KEGG   PATHWAY: eju04110
Entry
eju04110                    Pathway                                
Name
Cell cycle - Eumetopias jubatus (Steller sea lion)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
eju04110  Cell cycle
eju04110

Other DBs
GO: 0000278
Organism
Eumetopias jubatus (Steller sea lion) [GN:eju]
Gene
114220310  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
114222473  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
114204469  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
114214999  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
114221423  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
114210238  RB1; retinoblastoma-associated protein [KO:K06618]
114220815  RBL1; retinoblastoma-like protein 1 [KO:K04681]
114199582  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
114198844  ABL1; tyrosine-protein kinase ABL1 [KO:K06619] [EC:2.7.10.2]
114216997  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
114209980  HDAC2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
114220748  E2F1; transcription factor E2F1 [KO:K17454]
114203527  transcription factor E2F2-like [KO:K09389]
114203528  transcription factor E2F2-like isoform X1 [KO:K09389]
114212498  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
114203027  E2F4; LOW QUALITY PROTEIN: transcription factor E2F4 [KO:K04682]
114215386  E2F5; transcription factor E2F5 isoform X1 [KO:K04682]
114196612  TFDP1; transcription factor Dp-1 isoform X1 [KO:K04683]
114205615  TFDP2; transcription factor Dp-2 isoform X1 [KO:K09392]
114214730  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
114202548  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
114210508  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
114207516  TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
114204964  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
114206573  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
114204951  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
114211166  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
114213259  ZBTB17; zinc finger and BTB domain-containing protein 17 [KO:K10500]
114218214  tumor suppressor ARF-like isoform X1 [KO:K06621]
114218207  CDKN2B; cyclin-dependent kinase 4 inhibitor B isoform X1 [KO:K04685]
114212009  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
114197783  CDKN2D; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
114221704  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
114220468  CDKN1C; cyclin-dependent kinase inhibitor 1C [KO:K09993]
114222230  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
114224455  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
114214197  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
114215075  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
114209510  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
114211586  CUL1; cullin-1 isoform X1 [KO:K03347]
114218392  RBX1; E3 ubiquitin-protein ligase RBX1 isoform X1 [KO:K03868] [EC:2.3.2.32]
114204772  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
114208231  CCNA2; cyclin-A2 [KO:K06627]
114211510  CCNA1; cyclin-A1 [KO:K06627]
114222701  LOW QUALITY PROTEIN: cyclin-A1-like [KO:K06627]
114198488  CDC6; cell division control protein 6 homolog [KO:K02213]
114199240  CDT1; DNA replication factor Cdt1 [KO:K10727]
114212173  ORC1; origin recognition complex subunit 1 [KO:K02603]
114223658  ORC2; origin recognition complex subunit 2 isoform X1 [KO:K02604]
114213042  ORC3; origin recognition complex subunit 3 isoform X1 [KO:K02605]
114224563  ORC4; origin recognition complex subunit 4 [KO:K02606]
114221628  ORC5; origin recognition complex subunit 5 isoform X1 [KO:K02607]
114199354  ORC6; origin recognition complex subunit 6 isoform X1 [KO:K02608]
114207787  MCM2; DNA replication licensing factor MCM2 [KO:K02540] [EC:5.6.2.3]
114204394  MCM3; DNA replication licensing factor MCM3 [KO:K02541] [EC:5.6.2.3]
114220921  MCM4; DNA replication licensing factor MCM4 isoform X1 [KO:K02212] [EC:5.6.2.3]
114197526  MCM5; DNA replication licensing factor MCM5 [KO:K02209] [EC:5.6.2.3]
114207312  MCM6; DNA replication licensing factor MCM6 [KO:K02542] [EC:5.6.2.3]
114214520  MCM7; DNA replication licensing factor MCM7 isoform X1 [KO:K02210] [EC:5.6.2.3]
