KEGG ORTHOLOGY: K03172

ORTHOLOGY: K03172

Entry

K03172                      KO

Symbol

TRAF1

Name

TNF receptor-associated factor 1

Pathway

map04064

NF-kappa B signaling pathway

map04210

Apoptosis

map04668

TNF signaling pathway

map05200

Pathways in cancer

map05202

Transcriptional misregulation in cancer

map05203

Viral carcinogenesis

map05222

Small cell lung cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K03172  TRAF1; TNF receptor-associated factor 1
   04668 TNF signaling pathway
    K03172  TRAF1; TNF receptor-associated factor 1
09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K03172  TRAF1; TNF receptor-associated factor 1
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K03172  TRAF1; TNF receptor-associated factor 1
   05202 Transcriptional misregulation in cancer
    K03172  TRAF1; TNF receptor-associated factor 1
   05203 Viral carcinogenesis
    K03172  TRAF1; TNF receptor-associated factor 1
  09162 Cancer: specific types
   05222 Small cell lung cancer
    K03172  TRAF1; TNF receptor-associated factor 1

Genes

HSA:	7185(TRAF1)

PTR:	743748(TRAF1)

PPS:	100985558(TRAF1)

GGO:	101126795(TRAF1)

PON:	100172676(TRAF1)

PPYG:

129044168(TRAF1)

NLE:	100605879(TRAF1)

SSYN:

129478948(TRAF1)

MCC:	700583(TRAF1)

MTHB:

126936852

MNI:	105487148(TRAF1)

CSAB:

103218917(TRAF1)

CATY:

105600240(TRAF1)

PANU:

101001256(TRAF1)

TGE:	112608030(TRAF1)

MLEU:

105546333(TRAF1)

RRO:	104669131(TRAF1)

RBB:	108537107(TRAF1)

TFN:	117098744(TRAF1)

PTEH:

111550331(TRAF1)

CANG:

105501437(TRAF1)

CJC:	100389116(TRAF1)

SBQ:	101041198(TRAF1)

CIMI:

108285843(TRAF1)

ANAN:

105721249(TRAF1)

CSYR:

103258026(TRAF1)

MMUR:

105875121(TRAF1)

LCAT:

123646265(TRAF1)

ERUF:

138387529(TRAF1)

PCOQ:

105826431(TRAF1)

OGA:	100959720(TRAF1)

MMU:	22029(Traf1)

MCAL:

110289943(Traf1)

MPAH:

110319363(Traf1)

RNO:	687813(Traf1)

MCOC:

116090053(Traf1)

ANU:	117703605(Traf1)

ASYL:

127685280(Traf1)

MUN:	110563759(Traf1)

CGE:	100756802(Traf1)

MAUA:

101825347(Traf1)

PROB:

127222814(Traf1)

PLEU:

114704682(Traf1)

PMAV:

102918304(Traf1)

MORG:

121463026(Traf1)

MFOT:

126513423

AAMP:

119819361(Traf1)

CNL:	130864691(Traf1)

NGI:	103734496(Traf1)

HGL:	101710804(Traf1)

CPOC:

100723139(Traf1)

CCAN:

109699424(Traf1)

DORD:

105996183(Traf1)

DSP:	122107096(Traf1)

DMER:

138820826(Traf1) 138821396

PLOP:

125347818(Traf1)

NCAR:

124964504

MMMA:

107152135(Traf1)

ITI:	101959404(Traf1)

OCU:

100338847

OPI:	101532077(TRAF1)

OCZ:	121144618(TRAF1)

TUP:	102493987(TRAF1)

GVR:	103587301(TRAF1)

VVP:	112923107(TRAF1)

VLG:	121495157(TRAF1)

NPO:	129494886(TRAF1)

AML:	100464979(TRAF1)

UMR:	103670373(TRAF1)

UAH:	113266352(TRAF1)

UAR:	123788020(TRAF1)

ELK:

111146115

LLV:

125083470

MPUF:

101682095(TRAF1)

MNP:	132024461(TRAF1)

MLK:	131812230(TRAF1)

NVS:	122917303(TRAF1)

ORO:	101364536(TRAF1)

EJU:	114212777(TRAF1)

ZCA:	113934914(TRAF1)

MLX:	118017749(TRAF1)

NSU:	110581352(TRAF1)

