KEGG   PATHWAY: lcat04726
Entry
lcat04726                   Pathway                                
Name
Serotonergic synapse - Lemur catta (Ring-tailed lemur)
Description
Serotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endocrine secretion, as well as in pathological states including abnormal mood and cognition. Once released from presynaptic axonal terminals, 5-HT binds to receptors, which have been divided into 7 subfamilies on the basis of conserved structures and signaling mechanisms. These families include the ionotropic 5-HT3 receptors and G-protein-coupled 5-HT receptors, the 5-HT1 (Gi /Go -coupled), 5-HT2(Gq-coupled), 5-HT4/6/7 (Gs-coupled) and 5-HT5 receptors. Presynaptically localized 5-HT1B receptors are thought to be the autoreceptors that suppress excess 5-HT release. 5-HT's actions are terminated by transporter- mediated reuptake into neurons, leading to catabolism by monoamine oxidase.
Class
Organismal Systems; Nervous system
Pathway map
lcat04726  Serotonergic synapse
lcat04726

Other DBs
GO: 0007210
Organism
Lemur catta (Ring-tailed lemur) [GN:lcat]
Gene
123620239  SLC6A4; sodium-dependent serotonin transporter [KO:K05037]
123620748  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
123621118  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
123621261  ALOX15; polyunsaturated fatty acid lipoxygenase ALOX15 [KO:K00460] [EC:1.13.11.33]
123622057  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
123622065  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
123622308  [KO:K04632]
123622310  [KO:K04632]
123622795  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
123623167  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
123623249  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
123623574  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
123623917  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
123624366  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
123624654  PRKCG; LOW QUALITY PROTEIN: protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
123624805  GABRB1; LOW QUALITY PROTEIN: gamma-aminobutyric acid receptor subunit beta-1 [KO:K05181]
123625313  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
123626228  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
123626346  SLC18A1; chromaffin granule amine transporter isoform X1 [KO:K08155]
123626765  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
123626819  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
123626853  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
123627584  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
123628101  HTR2C; 5-hydroxytryptamine receptor 2C isoform X1 [KO:K04157]
123628637  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
123628833  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
123629407  PLA2G4B; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
123630054  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
123630120  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
123630130  TRPC1; short transient receptor potential channel 1 isoform X1 [KO:K04964]
123630132  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
123630284  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
123630472  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
123630660  [KO:K04520]
123630738  KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000]
123631427  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
123631625  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
123631640  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
123632177  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
123632192  HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153]
123632490  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
123632778  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
123632820  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
123633190  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
123634165  [KO:K07428] [EC:1.14.14.1]
123634435  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
123634740  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
123635002  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
123635081  NRAS; GTPase NRas [KO:K07828]
123635181  KCNJ9; G protein-activated inward rectifier potassium channel 3 [KO:K05002]
123635476  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
123635536  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
123635586  [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
123635587  [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
123635588  [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
123636000  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
123637148  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
123637429  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
123637477  [KO:K00274] [EC:1.4.3.4]
123637748  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
123637948  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
