KEGG   PATHWAY: hmh04110
Entry
hmh04110                    Pathway                                
Name
Cell cycle - Hylobates moloch (silvery gibbon)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
hmh04110  Cell cycle
hmh04110

Other DBs
GO: 0000278
Organism
Hylobates moloch (silvery gibbon) [GN:hmh]
Gene
116456166  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
116456172  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
116456638  TRIP13; pachytene checkpoint protein 2 homolog isoform X2 [KO:K22399]
116456708  ANAPC4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
116456903  NIPBL; nipped-B-like protein isoform X1 [KO:K06672]
116456910  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
116457097  PTTG2; securin-2 [KO:K06635]
116457129  PDS5A; sister chromatid cohesion protein PDS5 homolog A isoform X1 [KO:K11267]
116457130  [KO:K26093]
116457311  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
116457529  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
116457679  ORC1; origin recognition complex subunit 1 [KO:K02603]
116457933  [KO:K03357]
116457969  [KO:K06629]
116458026  [KO:K12456]
116458285  YWHAE; 14-3-3 protein epsilon [KO:K06630]
116458301  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
116458343  SMC1B; structural maintenance of chromosomes protein 1B isoform X1 [KO:K06636]
116458414  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
116458431  [KO:K06621]
116458432  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
116458544  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
116458592  CHEK2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
116458640  AURKB; aurora kinase B isoform X1 [KO:K11479] [EC:2.7.11.1]
116459052  TP53; cellular tumor antigen p53 [KO:K04451]
116459230  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
116459303  CDC45; cell division control protein 45 homolog isoform X1 [KO:K06628]
116459370  YWHAH; 14-3-3 protein eta [KO:K16198]
116459620  MAD2L1BP; MAD2L1-binding protein [KO:K26093]
116459745  MCM3; DNA replication licensing factor MCM3 isoform X1 [KO:K02541] [EC:5.6.2.3]
116459750  E2F3; transcription factor E2F3 isoform X2 [KO:K06620]
116460133  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
116460459  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
116460473  WAPL; wings apart-like protein homolog isoform X1 [KO:K25163]
116460475  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
116461064  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
116461198  PCNA; proliferating cell nuclear antigen [KO:K04802]
116461242  YWHAB; 14-3-3 protein beta/alpha isoform X1 [KO:K16197]
116461337  E2F1; transcription factor E2F1 [KO:K17454]
116461428  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
116461619  TFDP2; transcription factor Dp-2 isoform X6 [KO:K09392]
116461627  ESCO2; N-acetyltransferase ESCO2 [KO:K11268] [EC:2.3.1.-]
116461729  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
116461871  STAG1; cohesin subunit SA-1 isoform X1 [KO:K06671]
116462002  ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
116462032  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
116462484  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
116462488  CDK7; cyclin-dependent kinase 7 isoform X1 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
116462661  PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1 [KO:K06633] [EC:2.7.11.1]
116462715  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
116462850  MCM6; DNA replication licensing factor MCM6 isoform X1 [KO:K02542] [EC:5.6.2.3]
116462891  ORC4; origin recognition complex subunit 4 [KO:K02606]
116463000  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
116463165  [KO:K10292]
116463219  [KO:K10292]
116463438  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
116463533  [KO:K21770]
116463537  CCNA2; cyclin-A2 [KO:K06627]
116463752  [KO:K21770]
116464543  ANAPC10; anaphase-promoting complex subunit 10 isoform X2 [KO:K03357]
116464575  [KO:K02209] [EC:5.6.2.3]
116464576  [KO:K02209] [EC:5.6.2.3]
116466813  MCM2; DNA replication licensing factor MCM2 [KO:K02540] [EC:5.6.2.3]
116466895  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
116467081  CCNA1; cyclin-A1 isoform X1 [KO:K06627]
