KEGG   PATHWAY: lve04921
Entry
lve04921                    Pathway                                
Name
Oxytocin signaling pathway - Lipotes vexillifer (Yangtze River dolphin)
Description
Oxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and peripheral effects. However, its best-known and most well-established roles are stimulation of uterine contractions during parturition and milk release during lactation. Oxytocin also influences cardiovascular regulation and various social behaviors. The actions of OT are all mediated by one type of OT receptor (OTR). This is a transmembrane receptor belonging to the G-protein-coupled receptor superfamily. The main signaling pathway is the Gq/PLC/Ins3 pathway, but the MAPK and the RhoA/Rho kinase pathways are also activated, contributing to increased prostaglandin production and direct contractile effect on myometrial cells. In the cardiovascular system, OTR is associated with the ANP-cGMP and NO-cGMP pathways, which reduce the force and rate of contraction and increase vasodilatation.
Class
Organismal Systems; Endocrine system
Pathway map
lve04921  Oxytocin signaling pathway
lve04921

Organism
Lipotes vexillifer (Yangtze River dolphin) [GN:lve]
Gene
103077121  oxytocin-neurophysin 1-like [KO:K05243]
103076315  OXT; oxytocin-neurophysin 1 [KO:K05243]
103082873  OXTR; oxytocin receptor [KO:K04229]
103082420  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
103076043  HRAS; GTPase HRas isoform X1 [KO:K02833]
103077579  KRAS; GTPase KRas [KO:K07827]
103068734  NRAS; GTPase NRas [KO:K07828]
103087933  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
103082805  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
103090769  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103070260  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
103075543  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103090681  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
103090934  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
103089071  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
103083510  PLA2G4D; LOW QUALITY PROTEIN: cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
103083784  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
103088613  PTGS2; prostaglandin G/H synthase 2 isoform X1 [KO:K11987] [EC:1.14.99.1]
103088140  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5-like [KO:K04463] [EC:2.7.12.2]
103080813  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
103071861  JUN; transcription factor AP-1 [KO:K04448]
103084433  FOS; proto-oncogene c-Fos isoform X1 [KO:K04379]
103072956  uncharacterized protein LOC103072956 [KO:K04379]
103077870  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
103090612  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
103091628  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
103069357  RYR1; ryanodine receptor 1 isoform X1 [KO:K04961]
103085414  RYR2; ryanodine receptor 2-like [KO:K04962]
103087389  RYR3; ryanodine receptor 3 [KO:K04963]
103087769  CD38; ADP-ribosyl cyclase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
103080844  TRPM2; transient receptor potential cation channel subfamily M member 2 [KO:K04977] [EC:3.6.1.13]
103068985  KCNJ2; inward rectifier potassium channel 2 [KO:K04996]
103091333  KCNJ12; ATP-sensitive inward rectifier potassium channel 12 [KO:K05005]
103089776  KCNJ4; inward rectifier potassium channel 4 [KO:K04998]
103077293  KCNJ14; ATP-sensitive inward rectifier potassium channel 14 [KO:K05007]
103086280  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
103083884  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
103078639  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
103079287  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
103073028  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
103090549  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
103086653  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
103084838  EEF2K; eukaryotic elongation factor 2 kinase [KO:K08292] [EC:2.7.11.20]
103089975  EEF2; elongation factor 2 [KO:K03234]
103087340  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
103074544  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
103082192  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
103090575  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
103070949  CACNB1; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-1 [KO:K04862]
103079439  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
103075622  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
103089902  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
103082365  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
103076085  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
103076318  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
103076342  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
103073774  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
103089907  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
103090977  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
103073501  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
103087746  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
103086371  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
103088020  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
103079294  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
103078697  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
103070387  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
103091655  CALM3; calmodulin [KO:K02183]
103079915  CALML6; calmodulin-like protein 6 [KO:K02183]
103080762  CALM1; calmodulin isoform X1 [KO:K02183]
103087479  CALM2; calmodulin [KO:K02183]
103072156  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
103074541  LOW QUALITY PROTEIN: calmodulin-like protein 1-like [KO:K02183]
103074817  CALML5; calmodulin-like protein 5 [KO:K02183]
103088182  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103070526  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103090427  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103078845  PPP3R2; LOW QUALITY PROTEIN: calcineurin subunit B type 2 [KO:K06268]
103068473  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
103081110  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
103083433  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
103075954  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
103070958  RGS2; regulator of G-protein signaling 2 [KO:K18154]
103077665  RCAN1; calcipressin-1 [KO:K17901]
103090099  CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
