KEGG   PATHWAY: fca05020
Entry
fca05020                    Pathway                                
Name
Prion disease - Felis catus (domestic cat)
Description
Prion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of these diseases is thought to be associated with the conversion of a normal protein, PrPC, into an infectious, pathogenic form, PrPSc. The conversion is induced by prion infections (for example, variant Creutzfeldt-Jakob disease (vCJD), iatrogenic CJD, Kuru), mutations (familial CJD, Gerstmann-Straussler-Scheinker syndrome, fatal familial insomnia (FFI)) or unknown factors (sporadic CJD (sCJD)), and is thought to occur after PrPC has reached the plasma membrane or is re-internalized for degradation. The PrPSc form shows greater protease resistance than PrPC and accumulates in affected individuals, often in the form of extracellular plaques. Pathways that may lead to neuronal death comprise oxidative stress, regulated activation of complement, ubiquitin-proteasome and endosomal-lysosomal systems, synaptic alterations and dendritic atrophy, corticosteroid response, and endoplasmic reticulum stress. In addition, the conformational transition could lead to the lost of a beneficial activity of the natively folded protein, PrPC.
Class
Human Diseases; Neurodegenerative disease
Pathway map
fca05020  Prion disease
fca05020

Disease
H00061  Prion disease
Organism
Felis catus (domestic cat) [GN:fca]
Gene
100135767  CASP12; inactive caspase-12 [KO:K04741] [EC:3.4.22.-]
100188929  TUBB1; tubulin beta-1 chain [KO:K07375]
100271864  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
101080547  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
101080579  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
101080710  [KO:K03283]
101080736  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
101080870  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
101080975  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
101081009  PSMB7; proteasome subunit beta type-7 isoform X2 [KO:K02739] [EC:3.4.25.1]
101081453  CAV3; caveolin-3 [KO:K12959]
101081479  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 isoform X1 [KO:K11352]
101081660  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
101081685  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X2 [KO:K03947]
101081808  [KO:K02264]
101081819  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
101081992  [KO:K07374]
101082021  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
101082082  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
101082343  KLC2; kinesin light chain 2 isoform X1 [KO:K10407]
101082389  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
101082635  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
101082923  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
101083455  MCU; calcium uniporter protein, mitochondrial isoform X2 [KO:K20858]
101083475  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
101083630  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
101083819  COX7A1; cytochrome c oxidase subunit 7A1, mitochondrial isoform X2 [KO:K02270]
101084186  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
101084209  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
101084245  KLC3; kinesin light chain 3 [KO:K10407]
101084297  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101084324  TUBB4B; tubulin beta-4B chain [KO:K07375]
101084482  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
101084765  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101084784  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X7 [KO:K09047]
101084817  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial [KO:K03944]
101084876  TUBB2B; tubulin beta-2B chain [KO:K07375]
101084949  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
101084963  KLC4; kinesin light chain 4 [KO:K10407]
101084967  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
101085106  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
101085348  [KO:K03945]
101085528  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
101085531  [KO:K02271]
101085609  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
101085720  FYN; LOW QUALITY PROTEIN: tyrosine-protein kinase Fyn [KO:K05703] [EC:2.7.10.2]
101085859  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
101086110  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
101086207  CYBB; cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
101086215  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
101086294  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
101086493  [KO:K10881]
101086664  PSMB2; proteasome subunit beta type-2 isoform X1 [KO:K02734] [EC:3.4.25.1]
101086703  [KO:K00420]
101086911  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 isoform X1 [KO:K03957]
101086926  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101086953  TUBB4A; tubulin beta-4A chain [KO:K07375]
101087087  NCAM2; neural cell adhesion molecule 2 isoform X1 [KO:K06491]
101087097  CREB3L1; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
101087245  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
101087259  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
101087282  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
101087310  PRNP; major prion protein [KO:K05634]
101087362  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
101087422  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
101087614  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101087664  CSNK2B; casein kinase II subunit beta [KO:K03115]
101087716  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
101087808  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X2 [KO:K00236]
101087958  MAPK3; mitogen-activated protein kinase 3 isoform X2 [KO:K04371] [EC:2.7.11.24]
101087993  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
101088122  [KO:K08738]
101088226  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
101088298  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
101088339  [KO:K08738]
101088388  EGR1; early growth response protein 1 [KO:K09203]
101088394  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X8 [KO:K04851]
101088712  NCF2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
101089135  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
101089240  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X2 [KO:K03937]
101089258  [KO:K04565] [EC:1.15.1.1]
101089499  UQCRC1; cytochrome b-c1 complex subunit 1, mitochondrial isoform X2 [KO:K00414]
101089838  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
101089914  [KO:K02263]
101090177  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
101090190  RYR3; ryanodine receptor 3 [KO:K04963]
101090224  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
101090321  LAMC1; laminin subunit gamma-1 [KO:K05635]
