KEGG   PATHWAY: mcf04150
Entry
mcf04150                    Pathway                                
Name
mTOR signaling pathway - Macaca fascicularis (crab-eating macaque)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
mcf04150  mTOR signaling pathway
mcf04150

Organism
Macaca fascicularis (crab-eating macaque) [GN:mcf]
Gene
101925461  SLC7A5; large neutral amino acids transporter small subunit 1 [KO:K13780]
101866986  SLC3A2; 4F2 cell-surface antigen heavy chain isoform X1 [KO:K06519]
101866617  SLC38A9; sodium-coupled neutral amino acid transporter 9 isoform X1 [KO:K14995]
102128783  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
102115629  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
101925257  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
102139650  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform isoform X1 [KO:K02147]
102137126  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
101866706  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
101925234  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
102121520  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
101866302  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
102137390  V-type proton ATPase subunit E 1 [KO:K02150]
102116490  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
102139482  V-type proton ATPase subunit F-like [KO:K02151]
102117757  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
101926631  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
102146711  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
123567930  V-type proton ATPase subunit G 1-like [KO:K02152]
107130518  V-type proton ATPase subunit G 1-like [KO:K02152]
101926423  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
101925196  LAMTOR1; ragulator complex protein LAMTOR1 [KO:K20397]
102127312  LAMTOR2; ragulator complex protein LAMTOR2 [KO:K20398]
102128955  LAMTOR3; ragulator complex protein LAMTOR3 isoform X2 [KO:K04370]
102122108  LAMTOR4; ragulator complex protein LAMTOR4 isoform X1 [KO:K20399]
102133716  LAMTOR5; ragulator complex protein LAMTOR5 [KO:K16344]
102130800  FLCN; folliculin isoform X1 [KO:K09594]
102146074  FNIP1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
102143803  FNIP2; folliculin-interacting protein 2 isoform X1 [KO:K20401]
101865293  RRAGB; ras-related GTP-binding protein B isoform X1 [KO:K16185]
101865186  RRAGA; ras-related GTP-binding protein A [KO:K16185]
102146355  RRAGC; ras-related GTP-binding protein C [KO:K16186]
102121350  RRAGD; ras-related GTP-binding protein D isoform X2 [KO:K16186]
101866115  SESN2; sestrin-2 isoform X1 [KO:K20394]
102126082  CASTOR1; cytosolic arginine sensor for mTORC1 subunit 1 isoform X1 [KO:K23080]
102125585  CASTOR2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
102134153  MIOS; GATOR complex protein MIOS isoform X1 [KO:K20407]
102126077  SEH1L; nucleoporin SEH1 isoform X1 [KO:K14299]
107128337  WDR24; GATOR complex protein WDR24 [KO:K20408]
102142725  WDR59; GATOR complex protein WDR59 isoform X1 [KO:K20409]
102137586  SEC13; protein SEC13 homolog isoform X1 [KO:K14004]
102123621  DEPDC5; GATOR complex protein DEPDC5 isoform X1 [KO:K20404]
102142693  NPRL2; GATOR complex protein NPRL2 isoform X2 [KO:K20405]
101865473  NPRL3; GATOR complex protein NPRL3 isoform X1 [KO:K20406]
102114882  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
102144619  RNF152; E3 ubiquitin-protein ligase RNF152 isoform X2 [KO:K15705] [EC:2.3.2.27]
102116460  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
102139860  AKT1S1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
102128371  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
102124257  DEPTOR; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
102147013  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
102117832  TELO2; telomere length regulation protein TEL2 homolog isoform X7 [KO:K11137]
101866344  TTI1; TELO2-interacting protein 1 homolog isoform X1 [KO:K20403]
101925088  CLIP1; CAP-Gly domain-containing linker protein 1 isoform X10 [KO:K10421]
102117572  GRB10; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
102141799  LPIN3; phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
101926633  LPIN1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
102121328  LPIN2; phosphatidate phosphatase LPIN2 [KO:K15728] [EC:3.1.3.4]
102141167  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
101925926  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
102132583  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
102145554  EIF4E1B; eukaryotic translation initiation factor 4E type 1B isoform X1 [KO:K03259]
101867078  EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
102142223  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X3 [KO:K03259]
101925564  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X3 [KO:K04688] [EC:2.7.11.1]
102134845  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
101866211  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
123570260  eukaryotic translation initiation factor 4B-like [KO:K03258]
101867274  RPS6; 40S ribosomal protein S6 [KO:K02991]
102129682  LOW QUALITY PROTEIN: 40S ribosomal protein S6 [KO:K02991]
123574044  40S ribosomal protein S6-like [KO:K02991]
101926294  STRADA; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
101925290  STRADB; STE20-related kinase adapter protein beta [KO:K17532]
102143615  STK11; serine/threonine-protein kinase STK11 isoform X3 [KO:K07298] [EC:2.7.11.1]
