KEGG   PATHWAY: mmf04110
Entry
mmf04110                    Pathway                                
Name
Cell cycle - Molossus molossus (Pallas's mastiff bat)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
mmf04110  Cell cycle
mmf04110

Other DBs
GO: 0000278
Organism
Molossus molossus (Pallas's mastiff bat) [GN:mmf]
Gene
118628257  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
118624468  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
118621102  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
118624208  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
118620055  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
118622512  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
118618625  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
118639540  RBL2; retinoblastoma-like protein 2 [KO:K16332]
118629546  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
118626632  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
118621643  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
118624162  histone deacetylase 2-like [KO:K06067] [EC:3.5.1.98]
118618748  E2F1; transcription factor E2F1 [KO:K17454]
118626004  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
118626466  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
118631811  E2F5; transcription factor E2F5 [KO:K04682]
118622538  TFDP1; transcription factor Dp-1 isoform X1 [KO:K04683]
118633625  TFDP2; transcription factor Dp-2 isoform X1 [KO:K09392]
118617870  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
118638486  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
118640680  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
118633354  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
118618734  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
118638472  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
118618177  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
118631560  MYC; myc proto-oncogene protein [KO:K04377]
118626582  ZBTB17; zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500]
118629860  cyclin-dependent kinase 4 inhibitor B-like [KO:K06621]
118630258  cyclin-dependent kinase 4 inhibitor B [KO:K04685]
118626383  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
118615324  CDKN2D; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
118624260  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
118643195  CDKN1C; cyclin-dependent kinase inhibitor 1C isoform X1 [KO:K09993]
118621843  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
118631401  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
118639006  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
118624453  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
118621712  S-phase kinase-associated protein 1-like [KO:K03094]
118615636  SKP1; S-phase kinase-associated protein 1 isoform X1 [KO:K03094]
118638347  S-phase kinase-associated protein 1-like [KO:K03094]
118619799  CUL1; cullin-1 [KO:K03347]
118618357  E3 ubiquitin-protein ligase RBX1-like [KO:K03868] [EC:2.3.2.32]
118624414  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
118641733  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
118622835  CCNA1; cyclin-A1 [KO:K06627]
118615544  CCNA2; cyclin-A2 [KO:K06627]
118634432  CDC6; cell division control protein 6 homolog [KO:K02213]
118638976  CDT1; DNA replication factor Cdt1 [KO:K10727]
118626708  ORC1; origin recognition complex subunit 1 isoform X1 [KO:K02603]
118625309  ORC2; origin recognition complex subunit 2 isoform X1 [KO:K02604]
118621909  ORC3; origin recognition complex subunit 3 isoform X1 [KO:K02605]
118625256  ORC4; origin recognition complex subunit 4 isoform X1 [KO:K02606]
118620248  ORC5; origin recognition complex subunit 5 isoform X1 [KO:K02607]
118639308  ORC6; origin recognition complex subunit 6 [KO:K02608]
118618828  MCM2; DNA replication licensing factor MCM2 isoform X1 [KO:K02540] [EC:5.6.2.3]
118621149  MCM3; DNA replication licensing factor MCM3 [KO:K02541] [EC:5.6.2.3]
118631853  MCM4; DNA replication licensing factor MCM4 [KO:K02212] [EC:5.6.2.3]
118624011  MCM5; DNA replication licensing factor MCM5 [KO:K02209] [EC:5.6.2.3]
118625580  MCM6; DNA replication licensing factor MCM6 [KO:K02542] [EC:5.6.2.3]
118641640  MCM7; DNA replication licensing factor MCM7 isoform X1 [KO:K02210] [EC:5.6.2.3]
118640342  CDC45; cell division control protein 45 homolog [KO:K06628]