LWW:	102731373(TRAF1)

FCA:	101087620(TRAF1)

PYU:	121034913(TRAF1)

PCOO:

112849250(TRAF1)

PBG:	122475453(TRAF1)

PVIV:

125150641(TRAF1)

LRUF:

124503618

LGF:	123592679(TRAF1)

AJU:

106986638

PTG:	102961906(TRAF1)

PPAD:

109269887(TRAF1)

PUC:

125920844

PLEZ:

122205046(TRAF1)

HHV:	120233425(TRAF1)

BTA:	540944(TRAF1)

BOM:	102287586(TRAF1)

BIU:	109563408(TRAF1)

BBUB:

102399965(TRAF1)

BKE:	129650724(TRAF1)

BBIS:

104994766(TRAF1)

CHX:	102182975(TRAF1)

OAS:	101122077(TRAF1)

BTAX:

128052448(TRAF1)

CSUM:

138081186(TRAF1)

ODA:	120863585(TRAF1)

CCAD:

122431882(TRAF1)

MREE:

136176263(TRAF1)

OVR:	110137331(TRAF1)

MBEZ:

129557215(TRAF1)

SSC:	100627029(TRAF1)

CFR:	102511048(TRAF1)

CBAI:

105065268(TRAF1)

CDK:	105104470(TRAF1)

VPC:	102544593(TRAF1)

BACU:

103010571(TRAF1)

BMUS:

118897235(TRAF1)

LVE:	103085868(TRAF1)

OOR:	101279636(TRAF1)

LALB:

132523397(TRAF1)

GMF:	115854527(TRAF1)

DDP:	132427108(TRAF1)

DLE:	111177267(TRAF1)

PCAD:

102979844(TRAF1)

PSIU:

116755406(TRAF1)

PPHC:

136124684(TRAF1)

NASI:

112411542(TRAF1)

ECB:	100067681(TRAF1)

EPZ:	103550396(TRAF1)

EAI:	106824204(TRAF1)

MYB:	102239036(TRAF1)

MYD:	102773676(TRAF1)

MMYO:

118667115(TRAF1)

MLF:	102441839(TRAF1)

MDT:	132212319(TRAF1)

MYUM:

139020824(TRAF1)

PKL:	118716109(TRAF1)

EFUS:

103295679(TRAF1)

MNA:	107537677(TRAF1)

DRO:	112306476(TRAF1)

SHON:

118995980(TRAF1)

AJM:	119035933(TRAF1)

PDIC:

114507728(TRAF1)

PHAS:

123819750(TRAF1)

MMF:	118630181(TRAF1)

PPAM:

129079617(TRAF1)

HAI:	109385737(TRAF1)

RFQ:	117032180(TRAF1)

PALE:

102894412(TRAF1)

PGIG:

120605773(TRAF1)

PVP:	105292663(TRAF1)

RAY:	107516329(TRAF1)

MJV:	108391145(TRAF1)

TOD:	119230859(TRAF1)

SARA:

101558533(TRAF1)

SFUM:

130045826(TRAF1)

SETR:

126009381(TRAF1)

LAV:	100656766(TRAF1)

TMU:

101350627

ETF:	101663447(TRAF1)

DNM:	101422831(TRAF1)

MDO:	100015491(TRAF1)

GAS:	123235384(TRAF1)

SHR:	100932053(TRAF1)

AFZ:

127550532

PCW:	110211345(TRAF1)

TVP:	118844085(TRAF1)

PBRV:

138150386(TRAF1)

MLAO:

141505668(TRAF1)

OAA:	100681677(TRAF1)

TACU:

119926939 119927118

GGA:	417123(TRAF1)

PCOC:

116234352(TRAF1)

MGP:	100538378(TRAF1)

CJO:	107321799(TRAF1)

TPAI:

128074089(TRAF1)

LMUT:

125702711(TRAF1)

NMEL:

110406931(TRAF1)

APLA:

101796056(TRAF1)

AACU:

137842582(TRAF1)

ACYG:

106040726(TRAF1)

CATA:

118252329(TRAF1)

AFUL:

116496986(TRAF1)

TGU:	100230681(TRAF1)

LSR:	110477711(TRAF1)

SCAN:

103819114(TRAF1)

PMOA:

120512353(TRAF1)

OTC:	121337042(TRAF1)

