KEGG   PATHWAY: eju04151
Entry
eju04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Eumetopias jubatus (Steller sea lion)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
eju04151  PI3K-Akt signaling pathway
eju04151

Other DBs
GO: 0043491
Organism
Eumetopias jubatus (Steller sea lion) [GN:eju]
Gene
114196399  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
114196420  COMP; cartilage oligomeric matrix protein [KO:K04659]
114196446  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
114196618  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
114196641  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
114196710  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
114196720  ITGB3; integrin beta-3 [KO:K06493]
114196721  [KO:K05438]
114196799  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
114196996  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
114197031  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
114197263  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
114197320  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
114197336  THEM4; LOW QUALITY PROTEIN: acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
114197462  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
114197634  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
114197659  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
114197706  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
114197747  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
114197938  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X1 [KO:K01596] [EC:4.1.1.32]
114197985  RHEB; GTP-binding protein Rheb [KO:K07208]
114198019  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
114198341  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
114198363  [KO:K06237]
114198389  CSF3; granulocyte colony-stimulating factor [KO:K05423]
114198407  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
114198487  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
114198631  THBS3; thrombospondin-3 [KO:K04659]
114198644  [KO:K05462]
114198645  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
114198649  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
114198667  [KO:K05462]
114198669  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
114198708  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
114198841  TSC1; hamartin isoform X1 [KO:K07206]
114198881  LAMC3; laminin subunit gamma-3 [KO:K06247]
114199288  LAMA5; laminin subunit alpha-5 [KO:K06240]
114199310  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
114199341  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
114199406  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
114199481  NTF4; neurotrophin-4 [KO:K12457]
114199485  FGF21; fibroblast growth factor 21 [KO:K22429]
114199538  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
114199582  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
114199649  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
114200576  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
114200595  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
114200671  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
114200877  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
114201006  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
114201138  ITGA3; integrin alpha-3 [KO:K06482]
114201152  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 isoform X1 [KO:K04549]
114201157  COL1A1; LOW QUALITY PROTEIN: collagen alpha-1(I) chain [KO:K06236]
114201159  CHAD; chondroadherin [KO:K06248]
114201173  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
114201213  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
114201332  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
114201342  G6PC; glucose-6-phosphatase isoform X1 [KO:K01084] [EC:3.1.3.9]
114201560  HRAS; GTPase HRas isoform X1 [KO:K02833]
114201698  LAMB1; laminin subunit beta-1 [KO:K05636]
114201704  LAMB4; laminin subunit beta-4 [KO:K06245]
114201841  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
114201844  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
114201925  MTCP1; protein p13 MTCP-1 [KO:K16837]
114202233  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
114202353  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
114202397  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
114202586  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
114202732  [KO:K06591]
114202735  [KO:K06591]
114203023  [KO:K06481]
114203024  [KO:K06481]
114203171  [KO:K05070]
114203175  [KO:K05070]
114203265  [KO:K04456] [EC:2.7.11.1]
114203268  [KO:K04456] [EC:2.7.11.1]
114203593  [KO:K06465]
114203595  [KO:K06465]
114203804  IKBKG; NF-kappa-B essential modulator [KO:K07210]
114203888  [KO:K25414]
114203889  [KO:K25414]
114203954  [KO:K09049]
114203955  [KO:K09049]
114203962  [KO:K04392]
114203995  [KO:K05414]
114204026  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
114204306  [KO:K05414]
114204406  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
114204432  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
114204469  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
114204569  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
114204633  VEGFA; vascular endothelial growth factor A [KO:K05448]
114204709  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
114204716  FGF10; fibroblast growth factor 10 [KO:K04358]
114204719  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
114204778  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
114204796  GHR; growth hormone receptor [KO:K05080]
114204800  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
114204831  PRLR; prolactin receptor isoform X1 [KO:K05081]
114204861  OSMR; oncostatin-M-specific receptor subunit beta [KO:K05057]
114204946  TCL1B; T-cell leukemia/lymphoma protein 1B [KO:K16836]
114205010  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
114205025  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
114205060  PGF; placenta growth factor [KO:K16859]
114205178  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230]
114205217  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
114205290  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
114205469  FGF8; LOW QUALITY PROTEIN: fibroblast growth factor 8 [KO:K04358]
114205545  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
114205549  [KO:K06238]
114205584  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
114205617  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
114205695  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
114205939  YWHAQ; 14-3-3 protein theta [KO:K16197]
114206044  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
114206065  FGF20; fibroblast growth factor 20 [KO:K04358]
114206147  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
114206170  VEGFC; vascular endothelial growth factor C [KO:K05449]
114206175  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
114206298  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
114206423  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
114206512  ITGA11; integrin alpha-11 [KO:K06587]
114206513  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