116467092  PDS5B; sister chromatid cohesion protein PDS5 homolog B isoform X1 [KO:K11267]
116467261  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
116467589  TFDP1; transcription factor Dp-1 isoform X1 [KO:K04683]
116467598  CDC16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
116468535  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
116468563  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
116468642  TTK; dual specificity protein kinase TTK isoform X1 [KO:K08866] [EC:2.7.12.1]
116468681  ESCO1; N-acetyltransferase ESCO1 isoform X1 [KO:K11268] [EC:2.3.1.-]
116468701  NDC80; kinetochore protein NDC80 homolog [KO:K11547]
116468774  [KO:K16197]
116468973  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
116468982  CDCA5; sororin isoform X2 [KO:K17390]
116469117  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
116469140  CDKN1C; LOW QUALITY PROTEIN: cyclin-dependent kinase inhibitor 1C [KO:K09993]
116469555  ORC3; origin recognition complex subunit 3 isoform X1 [KO:K02605]
116469710  CDC14A; dual specificity protein phosphatase CDC14A isoform X2 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
116469781  CDC7; cell division cycle 7-related protein kinase isoform X1 [KO:K02214] [EC:2.7.11.1]
116469918  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
116470707  CDT1; DNA replication factor Cdt1 [KO:K10727]
116470866  [KO:K03347]
116471024  CCNH; cyclin-H isoform X1 [KO:K06634]
116471145  PLK1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
116471149  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
116471226  ORC6; origin recognition complex subunit 6 isoform X1 [KO:K02608]
116471255  RBL2; retinoblastoma-like protein 2 isoform X2 [KO:K16332]
116471374  E2F4; transcription factor E2F4 isoform X1 [KO:K04682]
116471506  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
116471508  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
116471550  CDC23; cell division cycle protein 23 homolog isoform X1 [KO:K03355]
116471552  CDC25C; M-phase inducer phosphatase 3 isoform X1 [KO:K05867] [EC:3.1.3.48]
116471799  PTTG1; securin [KO:K06635]
116472548  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
116472638  [KO:K06670]
116472656  DDX11; ATP-dependent DNA helicase DDX11 isoform X2 [KO:K11273] [EC:3.6.4.13]
116472702  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
116472739  [KO:K03094]
116472879  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
116473045  CDC20; cell division cycle protein 20 homolog isoform X1 [KO:K03363]
116473141  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
116473518  CDC25A; M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:3.1.3.48]
116473747  SGO1; shugoshin 1 isoform X1 [KO:K11580]
116474369  [KO:K05866] [EC:3.1.3.48]
116474779  CDC6; cell division control protein 6 homolog isoform X1 [KO:K02213]
116474956  [KO:K06629]
116475012  CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
116475043  [KO:K16197]
116475209  [KO:K03363]
116475228  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
116475288  CDC14B; dual specificity protein phosphatase CDC14B isoform X8 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
116475564  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
116475772  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
116475913  ANAPC2; anaphase-promoting complex subunit 2 isoform X1 [KO:K03349]
116476351  [KO:K06632] [EC:2.7.11.1]
116476528  WEE1; wee1-like protein kinase isoform X2 [KO:K06632] [EC:2.7.11.1]
116476630  ANAPC15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
116476898  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
116476925  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2 [KO:K03456]
116477131  CHEK1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
116477791  ANAPC5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
116477945  ANAPC7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
116478074  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
116478454  CDKN2D; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
116478498  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
116478741  MAU2; MAU2 chromatid cohesion factor homolog isoform X1 [KO:K11266]
