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Viral entry protein - human receptor protein interactions

Type Virus Taxid Genome Entry protein (KO) Human receptor PMID
dsDNA-RT HBV 10407 T40004 S (K23128) → HSPG2, (SLC10A1+EGFR) 26776362 26239691 30952782
ssRNA-RT HTLV-1 11908 T40003 gp46 (K24862) → SLC2A1, NRP1 21994754
HTLV-2 11909 gp46 (K24862) 14622599 16809290
HIV-1 11676 T40001 gp120 (K24266) → CD4, CCR5, CXCR4, CD209, CLEC4M 23806647 12960231 10721995 11226297
HIV-2 11709 T40002 gp120 (K24266) → CD4, CCR5, CXCR4, CLEC4M 12029140 11226297
dsRNA Rotavirus A 28875 T40092 VP4 (K19249) → (ITGA2+ITGB1) 9144247
VP7 (K24596) → (ITGAX+ITGB2), (ITGA4+ITGB1), (ITGAV+ITGB3) 15165605 9144247 11114176
Rotavirus C 36427 T40094 VP4 (K19249) → (ITGA2+ITGB1), (ITGA4+ITGB1), HSPA8 15165605 9144247 10590110 12805424
+ssRNA SARS-CoV-2 2697049 T40361 S (K24152) → ACE2, CD209, CLEC4M 32142651 32607506
SARS-CoV 227984 T40069 S (K24152) → ACE2, CD209, CLEC4M 14647384 15140961 15496474 17243893
MERS-CoV 1335626 T40090 S (K24324) → DPP4 23486063
HCoV-229E 11137 T40364 S (K19254) → ANPEP 12551991 1350662
HCoV-NL63 277944 T40365 S (K19254) → ACE2 15897467
Human poliovirus 1/2/3 138950 T40344 T40345 T40346 VP1 (K25127) +VP2+VP3 → PVR 25631086 12663789
Enterovirus A71 138948 T40343 VP1 (K25127) +VP2 → SCARB2 31924205
VP1 (K25127) → SELPLG, ANXA2, NCL, VIM, FN1 19543284 29467312 31924205
Coxsackievirus A16 138948 T40331 VP2 → SCARB2 22438546 31924205
Coxsackievirus A24 138950 T40332 VP1 (K25127) +VP2+VP3 → ICAM1 29284752
Coxsackievirus B3 12072 VP1+VP2 → CD55 31104841 35046043
Human parechovirus 1 12063 VP1 → (ITGAV+ITGB3), (ITGAV+ITGB1) 10846065
DENV 1-4 11053 11060 11069 11070 T40048 T40373 T40374 T40375 E (K25003) → CD209, MRC1, CLEC4M 22500135 18266465 12682107
DENV-2 11060 T40373 E (K25003) → (HSPA1+HSP90AB1), HSPA5 15795242 22500135 15098107
DENV 1-3 11053 11060 11069 T40048 T40373 T40374 E (K25003) → RPSA 15790424 22500135
JEV 11072 T40052 E (K25003) → HSPA1, PLVAP, CD209, CLEC4M 19068261 30082709 26629951 24623090
TBEV 11084 T40061 E (K25003) → RPSA, (ITGAV+ITGB3) 19961413 25319621
WNV 11082 T40029 E (K25003) → RPSA, (ITGAV+ITGB3), CLEC4M 18061925 20618137 16415006
ZIKV 64320 T40049 E (K25003) → HAVCR1, CD209, TYRO3 32641828 26085147
HCV 11103 T40066 E2 (K22272) → SCARB1, CD81, CLDN1, OCLN 24520529 23836234 29971069
CHIKV 37124 T40026 E2 (K25126) → MXRA8, PHB1 29769725
E1 (K25804) + E2 (K25126) → HAVCR1 33091085
EEEV 11021 T40054 E1 (K25804) + E2 (K25126) → HAVCR1 33091085 23555248
VEEV 11036 T40028 E2 (K25126) → RPSA 19961413
RRV 11029 T40071 E1 (K25804) + E2 (K25126) → HAVCR1 33091085
Sindbis virus 11034 T40377 E2 (K25126) → SLC11A2, CD209, CLEC4M 21843867 14581539
E1 (K25804) + E2 (K25126) → HAVCR1 33091085
Semliki Forest virus 11033 T40127 E2 (K25126) → CD209, CLEC4M 21738680
Rubella virus 11041 T40070 E1 (K25128) → MOG 21880773
