KEGG   PATHWAY: tup04971
Entry
tup04971                    Pathway                                
Name
Gastric acid secretion - Tupaia chinensis (Chinese tree shrew)
Description
Gastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections. The principal stimulants of acid secretion at the level of the parietal cell are histamine (paracrine), gastrin (hormonal), and acetycholine (ACh; neurocrine). Stimulation of acid secretion typically involves an initial elevation of intracellular calcium and cAMP, followed by activation of protein kinase cascades, which trigger the translocation of the proton pump, H+,K+-ATPase, from cytoplasmic tubulovesicles to the apical plasma membrane and thereby H+ secretion into the stomach lumen.
Class
Organismal Systems; Digestive system
Pathway map
tup04971  Gastric acid secretion
tup04971

Other DBs
GO: 0001696
Organism
Tupaia chinensis (Chinese tree shrew) [GN:tup]
Gene
102488209  CHRM3; cholinergic receptor muscarinic 3 [KO:K04131]
102483537  GAST; gastrin [KO:K13768]
102468133  CCKBR; cholecystokinin B receptor [KO:K04195]
102468263  GNAQ; G protein subunit alpha q [KO:K04634]
102477438  PLCB1; phospholipase C beta 1 [KO:K05858] [EC:3.1.4.11]
102476196  PLCB4; phospholipase C beta 4 [KO:K05858] [EC:3.1.4.11]
102472532  PLCB3; phospholipase C beta 3 [KO:K05858] [EC:3.1.4.11]
102492903  PLCB2; phospholipase C beta 2 [KO:K05858] [EC:3.1.4.11]
102495954  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
102469271  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
102497204  PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
102490073  EZR; ezrin [KO:K08007]
102479926  ACTB; actin beta [KO:K05692]
102498431  ACTG1; actin gamma 1 [KO:K05692]
102473622  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
102482868  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
102475587  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
102493041  CALM3; calmodulin 3 [KO:K02183]
102484707  neo-calmodulin-like [KO:K02183]
102479773  CALML5; calmodulin like 5 [KO:K02183]
102475973  CALML3; calmodulin-like protein 3 [KO:K02183]
102485493  calmodulin-like [KO:K02183]
102472462  CALM1; calmodulin 1 [KO:K02183]
102493190  CALM2; calmodulin 2 [KO:K02183]
102468681  CALML6; calmodulin like 6 [KO:K02183]
102495258  CALMODULIN; calmodulin-alpha [KO:K02183]
102483795  CALML4; calmodulin like 4 [KO:K02183]
102494625  CAMK2A; calcium/calmodulin dependent protein kinase II alpha [KO:K04515] [EC:2.7.11.17]
102482912  CAMK2D; calcium/calmodulin dependent protein kinase II delta [KO:K04515] [EC:2.7.11.17]
102472689  CAMK2B; calcium/calmodulin dependent protein kinase II beta [KO:K04515] [EC:2.7.11.17]
102503259  CAMK2G; calcium/calmodulin dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17]
102498032  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
102476504  MYLK; myosin light chain kinase [KO:K00907] [EC:2.7.11.18]
102489117  MYLK2; myosin light chain kinase 2 [KO:K00907] [EC:2.7.11.18]
102468205  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
102479367  HRH2; histamine receptor H2 [KO:K04150]
102489563  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas [KO:K04632]
102501321  neuroendocrine secretory protein 55 [KO:K04632]
102468873  ADCY1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1]
102492353  ADCY2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1]
102477532  ADCY3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
102490273  ADCY4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
102490639  ADCY5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
102468478  ADCY6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1]
102496578  ADCY7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
102472317  ADCY8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
102477344  ADCY9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
102494418  SST; somatostatin [KO:K05237]
102482463  SSTR2; somatostatin receptor 2 [KO:K04218]
102476737  GNAI3; G protein subunit alpha i3 [KO:K04630]
102479323  GNAI1; G protein subunit alpha i1 [KO:K04630]
102475420  GNAI2; G protein subunit alpha i2 [KO:K04630]
102502506  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
102478525  PRKACA; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102480463  ATP4A; ATPase H+/K+ transporting alpha subunit [KO:K01542] [EC:7.2.2.19]
102472050  ATP4B; ATPase H+/K+ transporting beta subunit [KO:K01543] [EC:7.2.2.19]
102491324  KCNE2; potassium voltage-gated channel subfamily E regulatory subunit 2 [KO:K04896]
102500494  KCNQ1; potassium voltage-gated channel subfamily Q member 1 [KO:K04926]
102483086  KCNJ1; potassium voltage-gated channel subfamily J member 1 [KO:K04995]
102498964  KCNJ2; potassium voltage-gated channel subfamily J member 2 [KO:K04996]
