KEGG   PATHWAY: bta03040
Entry
bta03040                    Pathway                                
Name
Spliceosome - Bos taurus (cow)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
bta03040  Spliceosome
bta03040

Other DBs
GO: 0005681
Organism
Bos taurus (cow) [GN:bta]
Gene
107132278  U1 spliceosomal RNA [KO:K14276]
112443614  U1 spliceosomal RNA [KO:K14276]
112442795  U1 spliceosomal RNA [KO:K14276]
112443339  U1 spliceosomal RNA [KO:K14276]
112443625  U1 spliceosomal RNA [KO:K14276]
112441908  U1 spliceosomal RNA [KO:K14276]
112442101  U1 spliceosomal RNA [KO:K14276]
112442784  U1 spliceosomal RNA [KO:K14276]
112442807  U1 spliceosomal RNA [KO:K14276]
112442818  U1 spliceosomal RNA [KO:K14276]
112442826  U1 spliceosomal RNA [KO:K14276]
112443041  U1 spliceosomal RNA [KO:K14276]
112443327  U1 spliceosomal RNA [KO:K14276]
112443337  U1 spliceosomal RNA [KO:K14276]
112443341  U1 spliceosomal RNA [KO:K14276]
112443342  U1 spliceosomal RNA [KO:K14276]
112443343  U1 spliceosomal RNA [KO:K14276]
112443344  U1 spliceosomal RNA [KO:K14276]
112443636  U1 spliceosomal RNA [KO:K14276]
112444219  U1 spliceosomal RNA [KO:K14276]
112444220  U1 spliceosomal RNA [KO:K14276]
112444654  U1 spliceosomal RNA [KO:K14276]
112446125  U1 spliceosomal RNA [KO:K14276]
112446128  U1 spliceosomal RNA [KO:K14276]
112446129  U1 spliceosomal RNA [KO:K14276]
112446130  U1 spliceosomal RNA [KO:K14276]
112446131  U1 spliceosomal RNA [KO:K14276]
112446132  U1 spliceosomal RNA [KO:K14276]
112446133  U1 spliceosomal RNA [KO:K14276]
112446134  U1 spliceosomal RNA [KO:K14276]
112446135  U1 spliceosomal RNA [KO:K14276]
112446136  U1 spliceosomal RNA [KO:K14276]
112446137  U1 spliceosomal RNA [KO:K14276]
112446509  U1 spliceosomal RNA [KO:K14276]
112446884  U1 spliceosomal RNA [KO:K14276]
112446885  U1 spliceosomal RNA [KO:K14276]
112447196  U1 spliceosomal RNA [KO:K14276]
112447633  U1 spliceosomal RNA [KO:K14276]
112447936  U1 spliceosomal RNA [KO:K14276]
112448337  U1 spliceosomal RNA [KO:K14276]
112448627  U1 spliceosomal RNA [KO:K14276]
112448628  U1 spliceosomal RNA [KO:K14276]
112448941  U1 spliceosomal RNA [KO:K14276]
112448942  U1 spliceosomal RNA [KO:K14276]
112449179  U1 spliceosomal RNA [KO:K14276]
112449629  U1 spliceosomal RNA [KO:K14276]
112449630  U1 spliceosomal RNA [KO:K14276]
112442843  U2 spliceosomal RNA [KO:K14277]
112442846  U2 spliceosomal RNA [KO:K14277]
112442845  U2 spliceosomal RNA [KO:K14277]
112442857  U2 spliceosomal RNA [KO:K14277]
112442855  U2 spliceosomal RNA [KO:K14277]
112442854  U2 spliceosomal RNA [KO:K14277]
112444936  U2 spliceosomal RNA [KO:K14277]
112442856  U2 spliceosomal RNA [KO:K14277]
112441909  U2 spliceosomal RNA [KO:K14277]
112447642  U2 spliceosomal RNA [KO:K14277]
112442853  U2 spliceosomal RNA [KO:K14277]
112442852  U2 spliceosomal RNA [KO:K14277]
112442844  U2 spliceosomal RNA [KO:K14277]
112442849  U2 spliceosomal RNA [KO:K14277]
