KEGG   PATHWAY: anu00230
Entry
anu00230                    Pathway                                
Name
Purine metabolism - Arvicanthis niloticus (African grass rat)
Class
Metabolism; Nucleotide metabolism
Pathway map
anu00230  Purine metabolism
anu00230

Module
anu_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:anu00230]
anu_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:anu00230]
anu_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:anu00230]
anu_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:anu00230]
anu_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:anu00230]
anu_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:anu00230]
anu_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:anu00230]
Other DBs
GO: 0006163 0042278
Organism
Arvicanthis niloticus (African grass rat) [GN:anu]
Gene
117699972  Nudt9; ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
117710164  Adprm; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
117713638  Nudt5; ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
117708805  Pgm1; phosphoglucomutase-1 isoform X1 [KO:K01835] [EC:5.4.2.2]
117713066  Pgm2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
117716933  ribose-phosphate pyrophosphokinase 1-like [KO:K00948] [EC:2.7.6.1]
117717134  Prps1l1; ribose-phosphate pyrophosphokinase 3 [KO:K00948] [EC:2.7.6.1]
117694776  Prps2; ribose-phosphate pyrophosphokinase 2 isoform X1 [KO:K00948] [EC:2.7.6.1]
117694871  Prps1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
117712644  Ppat; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
117717807  Gart; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
117710419  Pfas; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
117712646  Paics; multifunctional protein ADE2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
117719158  Adsl; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
117705768  Atic; bifunctional purine biosynthesis protein PURH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
117722918  Aprt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
117711755  Nt5c; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
117723670  snake venom 5'-nucleotidase-like [KO:K01081] [EC:3.1.3.5]
117717199  cytosolic 5'-nucleotidase 1B isoform X1 [KO:K01081] [EC:3.1.3.5]
117707176  Nt5c2; cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
117709190  Nt5c1a; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
117710009  Nt5m; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
117693338  Nt5e; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
117706049  Pnp; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
117706207  Lacc1; laccase domain-containing protein 1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
117695319  Hprt1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
117693339  Impdh2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
117720427  Impdh1; inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
117711547  Nme4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
117716085  Nme7; nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
117693833  Nme6; nucleoside diphosphate kinase 6 isoform X1 [KO:K00940] [EC:2.7.4.6]
117701571  nucleoside diphosphate kinase 6-like [KO:K00940] [EC:2.7.4.6]
117710483  Nme2; nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
117710484  Nme1; nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
117710647  Nme3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
117724784  Ak9; adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
117711345  Entpd8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X1 [KO:K01510] [EC:3.6.1.5]
117697720  Entpd1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
117725069  Entpd3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
117711221  Cant1; soluble calcium-activated nucleotidase 1 isoform X1 [KO:K12304] [EC:3.6.1.6]
117705335  Entpd4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
117697119  Entpd5; ectonucleoside triphosphate diphosphohydrolase 5 [KO:K01511] [EC:3.6.1.6]
117704118  Entpd6; ectonucleoside triphosphate diphosphohydrolase 6 isoform X1 [KO:K01511] [EC:3.6.1.6]
117693594  U8 snoRNA-decapping enzyme-like [KO:K16855] [EC:3.6.1.62 3.6.1.64]
117693867  U8 snoRNA-decapping enzyme [KO:K16855] [EC:3.6.1.62 3.6.1.64]
117703815  Itpa; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
117716905  Xdh; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
117708899  Nudt2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
117707548  Gmps; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
117705903  Gmpr2; GMP reductase 2 isoform X1 [KO:K00364] [EC:1.7.1.7]
117713665  Gmpr; GMP reductase 1 isoform X1 [KO:K00364] [EC:1.7.1.7]
117715259  Gda; guanine deaminase isoform X1 [KO:K01487] [EC:3.5.4.3]
117711533  Guk1; guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
117713499  Rrm1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
117717299  Rrm2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
117719023  Rrm2b; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
117700861  Hddc2; 5'-deoxynucleotidase HDDC2 [KO:K07023] [EC:3.1.3.89]
117715646  Dguok; deoxyguanosine kinase, mitochondrial isoform X1 [KO:K00904] [EC:2.7.1.113]
117713148  Dck; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
117710082  Hddc3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform X1 [KO:K21138] [EC:3.1.7.2]
117706614  Prune1; exopolyphosphatase PRUNE1 isoform X1 [KO:K01514] [EC:3.6.1.11]
117712590  Adcy1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
117723703  Adcy2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
117716811  Adcy3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
117704978  Adcy4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