Hom-1 vesivirus 1960046 VP1 → F11R 28196955
-ssRNA Measles virus 11234 T40033 H (K19378) → CD46, SLAMF1, NECTIN4 22049305 16690907 21901103
F (K19379) + H (K19378) → CD209 22049305 16690907
N (K19380) → FCGR2B 16690907 22049305
HMPV 162145 T40095 G/SH → CD209, CLEC4M 27334579
Hendra henipavirus 63330 T40046 G (K24957) → EFNB2, EFNB3 17376907
Nipah henipavirus 121791 T40047 G (K24957) → EFNB2, EFNB3 16007075 16477309
RSV 11250 T40045 F (K19261) → IGF1R, NCL 32494007 21841784 27903593
G (K22613) → TLR4, CX3CR1 27903593
Rabies virus 11292 T40022 G (K24589) → CHRNA1, NCAM1, NGFR 15804965 9696812
European bat 2 lyssavirus 57483 T40025 G (K24589) → NGFR 11714960
ZEBOV 186538 T40012 GP (K24534) → HAVCR1, CD209, CLEC4M 21536871 12504546
ZEBOV, SEBOV, BDBV 186538 186540 565995 T40012 T40014 T40121 GP (K24534) → NPC1 21866101
MARV 11269 T40015 GP (K24535) → ASGR1 7844558
MACV, GTOV, JUNV, SABV 11628 45219 2169991 2907957 T40006 T40007 T40005 T40008 GP1 (K25122) → TFRC 17287727
LASV 11620 T40010 GP1 (K25125) → LAMP1 24970085
LCMV 11623 T40091 GP1 (K25125) → DAG1 9851928
LUJV 649188 T40333 GP1 (K25125) → NRP2 30150732
ANDV 1980456 T40021 Gn/Gc (K24571) → PCDH1 30464266
SNV 1980491 T40020 Gn/Gc (K24571) → PCDH1 30464266
CCHFV 1980519 T40011 GP (K24573) → CD209 26935918
LACV 11577 T40056 Gn/Gc (K24572) → CD209 23388721
SFTSV 992212 T40096 Gn/Gc (K24859) → CD209 23388721
Gn → MYH9 24155382
RVFV 11588 T40030 Gn/Gc (K24859) → CD209 21767814 27223297
Uukuniemi virus 11591 Gn/Gc (K24859) → CD209 21767814
dsDNA HSV-1 10298 T40073 gB (K19255) → PILRA 20221426 15056211
gD (K19264) → TNFRSF14, NECTIN1, NECTIN2, IGF2R 20221426 15056211 7745699
gH (K19434) → (ITGA5+ITGB3) 23150579
gL (K19435) → (ITGA5+ITGB3) 23150579
HSV-2 10310 T40074 gD (K19264) → TNFRSF14, NECTIN1, NECTIN2, IGF2R 11511370 8898196 9696799 9657005 7745699
B virus 10325 T40077 gD (K19264) → NECTIN1 22345445
VZV 10335 T40078 gE (K24958) → IDE 17055432
HCMV 10359 T40080 gB (K22773) → EGFR, PDGFRA, CD209, CLEC4M 12879076 24839861 12433371
gH (K22777) → (ITGAV+ITGB3) 15834425
gH (K22777) + gL (K22778) + gO (K25798) → PDGFRA 27573107
gH (K22777) + gL (K22778) + UL128 + UL130 (K25799) + UL131A (K25800) → NRP2, OR14I1 30057110 30894498
HHV-6A 32603 gH (K24959) + gL (K24960) + gQ (K24961) → CD46 12663806
HHV-6B 32604 T40075 gH (K24959) + gL (K24960) + gQ (K24961) → TNFRSF4 23674671
EBV 10376 T40079 gp350 (K19450) → CR2 28408983 21429244
gp42 (K19453) → HLA-DR 28408983 21429244
gB (K19255) → EPHA2 29292383
gH (K19451) + gL (K19452) → EPHA2 29292383
KSHV 37296 T40081 gB (K19255) → (ITGA3+ITGB1), (ITGAV+ITGB3), (ITGAV+ITGB5) 11853674 18045938 18829766
VACV 10245 T40360 A26L (K25071) → DAG1 17166913 22983091
Human mastadenovirus A 129875 T40337 L5 (K19262) → CXADR 9733828 16160140
Human mastadenovirus B 108098 T40100 L5 (K19262) → CD46, CD80, CD86 15078926 15110532
