KEGG   PATHWAY: fca04141
Entry
fca04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Felis catus (domestic cat)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
fca04141  Protein processing in endoplasmic reticulum
fca04141

Other DBs
GO: 0030433 0034976
Organism
Felis catus (domestic cat) [GN:fca]
Gene
101089426  SEC61A1; protein transport protein Sec61 subunit alpha [KO:K10956]
101086402  SEC61A2; protein transport protein Sec61 subunit alpha isoform X1 [KO:K10956]
101084323  SEC61B; protein transport protein Sec61 subunit beta [KO:K09481]
101084431  SEC61G; protein transport protein Sec61 subunit gamma [KO:K07342]
101084567  protein transport protein Sec61 subunit gamma-like [KO:K07342]
101088021  SEC62; translocation protein SEC62 [KO:K12275]
101093937  SEC63; translocation protein SEC63 homolog [KO:K09540]
101087978  RPN1; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [KO:K12666]
101101302  RPN2; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform X2 [KO:K12667]
101088756  DAD1; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 isoform X3 [KO:K12668]
101093032  DDOST; dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
101083108  STT3A; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
101092883  STT3B; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
101085275  MAGT1; magnesium transporter protein 1 isoform X1 [KO:K19478]
101081724  TUSC3; tumor suppressor candidate 3 isoform X1 [KO:K19478]
101089606  OSTC; oligosaccharyltransferase complex subunit OSTC [KO:K26501]
101083452  TMEM258; transmembrane protein 258 [KO:K26502]
101086221  MOGS; mannosyl-oligosaccharide glucosidase [KO:K01228] [EC:3.2.1.106]
101089875  CKAP4; cytoskeleton-associated protein 4 [KO:K13999]
100101124  RRBP1; ribosome-binding protein 1 isoform X1 [KO:K14000]
101089979  SIL1; nucleotide exchange factor SIL1 isoform X2 [KO:K14001]
101094621  HYOU1; hypoxia up-regulated protein 1 isoform X2 [KO:K09486]
101083630  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
101100077  DNAJB11; dnaJ homolog subfamily B member 11 [KO:K09517]
101095666  DNAJC1; dnaJ homolog subfamily C member 1 isoform X1 [KO:K09521]
101099171  DNAJC3; dnaJ homolog subfamily C member 3 [KO:K09523]
101083533  DNAJC10; dnaJ homolog subfamily C member 10 [KO:K09530] [EC:1.8.4.-]
101082249  HSP90B1; endoplasmin [KO:K09487]
101089297  GANAB; neutral alpha-glucosidase AB isoform X1 [KO:K05546] [EC:3.2.1.207]
101081869  PRKCSH; glucosidase 2 subunit beta isoform X1 [KO:K08288]
101085686  CANX; calnexin isoform X2 [KO:K08054]
101097245  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
101087384  CALR; calreticulin isoform X1 [KO:K08057]
101100723  MAN1A1; mannosyl-oligosaccharide 1,2-alpha-mannosidase IA isoform X1 [KO:K01230] [EC:3.2.1.113]
101099737  MAN1C1; mannosyl-oligosaccharide 1,2-alpha-mannosidase IC isoform X1 [KO:K01230] [EC:3.2.1.113]
101086830  MAN1A2; mannosyl-oligosaccharide 1,2-alpha-mannosidase IB isoform X1 [KO:K01230] [EC:3.2.1.113]
111557571  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like isoform X1 [KO:K23741] [EC:3.2.1.209]
123381672  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like isoform X1 [KO:K23741] [EC:3.2.1.209]
101099687  LMAN2; vesicular integral-membrane protein VIP36 isoform X1 [KO:K10082]
101080833  LMAN1; protein ERGIC-53 isoform X1 [KO:K10080]
101085128  LMAN1L; protein ERGIC-53-like isoform X1 [KO:K10081]
101101304  PREB; prolactin regulatory element-binding protein isoform X1 [KO:K14003]
101100438  SAR1B; GTP-binding protein SAR1b isoform X1 [KO:K07953] [EC:3.6.5.-]
101096170  SAR1A; GTP-binding protein SAR1a [KO:K07953] [EC:3.6.5.-]
101087389  SEC13; protein SEC13 homolog isoform X1 [KO:K14004]
101086474  SEC31A; protein transport protein Sec31A isoform X10 [KO:K14005]
101096608  SEC31B; protein transport protein Sec31B isoform X4 [KO:K14005]
101101125  SEC23B; protein transport protein Sec23B [KO:K14006]
101086569  SEC23A; protein transport protein Sec23A isoform X1 [KO:K14006]
101088112  SEC24C; protein transport protein Sec24C isoform X2 [KO:K14007]
101095976  SEC24D; protein transport protein Sec24D isoform X1 [KO:K14007]
101086446  SEC24A; protein transport protein Sec24A isoform X2 [KO:K14007]
101087154  SEC24B; protein transport protein Sec24B isoform X1 [KO:K14007]
101099423  UGGT2; UDP-glucose:glycoprotein glucosyltransferase 2 isoform X1 [KO:K11718] [EC:2.4.1.-]
101091643  UGGT1; UDP-glucose:glycoprotein glucosyltransferase 1 isoform X1 [KO:K11718] [EC:2.4.1.-]