112442859  U2 spliceosomal RNA [KO:K14277]
112442110  U4 spliceosomal RNA [KO:K14278]
112442111  U4 spliceosomal RNA [KO:K14278]
112447202  U4 spliceosomal RNA [KO:K14278]
112443348  U4 spliceosomal RNA [KO:K14278]
112442112  U4 spliceosomal RNA [KO:K14278]
112441916  U5 spliceosomal RNA [KO:K14279]
112448638  U5 spliceosomal RNA [KO:K14279]
112444363  U5 spliceosomal RNA [KO:K14279]
112446153  U5 spliceosomal RNA [KO:K14279]
112448637  U5 spliceosomal RNA [KO:K14279]
112446152  U5 spliceosomal RNA [KO:K14279]
112445285  U6 spliceosomal RNA [KO:K14280]
112443534  U6 spliceosomal RNA [KO:K14280]
112448645  U6 spliceosomal RNA [KO:K14280]
112443914  U6 spliceosomal RNA [KO:K14280]
112441918  U6 spliceosomal RNA [KO:K14280]
112449644  U6 spliceosomal RNA [KO:K14280]
112443354  U6 spliceosomal RNA [KO:K14280]
112443691  U6 spliceosomal RNA [KO:K14280]
112443912  U6 spliceosomal RNA [KO:K14280]
112443533  U6 spliceosomal RNA [KO:K14280]
112443537  U6 spliceosomal RNA [KO:K14280]
112443885  U6 spliceosomal RNA [KO:K14280]
112447205  U6 spliceosomal RNA [KO:K14280]
112446907  U6 spliceosomal RNA [KO:K14280]
112446156  U6 spliceosomal RNA [KO:K14280]
112448959  U6 spliceosomal RNA [KO:K14280]
112442114  U6 spliceosomal RNA [KO:K14280]
112441686  U6 spliceosomal RNA [KO:K14280]
112441926  U6 spliceosomal RNA [KO:K14280]
112448361  U6 spliceosomal RNA [KO:K14280]
112442454  U6 spliceosomal RNA [KO:K14280]
112448183  U6 spliceosomal RNA [KO:K14280]
112444540  U6 spliceosomal RNA [KO:K14280]
112443688  U6 spliceosomal RNA [KO:K14280]
112442115  U6 spliceosomal RNA [KO:K14280]
112448646  U6 spliceosomal RNA [KO:K14280]
112443701  U6 spliceosomal RNA [KO:K14280]
112443054  U6 spliceosomal RNA [KO:K14280]
112442873  U6 spliceosomal RNA [KO:K14280]
112444235  U6 spliceosomal RNA [KO:K14280]
112443934  U6 spliceosomal RNA [KO:K14280]
112442760  U6 spliceosomal RNA [KO:K14280]
112447667  U6 spliceosomal RNA [KO:K14280]
112441685  U6 spliceosomal RNA [KO:K14280]
112443699  U6 spliceosomal RNA [KO:K14280]
112449426  U6 spliceosomal RNA [KO:K14280]
112446519  U6 spliceosomal RNA [KO:K14280]
112443364  U6 spliceosomal RNA [KO:K14280]
112443538  U6 spliceosomal RNA [KO:K14280]
112448359  U6 spliceosomal RNA [KO:K14280]
112446158  U6 spliceosomal RNA [KO:K14280]
112448654  U6 spliceosomal RNA [KO:K14280]
112446897  U6 spliceosomal RNA [KO:K14280]
112449649  U6 spliceosomal RNA [KO:K14280]
112447660  U6 spliceosomal RNA [KO:K14280]
112448955  U6 spliceosomal RNA [KO:K14280]
112448957  U6 spliceosomal RNA [KO:K14280]
112443360  U6 spliceosomal RNA [KO:K14280]
112444230  U6 spliceosomal RNA [KO:K14280]
112447208  U6 spliceosomal RNA [KO:K14280]
112446523  U6 spliceosomal RNA [KO:K14280]
112442455  U6 spliceosomal RNA [KO:K14280]
112448180  U6 spliceosomal RNA [KO:K14280]
112445669  U6 spliceosomal RNA [KO:K14280]
112447650  U6 spliceosomal RNA [KO:K14280]
112441919  U6 spliceosomal RNA [KO:K14280]
