KEGG   PATHWAY: uar04530
Entry
uar04530                    Pathway                                
Name
Tight junction - Ursus americanus (American black bear)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
uar04530  Tight junction
uar04530

Other DBs
GO: 0005923
Organism
Ursus americanus (American black bear) [GN:uar]
Gene
123775438  AFDN; afadin isoform X1 [KO:K05702]
123775866  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
123775936  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
123776549  TJP2; tight junction protein ZO-2 isoform X1 [KO:K06098]
123777257  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
123777282  CLDN15; claudin-15 isoform X1 [KO:K06087]
123777322  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
123777464  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
123777533  ARHGEF18; rho guanine nucleotide exchange factor 18 isoform X1 [KO:K21066]
123777544  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
123777771  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
123777926  ACTG1; actin, cytoplasmic 2 [KO:K05692]
123777967  MYH14; LOW QUALITY PROTEIN: myosin-14 [KO:K10352]
123777991  [KO:K03456]
123778141  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
123778390  CTTN; src substrate cortactin isoform X1 [KO:K06106]
123778441  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
123778572  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
123778591  MYH11; myosin-11 isoform X1 [KO:K10352]
123778728  SYMPK; symplekin [KO:K06100]
123778832  ARHGAP17; rho GTPase-activating protein 17 isoform X1 [KO:K20638]
123778881  AMOT; angiomotin isoform X1 [KO:K16819]
123779010  CRB3; protein crumbs homolog 3 [KO:K06090]
123779111  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
123779195  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
123779251  [KO:K07839]
123779329  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
123779417  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
123779439  [KO:K07374]
123779467  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
123779529  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
123779758  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
123779934  RAB8A; LOW QUALITY PROTEIN: ras-related protein Rab-8A [KO:K07901]
123780073  RHOA; transforming protein RhoA [KO:K04513]
123780362  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
123780894  MYH9; myosin-9 [KO:K10352]
123780995  EPB41L4B; band 4.1-like protein 4B isoform X1 [KO:K21111]
123781003  MPDZ; multiple PDZ domain protein isoform X1 [KO:K06095]
123781569  YBX3; Y-box-binding protein 3 isoform X1 [KO:K06099]
123782001  [KO:K12757]
123782002  [KO:K12757]
123782085  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
123782153  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
123783272  [KO:K06448]
123783326  [KO:K06448]
123783349  [KO:K06448]
123783387  ARHGEF2; rho guanine nucleotide exchange factor 2 isoform X1 [KO:K12791]
123783500  [KO:K06448]
123783516  F11R; LOW QUALITY PROTEIN: junctional adhesion molecule A [KO:K06089]
123783571  [KO:K06448]
123783615  [KO:K06448]
123783616  [KO:K06448]
123783617  [KO:K06448]
123783618  [KO:K06448]
123783620  [KO:K06448]
123783635  CD1D; antigen-presenting glycoprotein CD1d [KO:K06448]
123783649  CLDN9; LOW QUALITY PROTEIN: claudin-9 [KO:K06087]
123783655  RAB13; ras-related protein Rab-13 isoform X1 [KO:K06109]
123783702  [KO:K06448]
123783720  CLDN6; claudin-6 [KO:K06087]
123784168  JAM2; junctional adhesion molecule B isoform X1 [KO:K06735]
123784191  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
123784224  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
123784360  CLDN17; claudin-17 [KO:K06087]
123784361  CLDN8; claudin-8 [KO:K06087]
123784522  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
123784534  [KO:K06087]
123784555  [KO:K06087]
123784736  CLDN4; claudin-4 [KO:K06087]
123784782  CLDN3; claudin-3 [KO:K06087]
123784872  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
123784876  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
123785508  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
123785632  CLDN2; claudin-2 [KO:K06087]
123785735  [KO:K07374]
123785895  PRKCE; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
123786000  ACTR2; actin-related protein 2 [KO:K17260]
123786026  CGNL1; cingulin-like protein 1 isoform X1 [KO:K21110]
123786380  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
123786382  CLDN11; claudin-11 [KO:K06087]
123787201  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
123787258  MYL6B; myosin light chain 6B isoform X1 [KO:K12751]
123787259  MYL6; myosin light polypeptide 6 isoform X1 [KO:K12751]
123787421  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
123787508  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
123787706  CGN; cingulin isoform X1 [KO:K06102]
123787832  JAM3; junctional adhesion molecule C [KO:K06785]
123787856  AMOTL1; angiomotin-like protein 1 isoform X1 [KO:K06104]
123787970  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
123787979  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