114201858  CDC45; cell division control protein 45 homolog isoform X1 [KO:K06628]
114223286  TICRR; treslin [KO:K26117]
114199081  MTBP; mdm2-binding protein isoform X1 [KO:K26116]
114196873  CDC7; cell division cycle 7-related protein kinase isoform X1 [KO:K02214] [EC:2.7.11.1]
114221916  DBF4; protein DBF4 homolog A isoform X1 [KO:K06629]
114200609  DBF4B; protein DBF4 homolog B isoform X1 [KO:K06629]
114224740  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
114198232  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
114206445  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
114200700  CCNB3; G2/mitotic-specific cyclin-B3 isoform X1 [KO:K21771]
114220705  CDC25B; LOW QUALITY PROTEIN: M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
114209504  CDC25C; M-phase inducer phosphatase 3 [KO:K05867] [EC:3.1.3.48]
114214138  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
114205939  YWHAQ; 14-3-3 protein theta [KO:K16197]
114223129  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
114213902  YWHAE; 14-3-3 protein epsilon [KO:K06630]
114225187  YWHAH; 14-3-3 protein eta [KO:K16198]
114214367  YWHAG; 14-3-3 protein gamma [KO:K16198]
114198766  PLK1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
114211588  WEE2; wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
114219368  WEE1; wee1-like protein kinase [KO:K06632] [EC:2.7.11.1]
114215605  PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1 [KO:K06633] [EC:2.7.11.1]
114217623  CCNH; cyclin-H isoform X1 [KO:K06634]
114198244  CDK7; cyclin-dependent kinase 7 isoform X1 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
114223437  ANAPC1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
114201745  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
114196722  CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
114197029  ANAPC4; anaphase-promoting complex subunit 4 [KO:K03351]
114219125  ANAPC5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
114196603  CDC16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
114207308  LOW QUALITY PROTEIN: cell division cycle protein 16 homolog [KO:K03353]
114219070  ANAPC7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
114209565  CDC23; cell division cycle protein 23 homolog [KO:K03355]
114208275  ANAPC10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
114216264  ANAPC11; anaphase-promoting complex subunit 11 isoform X1 [KO:K03358]
114212921  CDC26; anaphase-promoting complex subunit CDC26 isoform X1 [KO:K03359]
114205621  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
114218644  ANAPC15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
114214139  ANAPC16; anaphase-promoting complex subunit 16 isoform X1 [KO:K25229]
114224184  CDC20; cell division cycle protein 20 homolog [KO:K03363]
114200310  securin-like [KO:K06635]
114211917  PTTG1; securin isoform X1 [KO:K06635]
114203916  LOW QUALITY PROTEIN: securin-like [KO:K06635]
114225726  ESPL1; separin [KO:K02365] [EC:3.4.22.49]
114200631  SMC1A; structural maintenance of chromosomes protein 1A [KO:K06636]
114218297  SMC1B; structural maintenance of chromosomes protein 1B isoform X1 [KO:K06636]
114203225  structural maintenance of chromosomes protein 3 [KO:K06669]
114203227  structural maintenance of chromosomes protein 3 [KO:K06669]
114223535  RAD21; double-strand-break repair protein rad21 homolog [KO:K06670]
114218064  cohesin subunit SA-2-like [KO:K06671]
114205641  STAG1; cohesin subunit SA-1 isoform X1 [KO:K06671]
114223711  STAG2; cohesin subunit SA-2 isoform X1 [KO:K06671]
114207424  ATRX; transcriptional regulator ATRX isoform X1 [KO:K10779]
114222538  DDX11; ATP-dependent DNA helicase DDX11 isoform X1 [KO:K11273] [EC:5.6.2.7]
114204894  NIPBL; nipped-B-like protein isoform X1 [KO:K06672]
114196499  MAU2; MAU2 chromatid cohesion factor homolog isoform X1 [KO:K11266]
114207544  HDAC8; histone deacetylase 8 isoform X1 [KO:K11405] [EC:3.5.1.98]
114200406  ESCO1; N-acetyltransferase ESCO1 isoform X1 [KO:K11268] [EC:2.3.1.-]
114217480  ESCO2; N-acetyltransferase ESCO2 [KO:K11268] [EC:2.3.1.-]
114211357  PDS5B; sister chromatid cohesion protein PDS5 homolog B isoform X1 [KO:K11267]
114196701  PDS5A; sister chromatid cohesion protein PDS5 homolog A [KO:K11267]
114205280  WAPL; wings apart-like protein homolog isoform X1 [KO:K25163]