103069202  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
103074848  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
103089470  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
103085288  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
103079524  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200]
103079471  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
103079195  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
103090123  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
103087450  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G isoform X1 [KO:K08794] [EC:2.7.11.17]
103075255  CAMK1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
103088458  CAMK2D; LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
103075213  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
103072903  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
103081366  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
103081119  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
103087259  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
103069938  GUCY1A2; guanylate cyclase soluble subunit alpha-2-like [KO:K12318] [EC:4.6.1.2]
103075302  guanylate cyclase soluble subunit alpha-1-like [KO:K12318] [EC:4.6.1.2]
103075578  GUCY1B3; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
103080153  NPPA; natriuretic peptides A [KO:K12334]
103088382  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
103087466  NPR2; atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
103077707  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
103079981  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
103083551  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
103090456  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
103085658  MYL6; myosin light polypeptide 6 isoform X1 [KO:K12751]
103086140  MYL6B; myosin light chain 6B [KO:K12751]
103077228  MYL9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
103086383  ACTG1; actin, cytoplasmic 2 [KO:K05692]
103077223  ACTB; actin, cytoplasmic 1 [KO:K05692]
103074732  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
103082455  rho-associated protein kinase 1-like [KO:K04514] [EC:2.7.11.1]
103081507  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
103086084  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-gamma catalytic subunit B-like [KO:K06269] [EC:3.1.3.16]
103072994  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
103074387  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
103080471  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
103071997  PPP1R12A; protein phosphatase 1 regulatory subunit 12A-like isoform X1 [KO:K06270]
103071840  PPP1R12B; protein phosphatase 1 regulatory subunit 12B [KO:K12329]
103085204  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
103089051  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas-like [KO:K04632]
103085385  neuroendocrine secretory protein 55-like [KO:K04632]
103081539  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
103084817  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
103076182  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
103075499  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
103091169  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
103075153  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
103078677  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
103085845  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
103070451  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
103077464  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
103074112  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
103080185  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
103077308  GNAI2; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
103081367  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
103091025  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
103069455  PIK3CG; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
103076917  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
103076642  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
103072342  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
103084183  KCNJ3; G protein-activated inward rectifier potassium channel 1 isoform X1 [KO:K04997]
103081022  KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000]
103076011  KCNJ9; LOW QUALITY PROTEIN: G protein-activated inward rectifier potassium channel 3 [KO:K05002]
103081345  KCNJ5; G protein-activated inward rectifier potassium channel 4 isoform X1 [KO:K04999]
103071962  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
103080733  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00238  Potassium cation
C00427  Prostaglandin H2
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C13050  Cyclic ADP-ribose
Reference
PMID:18655881
  Authors
Devost D, Wrzal P, Zingg HH
  Title
Oxytocin receptor signalling.
  Journal
Prog Brain Res 170:167-76 (2008)
DOI:10.1016/S0079-6123(08)00415-9
Reference
PMID:20626426
  Authors
Viero C, Shibuya I, Kitamura N, Verkhratsky A, Fujihara H, Katoh A, Ueta Y, Zingg HH, Chvatal A, Sykova E, Dayanithi G
  Title
REVIEW: Oxytocin: Crossing the bridge between basic science and pharmacotherapy.
  Journal
CNS Neurosci Ther 16:e138-56 (2010)
DOI:10.1111/j.1755-5949.2010.00185.x
Reference
PMID:21981277
  Authors
Gutkowska J, Jankowski M
  Title
Oxytocin revisited: its role in cardiovascular regulation.
  Journal
J Neuroendocrinol 24:599-608 (2012)
DOI:10.1111/j.1365-2826.2011.02235.x
Reference
PMID:22190926
  Authors
Vrachnis N, Malamas FM, Sifakis S, Deligeoroglou E, Iliodromiti Z
  Title
The oxytocin-oxytocin receptor system and its antagonists as tocolytic agents.
  Journal
Int J Endocrinol 2011:350546 (2011)
DOI:10.1155/2011/350546
Reference
PMID:19840865
  Authors
Tom N, Assinder SJ
  Title
Oxytocin in health and disease.
  Journal
Int J Biochem Cell Biol 42:202-5 (2010)
DOI:10.1016/j.biocel.2009.10.008
Reference
PMID:9575824
  Authors
Strakova Z, Copland JA, Lolait SJ, Soloff MS
  Title
ERK2 mediates oxytocin-stimulated PGE2 synthesis.
  Journal
Am J Physiol 274:E634-41 (1998)
DOI:10.1152/ajpendo.1998.274.4.E634
Reference
PMID:12009385
  Authors
Slater DM, Zervou S, Thornton S
  Title
Prostaglandins and prostanoid receptors in human pregnancy and parturition.
  Journal
J Soc Gynecol Investig 9:118-24 (2002)
Reference
PMID:16787565
  Authors
Shmygol A, Gullam J, Blanks A, Thornton S
  Title
Multiple mechanisms involved in oxytocin-induced modulation of myometrial contractility.
