KEGG   PATHWAY: eee00230
Entry
eee00230                    Pathway                                
Name
Purine metabolism - Electrophorus electricus (electric eel)
Class
Metabolism; Nucleotide metabolism
Pathway map
eee00230  Purine metabolism
eee00230

Module
eee_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:eee00230]
eee_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:eee00230]
eee_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:eee00230]
eee_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:eee00230]
eee_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:eee00230]
eee_M00546  Purine degradation, xanthine => urea [PATH:eee00230]
eee_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:eee00230]
eee_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:eee00230]
Other DBs
GO: 0006163 0042278
Organism
Electrophorus electricus (electric eel) [GN:eee]
Gene
113567484  adcy5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
113568088  [KO:K00948] [EC:2.7.6.1]
113569929  adsl; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
113570093  [KO:K13293] [EC:3.1.4.53]
113570144  ak5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
113570153  [KO:K01835] [EC:5.4.2.2]
113570203  [KO:K00939] [EC:2.7.4.3]
113570382  hddc2; HD domain-containing protein 2 [KO:K07023] [EC:3.1.3.89]
113570533  rrm2; ribonucleoside-diphosphate reductase subunit M2 isoform X1 [KO:K10808] [EC:1.17.4.1]
113570557  allc; probable allantoicase [KO:K01477] [EC:3.5.3.4]
113570888  [KO:K07127] [EC:3.5.2.17]
113570913  adprm; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
113571186  [KO:K13298] [EC:3.1.4.17 3.1.4.35]
113571233  [KO:K12323] [EC:4.6.1.2]
113571381  adssl1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
113571794  ak2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
113571844  [KO:K00760] [EC:2.4.2.8]
113571871  [KO:K07127] [EC:3.5.2.17]
113571927  enpp1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
113572642  enpp4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
113572754  [KO:K03783] [EC:2.4.2.1]
113572978  prune1; exopolyphosphatase PRUNE1 [KO:K01514] [EC:3.6.1.11]
113572998  nme6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
113573043  ak8; adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
113573048  [KO:K00939] [EC:2.7.4.3]
113573396  pde6a; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha [KO:K08718] [EC:3.1.4.35]
113573439  nudt2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
113573486  [KO:K01081] [EC:3.1.3.5]
113573583  [KO:K03783] [EC:2.4.2.1]
113573773  [KO:K01509] [EC:3.6.1.-]
113573875  pde7a; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
113573958  rrm1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
113574179  prps1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
113574287  nt5m; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
113574576  gart; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
113574817  [KO:K12320] [EC:4.6.1.2]
113575046  [KO:K10808] [EC:1.17.4.1]
113575057  [KO:K01081] [EC:3.1.3.5]
113575079  gmpr; GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
113575168  [KO:K01081] [EC:3.1.3.5]
113575200  [KO:K00940] [EC:2.7.4.6]
113575230  [KO:K12304] [EC:3.6.1.6]
113575539  ampd2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
113575686  ak3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
113575710  aprt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
113575781  pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
113575865  impdh2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
113575922  [KO:K01466] [EC:3.5.2.5]
113575948  [KO:K01510] [EC:3.6.1.5]
113576155  urad; putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
113576273  [KO:K01081] [EC:3.1.3.5]
113576564  [KO:K12322] [EC:4.6.1.2]
113576829  [KO:K08049] [EC:4.6.1.1]
113577125  lacc1; laccase domain-containing protein 1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
113577172  [KO:K01081] [EC:3.1.3.5]
113577173  [KO:K00088] [EC:1.1.1.205]
113577306  pde8a; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A [KO:K18437] [EC:3.1.4.53]
113577377  ampd1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
113577669  entpd1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
113577945  [KO:K01509] [EC:3.6.1.-]
113578168  entpd4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
113578208  ampd3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
113578242  [KO:K12319] [EC:4.6.1.2]
113578299  [KO:K00364] [EC:1.7.1.7]
113578369  adss; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
113578463  [KO:K08042] [EC:4.6.1.1]
113578505  [KO:K00948] [EC:2.7.6.1]
113578734  gucy1a2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
113578938  [KO:K03783] [EC:2.4.2.1]
113579189  atic; bifunctional purine biosynthesis protein PURH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
113579199  [KO:K00760] [EC:2.4.2.8]
113579272  pde6g; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
113579283  pde5a; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
113579483  papss2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
113579541  pde6d; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform X1 [KO:K13758]
113579546  nme7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
113579603  [KO:K13761] [EC:3.1.4.35]
113579706  hddc3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform X1 [KO:K21138] [EC:3.1.7.2]
