Entry Name Prolactin signaling pathway - Pongo abelii (Sumatran orangutan)
Description Prolactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and metabolism, brain and behavior, and immunomodulation. PRL mediates its action through PRLR, a transmembrane protein of the hematopoietin cytokine receptor superfamily. At the protein level, the long PRLR isoform (long-R) and several short PRLR isoforms (short-R) have been detected. Acting through the long-R, PRL activates many signaling cascades including Jak2/Stat, the major cascade, Src kinase, phosphatidylinositol-3-kinase (PI3K)/AKT, and mitogen-activated protein kinase (MAPK) pathways. PRL cannot activate Jak2/Stat5 through the short-R, but can activate pathways including MAPK and PI3K pathways.
Class Organismal Systems; Endocrine systemBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Pongo abelii (Sumatran orangutan) [GN:
pon ]
Gene 100432846 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
100453779 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
103889133 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
100174298 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
100173589 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
100437617 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
100450314 CISH; cytokine-inducible SH2-containing protein isoform X2 [KO:K04701 ]
100173683 STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220 ]
100171541 STAT3; signal transducer and activator of transcription 3 [KO:K04692 ]
100461695 STAT5A; signal transducer and activator of transcription 5A isoform X1 [KO:K11223 ]
100462537 STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224 ]
100439883 TNFSF11; tumor necrosis factor ligand superfamily member 11 isoform X1 [KO:K05473 ]
100433235 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A isoform X2 [KO:K05147 ]
100461595 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
100458821 ELF5; ETS-related transcription factor Elf-5 isoform X2 [KO:K17101 ]
100437366 SLC2A2; solute carrier family 2, facilitated glucose transporter member 2 isoform X1 [KO:K07593 ]
Compound C00355 3,4-Dihydroxy-L-phenylalanine
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Binart N, Bachelot A, Bouilly J
Title Impact of prolactin receptor isoforms on reproduction.
Journal Reference Authors Bachelot A, Binart N
Title Reproductive role of prolactin.
Journal Reference Authors Hennighausen L, Robinson GW
Title Information networks in the mammary gland.
Journal Reference Authors Bouilly J, Sonigo C, Auffret J, Gibori G, Binart N
Title Prolactin signaling mechanisms in ovary.
Journal Reference Authors Oakes SR, Rogers RL, Naylor MJ, Ormandy CJ
Title Prolactin regulation of mammary gland development.
Journal Reference Authors Frasor J, Gibori G
Title Prolactin regulation of estrogen receptor expression.
Journal Reference Authors Bole-Feysot C, Goffin V, Edery M, Binart N, Kelly PA
Title Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice.
Journal Reference Authors Weinhaus AJ, Stout LE, Bhagroo NV, Brelje TC, Sorenson RL
Title Regulation of glucokinase in pancreatic islets by prolactin: a mechanism for increasing glucose-stimulated insulin secretion during pregnancy.
Journal Reference Authors Grattan DR, Kokay IC
Title Prolactin: a pleiotropic neuroendocrine hormone.
Journal Reference Authors Yu-Lee LY, Luo G, Book ML, Morris SM
Title Lactogenic hormone signal transduction.
Journal Reference Authors Tam SP, Lau P, Djiane J, Hilton DJ, Waters MJ
Title Tissue-specific induction of SOCS gene expression by PRL.
Journal Reference Authors Halperin J, Devi SY, Elizur S, Stocco C, Shehu A, Rebourcet D, Unterman TG, Leslie ND, Le J, Binart N, Gibori G
Title Prolactin signaling through the short form of its receptor represses forkhead transcription factor FOXO3 and its target gene galt causing a severe ovarian defect.
Journal Reference Authors Sakamoto K, Creamer BA, Triplett AA, Wagner KU
Title The Janus kinase 2 is required for expression and nuclear accumulation of cyclin D1 in proliferating mammary epithelial cells.
Journal Reference Authors Oakes SR, Hilton HN, Ormandy CJ
Title The alveolar switch: coordinating the proliferative cues and cell fate decisions that drive the formation of lobuloalveoli from ductal epithelium.
Journal Related KO pathway LinkDB All DBs
