Entry |
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Name |
p53 signaling pathway - Xenopus laevis (African clawed frog)
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Description |
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
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Class |
Cellular Processes; Cell growth and death
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Pathway map |

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Organism |
Xenopus laevis (African clawed frog) [GN: xla]
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Gene |
492305 | cdkn1a.L; cyclin-dependent kinase inhibitor 1A (p21, Cip1) L homeolog [KO:K06625] |
379224 | gadd45a.L; growth arrest and DNA damage inducible alpha L homeolog [KO:K04402] |
399196 | gadd45g.L; growth arrest and DNA damage inducible gamma L homeolog [KO:K04402] |
379285 | gadd45g.S; growth arrest and DNA damage inducible gamma S homeolog [KO:K04402] |
101027271 | gadd45b.S; growth arrest and DNA damage inducible beta S homeolog [KO:K04402] |
108714209 | growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402] |
108712402 | gadd45b.L; growth arrest and DNA damage inducible beta L homeolog [KO:K04402] |
447452 | gtse1.S; G2 and S-phase expressed 1 S homeolog [KO:K10129] |
734417 | gtse1.L; G2 and S-phase expressed 1 L homeolog [KO:K10129] |
108697171 | tumor necrosis factor receptor superfamily member 6-like [KO:K04390] |
108696050 | tumor necrosis factor receptor superfamily member 6-like [KO:K04390] |
108713866 | pidd1.L; p53-induced death domain protein 1 L homeolog [KO:K10130] |
404687 | tnfrsf10b.S; tumor necrosis factor receptor superfamily member 10b S homeolog [KO:K04722] |
404688 | tnfrsf10b.L; tumor necrosis factor receptor superfamily member 10b L homeolog [KO:K04722] |
724076 | bid.S; BH3 interacting domain death agonist S homeolog [KO:K04726] |
108704383 | bid.L; BH3 interacting domain death agonist L homeolog [KO:K04726] |
373637 | bax.L; BCL2-associated X protein L homeolog [KO:K02159] |
444383 | tp53i3.S; tumor protein p53 inducible protein 3 S homeolog [KO:K10133] [EC:1.-.-.-] |
444660 | perp.S; PERP, TP53 apoptosis effector S homeolog [KO:K10136] |
734854 | zmat3.L; zinc finger, matrin-type 3 L homeolog [KO:K10137] |
444261 | apaf1.L; apoptotic peptidase activating factor 1 L homeolog [KO:K02084] |
108696268 | aifm2.L; apoptosis inducing factor, mitochondria associated 2 L homeolog [KO:K22745] |
100049086 | aifm2.S; apoptosis inducing factor, mitochondria associated 2 S homeolog [KO:K22745] |
378699 | igf1.S; insulin like growth factor 1 S homeolog [KO:K05459] |
779433 | serpine1.L; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 L homeolog [KO:K03982] |
100049768 | serpine1.S; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 S homeolog [KO:K03982] |
444699 | serpinb5.S; serpin peptidase inhibitor, clade B (ovalbumin), member 5 S homeolog [KO:K10139] |
108718725 | serpinb5.L; serpin peptidase inhibitor, clade B (ovalbumin), member 5 L homeolog [KO:K10139] |
108713786 | ddb2.L; damage-specific DNA binding protein 2 L homeolog [KO:K10140] |
108715228 | ddb2.S; damage-specific DNA binding protein 2 S homeolog [KO:K10140] |
108701235 | steap3.L; STEAP3 metalloreductase L homeolog [KO:K10142] [EC:1.16.1.-] |
100158422 | rfwd2.L; ring finger and WD repeat domain 2, E3 ubiquitin protein ligase L homeolog [KO:K10143] [EC:2.3.2.27] |
108715625 | rfwd2.S; ring finger and WD repeat domain 2, E3 ubiquitin protein ligase S homeolog [KO:K10143] [EC:2.3.2.27] |
496013 | rchy1.L; ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase L homeolog [KO:K10144] [EC:2.3.2.27] |
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Reference |
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Authors |
Levine AJ, Hu W, Feng Z. |
Title |
The P53 pathway: what questions remain to be explored? |
Journal |
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Reference |
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Authors |
Harris SL, Levine AJ. |
Title |
The p53 pathway: positive and negative feedback loops. |
Journal |
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Reference |
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Authors |
Balint E E, Vousden KH. |
Title |
Activation and activities of the p53 tumour suppressor protein. |
Journal |
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Reference |
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Authors |
Taylor WR, Stark GR. |
Title |
Regulation of the G2/M transition by p53. |
Journal |
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Reference |
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Authors |
Hofseth LJ, Hussain SP, Harris CC. |
Title |
p53: 25 years after its discovery. |
Journal |
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Reference |
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Authors |
Pietenpol JA, Stewart ZA. |
Title |
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis. |
Journal |
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Reference |
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Authors |
Tokino T, Nakamura Y. |
Title |
The role of p53-target genes in human cancer. |
Journal |
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Reference |
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Authors |
Hermeking H, Benzinger A. |
Title |
14-3-3 proteins in cell cycle regulation. |
Journal |
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Reference |
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Authors |
Sherr CJ. |
Title |
Divorcing ARF and p53: an unsettled case. |
Journal |
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Reference |
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Authors |
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ. |
Title |
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways. |
Journal |
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Reference |
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Authors |
Resnick-Silverman L, Manfredi JJ |
Title |
Two Faces of SIVA. |
Journal |
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Reference |
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Authors |
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R |
Title |
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis. |
Journal |
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Reference |
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Authors |
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV |
Title |
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis. |
Journal |
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Reference |
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Authors |
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N |
Title |
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF). |
Journal |
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Related pathway |
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KO pathway |
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LinkDB |
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