118641023  TICRR; treslin [KO:K26117]
118631564  mdm2-binding protein isoform X1 [KO:K26116]
118626313  CDC7; cell division cycle 7-related protein kinase isoform X1 [KO:K02214] [EC:2.7.11.1]
118620136  DBF4; protein DBF4 homolog A isoform X1 [KO:K06629]
118634306  DBF4B; protein DBF4 homolog B [KO:K06629]
118632413  CDK1; cyclin-dependent kinase 1 isoform X1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
118641687  CCNB1; G2/mitotic-specific cyclin-B1 isoform X1 [KO:K05868]
118639800  CCNB2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
118636318  CCNB3; G2/mitotic-specific cyclin-B3 [KO:K21771]
118618281  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
118615143  CDC25C; M-phase inducer phosphatase 3 isoform X1 [KO:K05867] [EC:3.1.3.48]
118618301  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
118627272  LOW QUALITY PROTEIN: 14-3-3 protein zeta/delta-like [KO:K16197]
118635359  14-3-3 protein zeta/delta-like [KO:K16197]
118636127  LOW QUALITY PROTEIN: 14-3-3 protein beta/alpha-like [KO:K16197]
118631194  YWHAQ; 14-3-3 protein theta [KO:K16197]
118631396  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
118617540  LOW QUALITY PROTEIN: 14-3-3 protein epsilon-like [KO:K06630]
118633880  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
118640091  YWHAH; 14-3-3 protein eta [KO:K16198]
118642351  YWHAG; LOW QUALITY PROTEIN: 14-3-3 protein gamma [KO:K16198]
118642717  PLK1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
118620498  WEE2; wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
118628124  WEE1; wee1-like protein kinase [KO:K06632] [EC:2.7.11.1]
118641905  PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
118642905  CCNH; cyclin-H isoform X1 [KO:K06634]
118642719  CDK7; cyclin-dependent kinase 7 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
118622352  LOW QUALITY PROTEIN: cyclin-dependent kinase 7-like [KO:K02202] [EC:2.7.11.22 2.7.11.23]
118630618  ANAPC1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
118629440  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
118633961  CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
118639369  ANAPC4; anaphase-promoting complex subunit 4 [KO:K03351]
118640200  ANAPC5; LOW QUALITY PROTEIN: anaphase-promoting complex subunit 5 [KO:K03352]
118622830  CDC16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
118640020  ANAPC7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
118615179  CDC23; cell division cycle protein 23 homolog isoform X1 [KO:K03355]
118615949  ANAPC10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
118634180  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
118629713  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
118633221  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
118638149  anaphase-promoting complex subunit 15 [KO:K25228]
118627612  ANAPC15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
118625725  anaphase-promoting complex subunit 16-like [KO:K25229]
118632228  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
118626605  CDC20; cell division cycle protein 20 homolog [KO:K03363]
118615473  PTTG1; securin isoform X1 [KO:K06635]
118624167  ESPL1; separin [KO:K02365] [EC:3.4.22.49]
118641137  SMC1B; structural maintenance of chromosomes protein 1B isoform X1 [KO:K06636]
118635659  SMC1A; structural maintenance of chromosomes protein 1A isoform X1 [KO:K06636]
118632186  SMC3; structural maintenance of chromosomes protein 3 isoform X1 [KO:K06669]
118631498  RAD21; double-strand-break repair protein rad21 homolog isoform X1 [KO:K06670]
118633057  STAG1; cohesin subunit SA-1 isoform X1 [KO:K06671]
118635863  STAG2; cohesin subunit SA-2 isoform X1 [KO:K06671]
118635926  ATRX; transcriptional regulator ATRX isoform X1 [KO:K10779]
118624302  DDX11; ATP-dependent DNA helicase DDX11 [KO:K11273] [EC:5.6.2.7]
118641518  NIPBL; nipped-B-like protein isoform X1 [KO:K06672]
118643616  MAU2; MAU2 chromatid cohesion factor homolog isoform X1 [KO:K11266]
118635895  HDAC8; histone deacetylase 8 isoform X1 [KO:K11405] [EC:3.5.1.98]
118618313  ESCO1; N-acetyltransferase ESCO1 [KO:K11268] [EC:2.3.1.-]
118615342  ESCO2; N-acetyltransferase ESCO2 [KO:K11268] [EC:2.3.1.-]
118626030  PDS5A; sister chromatid cohesion protein PDS5 homolog A isoform X1 [KO:K11267]
118622245  PDS5B; sister chromatid cohesion protein PDS5 homolog B isoform X1 [KO:K11267]
118632789  WAPL; wings apart-like protein homolog isoform X1 [KO:K25163]
