Entry Name Homologous recombination - Homo sapiens (human)
Description Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class Genetic Information Processing; Replication and repairBRITE hierarchy
Pathway map Ortholog table Network Element N01439 Double-strand break signaling
N01446 DNA end resection and RPA loading
N01447 Double Holliday junction dissolution
N01449 Synthesis-dependent strand annealing
N01452 Homologous recombination
N01539 RAD51 -dsDNA destabilization
Drug Other DBs Organism Homo sapiens (human) [GN:
hsa ]
Gene 6742 SSBP1; single stranded DNA binding protein 1 [KO:K03111 ]
10111 RAD50; RAD50 double strand break repair protein [KO:K10866 ] [EC:3.6.-.-]
4361 MRE11; MRE11 homolog, double strand break repair nuclease [KO:K10865 ]
580 BARD1; BRCA1 associated RING domain 1 [KO:K10683 ]
5932 RBBP8; RB binding protein 8, endonuclease [KO:K20773 ] [EC:3.1.-.-]
11073 TOPBP1; DNA topoisomerase II binding protein 1 [KO:K10728 ]
84142 ABRAXAS1; abraxas 1, BRCA1 A complex subunit [KO:K20774 ]
51720 UIMC1; ubiquitin interaction motif containing 1 [KO:K20775 ]
29086 BABAM1; BRISC and BRCA1 A complex member 1 [KO:K20776 ]
9577 BABAM2; BRISC and BRCA1 A complex member 2 [KO:K12173 ]
79184 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [KO:K11864 ] [EC:3.4.19.-]
79728 PALB2; partner and localizer of BRCA2 [KO:K10897 ]
675 BRCA2; BRCA2 DNA repair associated [KO:K08775 ]
7979 SEM1; SEM1 26S proteasome subunit [KO:K10881 ]
50511 SYCP3; synaptonemal complex protein 3 [KO:K19528 ]
5893 RAD52; RAD52 homolog, DNA repair protein [KO:K10873 ]
7516 XRCC2; X-ray repair cross complementing 2 [KO:K10879 ]
7517 XRCC3; X-ray repair cross complementing 3 [KO:K10880 ]
5425 POLD2; DNA polymerase delta 2, accessory subunit [KO:K02328 ]
10714 POLD3; DNA polymerase delta 3, accessory subunit [KO:K03504 ]
57804 POLD4; DNA polymerase delta 4, accessory subunit [KO:K03505 ]
80198 MUS81; MUS81 structure-specific endonuclease subunit [KO:K08991 ] [EC:3.1.22.-]
146956 EME1; essential meiotic structure-specific endonuclease 1 [KO:K10882 ] [EC:3.1.22.-]
Reference Authors Maloisel L, Fabre F, Gangloff S.
Title DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
Journal Reference Authors Haruta-Takahashi N, Iwasaki H.
Title [Recombination mediators]
Journal Seikagaku 79:449-53 (2007)
Reference Authors Ouyang KJ, Woo LL, Ellis NA.
Title Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
Journal Reference Authors Kawabata M, Kawabata T, Nishibori M.
Title Role of recA/RAD51 family proteins in mammals.
Journal Reference Authors Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
Title Mitotic recombination in Saccharomyces cerevisiae.
Journal Reference Authors Heyer WD, Li X, Rolfsmeier M, Zhang XP.
Title Rad54: the Swiss Army knife of homologous recombination?
Journal Reference Authors Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
Title Recombination proteins and rescue of arrested replication forks.
Journal KO pathway LinkDB All DBs
