KEGG   PATHWAY: iti04152
Entry
iti04152                    Pathway                                
Name
AMPK signaling pathway - Ictidomys tridecemlineatus (thirteen-lined ground squirrel)
Description
AMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in the cellular AMP:ATP ratio caused by metabolic stresses that either interfere with ATP production (eg, deprivation for glucose or oxygen) or that accelerate ATP consumption (eg, muscle contraction). Several upstream kinases, including liver kinase B1 (LKB1), calcium/calmodulin kinase kinase-beta (CaMKK beta), and TGF-beta-activated kinase-1 (TAK-1), can activate AMPK by phosphorylating a threonine residue on its catalytic alpha-subunit. Once activated, AMPK leads to a concomitant inhibition of energy-consuming biosynthetic pathways, such as protein, fatty acid and glycogen synthesis, and activation of ATP-producing catabolic pathways, such as fatty acid oxidation and glycolysis.
Class
Environmental Information Processing; Signal transduction
Pathway map
iti04152  AMPK signaling pathway
iti04152

Other DBs
GO: 2000479
Organism
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) [GN:iti]
Gene
101954478  Gys1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
101954641  Pfkfb4; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 4 isoform X1 [KO:K19030] [EC:2.7.1.105 3.1.3.46]
101955522  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101955606  Rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
101956314  Irs2; insulin receptor substrate 2 [KO:K07187]
101956355  Rab10; ras-related protein Rab-10 [KO:K07903]
101957109  [KO:K00850] [EC:2.7.1.11]
101957141  Prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X2 [KO:K07198] [EC:2.7.11.31]
101957220  Rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
101957649  Lepr; leptin receptor isoform X1 [KO:K05062]
101957921  Foxo3; forkhead box protein O3 [KO:K09408]
101958043  Prkab1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
101958541  Adra1a; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
101958546  Ppp2cb; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
101958580  Rheb; GTP-binding protein Rheb isoform X1 [KO:K07208]
101958753  Rab2a; ras-related protein Rab-2A [KO:K07877]
101958865  Prkag2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X2 [KO:K07200]
101958947  Map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101959263  Adipor2; adiponectin receptor protein 2 [KO:K07297]
101959389  Creb5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
101959574  Stradb; STE20-related kinase adapter protein beta isoform X1 [KO:K17532]
101959632  Hmgcr; 3-hydroxy-3-methylglutaryl-Coenzyme A reductase [KO:K00021] [EC:1.1.1.34]
101959670  Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
101959829  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X2 [KO:K09048]
101959966  Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X2 [KO:K04354]
101959997  Irs4; insulin receptor substrate 4 isoform X2 [KO:K17446]
101960193  Cab39; calcium-binding protein 39 [KO:K08272]
101960452  Rab14; ras-related protein Rab-14 [KO:K07881]
101960744  Igf1r; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
101960881  Camkk2; calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
101960988  Fasn; fatty acid synthase [KO:K00665] [EC:2.3.1.85]
101961032  Cd36; platelet glycoprotein 4 [KO:K06259]
101962346  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 isoform X5 [KO:K06276] [EC:2.7.11.1]
101962360  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101962445  Ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X2 [KO:K11584]
101962660  [KO:K00922] [EC:2.7.1.153]
101962757  Pfkm; ATP-dependent 6-phosphofructokinase, muscle type isoform X2 [KO:K00850] [EC:2.7.1.11]
101962827  Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
101963110  Tsc1; hamartin isoform X1 [KO:K07206]
101963129  Pfkl; ATP-dependent 6-phosphofructokinase, liver type [KO:K00850] [EC:2.7.1.11]
101963148  Cab39l; calcium-binding protein 39-like [KO:K08272]
101963429  Prkag3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
101963540  Insr; insulin receptor [KO:K04527] [EC:2.7.10.1]
