KEGG   PATHWAY: xla04218
Entry
xla04218                    Pathway                                
Name
Cellular senescence - Xenopus laevis (African clawed frog)
Description
Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of factors, such as telomere shortening, oncogene activation, irradiation, DNA damage and oxidative stress. It is characterized by enlarged flattened morphology, senescence-associated beta-galactosidase (SA-b-gal) activity, secretion of inflammatory cytokines, growth factors and matrix metalloproteinases, as part of the senescence-associated secretory phenotype (SASP). Cellular senescence is functionally associated with many biological processes including aging, tumor suppression, placental biology, embryonic development, and wound healing.
Class
Cellular Processes; Cell growth and death
Pathway map
xla04218  Cellular senescence
xla04218

Other DBs
GO: 0090398
Organism
Xenopus laevis (African clawed frog) [GN:xla]
Gene
100036815  cxcl8.L; uncharacterized protein LOC100036815 precursor [KO:K10030]
100036852  e2f1.L; E2F transcription factor 1 L homeolog [KO:K17454]
100036963  sirt1.L; sirtuin 1 L homeolog [KO:K11411] [EC:2.3.1.286]
100037000  XB5945946.L; uncharacterized protein LOC100037000 precursor [KO:K10030]
100037005  mcu.L; calcium uniporter protein, mitochondrial [KO:K20858]
100049768  serpine1.S; plasminogen activator inhibitor 1 [KO:K03982]
100127267  XB5844015.L; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
100158306  lin9.L; lin-9 DREAM MuvB core complex component L homeolog [KO:K21773]
100189543  hipk1.S; homeodomain interacting protein kinase 1 S homeolog [KO:K08826] [EC:2.7.11.1]
100329215  mapk11.L; mitogen-activated protein kinase 11 L homeolog [KO:K04441] [EC:2.7.11.24]
100381102  ppp3cc.L; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100462912  cacna1d.L; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
100505423  [KO:K07827]
100505440  pten.S; uncharacterized protein LOC100505440 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
101027271  gadd45b.S; growth arrest and DNA damage inducible beta S homeolog [KO:K04402]
108695211  nfatc1.S; nuclear factor of activated T-cells, cytoplasmic 1 isoform X2 [KO:K04446]
108695369  e2f5.S; transcription factor E2F5 [KO:K04682]
108695961  [KO:K21774]
108696363  [KO:K07203] [EC:2.7.11.1]
108696394  chek1.L; serine/threonine-protein kinase Chk1-like isoform X1 [KO:K02216] [EC:2.7.11.1]
108696729  [KO:K07830]
108697451  sirt1.S; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
108697483  mcu.S; calcium uniporter protein, mitochondrial [KO:K20858]
108697778  [KO:K07830]
108697792  kras.S; GTPase HRas [KO:K07827]
108697884  lin37.S; protein lin-37 homolog isoform X1 [KO:K21774]
108698219  tsc1.L; hamartin isoform X1 [KO:K07206]
108698552  [KO:K06751]
108698659  [KO:K18753]
108698668  lin52.L; protein lin-52 homolog isoform X1 [KO:K21775]
108698710  [KO:K02183]
108698803  [KO:K04456] [EC:2.7.11.1]
108699188  ppid.L; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
108699282  [KO:K18753]
108699843  lin52.S; protein lin-52 homolog isoform X1 [KO:K21775]
108699932  tsc1.S; hamartin isoform X1 [KO:K07206]
108700136  slc25a5.S; ADP/ATP translocase 2 [KO:K05863]
108700276  tgfb1.S; transforming growth factor beta-1 proprotein-like [KO:K13375]