101090344  PPP3R1; calcineurin subunit B type 1 isoform X4 [KO:K06268]
101090365  PSMA6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
101090401  C5; complement C5 isoform X1 [KO:K03994]
101090494  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X3 [KO:K04345] [EC:2.7.11.11]
101090556  [KO:K07374]
101090590  [KO:K00417]
101090761  COX5B; cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
101090884  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
101091022  [KO:K03283]
101091174  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 isoform X3 [KO:K03951]
101091310  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101091412  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
101091455  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
101091536  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
101091655  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
101091665  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
101091693  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
101091711  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
101091740  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
101091745  CYBA; cytochrome b-245 light chain [KO:K08009]
101091804  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
101091823  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
101091850  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
101091892  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101092350  COX7A2L; cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform X1 [KO:K02270]
101092368  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
101092508  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
101092693  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396] [EC:5.6.1.3]
101092793  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
101092862  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
101093051  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
101093065  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
101093097  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
101093286  [KO:K02649]
101093382  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 isoform X3 [KO:K03959]
101093395  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
101093555  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
101093586  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101093608  COX7A2; cytochrome c oxidase subunit 7A2, mitochondrial isoform X1 [KO:K02270]
101093612  [KO:K03948]
101093631  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X4 [KO:K03954]
101093640  PSMA1; proteasome subunit alpha type-1 isoform X1 [KO:K02725] [EC:3.4.25.1]
101093741  [KO:K02135]
101093917  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
101094025  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
101094224  RYR1; ryanodine receptor 1 isoform X1 [KO:K04961]
101094239  CYC1; cytochrome c1, heme protein, mitochondrial [KO:K00413]
101094274  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101094305  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 isoform X3 [KO:K03033]
101094311  [KO:K00411] [EC:7.1.1.8]
101094356  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
101094384  NOTCH1; neurogenic locus notch homolog protein 1 isoform X2 [KO:K02599]
101094451  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X2 [KO:K03941] [EC:7.1.1.2]
101094482  C7; complement component C7 isoform X2 [KO:K03996]
101094736  GRIN3B; glutamate receptor ionotropic, NMDA 3B isoform X3 [KO:K05214]
101094768  KIF5A; kinesin heavy chain isoform X2 [KO:K10396] [EC:5.6.1.3]
101094773  C1QC; complement C1q subcomponent subunit C [KO:K03988]
101094849  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X4 [KO:K09049]
101094940  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
101095032  [KO:K00416]
101095061  GRIN2D; glutamate receptor ionotropic, NMDA 2D isoform X1 [KO:K05212]
101095118  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
101095155  C6; LOW QUALITY PROTEIN: complement component C6 [KO:K03995]
101095190  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
101095277  TUBA4A; tubulin alpha-4A chain isoform X2 [KO:K07374]
101095280  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
101095353  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101095435  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
101095457  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
101095507  NCF4; neutrophil cytosol factor 4 isoform X1 [KO:K08012]
101095657  TUBB; tubulin beta chain [KO:K07375]
101095773  [KO:K02266]
101095941  [KO:K05863]
101095973  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
101096082  C1QA; complement C1q subcomponent subunit A [KO:K03986]
101096309  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
101096331  C1QB; complement C1q subcomponent subunit B [KO:K03987]
101096376  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
101096402  [KO:K07374]
101096420  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
101096448  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
101096500  C8A; complement component C8 alpha chain [KO:K03997]
101096603  COX8A; cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
101096614  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
101096643  COX4I2; cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X2 [KO:K02263]
101096744  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
101096871  UQCRQ; cytochrome b-c1 complex subunit 8 [KO:K00418]
101096876  [KO:K02268]
101096902  TUBA1A; tubulin alpha-1A chain [KO:K07374]
101096914  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
101096948  C9; complement component C9 [KO:K04000]
101097006  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
101097080  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
101097110  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
101097144  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101097227  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
101097360  PSMC5; 26S proteasome regulatory subunit 8 isoform X2 [KO:K03066]
101097403  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
101097413  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101097436  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
101097623  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
101097762  STIP1; stress-induced-phosphoprotein 1 [KO:K09553]
101097765  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
101098213  [KO:K08738]
101098262  GRIN3A; glutamate receptor ionotropic, NMDA 3A isoform X1 [KO:K05213]
101098515  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
101098564  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X2 [KO:K03029]
101098629  COX7B2; cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