PRUF:

121362439(TRAF1)

ATRC:

139603339(TRAF1)

GFR:	102036248(TRAF1)

FAB:	101809418(TRAF1)

OMA:	130260072(TRAF1)

PHI:	102107913(TRAF1)

PMAJ:

107212135(TRAF1)

CCAE:

111937083(TRAF1)

CCW:	104688365(TRAF1)

CBRC:

103623221(TRAF1)

ACOE:

138119779(TRAF1)

ETL:	114058491(TRAF1)

ZAB:	102064941(TRAF1)

ZLE:	135454957(TRAF1)

ACHL:

103800762(TRAF1)

SVG:	106855421(TRAF1)

MMEA:

130577534(TRAF1)

HRT:	120761904(TRAF1)

SATI:

136369831(TRAF1)

CFAI:

136299614(TRAF1)

CCIC:

134051830(TRAF1)

FPG:	101913584(TRAF1)

FCH:	102052322(TRAF1)

CCRI:

104163578(TRAF1)

NNT:	104400409(TRAF1)

SHAB:

115616989(TRAF1)

ACUN:

113486515(TRAF1)

TALA:

104359133(TRAF1)

ACHC:

115335383(TRAF1)

HALD:

104324578(TRAF1)

HLE:	104834011(TRAF1)

AGEN:

126052326

HHAR:

128154551(TRAF1)

BBUT:

142043600(TRAF1)

GCL:

127023670

CSTI:

104564210(TRAF1)

LDI:	104345080(TRAF1)

MNB:	103778558(TRAF1)

DPUB:

104306545(TRAF1)

PPUS:

135190042(TRAF1)

AVIT:

104274851(TRAF1)

BRHI:

104495541(TRAF1)

EGZ:	104135230(TRAF1)

NNI:	104023308(TRAF1)

PCRI:

104029741

PCAO:

104050245(TRAF1)

PARX:

142065594(TRAF1)

PADL:

103915325(TRAF1)

AFOR:

103900025(TRAF1)

FGA:	104076045(TRAF1)

CBOR:

142091463(TRAF1)

GSTE:

104263428(TRAF1)

CBOY:

140661173(TRAF1)

MAME:

142418089(TRAF1)

CLV:	102092613(TRAF1)

CNIC:

135996525(TRAF1)

MUI:	104534572(TRAF1)

PGUU:

104467616(TRAF1)

PLET:

104623850(TRAF1)

EHS:	104517346(TRAF1)

CMAC:

104482990(TRAF1)

CUCA:

104066958(TRAF1)

TEO:	104376451(TRAF1)

BREG:

104643637(TRAF1)

OHA:	104335132(TRAF1)

ACAR:

104533088(TRAF1)

CPEA:

104389884(TRAF1)

CVF:	104292915(TRAF1)

RTD:	128917512(TRAF1)

CRID:

134523707(TRAF1)

LMIC:

141751651(TRAF1)

NARQ:

141473666(TRAF1)

AAM:	106482001 106482010

AROW:

112964305(TRAF1)

NPD:	112955786(TRAF1)

TGT:	104575841(TRAF1)

DNE:	112979923(TRAF1)

SCAM:

104148069(TRAF1)

ASN:	102376917 102377947(TRAF1)

AMJ:	102558770(TRAF1) 102567048

CPOO:

109314035(TRAF1)

GGN:	109293050(TRAF1)

PSS:	102463237(TRAF1)

CIZ:	142023924(TRAF1)

CMY:	102929689(TRAF1)

CCAY:

125621264 125621269 125623404(TRAF1)

LKP:	140899426(TRAF1)

NDS:	141998127 141999055 141999835(TRAF1)

DCC:	119844049(TRAF1)

CPIC:

101931215(TRAF1)

TST:	117889393(TRAF1)

CABI:

116817399(TRAF1)

MRV:	120386584(TRAF1)

ACS:

100553353

ASAO:

132763671(TRAF1) 132765668

PVT:	110069893 110087473

SUND:

121936031(TRAF1)

PBI:	112541689(TRAF1)

PMUR:

107293286 114923686

CTIG:

120300733(TRAF1) 120314272

TSR:	106553904 106556710

PGUT:

117665100(TRAF1) 117667931

PCAE:

139325806(TRAF1)

APRI:

131186237(TRAF1)

PTEX:

113443808(TRAF1) 113449341

NSS:	113423870 113424792

VKO:	123017945 123028171(TRAF1)

PMUA:

114589408(TRAF1) 114592055

PRAF:

128406948(TRAF1) 128409100 128409107

ZVI:	118084277(TRAF1)

HCG:	128338826(TRAF1)

GJA:	107109808 107124804

STOW:

125441533(TRAF1)

EMC:	129327747 129328932 129342373(TRAF1)

XLA:	108698201 108699917

XTR:	101734662(traf1)

NPR:	108793651(TRAF1)

RTEM:

120913809(TRAF1)

ACAT:

141108200(TRAF1)

PADS:

140343423(TRAF1)

BBUF:

120977869(TRAF1)

BGAR:

122946670

DTC:	141069460(TRAF1)

PWL:	138299131 138301319(TRAF1)

MUO:	115466229 115473001(TRAF1)

GSH:	117346871 117368254(TRAF1)

DRE:	100148503(traf1)

SRX:	107709033 107725291

SANH:

107664983 107674383

SGH:	107557184 107599053

CCAR:

109050654 109051965(traf1)

CAUA:

113107179

CGIB:

127964088

PTET:

122351114(traf1)

LROH:

127169182(traf1)

GRF:	141287552(traf1)

OMC:	131546362(traf1)

PPRM:

120474395(traf1)

RKG:	130091677(traf1)

MAMB:

125280000(traf1)

CIDE:

127517418

CERY:

137026262(traf1)

MASI:

127415154 127423948

TROS:

130567998(traf1)

TDW:	130406992(traf1)

MANU:

129414620(traf1)

PDAB:

135730439(traf1)

IPU:	108264960(traf1)

IFU:	128608121(traf1)

PHYP:

113534948

SMEO:

124399411(traf1)

TFD:	113645500(traf1)

TVC:	132854002(traf1)

CGAR:

128530801(traf1)

NGRA:

132892614(traf1)

TRN:	134317759(traf1)

AMEX:

103045252(traf1)

CMAO:

118813828(traf1)

EEE:

113577380

CHAR:

105890598(traf1)

SPIL:

134088368(traf1)

ASAD:

121715158(traf1)

SASA:

106585784

STRU:

115164885

OTW:	112248218(traf1)

OMY:	110525328(traf1)

OGO:	124034580(traf1)

ONE:

115111313

OKI:

109876020

OKE:	118392908(traf1)

OMM:	135522817(traf1)

OCLA:

139410673

SALP:

111973666

SNH:	120048862(traf1)

SFON:

129853158(traf1)

CCLU:

121550753 121584502(traf1)

ELS:

105014657

SFM:	108938498(traf1)

PKI:

111855439

AANG:

118237064(traf1)

AROT:

135233121(traf1)

CCOG:

133140846(traf1)

LOC:	102684289(traf1)

PSPA:

121306720

ARUT:

117396680 117422408 117433548 117433702 117433751 117433946

PSEX:

120536057(traf1)

LCM:

102352896

CMK:	103184611(traf1)

RTP:	109912223(traf1)

CPLA:

122564882(traf1)

CPUN:

140469435(traf1) 140469500

HOC:	132825871(traf1) 132825872

SCAU:

119955430(traf1)

LERI:

129711827(traf1) 129711828

HAKA:

140731203(traf1) 140731204

PMRN:

LRJ:

LVG:

SKO:

PFLL:

DSV:	119431494 119461244

RSAN:

ATEN:

RES:

Reference

PMID:7859281

Authors

Mosialos G, Birkenbach M, Yalamanchili R, VanArsdale T, Ware C, Kieff E

Title

The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family.

Journal

Cell 80:389-99 (1995)
DOI:10.1016/0092-8674(95)90489-1

Sequence

[hsa:7185]

Reference

PMID:18429822

Authors

Kato T Jr, Gotoh Y, Hoffmann A, Ono Y

Title

Negative regulation of constitutive NF-kappaB and JNK signaling by PKN1-mediated phosphorylation of TRAF1.

Journal

Genes Cells 13:509-20 (2008)
DOI:10.1111/j.1365-2443.2008.01182.x

Sequence

[hsa:7185] [mmu:22029]

LinkDB

DBGET integrated database retrieval system