108700293  XB5726464.S; mRNA decay activator protein ZFP36L1 [KO:K18753]
108700898  nfatc2.L; nuclear factor of activated T-cells, cytoplasmic 2 isoform X2 [KO:K17332]
108701656  tsc2.L; tuberin isoform X3 [KO:K07207]
108702600  nfatc2.S; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
108702771  rbl1.S; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
108702783  e2f1.S; transcription factor E2F1 [KO:K17454]
108702885  tgfbr2l.S; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
108702900  mras.S; ras-related protein M-Ras [KO:K07831]
108703213  tsc2.S; tuberin isoform X1 [KO:K07207]
108703451  tp53.S; cellular tumor antigen p53-like [KO:K04451]
108704012  raf1.L; RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
108704110  [KO:K21776]
108704179  [KO:K06269] [EC:3.1.3.16]
108704388  [KO:K04851]
108704610  mybl2.L; myb-related protein B-like isoform X1 [KO:K21769]
108705261  ppp3cc.S; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
108705979  slc25a4.S; ADP/ATP translocase 1 [KO:K05863]
108706143  [KO:K10030]
108706149  [KO:K10030]
108706736  nfkb1.S; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
108706768  cxcl2.S; growth-regulated alpha protein [KO:K10030]
108706769  cxcl8.S; interleukin-8 [KO:K10030]
108706884  pik3r2.S; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
108706939  cdkn2b.S; cyclin-dependent kinase inhibitor 2A [KO:K04685]
108707035  nfatc4.S; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
108707078  trpv4.S; transient receptor potential cation channel subfamily V member 4 [KO:K04973]
108708125  rassf5.L; ras association domain-containing protein 5 isoform X2 [KO:K08015]
108708144  [KO:K04441] [EC:2.7.11.24]
108709405  cdkn1a.S; cyclin-dependent kinase inhibitor 1 [KO:K06625]
108709441  [KO:K04960]
108709485  rassf5.S; ras association domain-containing protein 5 isoform X2 [KO:K08015]
108709804  rb1.S; retinoblastoma-associated protein isoform X1 [KO:K06618]
108709932  foxo1.S; forkhead box protein O1-like [KO:K07201]
108710178  [KO:K04959]
108710805  vdac1.L; voltage-dependent anion-selective channel protein 1 [KO:K05862]
108711085  cxcl2.L; interleukin-8 isoform X1 [KO:K10030]
108711090  [KO:K10030]
108711092  mdm2.L; E3 ubiquitin-protein ligase Mdm2-like isoform X1 [KO:K06643] [EC:2.3.2.27]
108711093  [KO:K10030]
108711159  [KO:K04441] [EC:2.7.11.24]
108711406  trpm7.L; transient receptor potential cation channel subfamily M member 7 L homeolog [KO:K04982] [EC:2.7.11.1]
108711407  [KO:K04982] [EC:2.7.11.1]
108711508  calml4.L; calmodulin-like protein 4 isoform X1 [KO:K02183]
108711789  [KO:K06751]
108712283  [KO:K04348] [EC:3.1.3.16]
108712402  gadd45b.L; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
108712520  krasl.S; GTPase KRas isoform X1 [KO:K07827]
108712561  hipk2.S; homeodomain-interacting protein kinase 2 [KO:K08826] [EC:2.7.11.1]
108712798  calml4.S; calmodulin-like protein 4 [KO:K02183]
108712801  smad3.S; mothers against decapentaplegic homolog 3 [KO:K23605]
108712802  map2k1.S; dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
108712895  trpm7.S; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
108713027  pik3r2.L; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
108713153  [KO:K06643] [EC:2.3.2.27]
108713276  rad50.S; DNA repair protein RAD50 [KO:K10866] [EC:3.6.-.-]