114206518  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114206626  [KO:K13302] [EC:2.7.11.1]
114206632  AREG; amphiregulin [KO:K09782]
114206716  EREG; proepiregulin [KO:K09784]
114206757  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
114206758  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
114206819  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
114206954  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
114206994  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
114207391  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
114207437  FGF16; fibroblast growth factor 16 [KO:K04358]
114207692  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
114207847  NGF; beta-nerve growth factor [KO:K02582]
114207930  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
114207931  NRAS; GTPase NRas [KO:K07828]
114208195  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
114208234  IL2; interleukin-2 [KO:K05429]
114208330  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
114208347  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
114208401  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
114208440  PKN2; serine/threonine-protein kinase N2 [KO:K23691]
114208489  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
114208602  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
114208656  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
114208721  FGF18; fibroblast growth factor 18 [KO:K04358]
114208751  EFNA5; ephrin-A5 [KO:K05462]
114208840  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
114208893  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
114209289  THBS2; thrombospondin-2 [KO:K04659]
114209410  [KO:K04736]
114209514  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
114209547  IL4; interleukin-4 [KO:K05430]
114209944  LAMA4; laminin subunit alpha-4 [KO:K06241]
114210013  FOXO3; forkhead box protein O3 [KO:K09408]
114210089  TLR2; toll-like receptor 2 [KO:K10159]
114210095  [KO:K04392]
114210145  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
114210245  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
114210280  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
114210281  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
114210371  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
114210625  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
114210795  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
114210819  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
114210848  IRS1; insulin receptor substrate 1 [KO:K16172]
114210852  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
114210864  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
114211007  KITLG; kit ligand [KO:K05461]
114211152  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
114211166  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
114211231  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
114211331  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
114211711  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
114211755  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
114211863  FGF9; fibroblast growth factor 9 [KO:K04358]
114211897  SOS2; son of sevenless homolog 2 [KO:K03099]
114211906  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
114211916  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
114211921  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
114212116  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
114212231  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
114212384  RPS6; 40S ribosomal protein S6 [KO:K02991]
114212404  IFNB1; interferon beta [KO:K05415]
114212415  [KO:K05414]
114212437  [KO:K05414]
114212451  [KO:K05414]
114212615  PRL; prolactin isoform X1 [KO:K05439]
114212737  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
114212775  TNC; tenascin [KO:K06252]
114212788  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
114212865  PKN3; serine/threonine-protein kinase N3 [KO:K23692]
114213130  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
114213175  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
114213180  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
114213333  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
114213399  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
114213489  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
114213525  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
114213645  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
114213730  VTN; vitronectin [KO:K06251]
114213794  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
114213902  YWHAE; 14-3-3 protein epsilon [KO:K06630]
114213967  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
114214130  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
114214138  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
114214197  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
114214288  [KO:K13304] [EC:2.7.11.1]
114214309  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
114214367  YWHAG; 14-3-3 protein gamma [KO:K16198]
114214409  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
114214546  EPO; erythropoietin [KO:K05437]
114214562  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
114214678  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
114214730  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
114214764  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
114214910  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
114214976  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
114214977  IL7; interleukin-7 [KO:K05431]
114214999  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
114215065  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
114215075  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
114215177  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
114215501  TSC2; tuberin isoform X1 [KO:K07207]
114215503  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
114215523  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114215733  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
114215744  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
114215923  FN1; fibronectin isoform X1 [KO:K05717]
114215947  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
114215964  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
114216073  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
114216141  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
114216301  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
114216508  ITGB6; integrin beta-6 [KO:K06589]
114216565  KRAS; GTPase KRas isoform X1 [KO:K07827]
114216642  GYS2; glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
114216966  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
114217308  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
114217356  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
114217424  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
114217539  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
114217613  THBS4; thrombospondin-4 [KO:K04659]
114217620  F2R; proteinase-activated receptor 1 [KO:K03914]
