KEGG   PATHWAY: mcf04810
Entry
mcf04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Macaca fascicularis (crab-eating macaque)
Class
Cellular Processes; Cell motility
Pathway map
mcf04810  Regulation of actin cytoskeleton
mcf04810

Other DBs
GO: 0030036
Organism
Macaca fascicularis (crab-eating macaque) [GN:mcf]
Gene
101864805  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X6 [KO:K06270]
101864894  LPAR1; lysophosphatidic acid receptor 1 isoform X2 [KO:K04289]
101864899  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
101864919  GSN; gelsolin isoform X1 [KO:K05768]
101865065  CRK; adapter molecule crk isoform X1 [KO:K04438]
101865181  VAV3; guanine nucleotide exchange factor VAV3 isoform X6 [KO:K05730]
101865259  SLC9A1; sodium/hydrogen exchanger 1 isoform X1 [KO:K05742]
101865297  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
101865336  GIT1; ARF GTPase-activating protein GIT1 isoform X4 [KO:K05737]
101865352  RDX; radixin isoform X1 [KO:K05762]
101865406  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
101865530  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
101865630  RHOA; transforming protein RhoA [KO:K04513]
101866035  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
101866132  PAK1; serine/threonine-protein kinase PAK 1 isoform X5 [KO:K04409] [EC:2.7.11.1]
101866246  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
101866299  CFL1; cofilin-1 isoform X4 [KO:K05765]
101866329  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
101866430  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X3 [KO:K05749]
101866436  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
101866570  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
101866593  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
101866800  WASL; actin nucleation-promoting factor WASL [KO:K23612]
101866811  ARPC1A; actin-related protein 2/3 complex subunit 1A isoform X1 [KO:K05757]
101866949  CFL2; cofilin-2 isoform X1 [KO:K05765]
101866966  ABI2; abl interactor 2 isoform X3 [KO:K05751]
101867121  CYRIB; CYFIP-related Rac1 interactor B isoform X1 [KO:K27976]
101867161  PDGFRB; platelet-derived growth factor receptor beta isoform X2 [KO:K05089] [EC:2.7.10.1]
101867234  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
101867258  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
101867382  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein isoform X1 [KO:K05754]
101867517  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
101925057  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
101925068  BAIAP2; BAR/IMD domain-containing adapter protein 2 isoform X1 [KO:K05627]
101925123  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
101925124  ITGB2; integrin beta-2 isoform X1 [KO:K06464]
101925249  ARAF; serine/threonine-protein kinase A-Raf isoform X2 [KO:K08845] [EC:2.7.11.1]
101925271  ITGA6; integrin alpha-6 isoform X3 [KO:K06485]
101925550  PTK2; focal adhesion kinase 1 isoform X14 [KO:K05725] [EC:2.7.10.2]
101925607  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X8 [KO:K00889] [EC:2.7.1.68]
101925661  DIAPH2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
101925728  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
101925802  ACTG1; actin, cytoplasmic 2 [KO:K05692]
101925934  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101925936  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
101925958  PFN2; profilin-2 isoform X1 [KO:K05759]
101926125  MYL12B; myosin regulatory light chain 12B [KO:K12757]
101926308  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
101926387  IQGAP2; ras GTPase-activating-like protein IQGAP2 isoform X2 [KO:K05767]
101926449  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
101926587  DIAPH1; protein diaphanous homolog 1 isoform X2 [KO:K05740]
101926721  PAK5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
101926790  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
102114845  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X4 [KO:K05726]
102114959  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
102114969  ITGA5; integrin alpha-5 [KO:K06484]
102115023  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
102115104  ITGAD; integrin alpha-D isoform X1 [KO:K06594]
102115437  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
102115695  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
102115749  MYL11; myosin regulatory light chain 11 [KO:K12758]
102116031  CYRIA; CYFIP-related Rac1 interactor A isoform X1 [KO:K27976]
102116032  C6; complement component C6 [KO:K03995]
102116225  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
102116235  NCKAP1L; nck-associated protein 1-like isoform X1 [KO:K05750]
102116249  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
102116640  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X7 [KO:K00921] [EC:2.7.1.150]
102116742  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
102116862  SCIN; scinderin [KO:K05768]
102116996  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
102117163  ACTR2; actin-related protein 2 [KO:K17260]
