KEGG   PATHWAY: cery04217
Entry
cery04217                   Pathway                                
Name
Necroptosis - Chanodichthys erythropterus (predatory carp)
Description
Necroptosis is a programmed form of necrosis. It can be initiated by different stimuli, such as tumor necrosis factor (TNF), TNF-related apoptosis-inducing ligand (TRAIL), Fas ligand (FasL), interferon (IFN), LPS, viral DNA or RNA, DNA-damage agent and requires the kinase activity of receptor-interacting protein 1 (RIPK1) and RIPK3. Its execution involves ROS generation, calcium overload, the opening of the mitochondrial permeability transition pore, mitochondrial fission, inflammatory response and chromatinolysis. Necroptosis participates in many pathogenesis of diseases, including neurological diseases, retinal disorders, acute kidney injury, inflammatory diseases and microbial infections.
Class
Cellular Processes; Cell growth and death
Pathway map
cery04217  Necroptosis
cery04217

Organism
Chanodichthys erythropterus (predatory carp) [GN:cery]
Gene
137002321  pla2g4aa; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
137002401  vps4b; vacuolar protein sorting-associated protein 4B isoform X1 [KO:K12196]
137002480  glula; glutamate-ammonia ligase (glutamine synthase) a [KO:K01915] [EC:6.3.1.2]
137002503  sharpin; ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K20894]
137002636  chmp5a; charged multivesicular body protein 5 [KO:K12198]
137002728  bcl2b; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
137003214  ripk1l; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
137003290  rnf31; E3 ubiquitin-protein ligase RNF31 [KO:K11974] [EC:2.3.2.31]
137003455  si:dkey-181m9.8; uncharacterized protein si:dkey-181m9.8 isoform X1 [KO:K11974] [EC:2.3.2.31]
137003529  [KO:K11217] [EC:2.7.10.2]
137004493  hmgb1b; high mobility group protein B1b [KO:K10802]
137006273  pla2g4f.2; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
137006286  [KO:K01367] [EC:3.4.22.52]
137006287  [KO:K01367] [EC:3.4.22.52]
137006440  pygb; glycogen phosphorylase, brain form isoform X1 [KO:K00688] [EC:2.4.1.1]
137006470  fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
137006484  chmp3; charged multivesicular body protein 3 [KO:K12193]
137006766  pla2g4f.1; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
137007004  [KO:K01367] [EC:3.4.22.52]
137007341  camk2g1; calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
137007352  chmp6b; charged multivesicular body protein 6 [KO:K12195]
137007403  glud1b; glutamate dehydrogenase 1b [KO:K00261] [EC:1.4.1.3]
137007419  stat5b; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
137007574  [KO:K15040]
137007791  irf9; interferon regulatory factor 9 isoform X1 [KO:K04693]
137007854  chmp2a; charged multivesicular body protein 2a [KO:K12191]
137008268  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
137009109  spata2; spermatogenesis-associated protein 2 [KO:K17595]
137009372  usp21; ubiquitin carboxyl-terminal hydrolase 21 isoform X1 [KO:K21634] [EC:3.4.19.12]
137009641  stat6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225]
137009801  chmp6a; charged multivesicular body protein 6 [KO:K12195]
137010665  ifnphi1; interferon phi 1 isoform X1 [KO:K05414]
137010678  ifnphi3; interferon phi 3 [KO:K05414]
137010908  cyldl; ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
137011077  [KO:K04398] [EC:3.4.22.61]
137011185  glulb; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
137011206  casp8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
