KEGG   PATHWAY: gas00230
Entry
gas00230                    Pathway                                
Name
Purine metabolism - Gracilinanus agilis (agile gracile opossum)
Class
Metabolism; Nucleotide metabolism
Pathway map
gas00230  Purine metabolism
gas00230

Module
gas_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:gas00230]
gas_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:gas00230]
gas_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:gas00230]
gas_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:gas00230]
gas_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:gas00230]
gas_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:gas00230]
gas_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:gas00230]
Other DBs
GO: 0006163 0042278
Organism
Gracilinanus agilis (agile gracile opossum) [GN:gas]
Gene
123230809  GUK1; guanylate kinase [KO:K00942] [EC:2.7.4.8]
123230862  AK3; GTP:AMP phosphotransferase AK3, mitochondrial isoform X1 [KO:K00944] [EC:2.7.4.10]
123230913  NME3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
123230945  NME4; nucleoside diphosphate kinase, mitochondrial isoform X1 [KO:K00940] [EC:2.7.4.6]
123231041  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
123231376  [KO:K00948] [EC:2.7.6.1]
123231423  AK6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
123231464  [KO:K01081] [EC:3.1.3.5]
123231736  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
123231909  [KO:K01587] [EC:4.1.1.21 6.3.2.6]
123231913  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
123232117  [KO:K00939] [EC:2.7.4.3]
123232409  NPR2; atrial natriuretic peptide receptor 2 isoform X1 [KO:K12324] [EC:4.6.1.2]
123232942  ADK; adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
123233052  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
123233197  NT5DC4; LOW QUALITY PROTEIN: 5'-nucleotidase domain-containing protein 4 [KO:K01081] [EC:3.1.3.5]
123233340  GDA; guanine deaminase [KO:K01487] [EC:3.5.4.3]
123233468  ALLC; LOW QUALITY PROTEIN: probable allantoicase [KO:K01477] [EC:3.5.3.4]
123233504  XDH; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
123233621  AK8; adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
123233664  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
123233825  PDE6A; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha [KO:K08718] [EC:3.1.4.35]
123234349  FHIT; bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
123234462  [KO:K01081] [EC:3.1.3.5]
123234593  [KO:K07127] [EC:3.5.2.17]
123234792  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511] [EC:3.6.1.6]
123234946  RRM2; ribonucleoside-diphosphate reductase subunit M2 isoform X1 [KO:K10808] [EC:1.17.4.1]
123235004  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
123235045  ADA; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
123235132  [KO:K01510] [EC:3.6.1.5]
123235147  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 isoform X1 [KO:K01509] [EC:3.6.1.-]
123235248  AK1; adenylate kinase isoenzyme 1 isoform X1 [KO:K00939] [EC:2.7.4.3]
123235526  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
123235675  AK7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
123235847  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 [KO:K01511] [EC:3.6.1.6]
123236083  [KO:K03783] [EC:2.4.2.1]
123236204  HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
123236275  [KO:K22600] [EC:4.6.1.2]
123236332  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
123236337  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
123236648  DGUOK; deoxyguanosine kinase, mitochondrial [KO:K00904] [EC:2.7.1.113]
123236656  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
123236768  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
123237113  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
123237191  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
123237618  ADSS1; adenylosuccinate synthetase isozyme 1 isoform X1 [KO:K01939] [EC:6.3.4.4]
123237681  [KO:K18532] [EC:2.7.4.3]
123237960  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
123237966  GMPR2; GMP reductase 2 [KO:K00364] [EC:1.7.1.7]
123238120  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A [KO:K18437] [EC:3.1.4.53]
123238149  NT5C2; cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
123238761  [KO:K00760] [EC:2.4.2.8]
123238764  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
123238823  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
123238865  URAD; putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
123238959  [KO:K00948] [EC:2.7.6.1]
123240125  ATIC; bifunctional purine biosynthesis protein ATIC [KO:K00602] [EC:2.1.2.3 3.5.4.10]
123240184  GMPR; GMP reductase 1 isoform X1 [KO:K00364] [EC:1.7.1.7]
123240426  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
123241196  [KO:K00760] [EC:2.4.2.8]
123241197  [KO:K00760] [EC:2.4.2.8]
123241209  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase [KO:K18283] [EC:3.1.4.17]
123241224  GUCY2F; retinal guanylyl cyclase 2 [KO:K12321] [EC:4.6.1.2]
123241248  [KO:K12319] [EC:4.6.1.2]
123241354  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
123241433  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
123241487  [KO:K13988] [EC:3.6.1.13]
123241596  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
123241644  PDE9A; LOW QUALITY PROTEIN: high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [KO:K13761] [EC:3.1.4.35]
123241677  [KO:K15779] [EC:5.4.2.2 5.4.2.7]
123242034  GMPS; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