Human mastadenovirus C 129951 T40338 L2 (K25066) → (ITGAM+ITGB2), (ITGAL+ITGB2) 8676475 16160140
L5 (K19262) → CXADR 9036860
Human mastadenovirus D 130310 T40102 L5 (K19262) → CXADR, CD46 9733828 15047806
Human mastadenovirus E 130308 T40101 L5 (K19262) → CXADR 9733828 16160140
Human mastadenovirus F 130309 T40339 L5 (K19262) → CXADR 9733828 16160140
HPV6b 10600 T40097 L1 (K19260) → (ITGA6+ITGB4), (ITGA6+ITGB1) 9032382
HPV18 337042 T40088 L1 (K19260) → (ITGA6+ITGB4), ITGA6 16781758 11341777
ssDNA B19 virus 10798 T40084 VP2 (K25797) → (ITGA5+ITGB1), XRCC5 12907437 16076874

Viral entry protein - non-protein receptor interactions

Type Virus Taxid Genome Entry protein (KO) Non-protein receptor Compound/Glycan PMID
ssRNA-RT HTLV-1 11908 T40003 gp46 (K24862) → Heparan sulfate proteoglycans (HSPGs) C00925 12941902
HIV-1 11676 T40001 gp160 (K19287) → Heparan sulfate C00925 7884870
dsRNA Rotavirus 28875 36427 VP4 (K19249) → GM1 ganglioside C04911 24501414
→ A-, H-type histo-blood group antigen (HBGA) G00266 G00285 G00246 22504179 22345472
+ssRNA HCoV-NL63 277944 T40365 → Heparan sulfate C00925 25187545
HCoV-OC43 31631 T40362 S1 (K24325) → 9-O-Acetylated sialic acid C04017 G13210 30679277 31160783
HCoV-HKU1 290028 T40363 S1 (K24325) → 9-O-Acetylated sialic acid C04017 G13210 30679277
MERS-CoV 1335626 T40090 S1 → α2,3-linked sialic acid (Sia) G00405 28923942
Norovirus GI 122928 T40107 VP1 → A-, H-type HBGAs G00266 G00285 G00254 12825167
Norovirus GII 122929 T40107 VP1 → A-, B-, H-type HBGAs G00266 G00271 G00285 G00254 21345963
EV-A71 138948 T40343 VP1 (K25127) → Heparan sulfate proteoglycans (HSPGs) C00925 31924205
Enterovirus D68 42789 VP1 (K25281) → α2,6-linked sialic acids G00299 G00255 24371050
EV70 138951 T40334 → α2,3-linked sialic acid G00405 15890948 12388686
CVA16 138948 T40331 VP1 (K25281) → Heparan sulfate glycosaminoglycans (HS GAGs) C00925 28745308
CVA24 138950 T40332 VP1 (K25127) → α2,3- and α2,6-linked sialic acids G00405 G00299 G01868 25329320 18184708
Hepatitis E virus 1678143 T40067 ORF2 → Heparan sulfate proteoglycans (HSPGs) C00925 19812150
CHIKV 37124 T40026 E2 (K25126) → Heparan sulfate C00925 31167876 28404855
EEEV 11021 T40054 E2 (K19288) → Heparan sulfate C00925 23720725 33091085
RRV 11029 T40071 E2 (K19288) → Heparan sulfate C00925 11413296 33091085
SFV 11033 T40127 → Heparan sulfate C00925 12239287 33091085
Sindbis virus 11034 T40377 E2 (K19288) → Heparan sulfate C00925 9696832 20300181
VEEV 11036 T40028 E2 (K25126) → Heparan sulfate C00925 11021998
DENV 1-4 11053 11060 11069 11070 T40048 T40373 T40374 T40375 E (K25003) → Heparan sulfate C00925 9256277 22500135
JEV 11072 T40052 E (K25003) → Heparan sulfate C00925 14981764
TBEV 11084 T40061 E (K25003) → Heparan sulfate C00925 11356970
YFV 11089 T40057 → Heparan sulfate C00925 28471403
ZIKV 64320 T40049 E (K25003) → Glycosaminoglycans (GAGs) C00925
 C00607 28151637