101963645  Cpt1c; carnitine O-palmitoyltransferase 1, brain isoform isoform X2 [KO:K19524] [EC:2.3.1.21]
101963747  Mlycd; LOW QUALITY PROTEIN: malonyl-CoA decarboxylase, mitochondrial [KO:K01578] [EC:4.1.1.9]
101963835  Cpt1a; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
101963921  Ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
101964237  Srebf1; sterol regulatory element-binding protein 1 isoform X3 [KO:K07197]
101964289  Pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
101964310  [KO:K00507] [EC:1.14.19.1]
101964513  Acacb; acetyl-CoA carboxylase 2 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
101964556  Sirt1; NAD-dependent protein deacetylase sirtuin-1 isoform X2 [KO:K11411] [EC:2.3.1.286]
101964684  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101964691  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
101964768  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
101965270  [KO:K00507] [EC:1.14.19.1]
101965711  Ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
101965763  Ulk1; serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
101965867  Ppp2r3b; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
101965906  [KO:K00922] [EC:2.7.1.153]
101965950  [KO:K00507] [EC:1.14.19.1]
101966207  Ins; insulin precursor [KO:K04526]
101966452  [KO:K00507] [EC:1.14.19.1]
101966469  G6pc2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
101966712  Irs1; insulin receptor substrate 1 [KO:K16172]
101966934  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
101967027  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X4 [KO:K03456]
101967037  Ccna2; cyclin-A2 [KO:K06627]
101967050  [KO:K07199]
101967206  Adipor1; adiponectin receptor protein 1 isoform X1 [KO:K07297]
101967230  Akt1s1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
101967417  Tsc2; tuberin isoform X1 [KO:K07207]
101967490  Foxo1; forkhead box protein O1 [KO:K07201]
101968093  Ppargc1a; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X3 [KO:K07202]
101968287  Pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
101968890  Igf1; insulin-like growth factor I isoform X2 [KO:K05459]
101968896  [KO:K00922] [EC:2.7.1.153]
101968976  [KO:K05424]
101969233  Fbp2; fructose-1,6-bisphosphatase isozyme 2 [KO:K03841] [EC:3.1.3.11]
101969397  Gys2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
101969507  Fbp1; fructose-1,6-bisphosphatase 1 [KO:K03841] [EC:3.1.3.11]
101969946  Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
101969987  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101970750  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101970841  Adipoq; adiponectin [KO:K07296]
101970847  Slc2a4; solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
101970848  Rps6kb2; ribosomal protein S6 kinase beta-2 isoform X2 [KO:K04688] [EC:2.7.11.1]
101970921  Prkag1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X5 [KO:K07200]
101971138  Eef2; elongation factor 2 [KO:K03234]
101971530  Cidea; cell death activator CIDE-A isoform X3 [KO:K25893]
101971812  G6pc3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
101971917  Strada; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
101972024  Cftr; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
101972098  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101972246  Ccna1; cyclin-A1 [KO:K06627]
101972336  Scd5; stearoyl-CoA desaturase 5 [KO:K00507] [EC:1.14.19.1]
101972551  Acaca; acetyl-CoA carboxylase 1 isoform X3 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
101972771  Hnf4a; hepatocyte nuclear factor 4-alpha isoform X2 [KO:K07292]
101972847  Ppp2r5e; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X4 [KO:K11584]
101972903  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
101973090  [KO:K07297]
101973150  Prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X2 [KO:K07198] [EC:2.7.11.31]
101973595  Pfkfb3; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform X3 [KO:K01103] [EC:2.7.1.105 3.1.3.46]
101973716  Eef2k; eukaryotic elongation factor 2 kinase isoform X1 [KO:K08292] [EC:2.7.11.20]
101973809  Ppp2r2b; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X2 [KO:K04354]
101973837  Elavl1; ELAV-like protein 1 [KO:K13088]
