KEGG   PATHWAY: mmu00380
Entry
mmu00380                    Pathway                                
Name
Tryptophan metabolism - Mus musculus (house mouse)
Class
Metabolism; Amino acid metabolism
Pathway map
mmu00380  Tryptophan metabolism
mmu00380

Module
mmu_M00037  Melatonin biosynthesis, animals, tryptophan => serotonin => melatonin [PATH:mmu00380]
mmu_M00038  Tryptophan metabolism, tryptophan => kynurenine => 2-aminomuconate [PATH:mmu00380]
mmu_M00912  NAD biosynthesis, tryptophan => quinolinate => NAD [PATH:mmu00380]
Other DBs
GO: 0006568 0009851
Organism
Mus musculus (house mouse) [GN:mmu]
Gene
56720  Tdo2; tryptophan 2,3-dioxygenase [KO:K00453] [EC:1.13.11.11]
15930  Ido1; indoleamine 2,3-dioxygenase 1 [KO:K00463] [EC:1.13.11.52]
209176  Ido2; indoleamine 2,3-dioxygenase 2 [KO:K00463] [EC:1.13.11.52]
71562  Afmid; arylformamidase [KO:K01432] [EC:3.5.1.9]
98256  Kmo; kynurenine 3-monooxygenase [KO:K00486] [EC:1.14.13.9]
70789  Kynu; kynureninase [KO:K01556] [EC:3.7.1.3]
107766  Haao; 3-hydroxyanthranilate 3,4-dioxygenase [KO:K00452] [EC:1.13.11.6]
266645  Acmsd; amino carboxymuconate semialdehyde decarboxylase [KO:K03392] [EC:4.1.1.45]
237320  Aldh8a1; aldehyde dehydrogenase 8 family, member A1 [KO:K23234] [EC:1.2.1.32]
209692  Dhtkd1; dehydrogenase E1 and transketolase domain containing 1 [KO:K15791] [EC:1.2.4.-]
78920  Dlst; dihydrolipoamide S-succinyltransferase [KO:K00658] [EC:2.3.1.61]
13382  Dld; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
270076  Gcdh; glutaryl-Coenzyme A dehydrogenase [KO:K00252] [EC:1.3.8.6]
97212  Hadha; hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha [KO:K07515] [EC:4.2.1.17 1.1.1.211]
74147  Ehhadh; enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
93747  Echs1; enoyl Coenzyme A hydratase, short chain, 1, mitochondrial [KO:K07511] [EC:4.2.1.17]
15107  Hadh; hydroxyacyl-Coenzyme A dehydrogenase [KO:K00022] [EC:1.1.1.35]
110460  Acat2; acetyl-Coenzyme A acetyltransferase 2 [KO:K00626] [EC:2.3.1.9]
110446  Acat1; acetyl-Coenzyme A acetyltransferase 1 [KO:K00626] [EC:2.3.1.9]
224530  Acat3; acetyl-Coenzyme A acetyltransferase 3 [KO:K00626] [EC:2.3.1.9]
229905  Kyat3; kynurenine aminotransferase 3 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
70266  Kyat1; kynurenine aminotransferase 1 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
23923  Aadat; aminoadipate aminotransferase [KO:K00825] [EC:2.6.1.7 2.6.1.39]
21990  Tph1; tryptophan hydroxylase 1 [KO:K00502] [EC:1.14.16.4]
216343  Tph2; tryptophan hydroxylase 2 [KO:K00502] [EC:1.14.16.4]
13195  Ddc; dopa decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
17161  Maoa; monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
109731  Maob; monoamine oxidase B [KO:K00274] [EC:1.4.3.4]
11669  Aldh2; aldehyde dehydrogenase 2, mitochondrial [KO:K00128] [EC:1.2.1.3]
11671  Aldh3a2; aldehyde dehydrogenase family 3, subfamily A2 [KO:K00128] [EC:1.2.1.3]
72535  Aldh1b1; aldehyde dehydrogenase 1 family, member B1 [KO:K00128] [EC:1.2.1.3]
110695  Aldh7a1; aldehyde dehydrogenase family 7, member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
56752  Aldh9a1; aldehyde dehydrogenase 9, subfamily A1 [KO:K00149] [EC:1.2.1.47 1.2.1.3]
213043  Aox2; aldehyde oxidase 2 [KO:K00157] [EC:1.2.3.1]
11761  Aox1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
71872  Aox4; aldehyde oxidase 4 [KO:K00157] [EC:1.2.3.1]
71724  Aox3; aldehyde oxidase 3 [KO:K00157] [EC:1.2.3.1]
107626  Asmt; acetylserotonin O-methyltransferase [KO:K00543] [EC:2.1.1.4]
11298  Aanat; arylalkylamine N-acetyltransferase [KO:K00669] [EC:2.3.1.87]
13076  Cyp1a1; cytochrome P450, family 1, subfamily a, polypeptide 1 [KO:K07408] [EC:1.14.14.1]
13077  Cyp1a2; cytochrome P450, family 1, subfamily a, polypeptide 2 [KO:K07409] [EC:1.14.14.1]