123788054  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
123788150  NF2; merlin isoform X1 [KO:K16684]
123788293  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
123788395  AMOTL2; angiomotin-like protein 2 isoform X1 [KO:K06104]
123788486  CLDN18; claudin-18 isoform X1 [KO:K06087]
123788750  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
123788759  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
123789030  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
123789308  CLDN12; claudin-12 [KO:K06087]
123790179  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
123790190  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
123790348  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
123790354  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
123790378  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
123790496  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
123790774  TJP1; tight junction protein ZO-1 isoform X1 [KO:K05701]
123790892  WAS; LOW QUALITY PROTEIN: wiskott-Aldrich syndrome protein [KO:K05747]
123791277  MSN; moesin [KO:K05763]
123791289  RAP2C; ras-related protein Rap-2c isoform X1 [KO:K07839]
123792097  MYH10; myosin-10 isoform X1 [KO:K10352]
123792165  CLDN7; claudin-7 [KO:K06087]
123792368  CLDN25; putative claudin-25 [KO:K06087]
123792543  RDX; radixin isoform X1 [KO:K05762]
123792556  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
123793179  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
123793541  GATA4; transcription factor GATA-4 isoform X1 [KO:K09183]
123793818  CLDN19; claudin-19 isoform X1 [KO:K06087]
123794034  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
123794771  TJAP1; tight junction-associated protein 1 [KO:K06105]
123794780  [KO:K07374]
123794781  TUBA1C; tubulin alpha-1C chain [KO:K07374]
123794782  [KO:K07374]
123794785  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
123795072  RAP1A; ras-related protein Rap-1A [KO:K04353]
123795272  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
123795367  PATJ; inaD-like protein isoform X1 [KO:K06092]
123795376  JUN; transcription factor AP-1 [KO:K04448]
123795384  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
123795654  [KO:K07374]
123796122  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
123796581  ACTR3; actin-related protein 3 [KO:K18584]
123796828  TJP3; tight junction protein ZO-3 [KO:K06097]
123796948  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
123796968  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
123797478  CLDN20; claudin-20 [KO:K06087]
123797494  EZR; ezrin isoform X1 [KO:K08007]
123798320  MPP4; MAGUK p55 subfamily member 4 [KO:K21109]
123798526  BVES; blood vessel epicardial substance isoform X1 [KO:K21108]
123798762  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
123799050  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
123799193  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
123799561  PCNA; proliferating cell nuclear antigen [KO:K04802]
123799614  [KO:K06274]
123800039  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
123800219  OCLN; occludin [KO:K06088]
123800237  MARVELD2; MARVEL domain-containing protein 2 [KO:K17291]
123800287  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
123800551  MARVELD3; MARVEL domain-containing protein 3 isoform X1 [KO:K21099]
123800685  PALS1; protein PALS1 isoform X1 [KO:K06091]
123800778  RAB8B; ras-related protein Rab-8B [KO:K07902]
123800905  CLDN23; claudin-23 [KO:K06087]
123801115  CLDN10; claudin-10 isoform X1 [KO:K06087]
123801274  CLDN16; LOW QUALITY PROTEIN: claudin-16 [KO:K06087]
123801286  CLDN1; claudin-1 [KO:K06087]
123801405  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
123801768  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
123802097  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
123802190  HCLS1; hematopoietic lineage cell-specific protein isoform X1 [KO:K06106]
123802293  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
123802360  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
123802532  ACTB; actin, cytoplasmic 1 [KO:K05692]
123802552  MICALL2; MICAL-like protein 2 isoform X1 [KO:K21068]
123802589  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
123802642  IGSF5; immunoglobulin superfamily member 5 isoform X1 [KO:K06786]
123802659  CLDN14; claudin-14 [KO:K06087]
123802696  [KO:K06099]
123802697  [KO:K06099]
123802720  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
123802782  CLDN34; claudin-34 [KO:K06087]
123802926  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
123803163  [KO:K04393]
123803201  LLGL2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
123803353  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
123803467  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
123803591  [KO:K07374]
123803601  CLDN5; LOW QUALITY PROTEIN: claudin-5 [KO:K06087]
123803648  SYNPO; synaptopodin isoform X1 [KO:K21112]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
uar04520  Adherens junction
uar04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

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