108713974  nfatc3.L; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
108714013  rbl2.L; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
108714169  e2f4.L; transcription factor E2F4-like [KO:K04682]
108714209  gadd45a.L; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
108714625  [KO:K04958]
108715006  nfatc4.L; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
108715128  rela.S; putative transcription factor p65 homolog [KO:K04735]
108715217  hipk3.S; homeodomain-interacting protein kinase 3 [KO:K08826] [EC:2.7.11.1]
108715661  trpv4.L; transient receptor potential cation channel subfamily V member 4 [KO:K04973]
108715909  [KO:K04441] [EC:2.7.11.24]
108716477  capn8.5.L; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
108716580  ppp3r1.L; calcineurin subunit B type 1 [KO:K06268]
108716826  [KO:K21124]
108717120  pik3cb.L; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
108717671  ppp1cb.S; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
108717686  lin9.S; protein lin-9 homolog [KO:K21773]
108717697  capn2.S; calpain-2 catalytic subunit isoform X1 [KO:K03853] [EC:3.4.22.53]
108717706  tgfb2.S; transforming growth factor beta-2 proprotein-like isoform X1 [KO:K13376]
108717943  foxo3.S; forkhead box protein O3-like isoform X1 [KO:K09408]
108718066  ccnb1.L; G2/mitotic-specific cyclin-B1-like [KO:K05868]
108718090  pik3ca.S; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108718190  pik3cb.S; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108718479  [KO:K02091] [EC:2.7.11.22]
108718487  il6.L; interleukin-6 [KO:K05405]
108718935  tgfbr2.L; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
108719029  [KO:K04674] [EC:2.7.11.30]
108719151  e2f3.L; transcription factor E2F3 [KO:K06620]
108719317  e2f5.L; transcription factor E2F5 isoform X1 [KO:K04682]
108719392  trpv4l.2.L; transient receptor potential cation channel subfamily V member 4 [KO:K04973]
108719393  trpv4l.1.L; transient receptor potential cation channel subfamily V member 4 [KO:K04973]
108719819  [KO:K07208]
108719900  [KO:K02091] [EC:2.7.11.22]
108719963  tgfbr2.S; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
121394752  [KO:K05863]
373667  ccnd2.L; G1/S-specific cyclin-D2 [KO:K10151]
373752  pik3ca.L; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
373801  tgfb2.L; transforming growth factor beta-2 proprotein precursor [KO:K13376]
373815  tgfbr2l.L; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
378633  smad3.L; SMAD family member 3 L homeolog [KO:K23605]
379048  ccnb3.S; cyclin B3 S homeolog [KO:K21771]
379052  myc.S; transcriptional regulator Myc-A [KO:K04377]
379161  ccnd1.S; G1/S-specific cyclin-D1 b [KO:K04503]
379224  gadd45a.S; growth arrest and DNA damage inducible alpha S homeolog [KO:K04402]
379285  gadd45g.S; uncharacterized protein LOC379285 [KO:K04402]
379406  cdk4.S; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
379610  sqstm1.L; sequestosome 1 L homeolog [KO:K14381]
379638  map2k6.L; mitogen-activated protein kinase kinase 6 L homeolog [KO:K04433] [EC:2.7.12.2]
379783  akt2.L; RAC-beta serine/threonine-protein kinase A [KO:K04456] [EC:2.7.11.1]
379785  cdk1.L; cyclin-dependent kinase 1-B [KO:K02087] [EC:2.7.11.22 2.7.11.23]
379888  ccnb1.2.L; cyclin B1 L homeolog [KO:K05868]