137011214  chmp4ba; charged multivesicular body protein 4b [KO:K12194]
137011268  casp8l1; caspase 8, apoptosis-related cysteine peptidase, like 1 [KO:K04398] [EC:3.4.22.61]
137011655  jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
137011712  stat2; signal transducer and activator of transcription 2 [KO:K11221]
137012019  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
137012056  jak2a; tyrosine-protein kinase JAK2a isoform X1 [KO:K04447] [EC:2.7.10.2]
137012088  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
137012107  si:dkeyp-50d11.2; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
137012171  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
137012239  [KO:K01915] [EC:6.3.1.2]
137012328  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
137012362  macroh2a1; core histone macro-H2A.1 [KO:K11251]
137012517  [KO:K01915] [EC:6.3.1.2]
137012734  pygma; glycogen phosphorylase, muscle form [KO:K00688] [EC:2.4.1.1]
137013066  birc2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
137013878  chmp4c; charged multivesicular body protein 4c isoform X1 [KO:K24782]
137013906  zgc:56095; ferritin, lower subunit-like [KO:K00522] [EC:1.16.3.1]
137014020  tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
137014046  bcl2a; apoptosis regulator Bcl-2a isoform X1 [KO:K02161]
137014506  [KO:K11251]
137014521  [KO:K11251]
137014541  [KO:K11251]
137014542  [KO:K11251]
137014544  [KO:K11251]
137014545  [KO:K11251]
137014546  [KO:K11251]
137014547  [KO:K11251]
137014548  [KO:K11251]
137014549  [KO:K11251]
137014602  dnm1l; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
137014730  chmp1a; charged multivesicular body protein 1a [KO:K12197]
137014861  [KO:K11251]
137014982  [KO:K11251]
137014983  [KO:K11251]
137014994  [KO:K11251]
137014995  [KO:K11251]
137015000  fth1b; ferritin, heavy polypeptide 1b [KO:K00522] [EC:1.16.3.1]
137015090  [KO:K08849] [EC:2.7.11.1]
137015276  vps4a; vacuolar protein sorting-associated protein 4A [KO:K12196]
137015493  [KO:K11251]
137017486  stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
137017587  [KO:K00522] [EC:1.16.3.1]
137017588  [KO:K00522] [EC:1.16.3.1]
137017589  [KO:K00522] [EC:1.16.3.1]
137017735  [KO:K02159]
137017831  tyk2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
137018537  parp1; poly [ADP-ribose] polymerase 1 [KO:K24070]
137018740  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
137019074  pla2g4ab; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
137019229  hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
137019265  sqstm1; sequestosome-1 [KO:K14381]
137019271  hsp90aa1.2; heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2 isoform X1 [KO:K04079]
137019273  hsp90aa1.1; heat shock protein HSP 90-alpha 1 [KO:K04079]
137019969  [KO:K10160]
137019989  macroh2a2; core histone macro-H2A.2 [KO:K11251]
137020174  pygl; glycogen phosphorylase, liver form [KO:K00688] [EC:2.4.1.1]
137020368  xiap; E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
137020384  tlr4bb; toll-like receptor 4b, duplicate b isoform X1 [KO:K10160]
137020385  [KO:K10160]
137020398  vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
137020440  capn1a; calpain 1, (mu/I) large subunit a [KO:K01367] [EC:3.4.22.52]
137020441  capn2a; calpain 2, (m/II) large subunit a [KO:K03853] [EC:3.4.22.53]
137020496  camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
137020505  glud1a; glutamate dehydrogenase 1a [KO:K00261] [EC:1.4.1.3]
137020639  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
137020793  tnfaip3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