101089086  EDEM1; ER degradation-enhancing alpha-mannosidase-like protein 1 [KO:K10084]
101083162  EDEM2; ER degradation-enhancing alpha-mannosidase-like protein 2 isoform X1 [KO:K10085]
101087192  EDEM3; ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X2 [KO:K10086]
101099917  P4HB; protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
101087568  PDIA4; protein disulfide-isomerase A4 [KO:K09582] [EC:5.3.4.1]
101095249  PDIA6; protein disulfide-isomerase A6 [KO:K09584] [EC:5.3.4.1]
101083974  ERP29; endoplasmic reticulum resident protein 29 [KO:K09586]
101098632  TXNDC5; thioredoxin domain-containing protein 5 isoform X1 [KO:K13984] [EC:5.3.4.1]
101090623  ERO1A; ERO1-like protein alpha [KO:K10950] [EC:1.8.4.-]
101080662  ERO1B; ERO1-like protein beta isoform X1 [KO:K10976] [EC:1.8.4.-]
101095992  OS9; protein OS-9 isoform X4 [KO:K10088]
101089431  ERLEC1; endoplasmic reticulum lectin 1 isoform X1 [KO:K14008]
101099638  SSR1; translocon-associated protein subunit alpha isoform X3 [KO:K13249]
101085095  SSR2; translocon-associated protein subunit beta [KO:K13250]
101085915  SSR3; translocon-associated protein subunit gamma [KO:K13251]
101081452  SSR4; translocon-associated protein subunit delta isoform X1 [KO:K04571]
101081202  BCAP31; B-cell receptor-associated protein 31 [KO:K14009]
101097373  TRAM1; translocating chain-associated membrane protein 1 [KO:K14010]
101095251  TRAM1L1; translocating chain-associated membrane protein 1-like 1 [KO:K14010]
101100445  DERL1; derlin-1 isoform X1 [KO:K11519]
101090404  DERL2; derlin-2 isoform X1 [KO:K13989]
101089806  DERL3; derlin-3 isoform X1 [KO:K13989]
101093453  UBXN4; UBX domain-containing protein 4 [KO:K24348]
101090896  UBXN1; UBX domain-containing protein 1 [KO:K24348]
101096145  UBXN2A; UBX domain-containing protein 2A [KO:K24349]
101081118  UBXN6; UBX domain-containing protein 6 isoform X1 [KO:K14011]
101090764  UBXN8; UBX domain-containing protein 8 isoform X1 [KO:K24351]
101100120  NSFL1C; NSFL1 cofactor p47 isoform X1 [KO:K14012]
105260979  small VCP/p97-interacting protein [KO:K14014]
101091411  VCP; transitional endoplasmic reticulum ATPase isoform X1 [KO:K13525]
101097934  NPLOC4; nuclear protein localization protein 4 homolog isoform X1 [KO:K14015]
101097924  UFD1; ubiquitin recognition factor in ER-associated degradation protein 1 isoform X2 [KO:K14016]
105260573  heat shock 70 kDa protein 1 [KO:K03283]
101091022  heat shock 70 kDa protein 1-like [KO:K03283]
101087422  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
101080710  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
101099237  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
101098261  DNAJA1; dnaJ homolog subfamily A member 1 [KO:K09502]
105261088  dnaJ homolog subfamily A member 1-like [KO:K09502]
101092886  LOW QUALITY PROTEIN: dnaJ homolog subfamily A member 1-like [KO:K09502]
101097624  LOW QUALITY PROTEIN: dnaJ homolog subfamily A member 1-like [KO:K09502]
102900016  LOW QUALITY PROTEIN: dnaJ homolog subfamily A member 1-like [KO:K09502]
101092976  DNAJA2; dnaJ homolog subfamily A member 2 [KO:K09503]
101092586  DNAJB1; dnaJ homolog subfamily B member 1 isoform X1 [KO:K09507]
101096504  DNAJB2; dnaJ homolog subfamily B member 2 isoform X2 [KO:K09508]
101082344  DNAJB12; dnaJ homolog subfamily B member 12 isoform X1 [KO:K09518]
101092017  DNAJC5; dnaJ homolog subfamily C member 5 [KO:K09525]
101087900  DNAJC5B; dnaJ homolog subfamily C member 5B isoform X2 [KO:K09525]
101090855  DNAJC5G; dnaJ homolog subfamily C member 5G isoform X2 [KO:K09525]
101095825  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
101094857  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
101086545  HSPA4L; heat shock 70 kDa protein 4L [KO:K09485]
101090575  HSPH1; heat shock protein 105 kDa isoform X1 [KO:K09485]
101101174  BAG1; BAG family molecular chaperone regulator 1 [KO:K09555]
101100209  BAG2; BAG family molecular chaperone regulator 2 [KO:K09556]
101085335  HSPBP1; hsp70-binding protein 1 isoform X2 [KO:K09562]
101083874  CRYAA; alpha-crystallin A chain [KO:K09541]
101092640  CRYAB; alpha-crystallin B chain [KO:K09542]
101090076  YOD1; ubiquitin thioesterase OTU1 isoform X8 [KO:K13719] [EC:3.1.2.-]
101091736  PLAA; phospholipase A-2-activating protein isoform X1 [KO:K14018]
101087644  RAD23A; UV excision repair protein RAD23 homolog A [KO:K10839]
101085414  RAD23B; UV excision repair protein RAD23 homolog B [KO:K10839]