379914  ppp1ca.L; protein phosphatase 1, catalytic subunit, alpha isozyme L homeolog [KO:K06269] [EC:3.1.3.16]
379937  ccnd1.L; G1/S-specific cyclin-D1 [KO:K04503]
379991  map2k1.L; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
379992  mapk14.S; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
380177  capn1.L; calpain 1, (mu/I) large subunit L homeolog [KO:K01367] [EC:3.4.22.52]
380186  rheb.L; Ras homolog, mTORC1 binding L homeolog [KO:K07208]
380187  slc25a5.L; adenine nucleotide translocator 2 [KO:K05863]
380219  ccne2.L; cyclin E2 L homeolog [KO:K06626]
380246  cdk1.S; cyclin-dependent kinase 1-A [KO:K02087] [EC:2.7.11.22 2.7.11.23]
380302  zfp36l2.S; mRNA decay activator protein ZFP36L2-A [KO:K18753]
380376  vdac1.S; voltage-dependent anion channel 1 S homeolog [KO:K05862]
380507  ppp3ca.S; protein phosphatase 3, catalytic subunit, alpha isoform [KO:K04348] [EC:3.1.3.16]
380558  calm2.S; calmodulin-2 A [KO:K02183]
380598  ppp1cc.S; serine/threonine-protein phosphatase PP1-gamma catalytic subunit B [KO:K06269] [EC:3.1.3.16]
394308  mre11.L; double-strand break repair protein MRE11 [KO:K10865]
394353  rela.L; putative transcription factor p65 homolog [KO:K04735]
394362  btrc.S; beta-TrCP [KO:K03362]
394371  ets1.S; protein c-ets-1-A [KO:K02678]
397742  ccnb1.2.S; G2/mitotic-specific cyclin-B1 [KO:K05868]
397743  ccnb2.S; G2/mitotic-specific cyclin-B2 [KO:K21770]
397767  ppp1cc.L; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
397771  kras.L; kirsten rat sarcoma viral oncogene homolog L homeolog [KO:K07827]
397778  tgfb1.L; transforming growth factor beta-1 proprotein precursor [KO:K13375]
397785  mapk1.L; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
397840  ccne1.L; G1/S-specific cyclin-E1 [KO:K06626]
397841  ccne1.S; G1/S-specific cyclin-E3 [KO:K06626]
397857  raf1.S; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
397885  ccna1.S; cyclin-A1 [KO:K06627]
397926  tp53.L; cellular tumor antigen p53 [KO:K04451]
397933  ccna2.S; cyclin-A2 [KO:K06627]
397957  ets1.L; protein c-ets-1-B [KO:K02678]
397988  btrc.L; beta-TrCP-like isoform X1 [KO:K03362]
398085  mybl2.S; myb-related protein B isoform X1 [KO:K21769]
398103  zfp36l2.L; mRNA decay activator protein ZFP36L2-B [KO:K18753]
398141  cdc25a.L; cell division cycle 25A L homeolog [KO:K06645] [EC:3.1.3.48]
398148  atm.L; ATM serine/threonine kinase L homeolog [KO:K04728] [EC:2.7.11.1]
398159  e2f3.S; E2F transcription factor 3 S homeolog [KO:K06620]
398162  [KO:K21770]
398163  ccnb1.S; cyclin B1 S homeolog [KO:K05868]
398179  chek2.L; checkpoint kinase 2 L homeolog [KO:K06641] [EC:2.7.11.1]
398191  chek1.S; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
398197  atr.L; serine/threonine-protein kinase atr [KO:K06640] [EC:2.7.11.1]
398288  capn11.S; calpain 11, (mu/I) large subunit a S homeolog [KO:K01367] [EC:3.4.22.52]
398297  nfatc3.S; nuclear factor of activated T cells 3 S homeolog [KO:K17333]
398405  rad1.L; RAD1 checkpoint DNA exonuclease L homeolog [KO:K02830] [EC:3.1.11.2]
398571  hus1.L; HUS1 checkpoint clamp component L homeolog [KO:K10903]
398592  mapk12.S; mitogen-activated protein kinase 12 S homeolog [KO:K04441] [EC:2.7.11.24]
398594  rad9a.L; RAD9 checkpoint clamp component A L homeolog [KO:K10994] [EC:3.1.11.2]