13078  Cyp1b1; cytochrome P450, family 1, subfamily b, polypeptide 1 [KO:K07410] [EC:1.14.14.1]
21743  Inmt; indolethylamine N-methyltransferase [KO:K00562] [EC:2.1.1.49 2.1.1.96]
14204  Il4i1; interleukin 4 induced 1 [KO:K03334] [EC:1.4.3.2]
100470  Lao1; L-amino acid oxidase 1 [KO:K03334] [EC:1.4.3.2]
100328588  Il4i1b; interleukin 4 induced 1B [KO:K03334] [EC:1.4.3.2]
73988  4930438A08Rik; RIKEN cDNA 4930438A08 gene [KO:K03334] [EC:1.4.3.2]
243376  Aoc1l1; amine oxidase copper containing 1-like 1 [KO:K11182] [EC:1.4.3.22]
243377  Aoc1l3; amine oxidase copper containing 1-like 3 [KO:K11182] [EC:1.4.3.22]
69761  Aoc1l2; amine oxidase copper containing 1-like 2 [KO:K11182] [EC:1.4.3.22]
76507  Aoc1; amine oxidase, copper-containing 1 [KO:K11182] [EC:1.4.3.22]
12359  Cat; catalase [KO:K03781] [EC:1.11.1.6]
Compound
C00024  Acetyl-CoA
C00078  L-Tryptophan
C00108  Anthranilate
C00322  2-Oxoadipate
C00328  L-Kynurenine
C00331  Indolepyruvate
C00332  Acetoacetyl-CoA
C00398  Tryptamine
C00463  Indole
C00527  Glutaryl-CoA
C00632  3-Hydroxyanthranilate
C00637  Indole-3-acetaldehyde
C00643  5-Hydroxy-L-tryptophan
C00780  Serotonin
C00877  Crotonoyl-CoA
C00954  Indole-3-acetate
C00955  Indole-3-ethanol
C00978  N-Acetylserotonin
C01111  7,8-Dihydroxykynurenate
C01144  (S)-3-Hydroxybutanoyl-CoA
C01249  7,8-Dihydro-7,8-dihydroxykynurenate
C01252  4-(2-Aminophenyl)-2,4-dioxobutanoate
C01598  Melatonin
C01717  4-Hydroxy-2-quinolinecarboxylic acid
C01987  2-Aminophenol
C02161  2-Aminophenoxazin-3-one
C02172  N-Acetylisatin
C02220  2-Aminomuconate
C02298  N-Acetylindoxyl
C02470  Xanthurenic acid
C02693  (Indol-3-yl)acetamide
C02700  L-Formylkynurenine
C02775  2,3-Dihydroxyindole
C02937  Indole-3-acetaldehyde oxime
C02938  3-Indoleacetonitrile
C03227  3-Hydroxy-L-kynurenine
C03230  (Indol-3-yl)glycolaldehyde
C03453  gamma-Oxalocrotonate
C03574  2-Formylaminobenzaldehyde
C03722  Quinolinate
C03824  2-Aminomuconate semialdehyde
C04409  2-Amino-3-carboxymuconate semialdehyde
C05634  5-Hydroxyindoleacetaldehyde
C05635  5-Hydroxyindoleacetate
C05636  3-Hydroxykynurenamine
C05637  4,8-Dihydroxyquinoline
C05638  5-Hydroxykynurenamine
C05639  4,6-Dihydroxyquinoline
C05640  Cinnavalininate
C05641  5-(3'-Carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinate
C05642  Formyl-N-acetyl-5-methoxykynurenamine
C05643  6-Hydroxymelatonin
C05644  3-Methylindolepyruvate
C05645  4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
C05646  5-Hydroxyindolepyruvate
C05647  Formyl-5-hydroxykynurenamine
C05648  5-Hydroxy-N-formylkynurenine
C05651  5-Hydroxykynurenine
C05652  4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate
C05653  Formylanthranilate
C05654  5-(2'-Formylethyl)-4,6-dihydroxypicolinate
C05655  5-(2'-Carboxyethyl)-4,6-dihydroxypicolinate
C05656  5-(3'-Carboxy-3'-oxopropyl)-4,6-dihydroxypicolinate
C05658  Indoxyl
C05659  5-Methoxytryptamine
C05660  5-Methoxyindoleacetate
C05663  6-Hydroxykynurenate
C05830  8-Methoxykynurenate
C05831  3-Methoxyanthranilate
C05832  5-Hydroxyindoleacetylglycine
C05834  3-Methyldioxyindole
C05835  2-Formaminobenzoylacetate
C05837  Glucobrassicin
C06212  N-Methylserotonin
C06213  N-Methyltryptamine
C08313  Skatole
C10164  Picolinic acid
C16516  Indolylmethylthiohydroximate
C16517  Indolylmethyl-desulfoglucosinolate
C16518  S-(Indolylmethylthiohydroximoyl)-L-cysteine
C17203  N-Hydroxyl-tryptamine
C22006  (R)-(Indol-3-yl)lactate
C22202  2-Oxoindole-3-acetate
Reference
PMID:15749753
  Authors
Woodward AW, Bartel B
  Title
Auxin: regulation, action, and interaction.
  Journal
Ann Bot 95:707-35 (2005)
DOI:10.1093/aob/mci083
Related
pathway
mmu00010  Glycolysis / Gluconeogenesis
mmu00400  Phenylalanine, tyrosine and tryptophan biosynthesis
mmu00760  Nicotinate and nicotinamide metabolism
KO pathway
ko00380   
LinkDB

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