118628247  CDCA5; sororin [KO:K17390]
118634179  AURKB; aurora kinase B isoform X1 [KO:K11479] [EC:2.7.11.1]
118633293  SGO1; shugoshin 1 isoform X1 [KO:K11580]
118622832  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
118643693  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
118627487  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
118638301  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
118628352  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
118620823  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
118636159  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform-like [KO:K11584]
118637920  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
118631218  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
118624718  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
118619066  NDC80; kinetochore protein NDC80 homolog [KO:K11547]
118628947  KNL1; kinetochore scaffold 1 isoform X1 [KO:K11542]
118621755  TTK; dual specificity protein kinase TTK isoform X1 [KO:K08866] [EC:2.7.12.1]
118615422  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
118615835  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
118626397  MAD2L2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
118634820  BUB1B; mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform X1 [KO:K06637] [EC:2.7.11.1]
118632548  BUB3; mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
118630505  BUB1; mitotic checkpoint serine/threonine-protein kinase BUB1 isoform X1 [KO:K02178] [EC:2.7.11.1]
118641791  TRIP13; pachytene checkpoint protein 2 homolog isoform X1 [KO:K22399]
118643702  LOW QUALITY PROTEIN: pachytene checkpoint protein 2 homolog [KO:K22399]
118621201  MAD2L1-binding protein [KO:K26093]
118615128  FZR1; fizzy-related protein homolog isoform X1 [KO:K03364]
118621155  FBXO5; F-box only protein 5 isoform X1 [KO:K10292]
118629614  CDC14B; dual specificity protein phosphatase CDC14B isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
118637227  CDC14A; dual specificity protein phosphatase CDC14A isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
118641604  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
118624243  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
118631854  PRKDC; DNA-dependent protein kinase catalytic subunit [KO:K06642] [EC:2.7.11.1]
118616826  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
118628940  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
118623649  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
118634552  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
118627118  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
118643440  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
118615490  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
118618985  PCNA; proliferating cell nuclear antigen isoform X1 [KO:K04802]
118626275  SFN; 14-3-3 protein sigma [KO:K06644]
118639911  CHEK1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
118639835  CHEK2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
118633065  CDC25A; M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:3.1.3.48]
Reference
PMID:7908906
  Authors
Matsuoka S, Yamaguchi M, Matsukage A
  Title
D-type cyclin-binding regions of proliferating cell nuclear antigen.
  Journal
J Biol Chem 269:11030-6 (1994)
Reference
PMID:8242749
  Authors
Welch PJ, Wang JY
  Title
A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.
  Journal
Cell 75:779-90 (1993)
DOI:10.1016/0092-8674(93)90497-E
Reference
PMID:16936746
  Authors
Macaluso M, Montanari M, Giordano A
  Title
Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes.
  Journal
Oncogene 25:5263-7 (2006)
DOI:10.1038/sj.onc.1209680
Reference
PMID:15838516
  Authors
Cobrinik D
  Title
Pocket proteins and cell cycle control.
  Journal
Oncogene 24:2796-809 (2005)
DOI:10.1038/sj.onc.1208619
Reference
PMID:17568790
  Authors
Boutros R, Lobjois V, Ducommun B
  Title
CDC25 phosphatases in cancer cells: key players? Good targets?
  Journal
Nat Rev Cancer 7:495-507 (2007)
DOI:10.1038/nrc2169
Reference
PMID:9832503
  Authors
Diehl JA, Cheng M, Roussel MF, Sherr CJ
  Title
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.
  Journal
Genes Dev 12:3499-511 (1998)
DOI:10.1101/gad.12.22.3499
Reference
PMID:19020303
  Authors
Klein EA, Assoian RK
  Title
Transcriptional regulation of the cyclin D1 gene at a glance.
