Homologous recombination - Homo sapiens (human)
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Genetic Information Processing; Replication and repair
Pathway map Ortholog table
Homo sapiens (human) [GN:
6742 SSBP1; single stranded DNA binding protein 1 [KO: K03111]
10111 RAD50; RAD50 double strand break repair protein [KO: K10866] [EC:3.6.-.-]
4361 MRE11; MRE11 homolog, double strand break repair nuclease [KO: K10865]
580 BARD1; BRCA1 associated RING domain 1 [KO: K10683]
5932 RBBP8; RB binding protein 8, endonuclease [KO: K20773] [EC:3.1.-.-]
11073 TOPBP1; DNA topoisomerase II binding protein 1 [KO: K10728]
84142 ABRAXAS1; abraxas 1, BRCA1 A complex subunit [KO: K20774]
51720 UIMC1; ubiquitin interaction motif containing 1 [KO: K20775]
29086 BABAM1; BRISC and BRCA1 A complex member 1 [KO: K20776]
9577 BABAM2; BRISC and BRCA1 A complex member 2 [KO: K12173]
79184 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [KO: K11864] [EC:3.4.19.-]
79728 PALB2; partner and localizer of BRCA2 [KO: K10897]
675 BRCA2; BRCA2 DNA repair associated [KO: K08775]
7979 SEM1; SEM1 26S proteasome subunit [KO: K10881]
50511 SYCP3; synaptonemal complex protein 3 [KO: K19528]
5893 RAD52; RAD52 homolog, DNA repair protein [KO: K10873]
7516 XRCC2; X-ray repair cross complementing 2 [KO: K10879]
7517 XRCC3; X-ray repair cross complementing 3 [KO: K10880]
5425 POLD2; DNA polymerase delta 2, accessory subunit [KO: K02328]
10714 POLD3; DNA polymerase delta 3, accessory subunit [KO: K03504]
57804 POLD4; DNA polymerase delta 4, accessory subunit [KO: K03505]
80198 MUS81; MUS81 structure-specific endonuclease subunit [KO: K08991] [EC:3.1.22.-]
146956 EME1; essential meiotic structure-specific endonuclease 1 [KO: K10882] [EC:3.1.22.-]
Maloisel L, Fabre F, Gangloff S.
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
Haruta-Takahashi N, Iwasaki H.
Seikagaku 79:449-53 (2007)
Ouyang KJ, Woo LL, Ellis NA.
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
Kawabata M, Kawabata T, Nishibori M.
Role of recA/RAD51 family proteins in mammals.
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
Mitotic recombination in Saccharomyces cerevisiae.
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
Rad54: the Swiss Army knife of homologous recombination?
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
Recombination proteins and rescue of arrested replication forks.
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