112447207  U6 spliceosomal RNA [KO:K14280]
112449156  U6 spliceosomal RNA [KO:K14280]
112441684  U6 spliceosomal RNA [KO:K14280]
112448363  U6 spliceosomal RNA [KO:K14280]
112443693  U6 spliceosomal RNA [KO:K14280]
112445291  U6 spliceosomal RNA [KO:K14280]
112449641  U6 spliceosomal RNA [KO:K14280]
112447215  U6 spliceosomal RNA [KO:K14280]
112442761  U6 spliceosomal RNA [KO:K14280]
112444779  U6 spliceosomal RNA [KO:K14280]
112449425  U6 spliceosomal RNA [KO:K14280]
112443700  U6 spliceosomal RNA [KO:K14280]
112447664  U6 spliceosomal RNA [KO:K14280]
112448653  U6 spliceosomal RNA [KO:K14280]
112443913  U6 spliceosomal RNA [KO:K14280]
112447657  U6 spliceosomal RNA [KO:K14280]
112444662  U6 spliceosomal RNA [KO:K14280]
112444659  U6 spliceosomal RNA [KO:K14280]
508660  DDX46; probable ATP-dependent RNA helicase DDX46 [KO:K12811] [EC:5.6.2.7]
540191  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
506405  DHX16; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [KO:K12813] [EC:5.6.2.6]
520046  DHX38; pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 [KO:K12815] [EC:5.6.2.6]
514003  CDC40; pre-mRNA-processing factor 17 [KO:K12816]
507639  PRPF18; pre-mRNA-splicing factor 18 [KO:K12817]
536093  DHX8; ATP-dependent RNA helicase DHX8 [KO:K12818] [EC:5.6.2.6]
512318  SLU7; pre-mRNA-splicing factor SLU7 [KO:K12819]
512327  DHX15; ATP-dependent RNA helicase DHX15 [KO:K12820] [EC:5.6.2.6]
613304  SNRPB; small nuclear ribonucleoprotein-associated protein B' [KO:K11086]
104971292  small nuclear ribonucleoprotein Sm D1-like [KO:K11087]
508788  SNRPD1; small nuclear ribonucleoprotein Sm D1 [KO:K11087]
104974918  small nuclear ribonucleoprotein Sm D1-like [KO:K11087]
107131841  small nuclear ribonucleoprotein Sm D1-like [KO:K11087]
514932  SNRPD2; small nuclear ribonucleoprotein Sm D2 [KO:K11096]
617823  SNRPD3; small nuclear ribonucleoprotein Sm D3 [KO:K11088]
531493  SNRPE; small nuclear ribonucleoprotein E [KO:K11097]
112442575  small nuclear ribonucleoprotein E-like [KO:K11097]
112442676  small nuclear ribonucleoprotein E-like [KO:K11097]
107132043  small nuclear ribonucleoprotein E-like [KO:K11097]
107132237  small nuclear ribonucleoprotein E-like [KO:K11097]
615240  SNRPF; small nuclear ribonucleoprotein F [KO:K11098]
107131530  small nuclear ribonucleoprotein F [KO:K11098]
522621  SNRPG; small nuclear ribonucleoprotein G [KO:K11099]
107131494  small nuclear ribonucleoprotein G [KO:K11099]
107132386  small nuclear ribonucleoprotein G-like [KO:K11099]
107132556  small nuclear ribonucleoprotein G-like [KO:K11099]
535113  SNRNP70; U1 small nuclear ribonucleoprotein 70 kDa [KO:K11093]
509802  SNRPA; U1 small nuclear ribonucleoprotein A [KO:K11091]
614553  SNRPC; U1 small nuclear ribonucleoprotein C [KO:K11095]
513782  PRPF40B; pre-mRNA-processing factor 40 homolog B isoform X7 [KO:K12821]