123242175  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
123242354  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
123242454  GART; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
123242547  PRPS2; ribose-phosphate pyrophosphokinase 2 isoform X1 [KO:K00948] [EC:2.7.6.1]
123242685  LACC1; purine nucleoside phosphorylase LACC1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
123242805  [KO:K01466] [EC:3.5.2.5]
123243245  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
123243588  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
123243756  PGM1; phosphoglucomutase-1 [KO:K01835] [EC:5.4.2.2]
123243778  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
123244078  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
123244126  PFAS; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
123244128  CANT1; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
123244286  PRUNE1; exopolyphosphatase PRUNE1 [KO:K01514] [EC:3.6.1.11]
123244366  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
123244603  [KO:K13988] [EC:3.6.1.13]
123244719  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
123244769  AK5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
123245013  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
123245031  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
123245158  GUCY2D; retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
123245193  NTPCR; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
123245466  [KO:K18532] [EC:2.7.4.3]
123245575  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
123245882  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
123245888  NME7; nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
123245945  [KO:K00602] [EC:2.1.2.3 3.5.4.10]
123246461  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
123246512  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
123246560  AK9; adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
123246708  AMPD2; AMP deaminase 2 [KO:K01490] [EC:3.5.4.6]
123246782  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
123247246  [KO:K03783] [EC:2.4.2.1]
123247570  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
123247602  [KO:K00940] [EC:2.7.4.6]
123247604  [KO:K00940] [EC:2.7.4.6]
123247826  NPR1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
123247862  HDDC2; 5'-deoxynucleotidase HDDC2 isoform X1 [KO:K07023] [EC:3.1.3.89]
123247912  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
123247954  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
123248048  ADSS2; adenylosuccinate synthetase isozyme 2 isoform X1 [KO:K01939] [EC:6.3.4.4]
123248828  ADA2; adenosine deaminase 2 [KO:K19572] [EC:3.5.4.4]
123248863  NME6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
123248950  ADSL; adenylosuccinate lyase isoform X1 [KO:K01756] [EC:4.3.2.2]
123249036  [KO:K00602] [EC:2.1.2.3 3.5.4.10]
123249097  GUCY2C; heat-stable enterotoxin receptor [KO:K12320] [EC:4.6.1.2]
123249109  NUDT5; ADP-sugar pyrophosphatase isoform X1 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
123249451  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
123249510  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
123249738  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
123250015  [KO:K01587] [EC:4.1.1.21 6.3.2.6]
123250226  [KO:K12324] [EC:4.6.1.2]
123250386  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
123250524  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
123250552  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
123250918  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase [KO:K13762] [EC:3.1.4.35]
123250978  PPAT; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
123250979  PAICS; multifunctional protein ADE2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
123251212  ITPA; inosine triphosphate pyrophosphatase isoform X1 [KO:K01519] [EC:3.6.1.66]
123251261  NUDT9; ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
123251467  GUCY1B1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
123251582  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B [KO:K18437] [EC:3.1.4.53]
123251603  GUCY1A1; guanylate cyclase soluble subunit alpha-1 isoform X1 [KO:K12318] [EC:4.6.1.2]
123251774  [KO:K00948] [EC:2.7.6.1]
123252021  PGM2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
123252145  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
123252199  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
123252504  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
123252531  AMPD3; AMP deaminase 3 [KO:K01490] [EC:3.5.4.6]
123252650  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
123252951  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
123253734  PRPS1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
123253985  [KO:K18532] [EC:2.7.4.3]
123254251  [KO:K18532] [EC:2.7.4.3]
123254992  [KO:K01081] [EC:3.1.3.5]
123255988  [KO:K18532] [EC:2.7.4.3]
123256007  [KO:K13293] [EC:3.1.4.53]
123256272  [KO:K00088] [EC:1.1.1.205]
123256280  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A [KO:K13293] [EC:3.1.4.53]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
gas00030  Pentose phosphate pathway
gas00220  Arginine biosynthesis
gas00250  Alanine, aspartate and glutamate metabolism
gas00260  Glycine, serine and threonine metabolism
gas00340  Histidine metabolism
gas00630  Glyoxylate and dicarboxylate metabolism
gas00730  Thiamine metabolism
gas00740  Riboflavin metabolism
gas00790  Folate biosynthesis
KO pathway
ko00230   

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