114220550  CDCA5; sororin [KO:K17390]
114225257  AURKB; aurora kinase B isoform X1 [KO:K11479] [EC:2.7.11.1]
114205734  SGO1; shugoshin 1 [KO:K11580]
114209514  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
114196799  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
114202397  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
114211331  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
114217682  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
114225923  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
114220366  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
114204406  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
114206044  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
114200320  NDC80; kinetochore protein NDC80 homolog isoform X1 [KO:K11547]
114198361  kinetochore protein NDC80 homolog [KO:K11547]
114221459  KNL1; kinetochore scaffold 1 isoform X1 [KO:K11542]
114213038  TTK; dual specificity protein kinase TTK isoform X1 [KO:K08866] [EC:2.7.12.1]
114199940  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
114208222  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
114213285  MAD2L2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
114221352  BUB1B; mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform X1 [KO:K06637] [EC:2.7.11.1]
114221825  BUB3; mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
114219669  BUB1; mitotic checkpoint serine/threonine-protein kinase BUB1 [KO:K02178] [EC:2.7.11.1]
114217071  pachytene checkpoint protein 2 homolog [KO:K22399]
114198561  TRIP13; pachytene checkpoint protein 2 homolog [KO:K22399]
114204362  MAD2L1BP; MAD2L1-binding protein [KO:K26093]
114226285  FZR1; fizzy-related protein homolog isoform X1 [KO:K03364]
114209310  FBXO5; F-box only protein 5 isoform X1 [KO:K10292]
114223341  CDC14B; dual specificity protein phosphatase CDC14B isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
114207875  CDC14A; dual specificity protein phosphatase CDC14A isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
114218518  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
114219895  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
114220887  PRKDC; DNA-dependent protein kinase catalytic subunit isoform X1 [KO:K06642] [EC:2.7.11.1]
114205634  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
114211448  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
114214910  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
114225325  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
114208474  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
114226210  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
114219801  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
114220817  PCNA; proliferating cell nuclear antigen [KO:K04802]
114217167  SFN; 14-3-3 protein sigma [KO:K06644]
114226008  CHEK1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
114225227  CHEK2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
114225128  CDC25A; M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:3.1.3.48]
Reference
PMID:7908906
  Authors
Matsuoka S, Yamaguchi M, Matsukage A
  Title
D-type cyclin-binding regions of proliferating cell nuclear antigen.
  Journal
J Biol Chem 269:11030-6 (1994)
Reference
PMID:8242749
  Authors
Welch PJ, Wang JY
  Title
A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.
  Journal
Cell 75:779-90 (1993)
DOI:10.1016/0092-8674(93)90497-E
Reference
PMID:16936746
  Authors
Macaluso M, Montanari M, Giordano A
  Title
Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes.
  Journal
Oncogene 25:5263-7 (2006)
DOI:10.1038/sj.onc.1209680
Reference
PMID:15838516
  Authors
Cobrinik D
  Title
Pocket proteins and cell cycle control.
  Journal
Oncogene 24:2796-809 (2005)
DOI:10.1038/sj.onc.1208619
Reference
PMID:17568790
  Authors
Boutros R, Lobjois V, Ducommun B
  Title
CDC25 phosphatases in cancer cells: key players? Good targets?
  Journal
Nat Rev Cancer 7:495-507 (2007)
DOI:10.1038/nrc2169
Reference
PMID:9832503
  Authors
Diehl JA, Cheng M, Roussel MF, Sherr CJ
  Title
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.
  Journal
Genes Dev 12:3499-511 (1998)
DOI:10.1101/gad.12.22.3499
Reference
PMID:19020303
  Authors
Klein EA, Assoian RK
  Title
Transcriptional regulation of the cyclin D1 gene at a glance.
