KEGG   PATHWAY: mcc04020
Entry
mcc04020                    Pathway                                
Name
Calcium signaling pathway - Macaca mulatta (rhesus monkey)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
mcc04020  Calcium signaling pathway
mcc04020

Other DBs
GO: 0019722
Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
100423096  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
100424360  SLN; sarcolipin [KO:K22642]
100424899  [KO:K04632]
100426104  PLN; cardiac phospholamban [KO:K05852]
100426598  ADRB1; beta-1 adrenergic receptor [KO:K04141]
100428682  PPP3R1; calcineurin subunit B type 1 isoform X3 [KO:K06268]
100429880  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
100430996  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
105274303  MRLN; myoregulin [KO:K22643]
106996003  [KO:K06856]
106999628  [KO:K06856]
114669757  [KO:K23449]
114673005  [KO:K13241] [EC:1.14.13.39]
114673806  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
114675805  [KO:K06856]
114679736  [KO:K06856]
574133  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
574136  FGF2; fibroblast growth factor 2 [KO:K18497]
574137  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
574193  SLC8A1; sodium/calcium exchanger 1 precursor [KO:K05849]
574209  VEGFA; vascular endothelial growth factor A isoform 1 precursor [KO:K05448]
574230  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 precursor [KO:K04809]
574258  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
574317  ATP2B4; plasma membrane calcium-transporting ATPase 4 [KO:K05850] [EC:7.2.2.10]
574330  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
574339  GRPR; gastrin-releasing peptide receptor [KO:K04169]
574345  FGF7; fibroblast growth factor 7 precursor [KO:K04358]
574362  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
574380  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
613027  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
613031  TGFA; protransforming growth factor alpha isoform X2 [KO:K08774]
613032  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
613251  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
653008  TACR1; substance-P receptor [KO:K04222]
653013  TACR3; neuromedin-K receptor [KO:K04224]
693341  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
693390  P2RX2; P2X purinoceptor 2 [KO:K05216]
693399  [KO:K04161]
693502  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
693523  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
693612  RYR1; ryanodine receptor 1 isoform X1 [KO:K04961]
693753  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
693781  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
693924  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
693937  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
694214  TFEB; transcription factor EB [KO:K15590]
694289  [KO:K04632]
694376  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
694730  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
694742  CCKAR; cholecystokinin receptor type A [KO:K04194]
694980  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
694996  RYR3; ryanodine receptor 3 isoform X1 [KO:K04963]
695102  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
695106  ADRA1B; alpha-1B adrenergic receptor isoform X2 [KO:K04136]
695226  HRH2; histamine H2 receptor [KO:K04150]
695328  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
695792  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
695803  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
695841  P2RX6; P2X purinoceptor 6 isoform X4 [KO:K05221]
695896  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
695963  AVPR1B; vasopressin V1b receptor [KO:K04227]
696306  [KO:K10785]
696317  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
696359  HRH1; histamine H1 receptor [KO:K04149]
696848  ADORA2B; adenosine receptor A2b [KO:K04267]
696860  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
697002  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
697047  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
697069  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
697230  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
697329  EDNRB; endothelin receptor type B isoform X2 [KO:K04198]
697573  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
697615  NTRK3; NT-3 growth factor receptor precursor [KO:K05101] [EC:2.7.10.1]
697661  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X3 [KO:K08794] [EC:2.7.11.17]
697796  DRD1; D(1A) dopamine receptor [KO:K04144]
697904  [KO:K10785]
698089  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X2 [KO:K04446]
698185  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
698293  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
698494  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
698511  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
698552  CALM1; calmodulin-1 isoform X1 [KO:K02183]
698571  GRIN2B; glutamate receptor ionotropic, NMDA 2B isoform X1 [KO:K05210]
698619  EGF; pro-epidermal growth factor isoform X2 [KO:K04357]
698736  GRM1; metabotropic glutamate receptor 1 precursor [KO:K04603]
698785  [KO:K10785]
698936  NTSR1; neurotensin receptor type 1 [KO:K04211]
699129  ADRB3; beta-3 adrenergic receptor [KO:K04143]
699216  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
699455  P2RX7; P2X purinoceptor 7 [KO:K05220]
699502  VEGFC; vascular endothelial growth factor C precursor [KO:K05449]
699569  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
699764  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform [KO:K07190]