100301114  PRPF40A; pre-mRNA-processing factor 40 homolog A isoform X6 [KO:K12821]
540258  RBM25; RNA-binding protein 25 [KO:K12822]
533700  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
540964  TCERG1; transcription elongation regulator 1 isoform X8 [KO:K12824]
280796  FUS; RNA-binding protein FUS [KO:K13098]
512584  SNRPA1; U2 small nuclear ribonucleoprotein A' [KO:K11092]
767873  SNRPB2; U2 small nuclear ribonucleoprotein B'' [KO:K11094]
504381  SF3A1; splicing factor 3A subunit 1 [KO:K12825]
789082  SF3A2; splicing factor 3A subunit 2 [KO:K12826]
523250  SF3A3; splicing factor 3A subunit 3 [KO:K12827]
510177  SF3B1; splicing factor 3B subunit 1 [KO:K12828]
531931  SF3B2; splicing factor 3B subunit 2 [KO:K12829]
504962  SF3B3; splicing factor 3B subunit 3 [KO:K12830]
506123  SF3B4; splicing factor 3B subunit 4 [KO:K12831]
782673  LOW QUALITY PROTEIN: splicing factor 3B subunit 4-like [KO:K12831]
574400  SF3B5; splicing factor 3B subunit 5 [KO:K12832]
508876  SF3B6; splicing factor 3B subunit 6 [KO:K12833]
507180  PHF5A; PHD finger-like domain-containing protein 5A [KO:K12834]
100140430  DDX42; LOW QUALITY PROTEIN: ATP-dependent RNA helicase DDX42 [KO:K12835] [EC:5.6.2.7]
512680  U2AF1; splicing factor U2AF 35 kDa subunit [KO:K12836]
615198  U2AF1L4; splicing factor U2AF 26 kDa subunit [KO:K12836]
507895  U2AF2; splicing factor U2AF 65 kDa subunit [KO:K12837]
512824  PUF60; poly(U)-binding-splicing factor PUF60 isoform 3 [KO:K12838]
520500  SMNDC1; survival of motor neuron-related-splicing factor 30 [KO:K12839]
512694  RBM17; splicing factor 45 [KO:K12840]
525110  CHERP; calcium homeostasis endoplasmic reticulum protein [KO:K12841]
505019  U2SURP; U2 snRNP-associated SURP motif-containing protein isoform X1 [KO:K12842]
615312  RP9; retinitis pigmentosa 9 protein isoform X1 [KO:K19604]
538662  LSM2; U6 snRNA-associated Sm-like protein LSm2 [KO:K12621]
614759  LSM3; U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
613634  LSM4; U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
615136  LSM5; U6 snRNA-associated Sm-like protein LSm5 [KO:K12624]
615916  LSM6; U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
107132243  U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
509920  LSM7; U6 snRNA-associated Sm-like protein LSm7 [KO:K12626]
613630  LSM8; LSM8 homolog, U6 small nuclear RNA associated [KO:K12627]
510322  PRPF3; U4/U6 small nuclear ribonucleoprotein Prp3 [KO:K12843]
508735  PRPF4; U4/U6 small nuclear ribonucleoprotein Prp4 [KO:K12662]
513428  PPIH; peptidyl-prolyl cis-trans isomerase H [KO:K09567] [EC:5.2.1.8]
513577  PRPF31; U4/U6 small nuclear ribonucleoprotein Prp31 [KO:K12844]
767931  SNU13; NHP2-like protein 1 [KO:K12845]
790677  SNRNP27; U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846]
532985  USP39; U4/U6.U5 tri-snRNP-associated protein 2 [KO:K12847]
615704  SART1; U4/U6.U5 tri-snRNP-associated protein 1 [KO:K11984]