101867149  CAB39; calcium-binding protein 39 [KO:K08272]
102123475  CAB39L; calcium-binding protein 39-like isoform X2 [KO:K08272]
102143726  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
102144683  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
102124229  TSC1; hamartin isoform X1 [KO:K07206]
102140628  TSC2; tuberin isoform X1 [KO:K07207]
101867486  TBC1 domain family member 7 [KO:K20396]
102127243  RHEB; GTP-binding protein Rheb [KO:K07208]
101866790  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
102120871  WNT1; proto-oncogene Wnt-1 [KO:K03209]
102130917  WNT2B; protein Wnt-2b [KO:K00182]
102129174  WNT2; protein Wnt-2 [KO:K00182]
102131688  WNT3A; protein Wnt-3a isoform X1 [KO:K00312]
102129654  WNT3; proto-oncogene Wnt-3 isoform X1 [KO:K00312]
102143058  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
102146380  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
102129552  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
102132660  WNT6; protein Wnt-6 [KO:K00445]
102137321  WNT7A; protein Wnt-7a isoform X1 [KO:K00572]
102135636  WNT7B; protein Wnt-7b isoform X2 [KO:K00572]
102121324  WNT8B; protein Wnt-8b [KO:K00714]
102120527  WNT8A; protein Wnt-8a [KO:K00714]
102130297  WNT9B; protein Wnt-9b isoform X1 [KO:K01064]
101867270  WNT9A; protein Wnt-9a [KO:K01064]
102121241  WNT10B; protein Wnt-10b isoform X1 [KO:K01357]
102133672  WNT10A; protein Wnt-10a [KO:K01357]
102130649  WNT11; protein Wnt-11 isoform X2 [KO:K01384]
102142460  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
102123369  FZD1; frizzled-1 [KO:K02432]
102128172  FZD7; frizzled-7 [KO:K02432]
102121830  FZD2; frizzled-2 [KO:K02235]
102115052  FZD3; frizzled-3 [KO:K02329]
102134081  FZD4; frizzled-4 isoform X2 [KO:K02354]
102129777  FZD8; frizzled-8 [KO:K02375]
102143139  FZD5; frizzled-5 [KO:K02375]
102131578  FZD6; frizzled-6 isoform X1 [KO:K02376]
102142058  FZD9; frizzled-9 [KO:K02842]
102127626  FZD10; frizzled-10 [KO:K02842]
102144265  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
102145061  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
102130032  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
102138928  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
102143975  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X2 [KO:K02353]
102133756  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
102139631  TNF; tumor necrosis factor isoform X1 [KO:K03156]
102135285  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102146604  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
102133184  INS; insulin [KO:K04526]
102128018  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
102139081  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
102130142  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
102118276  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
102135079  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102138313  SOS2; son of sevenless homolog 2 [KO:K03099]
102118744  HRAS; GTPase HRas isoform X1 [KO:K02833]
102131483  KRAS; GTPase KRas isoform X1 [KO:K07827]
102137913  NRAS; GTPase NRas [KO:K07828]
101866436  BRAF; serine/threonine-protein kinase B-raf isoform X4 [KO:K04365] [EC:2.7.11.1]
102125312  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102141214  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102140855  dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
102145011  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102116996  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
102138330  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
102118317  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
102134699  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X3 [KO:K04373] [EC:2.7.11.1]
102142347  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
102117978  IRS1; insulin receptor substrate 1 [KO:K16172]
102137291  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
101866246  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102124804  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102143464  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102142026  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102122725  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101867036  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
101866379  3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
102144461  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102142406  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102132744  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102115964  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
101925162  MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
102133053  RICTOR; rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267]
102128972  PRR5L; proline-rich protein 5-like isoform X1 [KO:K20411]
101865630  RHOA; transforming protein RhoA [KO:K04513]
102135875  PRKCA; protein kinase C alpha type isoform X4 [KO:K02677] [EC:2.7.11.13]
102116992  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101865773  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101866184  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
mcf00561  Glycerolipid metabolism
mcf04010  MAPK signaling pathway
mcf04140  Autophagy - animal
mcf04151  PI3K-Akt signaling pathway
mcf04152  AMPK signaling pathway
mcf04810  Regulation of actin cytoskeleton
mcf04910  Insulin signaling pathway
KO pathway
ko04150   
LinkDB

DBGET integrated database retrieval system