101973983  [KO:K07199]
101974357  G6pc1; glucose-6-phosphatase isoform X1 [KO:K01084] [EC:3.1.3.9]
101974392  Pfkfb2; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 isoform X3 [KO:K19029] [EC:2.7.1.105 3.1.3.46]
101974705  Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
101975051  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
101975090  [KO:K04354]
101975126  [KO:K17445]
101975227  Ppp2r3a; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X3 [KO:K11583]
101975531  Cpt1b; carnitine O-palmitoyltransferase 1, muscle isoform isoform X2 [KO:K19523] [EC:2.3.1.21]
101975616  Stk11; serine/threonine-protein kinase STK11 isoform X5 [KO:K07298] [EC:2.7.11.1]
101975748  Ppp2r5c; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
101975800  Rab8a; ras-related protein Rab-8A [KO:K07901]
101975939  Pfkfb1; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 1 isoform X3 [KO:K19028] [EC:2.7.1.105 3.1.3.46]
101976353  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101976361  Rab11b; ras-related protein Rab-11B [KO:K07905]
101976389  Lipe; hormone-sensitive lipase [KO:K07188] [EC:3.1.1.79]
101976929  Pparg; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
101977109  Crtc2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
101977585  Ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
101977662  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
101978230  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101978245  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
101978586  Creb3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
101978641  Tbc1d1; TBC1 domain family member 1 isoform X1 [KO:K18341]
120889971  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
Compound
C00003  NAD+
C00008  ADP
C00020  AMP
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00040  Acyl-CoA
C00076  Calcium cation
C00083  Malonyl-CoA
C00085  D-Fructose 6-phosphate
C00162  Fatty acid
C00354  D-Fructose 1,6-bisphosphate
C00389  Quercetin
C00665  beta-D-Fructose 2,6-bisphosphate
C00668  alpha-D-Glucose 6-phosphate
C00698  Cl-
C00757  Berberine
C01172  beta-D-Glucose 6-phosphate
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07151  Metformin
C09731  Epigallocatechin gallate
D08351  Phenformin (BAN)
Reference
PMID:19584320
  Authors
Steinberg GR, Kemp BE
  Title
AMPK in Health and Disease.
  Journal
Physiol Rev 89:1025-78 (2009)
DOI:10.1152/physrev.00011.2008
Reference
PMID:15509864
  Authors
Hardie DG.
  Title
The AMP-activated protein kinase pathway--new players upstream and downstream.
  Journal
J Cell Sci 117:5479-87 (2004)
DOI:10.1242/jcs.01540
Reference
PMID:23747347
  Authors
Russo GL, Russo M, Ungaro P
  Title
AMP-activated protein kinase: a target for old drugs against diabetes and cancer.
  Journal
Biochem Pharmacol 86:339-50 (2013)
DOI:10.1016/j.bcp.2013.05.023
Reference
PMID:19393004
  Authors
Ronnett GV, Ramamurthy S, Kleman AM, Landree LE, Aja S
  Title
AMPK in the brain: its roles in energy balance and neuroprotection.
  Journal
J Neurochem 109 Suppl 1:17-23 (2009)
DOI:10.1111/j.1471-4159.2009.05916.x
Reference
PMID:20010958
  Authors
Li J, McCullough LD
  Title
Effects of AMP-activated protein kinase in cerebral ischemia.
  Journal
J Cereb Blood Flow Metab 30:480-92 (2010)
DOI:10.1038/jcbfm.2009.255
Reference
PMID:22700795
  Authors
Sanchez AM, Candau RB, Csibi A, Pagano AF, Raibon A, Bernardi H
  Title
The role of AMP-activated protein kinase in the coordination of skeletal muscle turnover and energy homeostasis.
  Journal
Am J Physiol Cell Physiol 303:C475-85 (2012)
DOI:10.1152/ajpcell.00125.2012
Reference
PMID:16644802
  Authors
Viollet B, Foretz M, Guigas B, Horman S, Dentin R, Bertrand L, Hue L, Andreelli F
  Title
Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders.
  Journal
J Physiol 574:41-53 (2006)
DOI:10.1113/jphysiol.2006.108506
Reference
PMID:19629071
  Authors
Shackelford DB, Shaw RJ
  Title
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression.
  Journal
Nat Rev Cancer 9:563-75 (2009)
DOI:10.1038/nrc2676
Reference
PMID:22885100
  Authors
Chung JH, Manganiello V, Dyck JR
  Title
Resveratrol as a calorie restriction mimetic: therapeutic implications.
