KEGG   PATHWAY: cbr03013
Entry
cbr03013                    Pathway                                
Name
Nucleocytoplasmic transport - Caenorhabditis briggsae (nematode)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
cbr03013  Nucleocytoplasmic transport
cbr03013

Other DBs
GO: 0050658
Organism
Caenorhabditis briggsae (nematode) [GN:cbr]
Gene
CBG_00694  Cbr-hel-1; Protein CBR-HEL-1 [KO:K12812] [EC:5.6.2.7]
CBG_01003  [KO:K14326] [EC:5.6.2.5 5.6.2.3]
CBG_01720  Cbr-ubc-9; Protein CBR-UBC-9 [KO:K10577]
CBG_02744  Cbr-npp-3; Protein CBR-NPP-3 [KO:K14310]
CBG_02849  Cbr-npp-5; Protein CBR-NPP-5 [KO:K14301]
CBG_03017  Cbr-npp-19; Protein CBR-NPP-19 [KO:K14313]
CBG_03470  Cbr-npp-1; Protein CBR-NPP-1 [KO:K14308]
CBG_03573  Cbr-npp-18; Protein CBR-NPP-18 [KO:K14299]
CBG_03763  Cbr-npp-14; Protein CBR-NPP-14 [KO:K14317]
CBG_03784  Cbr-rae-1; Protein CBR-RAE-1 [KO:K14298]
CBG_04018  [KO:K13025] [EC:5.6.2.7]
CBG_04087  Cbr-npp-2; Protein CBR-NPP-2 [KO:K14304]
CBG_04218  Cbr-nxt-1; Protein CBR-NXT-1 [KO:K14285]
CBG_04621  Cbr-nxf-2; Protein CBR-NXF-2 [KO:K14284]
CBG_04623  Cbr-nxf-1; Protein CBR-NXF-1 [KO:K14284]
CBG_05145  [KO:K13025] [EC:5.6.2.7]
CBG_05231  [KO:K10577]
CBG_05463  Cbr-smg-3; Protein CBR-SMG-3 [KO:K14327]
CBG_05912  Cbr-ima-3; Protein CBR-IMA-3 [KO:K23583]
CBG_06234  Cbr-aly-3; Protein CBR-ALY-3 [KO:K12881]
CBG_07011  [KO:K13151]
CBG_07956  Cbr-rsr-1; Protein CBR-RSR-1 [KO:K13171]
CBG_08494  Cbr-smg-2; Protein CBR-SMG-2 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
CBG_09022  Cbr-npp-10; Protein CBR-NPP-10 [KO:K14297]
CBG_09105  Cbr-thoc-2; Protein CBR-THOC-2 [KO:K12879]
CBG_09489  [KO:K13114]
CBG_09629  [KO:K18460]
CBG_09807  [KO:K14294]
CBG_09828  [KO:K14291]
CBG_11089  Cbr-imb-2; Protein CBR-IMB-2 [KO:K18752]
CBG_11828  [KO:K12160]
CBG_11892  [KO:K07562]
CBG_12010  Cbr-npp-11; Protein CBR-NPP-11 [KO:K14306]
CBG_12282  Cbr-ran-2; Protein CBR-RAN-2 [KO:K14319]
CBG_12284  Cbr-npp-15; Protein CBR-NPP-15 [KO:K14300]
CBG_12621  Cbr-ncbp-1; Protein CBR-NCBP-1 [KO:K12882]
CBG_12629  Cbr-npp-12; Protein CBR-NPP-12 [KO:K14314]
CBG_13007  Cbr-npp-21; Protein CBR-NPP-21 [KO:K09291]
CBG_13313  Cbr-npp-16; Protein CBR-NPP-16 [KO:K14295]
CBG_13567  Cbr-npp-8; Protein CBR-NPP-8 [KO:K14312]
CBG_13889  Cbr-npp-20; Protein CBR-NPP-20 [KO:K14004]
CBG_15104  [KO:K12160]
CBG_15760  [KO:K20724]
CBG_16491  Cbr-eft-3.1; Protein CBR-EFT-3.1 [KO:K03231]
CBG_16828  [KO:K03231]
CBG_16850  [KO:K10577]
CBG_17706  Cbr-xpo-3; Protein CBR-XPO-3 [KO:K14288]
CBG_18074  Cbr-rnp-4; Protein CBR-RNP-4 [KO:K12876]
CBG_18317  Cbr-ran-1; Protein CBR-RAN-1 [KO:K07936]
CBG_18690  Cbr-mag-1; Protein CBR-MAG-1 [KO:K12877]
CBG_19371  [KO:K14328]
CBG_19980  [KO:K12881]
CBG_20155  [KO:K14324]
CBG_20393  [KO:K14323]
CBG_20440  Cbr-tsr-1; Protein CBR-TSR-1 [KO:K15436]
CBG_20495  Cbr-imb-1; Protein CBR-IMB-1 [KO:K14293]
CBG_20576  Cbr-xpo-1; Protein CBR-XPO-1 [KO:K14290]
CBG_21775  Cbr-aly-1; Protein CBR-ALY-1 [KO:K12881]
CBG_21776  [KO:K12881]
CBG_21777  [KO:K12881]
CBG_22062  Cbr-imb-3; Protein CBR-IMB-3 [KO:K20222]
CBG_22063  Cbr-xpo-2; Protein CBR-XPO-2 [KO:K18423]
CBG_22089  Cbr-npp-13; Protein CBR-NPP-13 [KO:K14309]
CBG_22194  Cbr-ncbp-2; Protein CBR-NCBP-2 [KO:K12883]
CBG_22301  Cbr-smo-1; Protein CBR-SMO-1 [KO:K12160]
CBG_22401  [KO:K13176]
CBG_22497  [KO:K25203]
CBG_22588  [KO:K14326] [EC:5.6.2.5 5.6.2.3]
CBG_23742  Cbr-npp-6; Protein CBR-NPP-6 [KO:K14303]
CBG_24189  Cbr-rnp-5; Protein CBR-RNP-5 [KO:K14325]
CBG_24217  Cbr-thoc-1; Protein CBR-THOC-1 [KO:K12878]
CBG_24566  Cbr-eft-3.2; Protein CBR-EFT-3.2 [KO:K03231]
CBG_24679  [KO:K13174]
CBG_25105  Cbr-thoc-3.2; Protein CBR-THOC-3.2 [KO:K12880]
CBG_27616  [KO:K03345] [EC:3.4.22.68]
CBG_29121  [KO:K14315]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
cbr03015  mRNA surveillance pathway
KO pathway
ko03013   

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