398772  capn11.L; calpain 11, (mu/I) large subunit a L homeolog [KO:K01367] [EC:3.4.22.52]
398888  ccnb2.L; uncharacterized protein LOC398888 [KO:K21770]
398985  mapk1.S; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
399075  capn2.L; calpain 2 L homeolog [KO:K03853] [EC:3.4.22.53]
399131  rbbp4.L; histone-binding protein RBBP4-A [KO:K10752]
399142  pten.L; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
399150  map2k3; MAP kinase activator XMEK3 [KO:K04433] [EC:2.7.12.2]
399170  akt1.S; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
399196  gadd45g.L; growth arrest and DNA damage inducible gamma L homeolog [KO:K04402]
399202  pik3r1.S; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
399215  ppp3r1.S; calcineurin subunit B type 1 [KO:K06268]
399254  itpr1.S; inositol 1,4,5-trisphosphate receptor type 1 S homeolog [KO:K04958]
399259  calm2.L; calmodulin-2 B [KO:K02183]
399295  tgfbr1.S; transforming growth factor beta receptor I S homeolog precursor [KO:K04674] [EC:2.7.11.30]
399302  gata4.S; transcription factor GATA-4 [KO:K09183]
399314  cdk2.S; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
399315  myc.L; transcriptional regulator Myc-B [KO:K04377]
399372  zfp36l1.S; ZFP36 ring finger protein-like 1 S homeolog [KO:K18753]
399406  hras.L; Harvey rat sarcoma viral oncogene homolog L homeolog [KO:K02833]
399442  smad2.L; SMAD family member 2 L homeolog [KO:K04500]
399446  nras.L; GTPase NRas [KO:K07828]
403373  nbn.L; nibrin L homeolog [KO:K10867]
431930  rbl1.L; retinoblastoma-like 1 L homeolog [KO:K04681]
432023  smad2.S; SMAD family member 2 S homeolog [KO:K04500]
432036  cdk2.L; uncharacterized protein LOC432036 [KO:K02206] [EC:2.7.11.22]
432084  mapkapk2.L; MAPK activated protein kinase 2 L homeolog [KO:K04443] [EC:2.7.11.1]
432106  ppp3cb.L; protein phosphatase 3, catalytic subunit, beta isozyme L homeolog [KO:K04348] [EC:3.1.3.16]
432172  akt2.S; RAC-beta serine/threonine-protein kinase B [KO:K04456] [EC:2.7.11.1]
432212  slc25a4.L; solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 L homeolog [KO:K05863]
432269  rbbp4.S; histone-binding protein RBBP4-B [KO:K10752]
443781  gata4.L; GATA binding protein 4 L homeolog [KO:K09183]
443782  vdac3.L; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
443852  ppp1cb.L; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
443932  mras.L; muscle RAS oncogene homolog L homeolog [KO:K07831]
443964  pik3r1.L; phosphoinositide-3-kinase regulatory subunit 1 L homeolog [KO:K02649]
444191  rras2.S; RAS related 2 S homeolog [KO:K07830]
444346  nfatc1.L; nuclear factor of activated T cells 1 L homeolog [KO:K04446]
444991  foxo1.L; forkhead box protein O1 [KO:K07201]
444992  foxo3.L; forkhead box protein O3 [KO:K09408]
446541  e2f4.S; transcription factor E2F4 [KO:K04682]
446786  pik3r3.S; phosphoinositide-3-kinase regulatory subunit 3 S homeolog [KO:K02649]
447196  ppp3ca.L; protein phosphatase 3, catalytic subunit, alpha isozyme L homeolog [KO:K04348] [EC:3.1.3.16]
447208  capn1.S; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
447494  ccna1.L; cyclin A1 L homeolog [KO:K06627]
447541  [KO:K04503]
447594  pik3r3.L; phosphoinositide-3-kinase regulatory subunit 3 L homeolog [KO:K02649]
447632  nfkb1.L; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 L homeolog [KO:K02580]
