Entry
Name
Cytokine-cytokine receptor interaction - Macaca fascicularis (crab-eating macaque)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
mcf04060 Cytokine-cytokine receptor interaction
Organism
Macaca fascicularis (crab-eating macaque) [GN:
mcf ]
Gene
101864918 TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
101865743 RELT; tumor necrosis factor receptor superfamily member 19L isoform X2 [KO:K05156 ]
101925182 TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376 ]
101925746 TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157 ]
101926138 IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060 ]
102115191 TNFRSF19; tumor necrosis factor receptor superfamily member 19 isoform X1 [KO:K05155 ]
102115306 NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
102116472 TNFRSF13C; tumor necrosis factor receptor superfamily member 13C isoform X2 [KO:K05151 ]
102116506 EDA2R; tumor necrosis factor receptor superfamily member 27 isoform X3 [KO:K05163 ]
102117911 IL22RA1; interleukin-22 receptor subunit alpha-1 isoform X3 [KO:K05138 ]
102118404 TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
102118696 CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160 ]
102118747 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
102119675 IL20RB; interleukin-20 receptor subunit beta isoform X2 [KO:K05137 ]
102120238 EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X1 [KO:K05162 ]
102121571 IL15RA; interleukin-15 receptor subunit alpha isoform X2 [KO:K05074 ]
102123087 CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423 ]
102123214 TNFSF13B; tumor necrosis factor ligand superfamily member 13B isoform X1 [KO:K05476 ]
102123605 IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068 ]
102126145 IL1RN; interleukin-1 receptor antagonist protein isoform X2 [KO:K05481 ]
102126451 TNFRSF13B; tumor necrosis factor receptor superfamily member 13B isoform X1 [KO:K05150 ]
102126587 TNFSF13; tumor necrosis factor ligand superfamily member 13 isoform X4 [KO:K05475 ]
102127961 TNFRSF9; tumor necrosis factor receptor superfamily member 9 isoform X1 [KO:K05146 ]
102128119 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147 ]
102128998 TNFSF12; tumor necrosis factor ligand superfamily member 12 isoform X1 [KO:K05474 ]
102129676 TNFSF9; tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
102130835 TNFSF14; tumor necrosis factor ligand superfamily member 14 isoform X1 [KO:K05477 ]
102131165 IL12RB2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064 ]
102132219 CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
102133222 IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723 ]
102133459 IL11RA; interleukin-11 receptor subunit alpha isoform X4 [KO:K05056 ]
102133649 IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071 ]
102133727 TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K04722 ]
102135082 OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057 ]
102135285 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158 ]
102135920 LTBR; tumor necrosis factor receptor superfamily member 3 isoform X1 [KO:K03159 ]
102136357 CLCF1; cardiotrophin-like cytokine factor 1 isoform X2 [KO:K05421 ]
102136544 TNFRSF10D; tumor necrosis factor receptor superfamily member 10D isoform X1 [KO:K22702 ]
102137685 TNFRSF25; tumor necrosis factor receptor superfamily member 25 isoform X1 [KO:K05160 ]
102137807 TNFRSF14; tumor necrosis factor receptor superfamily member 14 isoform X2 [KO:K05152 ]
102137811 TNFRSF8; tumor necrosis factor receptor superfamily member 8 isoform X1 [KO:K05145 ]
102137946 TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
102138714 IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069 ]
102139216 IL27RA; interleukin-27 receptor subunit alpha isoform X1 [KO:K19598 ]
102139406 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
102139461 IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135 ]
102139560 TNFRSF10A; tumor necrosis factor receptor superfamily member 10A [KO:K04722 ]
102139775 CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X4 [KO:K05066 ]
102140176 CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X5 [KO:K05059 ]
102140808 TNFSF18; tumor necrosis factor ligand superfamily member 18 [KO:K05479 ]
102141017 TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149 ]
102141570 IL20RA; interleukin-20 receptor subunit alpha isoform X2 [KO:K05136 ]
102141631 CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453 ]
102141877 TNFSF4; tumor necrosis factor ligand superfamily member 4 isoform X4 [KO:K05469 ]
102143353 CSF2RB; cytokine receptor common subunit beta isoform X2 [KO:K04738 ]
102143359 IL12RB1; interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063 ]
102143679 IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072 ]
102143966 TNFSF8; tumor necrosis factor ligand superfamily member 8 isoform X1 [KO:K05471 ]
102144224 TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141 ]
102144578 TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478 ]
102145399 TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153 ]
102145538 IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737 ]
102145978 TNFRSF4; tumor necrosis factor receptor superfamily member 4 isoform X2 [KO:K05142 ]
102146362 TNFRSF18; tumor necrosis factor receptor superfamily member 18 isoform X2 [KO:K05154 ]
107126607 TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143 ]
135964343 FAS; tumor necrosis factor receptor superfamily member 6 isoform X3 [KO:K04390 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway