.42]
122880699  [KO:K04725] [EC:2.3.2.27]
122880708  nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
122881515  ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
122881712  [KO:K12641]
122881813  si:ch211-1i11.3; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
122882040  casp2; caspase-2 isoform X1 [KO:K02186] [EC:3.4.22.55]
122882056  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
122882284  ctss2.1; cathepsin S, ortholog2, tandem duplicate 1 [KO:K01368] [EC:3.4.22.27]
122882285  ctsk; cathepsin K isoform X1 [KO:K01371] [EC:3.4.22.38]
122882287  mcl1b; induced myeloid leukemia cell differentiation protein Mcl-1b isoform X1 [KO:K02539]
122882429  ngfa; neurotrophin-7 [KO:K02582]
122882529  tuba1c; tubulin alpha-1C chain [KO:K07374]
122882530  tuba1a; LOW QUALITY PROTEIN: tubulin alpha-1A chain [KO:K07374]
122882531  [KO:K07374]
122882972  casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
122882978  dffb; DNA fragmentation factor subunit beta [KO:K02311] [EC:3.-.-.-]
122883037  birc5b; baculoviral IAP repeat-containing protein 5b [KO:K08731]
122883045  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
122883154  dffa; DNA fragmentation factor subunit alpha [KO:K02310]
122883224  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
122883257  bcl2l1; bcl-2-like protein 1 [KO:K04570]
122883572  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
122883627  tuba5; tubulin alpha 5 isoform X1 [KO:K07374]
122883693  [KO:K07374]
122883787  si:ch211-112c15.8; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
122883942  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
122884012  [KO:K01367] [EC:3.4.22.52]
122884013  [KO:K03853] [EC:3.4.22.53]
122884034  fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
122884087  [KO:K08738]
122884088  [KO:K08738]
122884174  bcl2l11; bcl-2-like protein 11 isoform X1 [KO:K16341]
122884588  [KO:K04467] [EC:2.7.11.10]
122884627  ngfb; nerve growth factor [KO:K02582]
122884935  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122885212  [KO:K08738]
122885376  [KO:K04724]
122885568  parp4; protein mono-ADP-ribosyltransferase PARP4 isoform X1 [KO:K10798] [EC:2.4.2.-]
122885571  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
122885921  casp10; caspase-8 [KO:K04398] [EC:3.4.22.61]
122886112  [KO:K01353] [EC:3.4.21.79]
122886126  [KO:K07374]
122886127  [KO:K07374]
122886128  [KO:K07374]
122886281  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
122886533  parp3; protein mono-ADP-ribosyltransferase PARP3 [KO:K10798] [EC:2.4.2.-]
122886592  [KO:K00922] [EC:2.7.1.153]
122886611  casp8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
122886613  [KO:K04398] [EC:3.4.22.61]
122887137  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
122887172  [KO:K08568] [EC:3.4.18.1]
122887224  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
122887265  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a isoform X1 [KO:K04402]
122887336  [KO:K04570]
122887413  ripk1l; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
122887478  parp2; poly [ADP-ribose] polymerase 2 [KO:K28005]
122887535  [KO:K02649]
122887568  [KO:K04448]
122887864  aifm1; apoptosis-inducing factor 1, mitochondrial isoform X1 [KO:K04727] [EC:1.-.-.-]
122888220  birc2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
122888423  [KO:K04456] [EC:2.7.11.1]
122888878  sept4a; septin 4a isoform X1 [KO:K16943]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00319  Sphingosine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:26615431
  Authors
Savitskaya MA, Onishchenko GE
  Title
Mechanisms of Apoptosis.
  Journal
Biochemistry (Mosc) 80:1393-417 (2015)
DOI:10.1134/S0006297915110012
Reference
PMID:23803157
  Authors
Schleich K, Lavrik IN
  Title
Mathematical modeling of apoptosis.
  Journal
Cell Commun Signal 11:44 (2013)
DOI:10.1186/1478-811X-11-44
Reference
PMID:15654015
  Authors
Lavrik I, Golks A, Krammer PH
  Title
Death receptor signaling.