116478827  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
116478988  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X2 [KO:K06643] [EC:2.3.2.27]
116480214  YWHAQ; 14-3-3 protein theta [KO:K16197]
116480647  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
116480850  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
116480938  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
116481009  ESPL1; separin isoform X1 [KO:K02365] [EC:3.4.22.49]
116481691  BUB1B; mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform X1 [KO:K06637] [EC:2.7.11.1]
116481801  TICRR; treslin [KO:K26117]
116482020  KNL1; kinetochore scaffold 1 isoform X1 [KO:K11542]
116482351  SMAD3; mothers against decapentaplegic homolog 3 isoform X2 [KO:K23605]
116482418  BUB3; mitotic checkpoint protein BUB3 isoform X2 [KO:K02180]
116482954  ANAPC1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
116483299  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
116483371  BUB1; mitotic checkpoint serine/threonine-protein kinase BUB1 isoform X2 [KO:K02178] [EC:2.7.11.1]
116483578  FZR1; fizzy-related protein homolog isoform X1 [KO:K03364]
116483748  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
116483767  SMC3; structural maintenance of chromosomes protein 3 [KO:K06669]
116484668  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
116809572  CDC14C; LOW QUALITY PROTEIN: dual specificity protein phosphatase CDC14C [KO:K06639] [EC:3.1.3.16 3.1.3.48]
116810056  [KO:K16197]
116810469  ORC2; origin recognition complex subunit 2 isoform X2 [KO:K02604]
116810477  [KO:K25228]
116810919  MCM7; DNA replication licensing factor MCM7 isoform X1 [KO:K02210] [EC:5.6.2.3]
116811050  [KO:K04802]
116811105  ATRX; transcriptional regulator ATRX [KO:K10779]
116811152  YWHAG; 14-3-3 protein gamma [KO:K16198]
116811258  [KO:K04683]
116811295  CCNB3; G2/mitotic-specific cyclin-B3 isoform X2 [KO:K21771]
116811706  [KO:K06636]
116811791  HDAC8; histone deacetylase 8 isoform X1 [KO:K11405] [EC:3.5.1.98]
116812020  STAG2; cohesin subunit SA-2 isoform X1 [KO:K06671]
116812928  MAD2L2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
116812969  ZBTB17; zinc finger and BTB domain-containing protein 17 isoform X2 [KO:K10500]
116813063  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
116813131  SFN; 14-3-3 protein sigma [KO:K06644]
116813227  [KO:K06635]
116813309  MCM4; DNA replication licensing factor MCM4 [KO:K02212] [EC:5.6.2.3]
116813310  PRKDC; DNA-dependent protein kinase catalytic subunit isoform X1 [KO:K06642] [EC:2.7.11.1]
116813373  E2F5; transcription factor E2F5 isoform X1 [KO:K04682]
116813431  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
116813534  RAD21; double-strand-break repair protein rad21 homolog [KO:K06670]
116813553  MTBP; mdm2-binding protein [KO:K26116]
116813588  MYC; myc proto-oncogene protein [KO:K04377]
116814109  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
116814139  DBF4; protein DBF4 homolog A isoform X3 [KO:K06629]
116814202  ORC5; origin recognition complex subunit 5 [KO:K02607]
116814436  WEE2; wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
116814485  CUL1; cullin-1 [KO:K03347]
Reference
PMID:7908906
  Authors
Matsuoka S, Yamaguchi M, Matsukage A
  Title
D-type cyclin-binding regions of proliferating cell nuclear antigen.
  Journal
J Biol Chem 269:11030-6 (1994)
Reference
PMID:8242749
  Authors
Welch PJ, Wang JY
  Title
A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.
  Journal
Cell 75:779-90 (1993)
DOI:10.1016/0092-8674(93)90497-E
Reference
PMID:16936746
  Authors
Macaluso M, Montanari M, Giordano A
  Title
Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes.
  Journal
Oncogene 25:5263-7 (2006)
DOI:10.1038/sj.onc.1209680
Reference
PMID:15838516
  Authors
Cobrinik D
  Title
Pocket proteins and cell cycle control.
  Journal
Oncogene 24:2796-809 (2005)
DOI:10.1038/sj.onc.1208619
Reference
PMID:17568790
  Authors
Boutros R, Lobjois V, Ducommun B
  Title
CDC25 phosphatases in cancer cells: key players? Good targets?
  Journal
Nat Rev Cancer 7:495-507 (2007)
DOI:10.1038/nrc2169
Reference
PMID:9832503
  Authors
Diehl JA, Cheng M, Roussel MF, Sherr CJ
  Title
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.