HCV 41856 T40066 E2 (K22272) → Heparan sulfate C00925 12867431
-ssRNA hPIV-1 12730 T40043 HN (K19247) → Neolacto-series gangliosides containing a terminal Neu5Acα2-3Galβ1-4GlcNAc G10388 11312330
hPIV-3 11216 T40044 HN (K19247) → Neolacto-series gangliosides containing a terminal Neu5Acα2-3Galβ1-4GlcNAc, Neu5Acα2-6Galβ1-4GlcNAc or Neu5Gcα2-3Galβ1-4GlcNAc G10388 G04168 G02685 11312330
hPIV-2 2560525 T40042 HN (K19247) → Sialylated molecules 16575518
hPIV-4 11224 T40122 HN (K19247) → Sialylated molecules 16575518
MuV 2560602 T40034 HN (K19247) → Trisaccharide containing α2,3-linked sialic acid G00436 G00253 27671656
HMPV 162145 T40095 F (K19261) → Heparan sulfate C00925 22238303
RSV 11250 T40045 G (K22613) → Iduronic acid-containing glycosaminoglycans C00374 C00925 C20908 10860881 16575518
IAV 211044 488241 335341 93838 1332244 130760 T40035 T40036 T40037 T40041 T40350 T40038 HA (K19251) → Neu5Acα2-6Gal G00299 G00255 24161712
IAV 93838 1332244 T40041 T40350 HA (K19251) → Neu5Acα2-3Gal G00405 G00253 24161712
IBV 518987 T40039 → Neu5Acα2-6Galβ1-4GlcNAc(6'-SLN) G00255 9191848
ICV 11553 T40040 HEF (K19253) → N-Acetyl-9-O-acetylneuraminic acid C04017 G13210 26215728
HDV 12475 T40085 → Heparan sulfate proteoglycans (HSPGs) C00925 23161433
dsDNA HSV-1 10298 T40073 gB (K19255) → Heparan sulfate C00925 18358807
gC (K19256)
gD (K19264) → 3-O-Sulfated heparan sulfate (3-OS HS) C22555 10520990
HSV-2 10310 T40074 gB (K19255) → Heparan sulfate C00925 22491462
gC (K19256)
VZV 10335 T40078 gB (K19255) → Heparan sulfate proteoglycans (HSPGs) C00925 9620211
HCMV 10359 T40080 gB (K22773) → Heparan sulfate glycosaminoglycans (HS GAGs) C00925 8384757 22440964
gM (K19257) /gN
HHV-7 10372 T40076 gB (K19255) → Heparan sulfate proteoglycans (HSPGs) C00925 9151851
gp65 10775589
KSHV 37296 T40081 gB (K19255) → Heparan sulfate C00925 19923183
gpK8.1A
ORF4 (K21649)
gH
VACV 10245 T40360 D8L → Chondroitin sulfate C00607 10482629
H3L → Heparan sulfate C00925 10708453
A27L (K19263) → Heparan sulfate C00925 9445060
MCPyV 493803 T40051 VP1 (K19248) → Neu5Acα2-3Gal disaccharide (3SLN, DSL, GD1a and GT1b oligosaccharides) G00405 22910713
→ Glycosaminoglycans (GAGs) C00925
BK polyomavirus 1891762 VP1 (K19248) → b-series gangliosides (GD3, GD2, GD1b and GT1b) C06133 C06134 C06141 C06140 24130487 16415013
JC virus 10632 T40072 VP1 (K19248) → Lactoseries tetrasaccharide c (LSTc) G11147 24089568
SV40 1891767 T40086 VP1 (K19248) → GM1 C04911 12941687 20023649
HPV18 337042 T40088 L1 (K19260) → Heparan sulfate oligosaccharide C00925 21115492
HPV16 333760 T40087 L1 (K19260) → Heparan sulfate oligosaccharide C00925 21115492
ssDNA Adeno-associated virus 2 10804 → Heparan sulfate proteoglycans (HSPGs) C00925 9445046
B19 virus 10798 T40084 VP1/VP2 (K25797) → Glycosphingolipid globoside (Gb4Cer) G00094 8211117 24889255

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Last updated: September 13, 2023