KEGG   PATHWAY: mcf04010
Entry
mcf04010                    Pathway                                
Name
MAPK signaling pathway - Macaca fascicularis (crab-eating macaque)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
mcf04010  MAPK signaling pathway
mcf04010

Other DBs
GO: 0000165
Organism
Macaca fascicularis (crab-eating macaque) [GN:mcf]
Gene
101865065  CRK; adapter molecule crk isoform X1 [KO:K04438]
101865075  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
101865175  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X4 [KO:K04850]
101865276  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
101865297  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
101865323  HSPB1; heat shock protein beta-1 [KO:K04455]
101865361  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
101865593  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
101865773  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101865975  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
101866070  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101866078  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
101866132  PAK1; serine/threonine-protein kinase PAK 1 isoform X4 [KO:K04409] [EC:2.7.11.1]
101866436  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
101866439  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
101866471  MAX; protein max isoform X1 [KO:K04453]
101866525  STMN1; stathmin [KO:K04381]
101866593  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
101866832  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
101867161  PDGFRB; platelet-derived growth factor receptor beta isoform X2 [KO:K05089] [EC:2.7.10.1]
101867258  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
101867305  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
101867324  RELA; transcription factor p65 isoform X1 [KO:K04735]
101867352  MAPK13; mitogen-activated protein kinase 13 isoform X2 [KO:K04441] [EC:2.7.11.24]
101867475  NF1; neurofibromin isoform X1 [KO:K08052]
101925060  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X4 [KO:K04433] [EC:2.7.12.2]
101925139  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
101925175  TRAF2; TNF receptor-associated factor 2 isoform X4 [KO:K03173] [EC:2.3.2.27]
101925182  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
101925240  [KO:K03283]
101925249  ARAF; serine/threonine-protein kinase A-Raf isoform X2 [KO:K08845] [EC:2.7.11.1]
101925455  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
101925493  PPM1B; protein phosphatase 1B isoform X3 [KO:K04461] [EC:3.1.3.16]
101925495  ANGPT2; angiopoietin-2 isoform X3 [KO:K05466]
101925622  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X3 [KO:K04423] [EC:2.7.11.25]
101925657  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X2 [KO:K04426] [EC:2.7.11.25]
101925720  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
101925838  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
101925869  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
101925889  STK3; serine/threonine-protein kinase 3 isoform X2 [KO:K04412]
101925934  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101925936  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
101926012  HSPA1L; heat shock 70 kDa protein 1-like isoform X1 [KO:K03283]
101926191  MAP3K11; mitogen-activated protein kinase kinase kinase 11 isoform X1 [KO:K04419] [EC:2.7.11.25]
101926461  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X3 [KO:K04345] [EC:2.7.11.11]
101926546  IL1A; interleukin-1 alpha isoform X2 [KO:K04383]
101926664  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
101926678  CACNG3; voltage-dependent calcium channel gamma-3 subunit isoform X1 [KO:K04868]
101926722  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
101926738  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101926770  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101926820  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
102115080  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
102115279  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
102115287  TGFBR1; TGF-beta receptor type-1 isoform X4 [KO:K04674] [EC:2.7.11.30]
102115306  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
102115345  DUSP16; dual specificity protein phosphatase 16 isoform X2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102115368  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
102115437  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
102115442  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
102115452  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X8 [KO:K04859]
102115733  STK4; serine/threonine-protein kinase 4 isoform X2 [KO:K04411]
102115964  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
102115998  ERBB3; receptor tyrosine-protein kinase ErbB-3 isoform X2 [KO:K05084] [EC:2.7.10.1]
102116137  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
102116284  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
102116296  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X2 [KO:K04349]
102116370  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
102116416  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X2 [KO:K18019] [EC:3.1.3.48]
102116823  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
102116992  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
102116996  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
102117414  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
102117465  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
102117632  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
102117741  VEGFC; vascular endothelial growth factor C [KO:K05449]
102117938  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
102118276  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
102118317  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
102118341  AREG; amphiregulin [KO:K09782]
102118497  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102118703  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
102118744  HRAS; GTPase HRas [KO:K02833]
102118759  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X4 [KO:K04463] [EC:2.7.12.2]
102118860  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102118990  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
102119101  DUSP9; dual specificity protein phosphatase 9 isoform X1 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
102119238  EREG; proepiregulin [KO:K09784]
102119414  MAPT; microtubule-associated protein tau isoform X11 [KO:K04380]
102119428  MAP3K13; mitogen-activated protein kinase kinase kinase 13 isoform X2 [KO:K04422] [EC:2.7.11.25]
102119749  IL1B; interleukin-1 beta [KO:K04519]
102119841  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X10 [KO:K04853]
102119907  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
102120346  FGF23; fibroblast growth factor 23 isoform X1 [KO:K22428]
102120448  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
102120710  FGF6; fibroblast growth factor 6 [KO:K04358]
102120963  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