137020795  ifngr1l; interferon gamma receptor 1-like [KO:K05132]
137021018  slc25a5; ADP/ATP translocase 2 [KO:K05863]
137021486  cflara; CASP8 and FADD-like apoptosis regulator a [KO:K04724]
137021499  cybb; cytochrome b-245 heavy chain isoform X1 [KO:K21421] [EC:1.-.-.-]
137022329  ppid; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
137022773  spata2l; spermatogenesis associated 2-like [KO:K17595]
137023367  bida; BH3 interacting domain death agonist [KO:K04726]
137023513  trpm7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
137023882  ifng1; interferon gamma 1 [KO:K04687]
137026607  chmp4bb; charged multivesicular body protein 4c [KO:K12194]
137026659  [KO:K12799]
137026794  vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
137026908  jak3; tyrosine-protein kinase JAK2 isoform X1 [KO:K11218] [EC:2.7.10.2]
137027295  ppiaa; peptidyl-prolyl cis-trans isomerase A [KO:K03767] [EC:5.2.1.8]
137027335  si:dkey-32e23.4; dynamin-1-like protein [KO:K17065] [EC:3.6.5.5]
137027345  chmp7; charged multivesicular body protein 7 isoform X1 [KO:K15053]
137027622  traf5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
137027661  stat1a; signal transducer and activator of transcription 1a isoform X1 [KO:K11220]
137027816  capn1b; calpain-1 catalytic subunit b [KO:K01367] [EC:3.4.22.52]
137027817  capn2b; calpain 2, (m/II) large subunit b [KO:K03853] [EC:3.4.22.53]
137027820  [KO:K03853] [EC:3.4.22.53]
137027872  rbck1; ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K10630] [EC:2.3.2.31]
137028067  ticam1; TIR domain-containing adapter molecule 1 [KO:K05842]
137028496  zgc:56235; voltage-dependent anion-selective channel protein 2-like [KO:K15041]
137028535  ppiab; peptidylprolyl isomerase Ab (cyclophilin A) [KO:K03767] [EC:5.2.1.8]
137028537  [KO:K04515] [EC:2.7.11.17]
137028546  h2az2b; H2A.Z variant histone 2b [KO:K11251]
137028548  [KO:K04519]
137028645  hmgb1a; high mobility group protein B1a [KO:K10802]
137028702  h2ax1; H2A.X variant histone family member 1 [KO:K11251]
137028755  smpd1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
137029107  [KO:K12196]
137029203  [KO:K03853] [EC:3.4.22.53]
137029204  [KO:K03853] [EC:3.4.22.53]
137029205  [KO:K03853] [EC:3.4.22.53]
137029208  [KO:K03853] [EC:3.4.22.53]
137029209  capn2l; calpain 2, (m/II) large subunit, like [KO:K03853] [EC:3.4.22.53]
137029412  [KO:K03767] [EC:5.2.1.8]
137029421  [KO:K04519]
137029422  [KO:K04519]
137029423  [KO:K04519]
137029424  [KO:K04519]
137029860  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
137029960  [KO:K11251]
137029961  [KO:K11251]
137029962  [KO:K11251]
137029966  capn1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
137030007  chmp5b; charged multivesicular body protein 5 isoform X1 [KO:K12198]
137030077  fadd; protein FADD [KO:K02373]
137030078  zgc:153993; apoptosis regulator BAX isoform X1 [KO:K02159]
137030139  camk2d1; calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
137030146  [KO:K11251]
137030184  ripk3; receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
137030291  [KO:K11251]
137030555  cyld3; ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:3.4.19.12]
137030597  [KO:K11251]
137030670  fth1a; ferritin, heavy polypeptide 1a [KO:K00522] [EC:1.16.3.1]
137030898  pygmb; phosphorylase, glycogen, muscle b [KO:K00688] [EC:2.4.1.1]
137031018  [KO:K11251]
137031019  [KO:K11251]
137031032  [KO:K11251]
137031033  [KO:K11251]
137031040  [KO:K11251]
137031117  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