  Journal
J Cell Sci 121:3853-7 (2008)
DOI:10.1242/jcs.039131
Reference
PMID:10385618
  Authors
Sherr CJ, Roberts JM
  Title
CDK inhibitors: positive and negative regulators of G1-phase progression.
  Journal
Genes Dev 13:1501-12 (1999)
DOI:10.1101/gad.13.12.1501
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:12925736
  Authors
Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N, Imaki H, Hatakeyama S, Nakayama K, Nakayama KI
  Title
Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.
  Journal
Proc Natl Acad Sci U S A 100:10231-6 (2003)
DOI:10.1073/pnas.1831009100
Reference
PMID:16212951
  Authors
Bond M, Sala-Newby GB, Wu YJ, Newby AC
  Title
Biphasic effect of p21Cip1 on smooth muscle cell proliferation: role of PI 3-kinase and Skp2-mediated degradation.
  Journal
Cardiovasc Res 69:198-206 (2006)
DOI:10.1016/j.cardiores.2005.08.020
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11099028
  Authors
Vogelstein B, Lane D, Levine AJ
  Title
Surfing the p53 network.
  Journal
Nature 408:307-10 (2000)
DOI:10.1038/35042675
Reference
PMID:7973727
  Authors
Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O'Connor PM, Fornace AJ Jr
  Title
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
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Science 266:1376-80 (1994)
DOI:10.1126/science.7973727
Reference
PMID:9889196
  Authors
Petersen BO, Lukas J, Sorensen CS, Bartek J, Helin K
  Title
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.
  Journal
EMBO J 18:396-410 (1999)
DOI:10.1093/emboj/18.2.396
Reference
PMID:17018296
  Authors
Sheu YJ, Stillman B
  Title
Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression.
  Journal
Mol Cell 24:101-13 (2006)
DOI:10.1016/j.molcel.2006.07.033
Reference
PMID:9029154
  Authors
Martinez AM, Afshar M, Martin F, Cavadore JC, Labbe JC, Doree M
  Title
Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.
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EMBO J 16:343-54 (1997)
DOI:10.1093/emboj/16.2.343
Reference
PMID:15876871
  Authors
Lolli G, Johnson LN
  Title
CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?
  Journal
Cell Cycle 4:572-7 (2005)
DOI:10.4161/cc.4.4.1607
Reference
PMID:17426725
  Authors
Musacchio A, Salmon ED
  Title
The spindle-assembly checkpoint in space and time.
  Journal
Nat Rev Mol Cell Biol 8:379-93 (2007)
DOI:10.1038/nrm2163
Reference
PMID:12573239
  Authors
Uhlmann F
  Title
Chromosome cohesion and separation: from men and molecules.
  Journal
Curr Biol 13:R104-14 (2003)
DOI:10.1016/S0960-9822(03)00039-3
Reference
PMID:15568976
  Authors
Stegmeier F, Amon A
  Title
Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.
  Journal
Annu Rev Genet 38:203-32 (2004)
DOI:10.1146/annurev.genet.38.072902.093051
Reference
PMID:9618481
  Authors
Moustakas A, Kardassis D
  Title
Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.
  Journal
Proc Natl Acad Sci U S A 95:6733-8 (1998)
DOI:10.1073/pnas.95.12.6733
Reference
PMID:26650195
  Authors
de Boer HR, Guerrero Llobet S, van Vugt MA
  Title
Controlling the response to DNA damage by the APC/C-Cdh1.
  Journal
Cell Mol Life Sci 73:949-60 (2016)
DOI:10.1007/s00018-015-2096-7
Reference
PMID:20935501
  Authors
Qiao X, Zhang L, Gamper AM, Fujita T, Wan Y
  Title
APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.
  Journal
Cell Cycle 9:3904-12 (2010)
DOI:10.4161/cc.9.19.13585
Related
pathway
mmf03030  DNA replication
mmf04010  MAPK signaling pathway
mmf04120  Ubiquitin mediated proteolysis
mmf04210  Apoptosis
KO pathway
ko04110   
LinkDB

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