102120965  CACNG7; voltage-dependent calcium channel gamma-7 subunit isoform X1 [KO:K04872]
102121261  FGF16; fibroblast growth factor 16 [KO:K04358]
102121272  MAPK10; mitogen-activated protein kinase 10 isoform X4 [KO:K04440] [EC:2.7.11.24]
102121734  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
102121929  DUSP8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102122008  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
102122204  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
102122216  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102122485  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
102122493  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
102122623  CRKL; crk-like protein [KO:K04438]
102123012  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X4 [KO:K04442] [EC:2.7.11.1]
102123041  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X3 [KO:K04416] [EC:2.7.11.25]
102123114  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
102123168  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
102123415  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
102123512  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
102123590  ARTN; artemin [KO:K25415]
102123748  PSPN; persephin [KO:K25416]
102123979  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X3 [KO:K04417] [EC:2.7.11.25]
102123994  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
102124214  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
102124252  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X3 [KO:K04425] [EC:2.7.11.25]
102124752  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
102124817  [KO:K04393]
102124885  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
102125035  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
102125087  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]
102125183  PDGFB; platelet-derived growth factor subunit B isoform X2 [KO:K17386]
102125312  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102125470  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X7 [KO:K05454]
102125484  SRF; serum response factor isoform X1 [KO:K04378]
102125726  [KO:K04393]
102125783  ARRB2; beta-arrestin-2 isoform X3 [KO:K04439]
102126294  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
102126339  MAPK8; mitogen-activated protein kinase 8 isoform X2 [KO:K04440] [EC:2.7.11.24]
102126446  JUN; transcription factor Jun [KO:K04448]
102126620  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
102126624  FGF21; fibroblast growth factor 21 [KO:K22429]
102126663  IGF2; insulin-like growth factor II [KO:K13769]
102126944  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
102126975  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X2 [KO:K04431] [EC:2.7.12.2]
102127655  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
102127718  FGF22; fibroblast growth factor 22 isoform X2 [KO:K04358]
102127908  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
102127966  MYC; myc proto-oncogene protein [KO:K04377]
102128018  IGF1; insulin-like growth factor I isoform X3 [KO:K05459]
102128083  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
102128329  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X5 [KO:K18018] [EC:3.1.3.48]
102128547  NTF3; neurotrophin-3 isoform X4 [KO:K04356]
102128596  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
102128947  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
102128955  LAMTOR3; ragulator complex protein LAMTOR3 isoform X2 [KO:K04370]
102129165  EFNA2; ephrin-A2 [KO:K05462]
102129342  CD14; monocyte differentiation antigen CD14 precursor [KO:K04391]
102129364  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
102129375  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X2 [KO:K04372] [EC:2.7.11.1]
102129417  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
102129546  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
102129741  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X2 [KO:K17534] [EC:2.7.11.25]
102130052  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
102130142  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
102130367  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
102130815  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
102130853  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
102130897  RASA1; ras GTPase-activating protein 1 [KO:K04352]
102131033  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X2 [KO:K04443] [EC:2.7.11.1]
102131144  [KO:K04375]
102131294  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
102131483  KRAS; GTPase KRas isoform X1 [KO:K07827]
102131553  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
102131580  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
102131632  DDIT3; DNA damage-inducible transcript 3 protein isoform X2 [KO:K04452]
102131750  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
102131855  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
102131922  FGF7; fibroblast growth factor 7 [KO:K04358]
102131958  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
102131991  RRAS; ras-related protein R-Ras [KO:K07829]
102132043  PDGFC; platelet-derived growth factor C [KO:K05450]
102132095  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
102132262  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
102132327  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
102132446  NTRK2; BDNF/NT-3 growth factors receptor isoform X3 [KO:K04360] [EC:2.7.10.1]
102132599  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
102132744  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102133022  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
102133074  EFNA1; ephrin-A1 [KO:K05462]
102133184  INS; insulin [KO:K04526]
102133212  MAPK7; mitogen-activated protein kinase 7 isoform X3 [KO:K04464] [EC:2.7.11.24]
102133222  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
102133233  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
102133679  FGF2; fibroblast growth factor 2 [KO:K18497]
102133712  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
102133907  HGF; hepatocyte growth factor isoform X2 [KO:K05460]
102134212  FGF3; fibroblast growth factor 3 [KO:K04358]
102134273  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
102134421  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
102134477  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
102134588  FGF4; fibroblast growth factor 4 [KO:K04358]
102134620  PGF; placenta growth factor isoform X5 [KO:K16859]
102134699  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
102134829  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
102134837  [KO:K04392]
102134957  FGF19; fibroblast growth factor 19 [KO:K22603]
102135079  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102135088  MEF2C; myocyte-specific enhancer factor 2C isoform X2 [KO:K04454]
102135274  CDC25B; M-phase inducer phosphatase 2 isoform X6 [KO:K05866] [EC:3.1.3.48]
102135285  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
102135480  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