123637998  GABRB2; gamma-aminobutyric acid receptor subunit beta-2 isoform X1 [KO:K05181]
123638125  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
123638644  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
123638899  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
123639915  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
123639921  KRAS; GTPase KRas [KO:K07827]
123640104  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
123640189  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
123640281  [KO:K17712] [EC:1.14.14.1]
123640282  [KO:K17712] [EC:1.14.14.1]
123640283  [KO:K17712] [EC:1.14.14.1]
123640470  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
123640652  TPH2; tryptophan 5-hydroxylase 2 [KO:K00502] [EC:1.14.16.4]
123640996  KCNJ5; G protein-activated inward rectifier potassium channel 4 [KO:K04999]
123641343  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
123641430  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
123641656  HTR3A; 5-hydroxytryptamine receptor 3A [KO:K04819]
123641830  [KO:K04819]
123641848  [KO:K04819]
123641870  [KO:K04819]
123641882  [KO:K04819]
123641980  HTR3B; 5-hydroxytryptamine receptor 3B [KO:K04819]
123642496  TPH1; tryptophan 5-hydroxylase 1 [KO:K00502] [EC:1.14.16.4]
123642522  HTR1F; 5-hydroxytryptamine receptor 1F [KO:K04153]
123642937  HRAS; GTPase HRas isoform X1 [KO:K02833]
123643282  [KO:K00274] [EC:1.4.3.4]
123643345  KCNJ3; G protein-activated inward rectifier potassium channel 1 isoform X1 [KO:K04997]
123643682  [KO:K04161]
123643858  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
123644640  GABRB3; gamma-aminobutyric acid receptor subunit beta-3 isoform X1 [KO:K05181]
123646101  PTGS1; prostaglandin G/H synthase 1 [KO:K00509] [EC:1.14.99.1]
123646308  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
123646347  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
123646542  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 isoform X1 [KO:K04545]
123647150  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
123647151  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
123647286  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
123647351  DDC; aromatic-L-amino-acid decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
123647376  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
123647642  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
123647777  KCND2; potassium voltage-gated channel subfamily D member 2 isoform X1 [KO:K04892]
123647997  HTR1A; 5-hydroxytryptamine receptor 1A [KO:K04153]
123648299  KCNN2; small conductance calcium-activated potassium channel protein 2 [KO:K04943]
123648542  [KO:K04542]
123648852  [KO:K00274] [EC:1.4.3.4]
123649230  [KO:K04157]
123649683  [KO:K17720] [EC:1.14.14.1]
123649961  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
123650024  ALOX5; polyunsaturated fatty acid 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
123650029  [KO:K04997]
123650042  [KO:K07413] [EC:1.14.14.1]
123650043  [KO:K17718] [EC:1.14.14.1]
123650045  [KO:K17718] [EC:1.14.14.1]
123650046  [KO:K07413] [EC:1.14.14.1]
123650047  [KO:K17718] [EC:1.14.14.1]
123650048  [KO:K17718] [EC:1.14.14.1]
123650138  [KO:K07413] [EC:1.14.14.1]
123650462  SLC18A2; synaptic vesicular amine transporter [KO:K08155]
123650840  ALOX12; polyunsaturated fatty acid lipoxygenase ALOX12 isoform X1 [KO:K00458] [EC:1.13.11.31]
123650917  ALOX15B; polyunsaturated fatty acid lipoxygenase ALOX15B isoform X1 [KO:K08022] [EC:1.13.11.33 1.13.11.-]
123650918  ALOX12B; arachidonate 12-lipoxygenase, 12R-type [KO:K08021] [EC:1.13.11.-]
Compound
C00076  Calcium cation
C00078  L-Tryptophan
C00165  Diacylglycerol
C00219  Arachidonate
C00238  Potassium cation
C00427  Prostaglandin H2
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00643  5-Hydroxy-L-tryptophan
C00696  Prostaglandin D2
C00780  Serotonin
C00909  Leukotriene A4
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C04822  8(R)-HPETE
C05356  5(S)-HPETE
C05635  5-Hydroxyindoleacetate
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14812  12(R)-HPETE
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14823  8(S)-HPETE
Reference
PMID:18676031
  Authors
Millan MJ, Marin P, Bockaert J, Mannoury la Cour C
  Title
Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions.
  Journal
Trends Pharmacol Sci 29:454-64 (2008)
DOI:10.1016/j.tips.2008.06.007
Reference
PMID:16896947
  Authors
Bockaert J, Claeysen S, Becamel C, Dumuis A, Marin P
  Title
Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation.
  Journal
Cell Tissue Res 326:553-72 (2006)
DOI:10.1007/s00441-006-0286-1
Reference
PMID:11916537
  Authors
Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS, Garnovskaya MN
  Title
Multiplicity of mechanisms of serotonin receptor signal transduction.
  Journal
Pharmacol Ther 92:179-212 (2001)
DOI:10.1016/S0163-7258(01)00169-3
Reference
PMID:15034221
  Authors
Noda M, Higashida H, Aoki S, Wada K
  Title
Multiple signal transduction pathways mediated by 5-HT receptors.