137031252  si:ch211-189a15.5; uncharacterized protein si:ch211-189a15.5 [KO:K17595]
137031290  shrprbck1r; ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K10630] [EC:2.3.2.31]
137031343  cyld; ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
137031750  tlr3; toll-like receptor 3 [KO:K05401]
137031784  [KO:K01370] [EC:3.4.22.36]
137031788  [KO:K12799]
137031887  slc25a4; ADP/ATP translocase 1 [KO:K05863]
137032098  ifngr1; interferon gamma receptor 1 [KO:K05132]
137032154  camk2d2; calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
137032780  [KO:K01370] [EC:3.4.22.36]
137032845  chmp2bb; charged multivesicular body protein 2b [KO:K12192]
137033101  h2af1al; H2A histone family member 1a like [KO:K11251]
137033102  [KO:K11251]
137033632  traf2a; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
137033763  chmp1b; charged multivesicular body protein 1b [KO:K12197]
137033820  camk2b1; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
137033832  pgam5; serine/threonine-protein phosphatase PGAM5, mitochondrial isoform X1 [KO:K15637] [EC:3.1.3.16]
137033892  [KO:K16342] [EC:3.1.1.4]
137033949  traf2b; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
137033975  hdr; hematopoietic death receptor isoform X1 [KO:K04722]
137033976  [KO:K03173] [EC:2.3.2.27]
137033981  aifm1; apoptosis-inducing factor 1, mitochondrial isoform X1 [KO:K04727] [EC:1.-.-.-]
137033991  [KO:K16342] [EC:3.1.1.4]
137034085  [KO:K16342] [EC:3.1.1.4]
137034225  h2az2a; histone H2A.V [KO:K11251]
137034241  si:dkey-251i10.1; ADP/ATP translocase 2 [KO:K05863]
137034510  h2ax; histone H2AX [KO:K11251]
137034980  casp22; LOW QUALITY PROTEIN: caspase-22 [KO:K04398] [EC:3.4.22.61]
137035008  [KO:K16342] [EC:3.1.1.4]
137035015  [KO:K16342] [EC:3.1.1.4]
137035016  [KO:K16342] [EC:3.1.1.4]
137035017  [KO:K16342] [EC:3.1.1.4]
137035018  [KO:K16342] [EC:3.1.1.4]
137035020  [KO:K16342] [EC:3.1.1.4]
137035021  [KO:K16342] [EC:3.1.1.4]
137035022  [KO:K16342] [EC:3.1.1.4]
137035023  [KO:K16342] [EC:3.1.1.4]
137035024  [KO:K16342] [EC:3.1.1.4]
137035025  [KO:K16342] [EC:3.1.1.4]
137035029  [KO:K16342] [EC:3.1.1.4]
137035030  [KO:K16342] [EC:3.1.1.4]
137035031  [KO:K16342] [EC:3.1.1.4]
137035134  jak2b; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
137035360  casp10; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
137035519  crfb2; cytokine receptor family member b2 isoform X1 [KO:K05131]
137035812  chmp2ba; charged multivesicular body protein 2Ba [KO:K12192]
137035849  slc25a6; ADP/ATP translocase 3 [KO:K05863]
137036066  caspa; caspase a [KO:K01370] [EC:3.4.22.36]
137036098  pycard; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
137036317  [KO:K04724]
137037220  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
Compound
C00002  ATP
C00027  Hydrogen peroxide
C00076  Calcium cation
C00195  N-Acylsphingosine
C00219  Arachidonate
C00305  Magnesium cation
C00319  Sphingosine
C00550  Sphingomyelin
C14592  N-Methyl-N'-nitro-N-nitrosoguanidine
C16844  Hydroxyl radical
Reference
PMID:20823910
  Authors
Vandenabeele P, Galluzzi L, Vanden Berghe T, Kroemer G
  Title
Molecular mechanisms of necroptosis: an ordered cellular explosion.
  Journal
Nat Rev Mol Cell Biol 11:700-14 (2010)
DOI:10.1038/nrm2970
Reference
PMID:26008591
  Authors
Brenner D, Blaser H, Mak TW
  Title
Regulation of tumour necrosis factor signalling: live or let die.
  Journal
Nat Rev Immunol 15:362-74 (2015)
DOI:10.1038/nri3834
Reference
PMID:26775689
  Authors
Conrad M, Angeli JP, Vandenabeele P, Stockwell BR
  Title
Regulated necrosis: disease relevance and therapeutic opportunities.