102135875  PRKCA; protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
102135879  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
102135998  TP53; cellular tumor antigen P53 [KO:K04451]
102136095  RASGRP3; ras guanyl-releasing protein 3 isoform X2 [KO:K12362]
102136160  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102136227  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
102136326  KITLG; kit ligand isoform X1 [KO:K05461]
102136554  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
102136845  RELB; transcription factor RelB isoform X1 [KO:K09253]
102137056  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
102137116  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X22 [KO:K04407] [EC:2.7.11.1]
102137242  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
102137250  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
102137357  [KO:K04375]
102137539  EFNA4; ephrin-A4 [KO:K05462]
102137672  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
102137812  CACNG4; voltage-dependent calcium channel gamma-4 subunit isoform X1 [KO:K04869]
102137898  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
102137913  NRAS; GTPase NRas [KO:K07828]
102137925  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
102138091  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
102138136  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
102138213  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X7 [KO:K04851]
102138273  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
102138313  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
102138330  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X2 [KO:K04373] [EC:2.7.11.1]
102138392  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102138509  FLNA; filamin-A isoform X1 [KO:K04437]
102138682  FGF20; fibroblast growth factor 20 [KO:K04358]
102138724  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
102138731  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X4 [KO:K04855]
102138771  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
102138932  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
102138964  CACNA1I; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
102139081  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
102139406  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102139452  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
102139472  [KO:K12457]
102139509  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
102139631  TNF; tumor necrosis factor [KO:K03156]
102139881  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
102139955  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102140164  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
102140231  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
102140241  VEGFA; vascular endothelial growth factor A, long form isoform X1 [KO:K05448]
102140498  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
102140602  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
102140725  FGF9; fibroblast growth factor 9 [KO:K04358]
102140855  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
102141214  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
102141308  ERBB4; receptor tyrosine-protein kinase ErbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
102141473  FGF18; fibroblast growth factor 18 [KO:K04358]
102141609  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
102141631  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
102142347  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
102142406  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102142443  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102142596  [KO:K16342] [EC:3.1.1.4]
102143026  [KO:K16342] [EC:3.1.1.4]
102143086  FGFR2; fibroblast growth factor receptor 2 isoform X3 [KO:K05093] [EC:2.7.10.1]
102143176  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
102143296  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
102143550  FGF10; fibroblast growth factor 10 [KO:K04358]
102143597  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
102143606  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
102143695  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
102143716  FOS; protein C-Fos [KO:K04379]
102143812  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
102144131  NRTN; neurturin [KO:K25414]
102144182  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
102144461  AKT3; RAC-gamma serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
102144463  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
102144586  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
102144714  FGFR1; fibroblast growth factor receptor 1 isoform X6 [KO:K04362] [EC:2.7.10.1]
102144988  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X4 [KO:K05092] [EC:2.7.10.1]
102145011  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102145250  CACNG2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
102145541  TGFA; protransforming growth factor alpha isoform X2 [KO:K08774]
102145584  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
102145680  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
102145800  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
102146081  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
102146108  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
102146168  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
102146180  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
102146285  NR4A1; nuclear receptor subfamily 4immunitygroup A member 1 isoform X1 [KO:K04465]
102146317  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
102146604  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
102146608  ERBB2; receptor tyrosine-protein kinase ErbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
102146999  JUND; transcription factor JunD [KO:K04449]
107126428  VEGFD; vascular endothelial growth factor D [KO:K05449]
107128294  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
123572795  [KO:K03283]
135964343  FAS; tumor necrosis factor receptor superfamily member 6 isoform X3 [KO:K04390]
135964355  [KO:K07210]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
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Reference
PMID:12191611
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Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
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Pharmacol Ther 93:193-202 (2002)
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Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
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Takeda K, Ichijo H
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Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
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Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
mcf04070  Phosphatidylinositol signaling system
mcf04110  Cell cycle
mcf04115  p53 signaling pathway
mcf04210  Apoptosis
mcf04310  Wnt signaling pathway
mcf04668  TNF signaling pathway
KO pathway
ko04010   

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