102485474  KCNJ10; potassium voltage-gated channel subfamily J member 10 [KO:K05003]
102478270  KCNJ15; potassium voltage-gated channel subfamily J member 15 [KO:K05008]
102499393  KCNJ16; potassium voltage-gated channel subfamily J member 16 [KO:K05009]
102490714  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
102488856  KCNK2; potassium two pore domain channel subfamily K member 2 [KO:K04913]
102482882  KCNK10; potassium two pore domain channel subfamily K member 10 [KO:K04920]
102475448  ATP1A3; ATPase Na+/K+ transporting subunit alpha 3 [KO:K01539] [EC:7.2.2.13]
102483255  ATP1A2; sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
102483994  ATP1A1; ATPase Na+/K+ transporting subunit alpha 1 [KO:K01539] [EC:7.2.2.13]
102481090  ATP1B1; ATPase Na+/K+ transporting subunit beta 1 [KO:K01540]
102467892  ATP1B2; ATPase Na+/K+ transporting subunit beta 2 [KO:K01540]
102486693  ATP1B3; ATPase Na+/K+ transporting subunit beta 3 [KO:K01540]
102493344  sodium/potassium-transporting ATPase subunit beta-3-like [KO:K01540]
102474656  ATP1B4; ATPase Na+/K+ transporting family member beta 4 [KO:K01540]
102501147  SLC9A1; solute carrier family 9 member A1 [KO:K05742]
102493946  SLC9A4; solute carrier family 9 member A4 [KO:K13961]
102489985  CA2; carbonic anhydrase 2 [KO:K18245] [EC:4.2.1.1]
102484123  SLC26A7; solute carrier family 26 member 7 [KO:K13962]
102497672  SLC4A2; solute carrier family 4 member 2 [KO:K13855]
Compound
C00001  H2O
C00011  CO2
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00238  Potassium cation
C00288  HCO3-
C00388  Histamine
C00575  3',5'-Cyclic AMP
C00698  Cl-
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01353  Carbonic acid
C01996  Acetylcholine
Reference
PMID:18474247
  Authors
Schubert ML, Peura DA
  Title
Control of gastric acid secretion in health and disease.
  Journal
Gastroenterology 134:1842-60 (2008)
DOI:10.1053/j.gastro.2008.05.021
Reference
PMID:9307437
  Authors
Urushidani T, Forte JG
  Title
Signal transduction and activation of acid secretion in the parietal cell.
  Journal
J Membr Biol 159:99-111 (1997)
DOI:10.1007/s002329900274
Reference
PMID:12500969
  Authors
Yao X, Forte JG
  Title
Cell biology of acid secretion by the parietal cell.
  Journal
Annu Rev Physiol 65:103-31 (2003)
DOI:10.1146/annurev.physiol.65.072302.114200
Reference
PMID:17928547
  Authors
Heitzmann D, Warth R
  Title
No potassium, no acid: K+ channels and gastric acid secretion.
  Journal
Physiology (Bethesda) 22:335-41 (2007)
DOI:10.1152/physiol.00016.2007
Reference
PMID:19889964
  Authors
Kopic S, Murek M, Geibel JP
  Title
Revisiting the parietal cell.
  Journal
Am J Physiol Cell Physiol 298:C1-C10 (2010)
DOI:10.1152/ajpcell.00478.2009
Reference
PMID:15703676
  Authors
Schubert ML
  Title
Gastric secretion.
  Journal
Curr Opin Gastroenterol 20:519-25 (2004)
DOI:10.1097/00001574-200411000-00003
Reference
PMID:16391411
  Authors
Konturek SJ, Konturek PC, Brzozowski T, Konturek JW, Pawlik WW
  Title
From nerves and hormones to bacteria in the stomach; Nobel prize for achievements in gastrology during last century.
  Journal
J Physiol Pharmacol 56:507-30 (2005)
Reference
PMID:20148676
  Authors
Forte JG, Zhu L
  Title
Apical recycling of the gastric parietal cell H,K-ATPase.
  Journal
Annu Rev Physiol 72:273-96 (2010)
DOI:10.1146/annurev-physiol-021909-135744
Reference
PMID:18061403
  Authors
Szaszak M, Christian F, Rosenthal W, Klussmann E
  Title
Compartmentalized cAMP signalling in regulated exocytic processes in non-neuronal cells.
  Journal
Cell Signal 20:590-601 (2008)
DOI:10.1016/j.cellsig.2007.10.020
Reference
PMID:18626068
  Authors
Heitzmann D, Warth R
  Title
Physiology and pathophysiology of potassium channels in gastrointestinal epithelia.
  Journal
Physiol Rev 88:1119-82 (2008)
DOI:10.1152/physrev.00020.2007
Reference
PMID:15579540
  Authors
Heitzmann D, Grahammer F, von Hahn T, Schmitt-Graff A, Romeo E, Nitschke R, Gerlach U, Lang HJ, Verrey F, Barhanin J, Warth R
  Title
Heteromeric KCNE2/KCNQ1 potassium channels in the luminal membrane of gastric parietal cells.
  Journal
J Physiol 561:547-57 (2004)
DOI:10.1113/jphysiol.2004.075168
Reference
PMID:20331540
  Authors
Seidler U, Song P, Xiao F, Riederer B, Bachmann O, Chen M
  Title
Recent advances in the molecular and functional characterization of acid/base and electrolyte transporters in the basolateral membranes of gastric and duodenal epithelial cells.
  Journal
Acta Physiol (Oxf) 201:3-20 (2011)
DOI:10.1111/j.1748-1716.2010.02107.x
Related
pathway
tup04020  Calcium signaling pathway
tup04530  Tight junction
tup04974  Protein digestion and absorption
KO pathway
ko04971   
LinkDB

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