699884  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X7 [KO:K00476] [EC:1.14.11.16]
700126  FGFR1; fibroblast growth factor receptor 1 precursor [KO:K04362] [EC:2.7.10.1]
700190  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
700212  CAMK1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
700236  PDGFC; platelet-derived growth factor C [KO:K05450]
700652  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
701149  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
701195  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
701584  FGF10; fibroblast growth factor 10 precursor [KO:K04358]
701758  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
701847  FGF20; fibroblast growth factor 20 [KO:K04358]
701951  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
702048  OXTR; oxytocin receptor [KO:K04229]
702072  FGF18; fibroblast growth factor 18 [KO:K04358]
702390  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X2 [KO:K17333]
702504  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X2 [KO:K04515] [EC:2.7.11.17]
702536  P2RX4; P2X purinoceptor 4 isoform X1 [KO:K05218]
702727  FGF22; fibroblast growth factor 22 precursor [KO:K04358]
703029  [KO:K10785]
703091  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
703173  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
703293  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X2 [KO:K05861] [EC:3.1.4.11]
703398  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X2 [KO:K04260]
703466  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
703514  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
703664  SMIM6; small integral membrane protein 6 [KO:K26468]
703669  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
703698  BDKRB2; B2 bradykinin receptor [KO:K03916]
703775  MCOLN1; mucolipin-1 [KO:K04992]
704135  EDNRA; endothelin-1 receptor precursor [KO:K04197]
704257  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
704310  PDGFD; platelet-derived growth factor D isoform X2 [KO:K05450]
704437  MST1R; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
704562  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
705116  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
705360  C5H4orf3; uncharacterized protein C4orf3 homolog [KO:K26467]
705445  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
705448  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
705450  CYSLTR2; cysteinyl leukotriene receptor 2 isoform X2 [KO:K04323]
705555  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
705612  FGF16; fibroblast growth factor 16 [KO:K04358]
705680  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
705811  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
705920  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
705970  FGF1; fibroblast growth factor 1 [KO:K18496]
705980  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
706230  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
706345  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
706351  [KO:K02183]
706503  P2RX3; P2X purinoceptor 3 [KO:K05217]
706659  FGF17; fibroblast growth factor 17 precursor [KO:K04358]
706663  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
706789  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
706921  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
706955  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X7 [KO:K04348] [EC:3.1.3.16]
706977  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X11 [KO:K04515] [EC:2.7.11.17]
707329  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
707361  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
707370  F2R; proteinase-activated receptor 1 [KO:K03914]
707535  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
707658  P2RX1; P2X purinoceptor 1 [KO:K05215]
707725  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
707768  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X3 [KO:K05853] [EC:7.2.2.10]
707865  ADORA2A; adenosine receptor A2a isoform X1 [KO:K04266]
708058  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
708141  HTR2C; 5-hydroxytryptamine receptor 2C isoform X1 [KO:K04157]
708146  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
708233  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
708316  HGF; hepatocyte growth factor isoform X3 [KO:K05460]
708334  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
708706  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
708714  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
708901  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
708918  FGF3; fibroblast growth factor 3 precursor [KO:K04358]
709016  FGF4; fibroblast growth factor 4 [KO:K04358]
709102  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X2 [KO:K05850] [EC:7.2.2.10]
709109  FGF19; fibroblast growth factor 19 [KO:K22603]
709391  TPCN2; two pore calcium channel protein 2 isoform X3 [KO:K14077]
709728  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
709757  NTRK2; BDNF/NT-3 growth factors receptor precursor [KO:K04360] [EC:2.7.10.1]
709773  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
710042  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
710045  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
710046  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
710146  ADRB2; beta-2 adrenergic receptor [KO:K04142]
710149  [KO:K10784]
710441  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
710540  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
710541  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
710601  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