  Journal
J Cell Sci 121:3853-7 (2008)
DOI:10.1242/jcs.039131
Reference
PMID:10385618
  Authors
Sherr CJ, Roberts JM
  Title
CDK inhibitors: positive and negative regulators of G1-phase progression.
  Journal
Genes Dev 13:1501-12 (1999)
DOI:10.1101/gad.13.12.1501
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:12925736
  Authors
Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N, Imaki H, Hatakeyama S, Nakayama K, Nakayama KI
  Title
Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.
  Journal
Proc Natl Acad Sci U S A 100:10231-6 (2003)
DOI:10.1073/pnas.1831009100
Reference
PMID:16212951
  Authors
Bond M, Sala-Newby GB, Wu YJ, Newby AC
  Title
Biphasic effect of p21Cip1 on smooth muscle cell proliferation: role of PI 3-kinase and Skp2-mediated degradation.
  Journal
Cardiovasc Res 69:198-206 (2006)
DOI:10.1016/j.cardiores.2005.08.020
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11099028
  Authors
Vogelstein B, Lane D, Levine AJ
  Title
Surfing the p53 network.
  Journal
Nature 408:307-10 (2000)
DOI:10.1038/35042675
Reference
PMID:7973727
  Authors
Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O'Connor PM, Fornace AJ Jr
  Title
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
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Science 266:1376-80 (1994)
DOI:10.1126/science.7973727
Reference
PMID:9889196
  Authors
Petersen BO, Lukas J, Sorensen CS, Bartek J, Helin K
  Title
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.
  Journal
EMBO J 18:396-410 (1999)
DOI:10.1093/emboj/18.2.396
Reference
PMID:17018296
  Authors
Sheu YJ, Stillman B
  Title
Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression.
  Journal
Mol Cell 24:101-13 (2006)
DOI:10.1016/j.molcel.2006.07.033
Reference
PMID:9029154
  Authors
Martinez AM, Afshar M, Martin F, Cavadore JC, Labbe JC, Doree M
  Title
Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.
  Journal
EMBO J 16:343-54 (1997)
DOI:10.1093/emboj/16.2.343
Reference
PMID:15876871
  Authors
Lolli G, Johnson LN
  Title
CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?
  Journal
Cell Cycle 4:572-7 (2005)
DOI:10.4161/cc.4.4.1607
Reference
PMID:17426725
  Authors
Musacchio A, Salmon ED
  Title
The spindle-assembly checkpoint in space and time.
  Journal
Nat Rev Mol Cell Biol 8:379-93 (2007)
DOI:10.1038/nrm2163
Reference
PMID:12573239
  Authors
Uhlmann F
  Title
Chromosome cohesion and separation: from men and molecules.
  Journal
Curr Biol 13:R104-14 (2003)
DOI:10.1016/S0960-9822(03)00039-3
Reference
PMID:15568976
  Authors
Stegmeier F, Amon A
  Title
Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.
  Journal
Annu Rev Genet 38:203-32 (2004)
DOI:10.1146/annurev.genet.38.072902.093051
Reference
PMID:9618481
  Authors
Moustakas A, Kardassis D
  Title
Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.
  Journal
Proc Natl Acad Sci U S A 95:6733-8 (1998)
DOI:10.1073/pnas.95.12.6733
Reference
PMID:26650195
  Authors
de Boer HR, Guerrero Llobet S, van Vugt MA
  Title
Controlling the response to DNA damage by the APC/C-Cdh1.
  Journal
Cell Mol Life Sci 73:949-60 (2016)
DOI:10.1007/s00018-015-2096-7
Reference
PMID:20935501
  Authors
Qiao X, Zhang L, Gamper AM, Fujita T, Wan Y
  Title
APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.
  Journal
Cell Cycle 9:3904-12 (2010)
DOI:10.4161/cc.9.19.13585
Related
pathway
eju03030  DNA replication
eju04010  MAPK signaling pathway
eju04120  Ubiquitin mediated proteolysis
eju04210  Apoptosis
KO pathway
ko04110   
LinkDB

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