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Genes Dev 12:3499-511 (1998)
DOI:10.1101/gad.12.22.3499
Reference
PMID:19020303
  Authors
Klein EA, Assoian RK
  Title
Transcriptional regulation of the cyclin D1 gene at a glance.
  Journal
J Cell Sci 121:3853-7 (2008)
DOI:10.1242/jcs.039131
Reference
PMID:10385618
  Authors
Sherr CJ, Roberts JM
  Title
CDK inhibitors: positive and negative regulators of G1-phase progression.
  Journal
Genes Dev 13:1501-12 (1999)
DOI:10.1101/gad.13.12.1501
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:12925736
  Authors
Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N, Imaki H, Hatakeyama S, Nakayama K, Nakayama KI
  Title
Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.
  Journal
Proc Natl Acad Sci U S A 100:10231-6 (2003)
DOI:10.1073/pnas.1831009100
Reference
PMID:16212951
  Authors
Bond M, Sala-Newby GB, Wu YJ, Newby AC
  Title
Biphasic effect of p21Cip1 on smooth muscle cell proliferation: role of PI 3-kinase and Skp2-mediated degradation.
  Journal
Cardiovasc Res 69:198-206 (2006)
DOI:10.1016/j.cardiores.2005.08.020
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
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Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11099028
  Authors
Vogelstein B, Lane D, Levine AJ
  Title
Surfing the p53 network.
  Journal
Nature 408:307-10 (2000)
DOI:10.1038/35042675
Reference
PMID:7973727
  Authors
Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O'Connor PM, Fornace AJ Jr
  Title
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
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Science 266:1376-80 (1994)
DOI:10.1126/science.7973727
Reference
PMID:9889196
  Authors
Petersen BO, Lukas J, Sorensen CS, Bartek J, Helin K
  Title
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.
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EMBO J 18:396-410 (1999)
DOI:10.1093/emboj/18.2.396
Reference
PMID:17018296
  Authors
Sheu YJ, Stillman B
  Title
Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression.
  Journal
Mol Cell 24:101-13 (2006)
DOI:10.1016/j.molcel.2006.07.033
Reference
PMID:9029154
  Authors
Martinez AM, Afshar M, Martin F, Cavadore JC, Labbe JC, Doree M
  Title
Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.
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EMBO J 16:343-54 (1997)
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Reference
PMID:15876871
  Authors
Lolli G, Johnson LN
  Title
CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?
  Journal
Cell Cycle 4:572-7 (2005)
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Reference
PMID:17426725
  Authors
Musacchio A, Salmon ED
  Title
The spindle-assembly checkpoint in space and time.
  Journal
Nat Rev Mol Cell Biol 8:379-93 (2007)
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Reference
PMID:12573239
  Authors
Uhlmann F
  Title
Chromosome cohesion and separation: from men and molecules.
  Journal
Curr Biol 13:R104-14 (2003)
DOI:10.1016/S0960-9822(03)00039-3
Reference
PMID:15568976
  Authors
Stegmeier F, Amon A
  Title
Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.
  Journal
Annu Rev Genet 38:203-32 (2004)
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Reference
PMID:9618481
  Authors
Moustakas A, Kardassis D
  Title
Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.
  Journal
Proc Natl Acad Sci U S A 95:6733-8 (1998)
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Reference
PMID:26650195
  Authors
de Boer HR, Guerrero Llobet S, van Vugt MA
  Title
Controlling the response to DNA damage by the APC/C-Cdh1.
  Journal
Cell Mol Life Sci 73:949-60 (2016)
DOI:10.1007/s00018-015-2096-7
Reference
PMID:20935501
  Authors
Qiao X, Zhang L, Gamper AM, Fujita T, Wan Y
  Title
APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.
  Journal
Cell Cycle 9:3904-12 (2010)
DOI:10.4161/cc.9.19.13585
Related
pathway
hmh03030  DNA replication
hmh04010  MAPK signaling pathway
hmh04120  Ubiquitin mediated proteolysis
hmh04210  Apoptosis
KO pathway
ko04110   

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