102117220  MYH9; myosin-9 [KO:K10352]
102117320  ARPC4; actin-related protein 2/3 complex subunit 4 isoform X3 [KO:K05755]
102117706  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
102117791  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
102118153  [KO:K05692]
102118744  HRAS; GTPase HRas [KO:K02833]
102118758  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
102118990  FGFR4; fibroblast growth factor receptor 4 isoform X4 [KO:K05095] [EC:2.7.10.1]
102119232  FN1; fibronectin isoform X1 [KO:K05717]
102119413  ITGA2B; integrin alpha-IIb isoform X4 [KO:K06476]
102119626  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
102119783  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
102119955  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
102120346  FGF23; fibroblast growth factor 23 isoform X1 [KO:K22428]
102120583  MYH14; myosin-14 isoform X1 [KO:K10352]
102120710  FGF6; fibroblast growth factor 6 [KO:K04358]
102120852  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
102120933  WASF2; actin-binding protein WASF2 [KO:K05748]
102121021  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X4 [KO:K12329]
102121261  FGF16; fibroblast growth factor 16 [KO:K04358]
102121587  VCL; vinculin isoform X1 [KO:K05700]
102122026  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
102122296  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
102122623  CRKL; crk-like protein [KO:K04438]
102122725  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102123329  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
102123415  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
102123453  BDKRB1; B1 bradykinin receptor [KO:K03915]
102123489  APC2; adenomatous polyposis coli protein 2 isoform X3 [KO:K02085]
102123619  ITGB5; integrin beta-5 [KO:K06588]
102124103  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
102124268  [KO:K10031]
102124550  MYL12A; myosin regulatory light chain 12A isoform X1 [KO:K12757]
102124633  ITGA11; integrin alpha-11 [KO:K06587]
102124671  KNG1; kininogen-1 [KO:K03898]
102124804  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102125183  PDGFB; platelet-derived growth factor subunit B isoform X2 [KO:K17386]
102125312  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102125329  ACTN4; alpha-actinin-4 isoform X3 [KO:K05699]
102125369  MYL5; myosin light chain 5 isoform X1 [KO:K12753]
102125524  PFN3; profilin-3 [KO:K05759]
102125640  [KO:K04289]
102125658  C5; complement C5 isoform X1 [KO:K03994]
102125726  [KO:K04393]
102126553  APC; adenomatous polyposis coli protein isoform X7 [KO:K02085]
102126620  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
102126624  FGF21; fibroblast growth factor 21 [KO:K22429]
102126692  C8G; complement component C8 gamma chain [KO:K03999]
102126927  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
102126944  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
102127158  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
102127232  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
102127530  [KO:K05752]
102127552  ACTN1; alpha-actinin-1 isoform X2 [KO:K05699]
102127641  [KO:K05764]
102127718  FGF22; fibroblast growth factor 22 isoform X3 [KO:K04358]
102127819  GNA13; guanine nucleotide-binding protein subunit alpha-13 isoform X1 [KO:K04639]
102128214  INSRR; insulin receptor-related protein isoform X2 [KO:K05086] [EC:2.7.10.1]
102128361  ITGAE; integrin alpha-E isoform X1 [KO:K06524]
102128433  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
102128947  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
102129058  MYH11; myosin-11 isoform X3 [KO:K10352]
102129121  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
102129759  SSH2; protein phosphatase Slingshot homolog 2 isoform X2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
102130281  MYH10; myosin-10 isoform X1 [KO:K10352]
102130741  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
102131020  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
102131483  KRAS; GTPase KRas isoform X1 [KO:K07827]
102131659  LIMK1; LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
102131922  FGF7; fibroblast growth factor 7 [KO:K04358]
102131974  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
102131991  RRAS; ras-related protein R-Ras [KO:K07829]
102132043  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
102132354  RGCC; regulator of cell cycle RGCC [KO:K26108]
102132595  ITGB4; integrin beta-4 isoform X10 [KO:K06525]
102132654  FGD1; FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
102132675  ITGA1; integrin alpha-1 [KO:K06480]
102132744  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102133054  ROCK2; rho-associated protein kinase 2 isoform X3 [KO:K17388] [EC:2.7.11.39]
102133184  INS; insulin [KO:K04526]
102133242  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
102133300  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
102133302  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
102133338  C8B; complement component C8 beta chain isoform X1 [KO:K03998]