113579773  ak7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
113579984  [KO:K00088] [EC:1.1.1.205]
113580048  [KO:K13293] [EC:3.1.4.53]
113580224  nme3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
113580669  pde1c; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
113580690  [KO:K08049] [EC:4.6.1.1]
113581011  [KO:K13761] [EC:3.1.4.35]
113581159  [KO:K00940] [EC:2.7.4.6]
113581230  entpd3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
113581231  [KO:K08047] [EC:4.6.1.1]
113581380  ada; adenosine deaminase isoform X1 [KO:K01488] [EC:3.5.4.4]
113581429  [KO:K13755] [EC:3.1.4.17]
113581583  pde2a; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1 [KO:K18283] [EC:3.1.4.17]
113581605  [KO:K00904] [EC:2.7.1.113]
113581895  [KO:K00365] [EC:1.7.3.3]
113581896  [KO:K13293] [EC:3.1.4.53]
113582066  [KO:K00856] [EC:2.7.1.20]
113582176  entpd6; ectonucleoside triphosphate diphosphohydrolase 6 isoform X1 [KO:K01511] [EC:3.6.1.6]
113582301  [KO:K01490] [EC:3.5.4.6]
113582316  pde11a; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
113582988  [KO:K08041] [EC:4.6.1.1]
113583096  adcy6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
113583134  adcy3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
113583148  pde8b; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B [KO:K18437] [EC:3.1.4.53]
113583319  [KO:K01081] [EC:3.1.3.5]
113583412  [KO:K12323] [EC:4.6.1.2]
113583504  ak6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
113583665  xdh; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
113583870  gucy1a1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
113583871  gucy1b1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
113583908  fhit; bis(5'-adenosyl)-triphosphatase isoform X1 [KO:K01522] [EC:3.6.1.29]
113584128  adcy8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
113584247  [KO:K13293] [EC:3.1.4.53]
113584341  [KO:K13755] [EC:3.1.4.17]
113584613  nudt5; ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
113584751  pde6c; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' isoform X1 [KO:K13757] [EC:3.1.4.35]
113584860  [KO:K12320] [EC:4.6.1.2]
113585089  pde1a; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
113585127  ak9; adenylate kinase 9 isoform X1 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
113585144  [KO:K03783] [EC:2.4.2.1]
113585194  [KO:K13293] [EC:3.1.4.53]
113585463  nt5c2; cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
113585491  pde10a; LOW QUALITY PROTEIN: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
113586263  [KO:K19572] [EC:3.5.4.4]
113586319  [KO:K12322] [EC:4.6.1.2]
113586370  [KO:K01587] [EC:4.1.1.21 6.3.2.6]
113586371  ppat; amidophosphoribosyltransferase isoform X1 [KO:K00764] [EC:2.4.2.14]
113586825  [KO:K12321] [EC:4.6.1.2]
113587035  entpd5; ectonucleoside triphosphate diphosphohydrolase 5 [KO:K01511] [EC:3.6.1.6]
113587108  [KO:K19021] [EC:3.1.4.17]
113587158  guk1; guanylate kinase [KO:K00942] [EC:2.7.4.8]
113587322  [KO:K18436] [EC:3.1.4.53]
113587366  ak1; adenylate kinase isoenzyme 1 [KO:K00939] [EC:2.7.4.3]
113587376  itpa; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
113587401  nt5e; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
113587535  [KO:K22600] [EC:4.6.1.2]
113587665  ntpcr; cancer-related nucleoside-triphosphatase isoform X1 [KO:K06928] [EC:3.6.1.15]
113587667  pgm2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
113587981  [KO:K16855] [EC:3.6.1.62 3.6.1.64]
113588044  pde4b; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
113588049  ak4; adenylate kinase 4, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
113588201  [KO:K13293] [EC:3.1.4.53]
113588239  npr2; atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
113588523  [KO:K01081] [EC:3.1.3.5]
113588648  [KO:K08041] [EC:4.6.1.1]
113589040  [KO:K13756] [EC:3.1.4.35]
113589069  [KO:K01513] [EC:3.1.4.1 3.6.1.9]
113589243  [KO:K19572] [EC:3.5.4.4]
113589373  [KO:K13760]
113589426  gmps; GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
113589693  [KO:K12304] [EC:3.6.1.6]
113590292  gda; guanine deaminase [KO:K01487] [EC:3.5.4.3]
113590334  [KO:K08042] [EC:4.6.1.1]
113590341  pgm1; phosphoglucomutase-1 [KO:K01835] [EC:5.4.2.2]
113590400  [KO:K13811] [EC:2.7.7.4 2.7.1.25]
113590627  pde9a; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
113590766  [KO:K01511] [EC:3.6.1.6]
113590809  [KO:K01939] [EC:6.3.4.4]
113590818  dck; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
113590941  [KO:K01490] [EC:3.5.4.6]
113591158  [KO:K08046] [EC:4.6.1.1]
113591263  [KO:K00856] [EC:2.7.1.20]
113591332  pfas; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
113591456  [KO:K03783] [EC:2.4.2.1]
113591496  [KO:K08044] [EC:4.6.1.1]
113591964  [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
113591980  papss1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
113592046  nudt9; ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
eee00030  Pentose phosphate pathway
eee00220  Arginine biosynthesis
eee00250  Alanine, aspartate and glutamate metabolism
eee00260  Glycine, serine and threonine metabolism
eee00340  Histidine metabolism
eee00630  Glyoxylate and dicarboxylate metabolism
eee00730  Thiamine metabolism
eee00740  Riboflavin metabolism
eee00790  Folate biosynthesis
KO pathway
ko00230   

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