  Journal
Nat Rev Drug Discov 15:348-66 (2016)
DOI:10.1038/nrd.2015.6
Reference
PMID:24129419
  Authors
Ofengeim D, Yuan J
  Title
Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death.
  Journal
Nat Rev Mol Cell Biol 14:727-36 (2013)
DOI:10.1038/nrm3683
Reference
PMID:27158445
  Authors
Murphy JM, Vince JE
  Title
Post-translational control of RIPK3 and MLKL mediated necroptotic cell death.
  Journal
F1000Res 4:F1000 Faculty Rev-1297 (2015)
DOI:10.12688/f1000research.7046.1
Reference
PMID:24452471
  Authors
Vanden Berghe T, Linkermann A, Jouan-Lanhouet S, Walczak H, Vandenabeele P
  Title
Regulated necrosis: the expanding network of non-apoptotic cell death pathways.
  Journal
Nat Rev Mol Cell Biol 15:135-47 (2014)
DOI:10.1038/nrm3737
Reference
PMID:27368376
  Authors
Dondelinger Y, Hulpiau P, Saeys Y, Bertrand MJ, Vandenabeele P
  Title
An evolutionary perspective on the necroptotic pathway.
  Journal
Trends Cell Biol 26:721-32 (2016)
DOI:10.1016/j.tcb.2016.06.004
Reference
PMID:27746097
  Authors
Thapa RJ, Ingram JP, Ragan KB, Nogusa S, Boyd DF, Benitez AA, Sridharan H, Kosoff R, Shubina M, Landsteiner VJ, Andrake M, Vogel P, Sigal LJ, tenOever BR, Thomas PG, Upton JW, Balachandran S
  Title
DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death.
  Journal
Cell Host Microbe 20:674-681 (2016)
DOI:10.1016/j.chom.2016.09.014
Reference
PMID:27984721
  Authors
Yuan J, Najafov A, Py BF
  Title
Roles of Caspases in Necrotic Cell Death.
  Journal
Cell 167:1693-1704 (2016)
DOI:10.1016/j.cell.2016.11.047
Reference
PMID:28138137
  Authors
Jorgensen I, Rayamajhi M, Miao EA
  Title
Programmed cell death as a defence against infection.
  Journal
Nat Rev Immunol 17:151-164 (2017)
DOI:10.1038/nri.2016.147
Reference
PMID:20354226
  Authors
Vandenabeele P, Declercq W, Van Herreweghe F, Vanden Berghe T
  Title
The role of the kinases RIP1 and RIP3 in TNF-induced necrosis.
  Journal
Sci Signal 3:re4 (2010)
DOI:10.1126/scisignal.3115re4
Reference
PMID:22075985
  Authors
Vanlangenakker N, Vanden Berghe T, Vandenabeele P
  Title
Many stimuli pull the necrotic trigger, an overview.
  Journal
Cell Death Differ 19:75-86 (2012)
DOI:10.1038/cdd.2011.164
Reference
PMID:23913919
  Authors
Moriwaki K, Chan FK
  Title
RIP3: a molecular switch for necrosis and inflammation.
  Journal
Genes Dev 27:1640-9 (2013)
DOI:10.1101/gad.223321.113
Reference
PMID:25146926
  Authors
Humphries F, Yang S, Wang B, Moynagh PN
  Title
RIP kinases: key decision makers in cell death and innate immunity.
  Journal
Cell Death Differ 22:225-36 (2015)
DOI:10.1038/cdd.2014.126
Reference
PMID:28126382
  Authors
Wegner KW, Saleh D, Degterev A
  Title
Complex Pathologic Roles of RIPK1 and RIPK3: Moving Beyond Necroptosis.
  Journal
Trends Pharmacol Sci 38:202-225 (2017)
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Related
pathway
cery00250  Alanine, aspartate and glutamate metabolism
cery04210  Apoptosis
KO pathway
ko04217   

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