102133679  FGF2; fibroblast growth factor 2 [KO:K18497]
102133722  C8A; complement component C8 alpha chain isoform X1 [KO:K03997]
102134090  ENAH; protein enabled homolog isoform X1 [KO:K05746]
102134164  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
102134212  FGF3; fibroblast growth factor 3 [KO:K04358]
102134588  FGF4; fibroblast growth factor 4 [KO:K04358]
102134841  PFN4; profilin-4 isoform X1 [KO:K05759]
102134957  FGF19; fibroblast growth factor 19 [KO:K22603]
102135079  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102135194  MYL10; myosin regulatory light chain 10 isoform X2 [KO:K12756]
102135642  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
102136064  ARHGEF4; rho guanine nucleotide exchange factor 4 isoform X1 [KO:K05769]
102136171  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
102136180  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
102137056  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
102137082  ITGB7; integrin beta-7 isoform X3 [KO:K06590]
102137130  F2R; proteinase-activated receptor 1 [KO:K03914]
102137291  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
102137382  C9; complement component C9 [KO:K04000]
102137531  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
102137913  NRAS; GTPase NRas [KO:K07828]
102137925  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
102137950  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X4 [KO:K13710]
102138249  PXN; paxillin isoform X3 [KO:K05760]
102138313  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
102138392  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102138402  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
102138682  FGF20; fibroblast growth factor 20 [KO:K04358]
102138724  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
102138894  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
102138998  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X2 [KO:K05729]
102139180  PFN1; profilin-1 isoform X1 [KO:K05759]
102139495  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
102139853  ACTB; actin, cytoplasmic 1 [KO:K05692]
102140602  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
102140725  FGF9; fibroblast growth factor 9 [KO:K04358]
102140731  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
102140851  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
102140855  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
102140928  SSH3; protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
102141214  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
102141473  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
102141491  IQGAP3; ras GTPase-activating-like protein IQGAP3 isoform X1 [KO:K05767]
102141940  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
102142026  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102142406  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102142487  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
102142497  ARPC2; actin-related protein 2/3 complex subunit 2 isoform X1 [KO:K05758]
102142988  MSN; moesin isoform X3 [KO:K05763]
102143042  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
102143086  FGFR2; fibroblast growth factor receptor 2 isoform X3 [KO:K05093] [EC:2.7.10.1]
102143296  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
102143377  WASF1; actin-binding protein WASF1 isoform X1 [KO:K05753]
102143380  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1 [KO:K00920] [EC:2.7.1.149]
102143411  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X5 [KO:K12330]
102143464  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102143550  FGF10; fibroblast growth factor 10 [KO:K04358]
102143597  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
102144461  AKT3; RAC-gamma serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
102144610  ITGB1; integrin beta-1 isoform X3 [KO:K05719]
102144714  FGFR1; fibroblast growth factor receptor 1 isoform X12 [KO:K04362] [EC:2.7.10.1]
102145011  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102145282  SSH1; protein phosphatase Slingshot homolog 1 isoform X2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
102145766  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
102145994  [KO:K05692]
102146180  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
102146291  EZR; ezrin isoform X1 [KO:K08007]
102146767  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
102146785  ACTR3; actin-related protein 3 [KO:K18584]
102147025  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
102147055  C7; complement component C7 [KO:K03996]
102147272  ITGAX; integrin alpha-X isoform X1 [KO:K06462]
107126378  BDKRB2; B2 bradykinin receptor [KO:K03916]
123571114  [KO:K05764]
123571795  BRK1; protein BRICK1 [KO:K05752]
135964439  TMSB4X; thymosin beta-4 [KO:K05764]
135967977  [KO:K05764]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
mcf04010  MAPK signaling pathway
mcf04510  Focal adhesion
mcf04520  Adherens junction
KO pathway
ko04810   

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