  Journal
J Cell Sci 118:265-7 (2005)
DOI:10.1242/jcs.01610
Reference
PMID:15725726
  Authors
Jin Z, El-Deiry WS
  Title
Overview of cell death signaling pathways.
  Journal
Cancer Biol Ther 4:139-63 (2005)
DOI:10.4161/cbt.4.2.1508
Reference
PMID:15322527
  Authors
Benn SC, Woolf CJ
  Title
Adult neuron survival strategies--slamming on the brakes.
  Journal
Nat Rev Neurosci 5:686-700 (2004)
DOI:10.1038/nrn1477
Reference
PMID:12838338
  Authors
Orrenius S, Zhivotovsky B, Nicotera P
  Title
Regulation of cell death: the calcium-apoptosis link.
  Journal
Nat Rev Mol Cell Biol 4:552-65 (2003)
DOI:10.1038/nrm1150
Reference
PMID:19148180
  Authors
Clarke P, Tyler KL
  Title
Apoptosis in animal models of virus-induced disease.
  Journal
Nat Rev Microbiol 7:144-55 (2009)
DOI:10.1038/nrmicro2071
Reference
PMID:22429822
  Authors
Wen X, Lin ZQ, Liu B, Wei YQ
  Title
Caspase-mediated programmed cell death pathways as potential therapeutic targets in cancer.
  Journal
Cell Prolif 45:217-24 (2012)
DOI:10.1111/j.1365-2184.2012.00814.x
Reference
PMID:25526085
  Authors
Shalini S, Dorstyn L, Dawar S, Kumar S
  Title
Old, new and emerging functions of caspases.
  Journal
Cell Death Differ 22:526-39 (2015)
DOI:10.1038/cdd.2014.216
Reference
PMID:15601572
  Authors
Philchenkov A
  Title
Caspases: potential targets for regulating cell death.
  Journal
J Cell Mol Med 8:432-44 (2004)
DOI:10.1111/j.1582-4934.2004.tb00468.x
Reference
PMID:9894605
  Authors
Stroh C, Schulze-Osthoff K
  Title
Death by a thousand cuts: an ever increasing list of caspase substrates.
  Journal
Cell Death Differ 5:997-1000 (1998)
DOI:10.1038/sj.cdd.4400451
Reference
PMID:23070002
  Authors
Safa AR
  Title
c-FLIP, a master anti-apoptotic regulator.
  Journal
Exp Oncol 34:176-84 (2012)
Reference
PMID:18304445
  Authors
Jeong SY, Seol DW
  Title
The role of mitochondria in apoptosis.
  Journal
BMB Rep 41:11-22 (2008)
DOI:10.5483/bmbrep.2008.41.1.011
Reference
PMID:20533903
  Authors
Parsons MJ, Green DR
  Title
Mitochondria in cell death.
  Journal
Essays Biochem 47:99-114 (2010)
DOI:10.1042/bse0470099
Reference
PMID:15719025
  Authors
Strasser A
  Title
The role of BH3-only proteins in the immune system.
  Journal
Nat Rev Immunol 5:189-200 (2005)
DOI:10.1038/nri1568
Reference
PMID:24278747
  Authors
Schonthal AH
  Title
Endoplasmic reticulum stress: its role in disease and novel prospects for therapy.
  Journal
Scientifica (Cairo) 2012:857516 (2012)
DOI:10.6064/2012/857516
Reference
PMID:21145844
  Authors
Malhi H, Kaufman RJ
  Title
Endoplasmic reticulum stress in liver disease.
  Journal
J Hepatol 54:795-809 (2011)
DOI:10.1016/j.jhep.2010.11.005
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:16397578
  Authors
Wu J, Kaufman RJ
  Title
From acute ER stress to physiological roles of the Unfolded Protein Response.