  Journal
Acta Pharmacol Sin 27:827-32 (2006)
DOI:10.1111/j.1745-7254.2006.00393.x
Reference
PMID:11861513
  Authors
Tahara M, Morishige K, Sawada K, Ikebuchi Y, Kawagishi R, Tasaka K, Murata Y
  Title
RhoA/Rho-kinase cascade is involved in oxytocin-induced rat uterine contraction.
  Journal
Endocrinology 143:920-9 (2002)
DOI:10.1210/endo.143.3.8696
Reference
PMID:12433531
  Authors
Slattery MM, Morrison JJ
  Title
Preterm delivery.
  Journal
Lancet 360:1489-97 (2002)
DOI:10.1016/S0140-6736(02)11476-0
Reference
PMID:22902539
  Authors
Pont JN, McArdle CA, Lopez Bernal A
  Title
Oxytocin-stimulated NFAT transcriptional activation in human myometrial cells.
  Journal
Mol Endocrinol 26:1743-56 (2012)
DOI:10.1210/me.2012-1057
Reference
PMID:9326674
  Authors
Gutkowska J, Jankowski M, Lambert C, Mukaddam-Daher S, Zingg HH, McCann SM
  Title
Oxytocin releases atrial natriuretic peptide by combining with oxytocin receptors in the heart.
  Journal
Proc Natl Acad Sci U S A 94:11704-9 (1997)
DOI:10.1073/pnas.94.21.11704
Reference
PMID:14715914
  Authors
Antunes-Rodrigues J, de Castro M, Elias LL, Valenca MM, McCann SM
  Title
Neuroendocrine control of body fluid metabolism.
  Journal
Physiol Rev 84:169-208 (2004)
DOI:10.1152/physrev.00017.2003
Reference
PMID:18555543
  Authors
Lee ES, Uhm KO, Lee YM, Kwon J, Park SH, Soo KH
  Title
Oxytocin stimulates glucose uptake in skeletal muscle cells through the calcium-CaMKK-AMPK pathway.
  Journal
Regul Pept 151:71-4 (2008)
DOI:10.1016/j.regpep.2008.05.001
Reference
PMID:9219843
  Authors
Cassoni P, Sapino A, Fortunati N, Munaron L, Chini B, Bussolati G
  Title
Oxytocin inhibits the proliferation of MDA-MB231 human breast-cancer cells via cyclic adenosine monophosphate and protein kinase A.
  Journal
Int J Cancer 72:340-4 (1997)
DOI:10.1002/(SICI)1097-0215(19970717)72:2<340::AID-IJC23>3.0.CO;2-I
Reference
PMID:23356278
  Authors
Busnelli M, Peverelli E, Mantovani G, Spada A, Chini B
  Title
Deciphering the specific role of G(alphai/o) isoforms: functional selective oxytocin ligands and somatostatin SST5 receptor mutants.
  Journal
Biochem Soc Trans 41:166-71 (2013)
DOI:10.1042/BST20120306
Reference
PMID:16966388
  Authors
Reversi A, Rimoldi V, Brambillasca S, Chini B
  Title
Effects of cholesterol manipulation on the signaling of the human oxytocin receptor.
  Journal
Am J Physiol Regul Integr Comp Physiol 291:R861-9 (2006)
DOI:10.1152/ajpregu.00333.2006
Reference
PMID:20141572
  Authors
Salmina AB, Lopatina O, Ekimova MV, Mikhutkina SV, Higashida H
  Title
CD38/cyclic ADP-ribose system: a new player for oxytocin secretion and regulation of social behaviour.
  Journal
J Neuroendocrinol 22:380-92 (2010)
DOI:10.1111/j.1365-2826.2010.01970.x
Reference
PMID:22227279
  Authors
Higashida H, Yokoyama S, Kikuchi M, Munesue T
  Title
CD38 and its role in oxytocin secretion and social behavior.
  Journal
Horm Behav 61:351-8 (2012)
DOI:10.1016/j.yhbeh.2011.12.011
Reference
PMID:23335873
  Authors
Lopatina O, Inzhutova A, Salmina AB, Higashida H
  Title
The roles of oxytocin and CD38 in social or parental behaviors.
  Journal
Front Neurosci 6:182 (2012)
DOI:10.3389/fnins.2012.00182
Reference
PMID:16156781
  Authors
Guse AH
  Title
Second messenger function and the structure-activity relationship of cyclic adenosine diphosphoribose (cADPR).
  Journal
FEBS J 272:4590-7 (2005)
DOI:10.1111/j.1742-4658.2005.04863.x
Related
pathway
lve00590  Arachidonic acid metabolism
lve04010  MAPK signaling pathway
lve04020  Calcium signaling pathway
lve04110  Cell cycle
KO pathway
ko04921   
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