Entry Name Regulation of lipolysis in adipocytes - Ailuropoda melanoleuca (giant panda)
Description Lipolysis in adipocytes, the hydrolysis of triacylglycerol (TAG) to release fatty acids (FAs) and glycerol for use by other organs as energy substrates, is a unique function of white adipose tissue. Lipolysis is under tight hormonal control. During fasting, catecholamines, by binding to Gs-coupled-adrenergic receptors (-AR), activate adenylate cyclase (AC) to increase cAMP and activate protein kinase A (PKA). PKA phosphorylates target protein such as hormone-sensitive lipase (HSL) and perilipin 1 (PLIN). PLIN phosphorylation is a key event in the sequential activation of TAG hydrolysis involving adipose triglyceride lipase (ATGL), HSL, and monoglyceride lipase (MGL). During the fed state, insulin, through activation of phosphodiesterase-3B (PDE-3B), inhibits catecholamine-induced lipolysis via the degradation of cAMP.
Class Organismal Systems; Endocrine systemBRITE hierarchy
Pathway map aml04923 Regulation of lipolysis in adipocytes
Other DBs Organism Ailuropoda melanoleuca (giant panda) [GN:
aml ]
Gene 100463775 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
100466408 GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630 ]
100467916 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
100471252 ADRB1; LOW QUALITY PROTEIN: beta-1 adrenergic receptor [KO:K04141 ]
100471767 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
100475291 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
100477685 IRS2; LOW QUALITY PROTEIN: insulin receptor substrate 2 [KO:K07187 ]
100479294 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
100479580 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
100480537 PTGER3; prostaglandin E2 receptor EP3 subtype isoform X2 [KO:K04260 ]
100483828 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
100484933 GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
105240373 IRS4; LOW QUALITY PROTEIN: insulin receptor substrate 4 [KO:K17446 ]
Compound Reference Authors Ahmadian M, Wang Y, Sul HS
Title Lipolysis in adipocytes.
Journal Reference Authors Ahmadian M, Duncan RE, Sul HS
Title The skinny on fat: lipolysis and fatty acid utilization in adipocytes.
Journal Reference Authors Wang S, Soni KG, Semache M, Casavant S, Fortier M, Pan L, Mitchell GA
Title Lipolysis and the integrated physiology of lipid energy metabolism.
Journal Reference Authors Lafontan M
Title Historical perspectives in fat cell biology: the fat cell as a model for the investigation of hormonal and metabolic pathways.
Journal Reference Authors Fruhbeck G, Mendez-Gimenez L, Fernandez-Formoso JA, Fernandez S, Rodriguez A
Title Regulation of adipocyte lipolysis.
Journal Reference Authors Proenca AR, Sertie RA, Oliveira AC, Campana AB, Caminhotto RO, Chimin P, Lima FB
Title New concepts in white adipose tissue physiology.
Journal Reference Authors Duncan RE, Ahmadian M, Jaworski K, Sarkadi-Nagy E, Sul HS
Title Regulation of lipolysis in adipocytes.
Journal Reference Authors Lafontan M
Title Advances in adipose tissue metabolism.
Journal Reference Authors Jaworski K, Sarkadi-Nagy E, Duncan RE, Ahmadian M, Sul HS
Title Regulation of triglyceride metabolism. IV. Hormonal regulation of lipolysis in adipose tissue.
Journal Reference Authors Thompson D, Karpe F, Lafontan M, Frayn K
Title Physical activity and exercise in the regulation of human adipose tissue physiology.
Journal Reference Authors Lafontan M, Langin D
Title Lipolysis and lipid mobilization in human adipose tissue.
Journal Reference Authors Arner P, Langin D
Title Lipolysis in lipid turnover, cancer cachexia, and obesity-induced insulin resistance.
Journal Reference Authors Brasaemle DL
Title Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis.
Journal Reference Authors Lampidonis AD, Rogdakis E, Voutsinas GE, Stravopodis DJ
Title The resurgence of Hormone-Sensitive Lipase (HSL) in mammalian lipolysis.
Journal Reference Authors Bickel PE, Tansey JT, Welte MA
Title PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores.
Journal Reference Authors Grahn THM, Kaur R, Yin J, Schweiger M, Sharma VM, Lee MJ, Ido Y, Smas CM, Zechner R, Lass A, Puri V
Title Fat-specific protein 27 (FSP27) interacts with adipose triglyceride lipase (ATGL) to regulate lipolysis and insulin sensitivity in human adipocytes.
Journal Reference Authors Zhao XH, Ruan L
Title Recent advances on the role of G0S2.
Journal Related KO pathway