447715  ppid.S; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
447748  ccndx.L; G1/S-specific cyclin-D1 [KO:K04503]
492305  cdkn1a.L; cyclin-dependent kinase inhibitor 1 [KO:K06625]
494669  mapk11.S; mitogen-activated protein kinase 11 S homeolog [KO:K04441] [EC:2.7.11.24]
495064  rad50.L; RAD50 homolog, double strand break repair protein L homeolog [KO:K10866] [EC:3.6.-.-]
495118  mapkapk2.S; uncharacterized protein LOC495118 [KO:K04443] [EC:2.7.11.1]
495265  hipk2.L; homeodomain interacting protein kinase 2 L homeolog [KO:K08826] [EC:2.7.11.1]
495419  ccne2.S; uncharacterized protein LOC495419 [KO:K06626]
495423  hipk1.L; homeodomain interacting protein kinase 1 L homeolog [KO:K08826] [EC:2.7.11.1]
495703  hipk3.L; homeodomain-interacting protein kinase 3 isoform X1 [KO:K08826] [EC:2.7.11.1]
496251  rad9b.L; cell cycle checkpoint control protein RAD9B isoform X1 [KO:K10995]
496334  cdk6.L; cyclin-dependent kinase 6 L homeolog [KO:K02089] [EC:2.7.11.22]
496385  foxm1.S; forkhead box protein M1 [KO:K09406]
606721  calm1.S; calmodulin-1 [KO:K02183]
734449  vdac2.S; voltage-dependent anion-selective channel protein 2 [KO:K15040]
734734  cdc25a.S; cell division cycle 25A S homeolog [KO:K06645] [EC:3.1.3.48]
734775  ccna2.L; cyclin A2 L homeolog [KO:K06627]
734882  ccnd2.S; cyclin D2 S homeolog [KO:K10151]
735153  XB956263.L; uncharacterized protein LOC735153 [KO:K04441] [EC:2.7.11.24]
779088  [KO:K07830]
779240  cdkn2b.L; cyclin-dependent kinase inhibitor 2B L homeolog [KO:K04685]
779404  ccnb3.L; cyclin B3 L homeolog [KO:K21771]
779433  serpine1.L; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 L homeolog precursor [KO:K03982]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07909  Sirolimus
C16844  Hydroxyl radical
Reference
PMID:24954210
  Authors
Munoz-Espin D, Serrano M
  Title
Cellular senescence: from physiology to pathology.
  Journal
Nat Rev Mol Cell Biol 15:482-96 (2014)
DOI:10.1038/nrm3823
Reference
PMID:26646499
  Authors
Childs BG, Durik M, Baker DJ, van Deursen JM
  Title
Cellular senescence in aging and age-related disease: from mechanisms to therapy.
  Journal
Nat Med 21:1424-35 (2015)
DOI:10.1038/nm.4000
Reference
PMID:26105537
  Authors
Sharpless NE, Sherr CJ
  Title
Forging a signature of in vivo senescence.
  Journal
Nat Rev Cancer 15:397-408 (2015)
DOI:10.1038/nrc3960
Reference
PMID:26435346
  Authors
Fridlyanskaya I, Alekseenko L, Nikolsky N
  Title
Senescence as a general cellular response to stress: A mini-review.
  Journal
Exp Gerontol 72:124-8 (2015)
DOI:10.1016/j.exger.2015.09.021
Reference
PMID:27417123
  Authors
Lujambio A
  Title
To clear, or not to clear (senescent cells)? That is the question.
  Journal
Bioessays 38 Suppl 1:S56-64 (2016)
DOI:10.1002/bies.201670910
Reference
PMID:26564316
  Authors
Di Mitri D, Alimonti A
  Title
Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer.
  Journal
Trends Cell Biol 26:215-26 (2016)
DOI:10.1016/j.tcb.2015.10.005
Reference
PMID:27574725
  Authors
Francica P, Aebersold DM, Medova M
  Title
Senescence as biologic endpoint following pharmacological targeting of receptor tyrosine kinases in cancer.
  Journal
Biochem Pharmacol 126:1-12 (2017)
DOI:10.1016/j.bcp.2016.08.022
Reference
PMID:23982440
  Authors
Bartling B
  Title
Cellular senescence in normal and premature lung aging.