114217682  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
114217727  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
114217798  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
114217895  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
114217975  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
114218039  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
114218041  IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
114218047  VEGFD; vascular endothelial growth factor D [KO:K05449]
114218235  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
114218277  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
114218365  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
114218415  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
114218458  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
114218919  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
114219632  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
114219700  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
114219726  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
114219748  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
114220007  BDNF; brain-derived neurotrophic factor [KO:K04355]
114220110  IBSP; bone sialoprotein 2 [KO:K06253]
114220121  SPP1; osteopontin isoform X1 [KO:K06250]
114220212  FGF4; fibroblast growth factor 4 [KO:K04358]
114220243  FGF3; fibroblast growth factor 3 [KO:K04358]
114220310  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
114220313  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
114220328  BAD; bcl2-associated agonist of cell death [KO:K02158]
114220332  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
114220346  RELA; transcription factor p65 [KO:K04735]
114220366  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
114220405  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
114220406  [KO:K04526]
114220439  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
114220475  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
114220602  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X1 [KO:K04548]
114220642  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
114220677  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
114220746  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
114220766  COL1A2; collagen alpha-2(I) chain [KO:K06236]
114220801  ANGPT4; angiopoietin-4 [KO:K05467]
114220836  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
114221027  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
114221076  [KO:K02991]
114221152  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
114221211  IL6; interleukin-6 isoform X1 [KO:K05405]
114221286  THBS1; thrombospondin-1 [KO:K16857]
114221299  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
114221423  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
114221655  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
114221704  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
114221842  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
114222060  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
114222095  TNXB; tenascin-X [KO:K06252]
114222230  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
114222402  ITGB1; integrin beta-1 [KO:K05719]
114222462  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
114222470  FGF23; fibroblast growth factor 23 [KO:K22428]
114222473  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
114222474  FGF6; fibroblast growth factor 6 [KO:K04358]
114222568  VWF; von Willebrand factor [KO:K03900]
114222592  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
114222620  NTF3; LOW QUALITY PROTEIN: neurotrophin-3 [KO:K04356]
114222658  EGF; pro-epidermal growth factor [KO:K04357]
114222728  G6PC2; glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
114222807  LAMC1; laminin subunit gamma-1 [KO:K05635]
114222885  LAMC2; laminin subunit gamma-2 [KO:K06246]
114222942  HSP90B1; endoplasmin [KO:K09487]
114222977  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
114223046  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
114223129  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
114223185  SGK2; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
114223322  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
114223345  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
114223458  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
114223793  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
114223943  TNN; LOW QUALITY PROTEIN: tenascin-N [KO:K06252]
114223997  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
114224014  TNR; tenascin-R isoform X1 [KO:K06252]
114224064  COL2A1; collagen alpha-1(II) chain [KO:K19719]
114224124  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
114224167  ARTN; artemin [KO:K25415]
114224260  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
114224308  [KO:K02649]
114224455  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
114224631  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
114224715  LAMA1; laminin subunit alpha-1 [KO:K05637]
114224838  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
114224851  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
114224933  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
114225019  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
114225187  YWHAH; 14-3-3 protein eta [KO:K16198]
114225213  OSM; oncostatin-M [KO:K05418]
114225299  [KO:K19719]
114225321  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
114225323  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
114225325  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
114225654  LAMA2; laminin subunit alpha-2 [KO:K05637]
114225658  [KO:K13302] [EC:2.7.11.1]
114225663  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
114225725  ITGB7; integrin beta-7 [KO:K06590]
114225738  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
114225746  ITGA5; integrin alpha-5 [KO:K06484]
114225887  [KO:K04465]
114225908  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
114225917  LAMB3; laminin subunit beta-3 [KO:K06244]
114225923  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
114226124  EFNA2; ephrin-A2 [KO:K05462]
114226177  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
114226217  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
114226280  PSPN; persephin [KO:K25416]
114226331  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
114226347  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
114226659  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
eju00010  Glycolysis / Gluconeogenesis
eju04010  MAPK signaling pathway
eju04012  ErbB signaling pathway
eju04062  Chemokine signaling pathway
eju04064  NF-kappa B signaling pathway
eju04068  FoxO signaling pathway
eju04110  Cell cycle
eju04115  p53 signaling pathway
eju04150  mTOR signaling pathway
eju04210  Apoptosis
eju04370  VEGF signaling pathway
eju04510  Focal adhesion
eju04620  Toll-like receptor signaling pathway
eju04630  JAK-STAT signaling pathway
eju04662  B cell receptor signaling pathway
eju04910  Insulin signaling pathway
KO pathway
ko04151   

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