101097874  UBQLN2; ubiquilin-2 [KO:K04523]
101094292  UBQLN3; ubiquilin-3 [KO:K04523]
101098901  UBQLN1; ubiquilin-1 isoform X1 [KO:K04523]
101086695  UBQLN4; ubiquilin-4 isoform X2 [KO:K04523]
101086171  NGLY1; peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase isoform X1 [KO:K01456] [EC:3.5.1.52]
101096738  ATXN3; ataxin-3 isoform X7 [KO:K11863] [EC:3.4.22.-]
101095271  UBE4B; ubiquitin conjugation factor E4 B isoform X7 [KO:K10597] [EC:2.3.2.27]
101095973  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
101091455  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
101098812  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X2 [KO:K05638]
101084297  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101084589  PPP1R15A; protein phosphatase 1 regulatory subunit 15A isoform X1 [KO:K14019]
101081819  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
493934  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
101086780  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
101094849  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X4 [KO:K09049]
101092024  WFS1; wolframin [KO:K14020]
101081852  MBTPS1; membrane-bound transcription factor site-1 protease [KO:K08653] [EC:3.4.21.112]
101084262  MBTPS2; membrane-bound transcription factor site-2 protease isoform X1 [KO:K07765] [EC:3.4.24.85]
101092150  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
101084148  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
101096363  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
101082912  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
101095157  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101091310  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101101463  MAPK10; mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
101084765  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
493837  BAX; apoptosis regulator BAX [KO:K02159]
101093435  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
101096916  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
101083231  CAPN2; calpain-2 catalytic subunit isoform X2 [KO:K03853] [EC:3.4.22.53]
100135767  CASP12; inactive caspase-12 [KO:K04741] [EC:3.4.22.-]
101092915  MARCHF6; E3 ubiquitin-protein ligase MARCHF6 isoform X2 [KO:K10661] [EC:2.3.2.27]
101093860  UBE2J1; ubiquitin-conjugating enzyme E2 J1 isoform X1 [KO:K10578] [EC:2.3.2.23]
101101628  UBE2J2; ubiquitin-conjugating enzyme E2 J2 isoform X2 [KO:K04554] [EC:2.3.2.23]
101087018  UBE2G1; ubiquitin-conjugating enzyme E2 G1 isoform X3 [KO:K10575] [EC:2.3.2.23]
101088019  UBE2G2; ubiquitin-conjugating enzyme E2 G2 isoform X1 [KO:K04555] [EC:2.3.2.23]
101084316  SYVN1; E3 ubiquitin-protein ligase synoviolin isoform X1 [KO:K10601] [EC:2.3.2.27]
101096477  RNF5; E3 ubiquitin-protein ligase RNF5 isoform X1 [KO:K10666] [EC:2.3.2.27]
101096516  RNF185; E3 ubiquitin-protein ligase RNF185 [KO:K10666] [EC:2.3.2.27]
101081301  SELENOS; selenoprotein S isoform X1 [KO:K14025]
101088673  SEL1L; protein sel-1 homolog 1 [KO:K14026]
101094751  SEL1L2; protein sel-1 homolog 2 isoform X6 [KO:K14026]
101082710  HERPUD1; homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein isoform X1 [KO:K14027]
101091066  AMFR; E3 ubiquitin-protein ligase AMFR isoform X1 [KO:K10636] [EC:2.3.2.36]
101092817  STUB1; E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
101092081  UBE2D2; ubiquitin-conjugating enzyme E2 D2 isoform X3 [KO:K06689] [EC:2.3.2.23]
101094845  UBE2D3; ubiquitin-conjugating enzyme E2 D3 isoform X2 [KO:K06689] [EC:2.3.2.23]
101099079  UBE2D1; ubiquitin-conjugating enzyme E2 D1 isoform X1 [KO:K06689] [EC:2.3.2.23]
101098228  PRKN; E3 ubiquitin-protein ligase parkin isoform X3 [KO:K04556] [EC:2.3.2.31]
101087758  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
101087051  CUL1; cullin-1 isoform X3 [KO:K03347]
101099017  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
101084045  S-phase kinase-associated protein 1-like [KO:K03094]
101099135  FBXO2; F-box only protein 2 isoform X2 [KO:K10099]
101100065  FBXO6; F-box only protein 6 isoform X2 [KO:K10100]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
fca00510  N-Glycan biosynthesis
fca03050  Proteasome
fca03060  Protein export
fca04210  Apoptosis
fca04930  Type II diabetes mellitus
fca05010  Alzheimer disease
fca05012  Parkinson disease
fca05020  Prion disease
KO pathway
ko04141   
LinkDB

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