  Journal
Mol Neurobiol 29:31-9 (2004)
DOI:10.1385/MN:29:1:31
Reference
PMID:20561690
  Authors
Daubert EA, Condron BG
  Title
Serotonin: a regulator of neuronal morphology and circuitry.
  Journal
Trends Neurosci 33:424-34 (2010)
DOI:10.1016/j.tins.2010.05.005
Reference
PMID:16826372
  Authors
Chameau P, van Hooft JA
  Title
Serotonin 5-HT(3) receptors in the central nervous system.
  Journal
Cell Tissue Res 326:573-81 (2006)
DOI:10.1007/s00441-006-0255-8
Reference
PMID:9651340
  Authors
Tournois C, Mutel V, Manivet P, Launay JM, Kellermann O
  Title
Cross-talk between 5-hydroxytryptamine receptors in a serotonergic cell line. Involvement of arachidonic acid metabolism.
  Journal
J Biol Chem 273:17498-503 (1998)
DOI:10.1074/jbc.273.28.17498
Reference
PMID:19545642
  Authors
Iliff JJ, Jia J, Nelson J, Goyagi T, Klaus J, Alkayed NJ
  Title
Epoxyeicosanoid signaling in CNS function and disease.
  Journal
Prostaglandins Other Lipid Mediat 91:68-84 (2010)
DOI:10.1016/j.prostaglandins.2009.06.004
Reference
PMID:12676358
  Authors
Adayev T, Ray I, Sondhi R, Sobocki T, Banerjee P
  Title
The G protein-coupled 5-HT1A receptor causes suppression of caspase-3 through MAPK and protein kinase Calpha.
  Journal
Biochim Biophys Acta 1640:85-96 (2003)
DOI:10.1016/S0167-4889(03)00023-5
Reference
PMID:11701344
  Authors
Albert PR, Tiberi M
  Title
Receptor signaling and structure: insights from serotonin-1 receptors.
  Journal
Trends Endocrinol Metab 12:453-60 (2001)
DOI:10.1016/S1043-2760(01)00498-2
Reference
PMID:9658404
  Authors
Durham PL, Russo AF
  Title
Serotonergic repression of mitogen-activated protein kinase control of the calcitonin gene-related peptide enhancer.
  Journal
Mol Endocrinol 12:1002-9 (1998)
DOI:10.1210/mend.12.7.0135
Reference
PMID:15710402
  Authors
Robert S, Maillet M, Morel E, Launay JM, Fischmeister R, Mercken L, Lezoualc'h F
  Title
Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac.
  Journal
FEBS Lett 579:1136-42 (2005)
DOI:10.1016/j.febslet.2005.01.010
Reference
PMID:12543273
  Authors
Lezoualc'h F, Robert SJ
  Title
The serotonin 5-HT4 receptor and the amyloid precursor protein processing.
  Journal
Exp Gerontol 38:159-66 (2003)
DOI:10.1016/S0531-5565(02)00157-2
Reference
PMID:11043573
  Authors
Durham PL, Russo AF
  Title
Differential regulation of mitogen-activated protein kinase-responsive genes by the duration of a calcium signal.
  Journal
Mol Endocrinol 14:1570-82 (2000)
DOI:10.1210/mend.14.10.0529
Reference
PMID:9542727
  Authors
Hagberg GB, Blomstrand F, Nilsson M, Tamir H, Hansson E
  Title
Stimulation of 5-HT2A receptors on astrocytes in primary culture opens voltage-independent Ca2+ channels.
  Journal
Neurochem Int 32:153-62 (1998)
DOI:10.1016/S0197-0186(97)00087-9
Reference
  Authors
Nestler EJ, Hyman SE, Malenka RC.
  Title
Molecular neuropharmacology: A foundation for clinical neuroscience
  Journal
The McGraw-Hill Companies, Inc. (2001)
Related
pathway
lcat00380  Tryptophan metabolism
lcat00590  Arachidonic acid metabolism
lcat04020  Calcium signaling pathway
lcat04721  Synaptic vesicle cycle
lcat04976  Bile secretion
KO pathway
ko04726   

DBGET integrated database retrieval system