  Journal
Trends Cell Biol 22:546-54 (2012)
DOI:10.1016/j.tcb.2012.07.004
Reference
PMID:20357764
  Authors
Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi YK, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T
  Title
Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1.
  Journal
Nature 464:1313-9 (2010)
DOI:10.1038/nature08991
Reference
PMID:17307971
  Authors
Towler MC, Hardie DG
  Title
AMP-activated protein kinase in metabolic control and insulin signaling.
  Journal
Circ Res 100:328-41 (2007)
DOI:10.1161/01.RES.0000256090.42690.05
Reference
PMID:23899560
  Authors
Richter EA, Hargreaves M
  Title
Exercise, GLUT4, and skeletal muscle glucose uptake.
  Journal
Physiol Rev 93:993-1017 (2013)
DOI:10.1152/physrev.00038.2012
Reference
PMID:16054041
  Authors
Kahn BB, Alquier T, Carling D, Hardie DG
  Title
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.
  Journal
Cell Metab 1:15-25 (2005)
DOI:10.1016/j.cmet.2004.12.003
Reference
PMID:23565491
  Authors
Minokoshi Y, Toda C, Okamoto S
  Title
Regulatory role of leptin in glucose and lipid metabolism in skeletal muscle.
  Journal
Indian J Endocrinol Metab 16:S562-8 (2012)
DOI:10.4103/2230-8210.105573
Reference
PMID:16723978
  Authors
Guggino WB, Stanton BA
  Title
New insights into cystic fibrosis: molecular switches that regulate CFTR.
  Journal
Nat Rev Mol Cell Biol 7:426-36 (2006)
DOI:10.1038/nrm1949
Reference
PMID:16479585
  Authors
Cheng A, Saltiel AR
  Title
More TORC for the gluconeogenic engine.
  Journal
Bioessays 28:231-4 (2006)
DOI:10.1002/bies.20375
Reference
PMID:19197243
  Authors
Herrero-Martin G, Hoyer-Hansen M, Garcia-Garcia C, Fumarola C, Farkas T, Lopez-Rivas A, Jaattela M
  Title
TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells.
  Journal
EMBO J 28:677-85 (2009)
DOI:10.1038/emboj.2009.8
Reference
PMID:19724019
  Authors
Morris DL, Rui L
  Title
Recent advances in understanding leptin signaling and leptin resistance.
  Journal
Am J Physiol Endocrinol Metab 297:E1247-59 (2009)
DOI:10.1152/ajpendo.00274.2009
Reference
PMID:18725075
  Authors
Minokoshi Y, Shiuchi T, Lee S, Suzuki A, Okamoto S
  Title
Role of hypothalamic AMP-kinase in food intake regulation.
  Journal
Nutrition 24:786-90 (2008)
DOI:10.1016/j.nut.2008.06.002
Reference
PMID:23024365
  Authors
Miyamoto L, Ebihara K, Kusakabe T, Aotani D, Yamamoto-Kataoka S, Sakai T, Aizawa-Abe M, Yamamoto Y, Fujikura J, Hayashi T, Hosoda K, Nakao K
  Title
Leptin activates hepatic 5'-AMP-activated protein kinase through sympathetic nervous system and alpha1-adrenergic receptor: a potential mechanism for improvement of fatty liver in lipodystrophy by leptin.
  Journal
J Biol Chem 287:40441-7 (2012)
DOI:10.1074/jbc.M112.384545
Related
pathway
iti00010  Glycolysis / Gluconeogenesis
iti00061  Fatty acid biosynthesis
iti00500  Starch and sucrose metabolism
iti01040  Biosynthesis of unsaturated fatty acids
iti04110  Cell cycle
iti04140  Autophagy - animal
iti04150  mTOR signaling pathway
iti04151  PI3K-Akt signaling pathway
iti04910  Insulin signaling pathway
iti04920  Adipocytokine signaling pathway
KO pathway
ko04152   

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