710643  FGF23; fibroblast growth factor 23 precursor [KO:K22428]
710702  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X3 [KO:K05853] [EC:7.2.2.10]
710739  FGF6; fibroblast growth factor 6 [KO:K04358]
710909  MCOLN2; mucolipin-2 [KO:K04993]
710987  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
711353  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
711407  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
711681  NGF; beta-nerve growth factor [KO:K02582]
711808  HTR2B; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
711842  TACR2; substance-K receptor [KO:K04223]
712159  CALML5; calmodulin-like protein 5 [KO:K02183]
712251  BDKRB1; B1 bradykinin receptor [KO:K03915]
712322  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
712360  ORAI3; protein orai-3 [KO:K16058]
712373  CASQ2; calsequestrin-2 isoform X1 [KO:K23445]
712509  ADRA1A; alpha-1A adrenergic receptor [KO:K04135]
712654  VEGFD; vascular endothelial growth factor D [KO:K05449]
712773  AGTR1; type-1 angiotensin II receptor isoform X2 [KO:K04166]
712787  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
712829  FGFR3; fibroblast growth factor receptor 3 isoform X10 [KO:K05094] [EC:2.7.10.1]
712830  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
712862  DRD5; D(1B) dopamine receptor [KO:K05840]
712939  CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195]
712964  TPCN1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
713061  SLC8A3; sodium/calcium exchanger 3 isoform X2 [KO:K05849]
713373  [KO:K23449]
714173  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
714231  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
714399  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
714419  [KO:K06856]
714684  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
714780  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
714785  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X2 [KO:K17334]
714917  ORAI2; protein orai-2 [KO:K16057]
715270  CALM2; calmodulin-2 [KO:K02183]
715422  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
715787  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
715924  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
715949  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
715999  LHCGR; lutropin-choriogonadotropic hormone receptor isoform X1 [KO:K04248]
716012  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
716132  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
716134  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
716390  PHKB; phosphorylase b kinase regulatory subunit beta [KO:K07190]
716412  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
716584  CALM3; calmodulin-3 isoform X1 [KO:K02183]
716776  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
716788  PTAFR; platelet-activating factor receptor [KO:K04279]
716892  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
717041  AVPR1A; vasopressin V1a receptor [KO:K04226]
717179  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
717270  TNNC2; troponin C, skeletal muscle [KO:K12042]
717624  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G isoform X2 [KO:K08794] [EC:2.7.11.17]
717686  [KO:K02183]
717764  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
717945  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
717963  STIM1; stromal interaction molecule 1 precursor [KO:K16059]
718040  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
718088  SPHK2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
718092  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
718243  SLC8A2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
718288  FGF21; fibroblast growth factor 21 [KO:K22429]
718291  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X5 [KO:K04344]
718387  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
718412  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
718418  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858] [EC:3.1.4.11]
718632  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
718647  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein isoform X1 [KO:K23450]
719670  NTRK1; high affinity nerve growth factor receptor isoform X3 [KO:K03176] [EC:2.7.10.1]
719811  [KO:K05863]
720233  CASQ1; calsequestrin-1 [KO:K23468]
720263  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
720452  [KO:K06856]
720904  [KO:K06856]
720935  [KO:K06856]
720985  [KO:K06856]
721002  [KO:K06856]
721083  [KO:K06856]
721155  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
721324  FGF9; fibroblast growth factor 9 [KO:K04358]
721452  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
721476  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
721649  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
721669  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
721721  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X13 [KO:K04850]
721732  TBXA2R; thromboxane A2 receptor [KO:K04264]
722078  ITPKC; inositol-trisphosphate 3-kinase C isoform X1 [KO:K00911] [EC:2.7.1.127]
722115  VEGFB; vascular endothelial growth factor B isoform X2 [KO:K16858]
722278  [KO:K06856]
722394  FGF8; fibroblast growth factor 8 [KO:K04358]
722407  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
722513  CALML3; calmodulin-like protein 3 [KO:K02183]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
mcc04010  MAPK signaling pathway
mcc04070  Phosphatidylinositol signaling system
mcc04210  Apoptosis
mcc04720  Long-term potentiation
mcc04730  Long-term depression
KO pathway
ko04020   

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