101098780  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
101098797  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
101098808  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
101098834  C8G; complement component C8 gamma chain isoform X2 [KO:K03999]
101098840  NCF1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
101098883  KIF5C; kinesin heavy chain [KO:K10396] [EC:5.6.1.3]
101098912  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
101099010  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
101099117  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
101099130  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
101099229  C8B; complement component C8 beta chain isoform X1 [KO:K03998]
101099237  [KO:K03283]
101099268  [KO:K07374]
101099589  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X4 [KO:K09565] [EC:5.2.1.8]
101099742  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
101099952  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
101099992  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
101100189  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
101100266  [KO:K02267]
101100293  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
101100442  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X4 [KO:K09048]
101100487  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X2 [KO:K02128]
101100546  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X2 [KO:K04958]
101100747  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
101100851  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
101100868  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
101100947  [KO:K08738]
101101060  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
101101091  PSMA8; proteasome subunit alpha-type 8 isoform X1 [KO:K02731] [EC:3.4.25.1]
101101113  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
101101135  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101101230  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
101101277  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X3 [KO:K04392]
101101463  MAPK10; mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
101101591  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 isoform X2 [KO:K03039]
101101674  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
101101684  UQCRC2; cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
102899183  [KO:K02272]
102899304  [KO:K05862]
102899476  [KO:K02265]
102900799  [KO:K00420]
102901624  [KO:K02128]
102902352  [KO:K15041]
105260413  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
105260573  [KO:K03283]
105260786  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
105261050  UQCR10; uncharacterized protein UQCR10 isoform X1 [KO:K00419]
105261211  [KO:K02267]
105261306  COX6A2; cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
109496610  [KO:K02267]
109499596  TUBB2A; tubulin beta-2A chain [KO:K07375]
109502991  [KO:K02128]
109503558  [KO:K08738]
111556320  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
111559153  [KO:K02267]
111560594  [KO:K10881]
123380058  [KO:K03957]
123381617  [KO:K02128]
123384428  [KO:K02128]
123386183  [KO:K02264]
493667  CAV2; caveolin-2 [KO:K12958]
493668  CAV1; caveolin-1 [KO:K06278]
493687  IL6; interleukin-6 precursor [KO:K05405]
493689  CCL5; C-C motif chemokine 5 precursor [KO:K12499]
493755  TNF; tumor necrosis factor precursor [KO:K03156]
493837  BAX; apoptosis regulator BAX [KO:K02159]
493932  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
493944  IL1A; interleukin-1 alpha precursor [KO:K04383]
493956  NCAM1; neural cell adhesion molecule 1 precursor [KO:K06491]
654399  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
751617  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform X1 [KO:K00235] [EC:1.3.5.1]
751619  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
768257  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
768260  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
768269  BAD; bcl2-associated agonist of cell death [KO:K02158]
768274  IL1B; interleukin-1 beta [KO:K04519]
807928  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
807929  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
807930  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
807931  CYTB; cytochrome b [KO:K00412]
807932  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
807933  COX3; cytochrome c oxidase subunit III [KO:K02262]
807934  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
807935  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
807936  COX2; cytochrome c oxidase subunit II [KO:K02261]
807937  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
807938  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
807939  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
807940  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00575  3',5'-Cyclic AMP
C00704  Superoxide
C02140  Corticosterone
Reference
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  Title
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Expert Rev Mol Med 18:e5 (2016)
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Mol Cell Neurosci 66:12-20 (2015)
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Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD.
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Reference
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Front Aging Neurosci 9:120 (2017)
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Reference
PMID:20205843
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  Title
PrPSc accumulation in neuronal plasma membranes links Notch-1 activation to dendritic degeneration in prion diseases.
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Reference
PMID:29998397
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Mol Neurobiol 56:2159-2173 (2019)
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Reference
PMID:28714865
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Reference
PMID:15342004
  Authors
Mabbott NA
  Title
The complement system in prion diseases.
  Journal
Curr Opin Immunol 16:587-93 (2004)
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Reference
PMID:15611724
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Mallucci G, Collinge J
  Title
Rational targeting for prion therapeutics.
  Journal
Nat Rev Neurosci 6:23-34 (2005)
DOI:10.1038/nrn1584
Related
pathway
fca00190  Oxidative phosphorylation
fca03050  Proteasome
fca04020  Calcium signaling pathway
fca04140  Autophagy - animal
fca04141  Protein processing in endoplasmic reticulum
fca04142  Lysosome
fca04144  Endocytosis
fca04210  Apoptosis
fca04330  Notch signaling pathway
fca04610  Complement and coagulation cascades
fca04668  TNF signaling pathway
KO pathway
ko05020   

DBGET integrated database retrieval system