  Journal
Cell Death Differ 13:374-84 (2006)
DOI:10.1038/sj.cdd.4401840
Reference
PMID:21914490
  Authors
Repnik U, Stoka V, Turk V, Turk B
  Title
Lysosomes and lysosomal cathepsins in cell death.
  Journal
Biochim Biophys Acta 1824:22-33 (2012)
DOI:10.1016/j.bbapap.2011.08.016
Reference
PMID:22465226
  Authors
Cesen MH, Pegan K, Spes A, Turk B
  Title
Lysosomal pathways to cell death and their therapeutic applications.
  Journal
Exp Cell Res 318:1245-51 (2012)
DOI:10.1016/j.yexcr.2012.03.005
Reference
PMID:26231733
  Authors
Dashzeveg N, Yoshida K
  Title
Cell death decision by p53 via control of the mitochondrial membrane.
  Journal
Cancer Lett 367:108-12 (2015)
DOI:10.1016/j.canlet.2015.07.019
Reference
PMID:22075987
  Authors
Bouchier-Hayes L, Green DR
  Title
Caspase-2: the orphan caspase.
  Journal
Cell Death Differ 19:51-7 (2012)
DOI:10.1038/cdd.2011.157
Reference
PMID:18238895
  Authors
Baptiste-Okoh N, Barsotti AM, Prives C
  Title
A role for caspase 2 and PIDD in the process of p53-mediated apoptosis.
  Journal
Proc Natl Acad Sci U S A 105:1937-42 (2008)
DOI:10.1073/pnas.0711800105
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:14737178
  Authors
Steelman LS, Pohnert SC, Shelton JG, Franklin RA, Bertrand FE, McCubrey JA.
  Title
JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis.
  Journal
Leukemia 18:189-218 (2004)
DOI:10.1038/sj.leu.2403241
Reference
PMID:9916983
  Authors
Dragovich T, Rudin CM, Thompson CB
  Title
Signal transduction pathways that regulate cell survival and cell death.
  Journal
Oncogene 17:3207-13 (1998)
DOI:10.1038/sj.onc.1202587
Reference
PMID:11520933
  Authors
Sofroniew MV, Howe CL, Mobley WC
  Title
Nerve growth factor signaling, neuroprotection, and neural repair.
  Journal
Annu Rev Neurosci 24:1217-81 (2001)
DOI:10.1146/annurev.neuro.24.1.1217
Reference
PMID:24769728
  Authors
Kristiansen M, Ham J
  Title
Programmed cell death during neuronal development: the sympathetic neuron model.
  Journal
Cell Death Differ 21:1025-35 (2014)
DOI:10.1038/cdd.2014.47
Reference
PMID:18208375
  Authors
Logue SE, Martin SJ
  Title
Caspase activation cascades in apoptosis.
  Journal
Biochem Soc Trans 36:1-9 (2008)
DOI:10.1042/BST0360001
Reference
PMID:19770840
  Authors
Boivin WA, Cooper DM, Hiebert PR, Granville DJ
  Title
Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma.
  Journal
Lab Invest 89:1195-220 (2009)
DOI:10.1038/labinvest.2009.91
Reference
PMID:20075940
  Authors
Cullen SP, Brunet M, Martin SJ
  Title
Granzymes in cancer and immunity.
  Journal
Cell Death Differ 17:616-23 (2010)
DOI:10.1038/cdd.2009.206
Reference
PMID:36652128
  Authors
Liu K, Lan D, Li C, Liu S, Dai X, Song T, Wang X, Kong Q, He Z, Tan J, Zhang J
  Title
A double-edged sword: role of apoptosis repressor with caspase recruitment domain (ARC) in tumorigenesis and ischaemia/reperfusion (I/R) injury.
  Journal
Apoptosis 28:313-325 (2023)
DOI:10.1007/s10495-022-01802-4
Related
pathway
schu04010  MAPK signaling pathway
schu04020  Calcium signaling pathway
schu04115  p53 signaling pathway
schu04141  Protein processing in endoplasmic reticulum
KO pathway
ko04210   

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