  Journal
Z Gerontol Geriatr 46:613-22 (2013)
DOI:10.1007/s00391-013-0543-3
Reference
PMID:24238962
  Authors
Munoz-Espin D, Canamero M, Maraver A, Gomez-Lopez G, Contreras J, Murillo-Cuesta S, Rodriguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M, Serrano M
  Title
Programmed cell senescence during mammalian embryonic development.
  Journal
Cell 155:1104-18 (2013)
DOI:10.1016/j.cell.2013.10.019
Reference
PMID:26697828
  Authors
Herranz N, Gallage S, Gil J
  Title
TORn about SASP regulation.
  Journal
Cell Cycle 14:3771-2 (2015)
DOI:10.1080/15384101.2015.1105694
Reference
PMID:28410770
  Authors
Martin N, Bernard D
  Title
Calcium signaling and cellular senescence.
  Journal
Cell Calcium S0143-4160(17)30049-0 (2017)
DOI:10.1016/j.ceca.2017.04.001
Reference
PMID:25764980
  Authors
Farfariello V, Iamshanova O, Germain E, Fliniaux I, Prevarskaya N
  Title
Calcium homeostasis in cancer: A focus on senescence.
  Journal
Biochim Biophys Acta 1853:1974-9 (2015)
DOI:10.1016/j.bbamcr.2015.03.005
Reference
PMID:24062309
  Authors
McCarthy DA, Clark RR, Bartling TR, Trebak M, Melendez JA
  Title
Redox control of the senescence regulator interleukin-1alpha and the secretory phenotype.
  Journal
J Biol Chem 288:32149-59 (2013)
DOI:10.1074/jbc.M113.493841
Reference
PMID:27288568
  Authors
Donninger H, Schmidt ML, Mezzanotte J, Barnoud T, Clark GJ
  Title
Ras signaling through RASSF proteins.
  Journal
Semin Cell Dev Biol 58:86-95 (2016)
DOI:10.1016/j.semcdb.2016.06.007
Reference
PMID:28455242
  Authors
Barnoud T, Schmidt ML, Donninger H, Clark GJ
  Title
The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence.
  Journal
Cancer Lett 400:30-36 (2017)
DOI:10.1016/j.canlet.2017.04.030
Reference
PMID:26404840
  Authors
Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ
  Title
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.
  Journal
Science 349:aaa5612 (2015)
DOI:10.1126/science.aaa5612
Reference
PMID:26777575
  Authors
Cao X, Li M
  Title
A New Pathway for Senescence Regulation.
  Journal
Genomics Proteomics Bioinformatics 13:333-5 (2015)
DOI:10.1016/j.gpb.2015.11.002
Reference
PMID:25564883
  Authors
Gire V, Dulic V
  Title
Senescence from G2 arrest, revisited.
  Journal
Cell Cycle 14:297-304 (2015)
DOI:10.1080/15384101.2014.1000134
Reference
PMID:24981831
  Authors
Mowla SN, Lam EW, Jat PS
  Title
Cellular senescence and aging: the role of B-MYB.
  Journal
Aging Cell 13:773-9 (2014)
DOI:10.1111/acel.12242
Reference
PMID:22546858
  Authors
Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Ronty M, Kinnula VL, Rahman I
  Title
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.
  Journal
J Clin Invest 122:2032-45 (2012)
DOI:10.1172/JCI60132
Reference
PMID:23542362
  Authors
Hwang JW, Yao H, Caito S, Sundar IK, Rahman I
  Title
Redox regulation of SIRT1 in inflammation and cellular senescence.
  Journal
Free Radic Biol Med 61:95-110 (2013)
DOI:10.1016/j.freeradbiomed.2013.03.015
Related
pathway
xla04020  Calcium signaling pathway
xla04068  FoxO signaling pathway
xla04110  Cell cycle
xla04115  p53 signaling pathway
xla04150  mTOR signaling pathway
KO pathway
ko04218   

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