117717749  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
117718589  Adcy6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
117723273  Adcy7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
117718712  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
117710708  Adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
117716179  Adcy10; adenylate cyclase type 10 isoform X1 [KO:K11265] [EC:4.6.1.1]
117707127  Gucy1a1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
117699770  Gucy1a2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
117705549  guanylate cyclase soluble subunit beta-2 isoform X1 [KO:K12319] [EC:4.6.1.2]
117707617  Gucy1b1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
117715258  Gucy2c; heat-stable enterotoxin receptor isoform X1 [KO:K12320] [EC:4.6.1.2]
117722973  guanylate cyclase D [KO:K12321] [EC:4.6.1.2]
117710716  Gucy2d; retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
117694674  Gucy2f; retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
117717640  guanylate cyclase 2G [KO:K22600] [EC:4.6.1.2]
117706967  Npr1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
117708437  Npr2; atrial natriuretic peptide receptor 2 isoform X1 [KO:K12324] [EC:4.6.1.2]
117718548  Pde1b; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
117703435  Pde1a; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
117720661  Pde1c; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
117715490  Pde2a; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1 [KO:K18283] [EC:3.1.4.17]
117715591  Pde3a; cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
117696410  Pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
117707002  Pde5a; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
117719663  Pde6a; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha [KO:K08718] [EC:3.1.4.35]
117712927  Pde6b; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta isoform X1 [KO:K13756] [EC:3.1.4.35]
117701021  Pde6c; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
117722296  Pde6d; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform X1 [KO:K13758]
117711287  Pde6g; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
117715318  Pde6h; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
117724375  Pde9a; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [KO:K13761] [EC:3.1.4.35]
117700127  Pde10a; LOW QUALITY PROTEIN: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
117704115  Pde11a; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
117697537  Adss1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
117721665  Adss2; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
117707023  Ampd1; AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
117707120  Ampd2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
117719082  Ampd3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
117696117  LOW QUALITY PROTEIN: AMP deaminase 2-like [KO:K01490] [EC:3.5.4.6]
117705153  Adk; adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
117703604  Ada; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
117697434  Ak7; adenylate kinase 7 isoform X1 [KO:K00939] [EC:2.7.4.3]
117705495  adenylate kinase isoenzyme 1-like [KO:K00939] [EC:2.7.4.3]
117707707  Ak5; adenylate kinase isoenzyme 5 isoform X1 [KO:K00939] [EC:2.7.4.3]
117709123  Ak2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
117709618  Ak4; adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
117704061  Ak8; adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
117704205  Ak1; adenylate kinase isoenzyme 1 isoform X1 [KO:K00939] [EC:2.7.4.3]
117723750  Ak6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
117693648  Ak3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
117712019  Entpd2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
117722862  Ntpcr; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
117701057  Enpp3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
117701148  Enpp1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
117722041  Pde4c; cAMP-specific 3',5'-cyclic phosphodiesterase 4C [KO:K13293] [EC:3.1.4.53]
117723875  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
117708203  Pde4b; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
117713328  Pde4a; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
117707683  Pde7a; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A [KO:K18436] [EC:3.1.4.53]
117701110  Pde7b; cAMP-specific 3',5'-cyclic phosphodiesterase 7B [KO:K18436] [EC:3.1.4.53]
117700413  Pde8b; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
117710691  Pde8a; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A [KO:K18437] [EC:3.1.4.53]
117705411  Fhit; bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
117722659  Enpp4; bis(5'-adenosyl)-triphosphatase ENPP4 isoform X1 [KO:K18424] [EC:3.6.1.29]
117705925  Papss2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
117707104  Papss1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
117707839  uricase [KO:K00365] [EC:1.7.3.3]
117718015  5-hydroxyisourate hydrolase isoform X1 [KO:K07127] [EC:3.5.2.17]
117697748  Urad; putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
117717206  Allc; probable allantoicase [KO:K01477] [EC:3.5.3.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
anu00030  Pentose phosphate pathway
anu00220  Arginine biosynthesis
anu00250  Alanine, aspartate and glutamate metabolism
anu00260  Glycine, serine and threonine metabolism
anu00340  Histidine metabolism
anu00630  Glyoxylate and dicarboxylate metabolism
anu00730  Thiamine metabolism
anu00740  Riboflavin metabolism
anu00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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