782132  ZMAT2; zinc finger matrin-type protein 2 [KO:K12848]
507240  PRPF38A; pre-mRNA-splicing factor 38A [KO:K12849]
100299693  PRPF38B; pre-mRNA-splicing factor 38B [KO:K12850]
509425  EFTUD2; 116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852]
510529  SNRNP200; U5 small nuclear ribonucleoprotein 200 kDa helicase [KO:K12854] [EC:5.6.2.6]
534228  PRPF6; pre-mRNA-processing factor 6 [KO:K12855]
507371  PRPF8; pre-mRNA-processing-splicing factor 8 [KO:K12856]
534645  SNRNP40; U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
537395  DDX23; probable ATP-dependent RNA helicase DDX23 [KO:K12858] [EC:5.6.2.7]
535457  TXNL4A; thioredoxin-like protein 4A [KO:K12859]
513868  PRPF19; pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
767817  CDC5L; cell division cycle 5-like protein [KO:K12860]
507944  BCAS2; pre-mRNA-splicing factor SPF27 [KO:K12861]
533951  PLRG1; pleiotropic regulator 1 [KO:K12862]
535258  CWC15; spliceosome-associated protein CWC15 homolog [KO:K12863]
282421  CTNNBL1; beta-catenin-like protein 1 [KO:K12864]
282254  HSPA1A; heat shock 70 kDa protein 1B [KO:K03283]
281831  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
540190  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
539835  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
534894  PQBP1; polyglutamine-binding protein 1 [KO:K12865]
534416  WBP11; WW domain-binding protein 11 [KO:K12866]
326578  SNW1; SNW domain-containing protein 1 [KO:K06063]
528991  XAB2; pre-mRNA-splicing factor SYF1 [KO:K12867]
522372  SYF2; pre-mRNA-splicing factor SYF2 [KO:K12868]
526536  CRNKL1; crooked neck-like protein 1 [KO:K12869]
783414  ISY1; pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
508179  PPIL1; peptidyl-prolyl cis-trans isomerase-like 1 [KO:K12733] [EC:5.2.1.8]
787681  PPIE; peptidyl-prolyl cis-trans isomerase E [KO:K09564] [EC:5.2.1.8]
617519  CCDC12; coiled-coil domain-containing protein 12 [KO:K12871]
512330  RBM22; pre-mRNA-splicing factor RBM22 [KO:K12872]
533977  BUD31; protein BUD31 homolog [KO:K12873]
537445  AQR; RNA helicase aquarius [KO:K12874]
534600  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
515145  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
518045  RBM8A; RNA-binding protein 8A [KO:K12876]
505417  MAGOH; protein mago nashi homolog [KO:K12877]
541013  MAGOHB; protein mago nashi homolog 2 [KO:K12877]
100138748  THOC1; THO complex subunit 1 [KO:K12878]
507738  THOC2; THO complex subunit 2 [KO:K12879]
100299503  THO complex subunit 2 [KO:K12879]
529231  THOC3; THO complex subunit 3 [KO:K12880]
537706  ALYREF; THO complex subunit 4 [KO:K12881]
100124428  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
510872  NCBP2; nuclear cap-binding protein subunit 2 [KO:K12883]
107132038  NCBP2L; LOW QUALITY PROTEIN: nuclear cap-binding protein subunit 2-like [KO:K12883]
782669  HNRNPA3; heterogeneous nuclear ribonucleoprotein A3 [KO:K12741]
505093  HNRNPA1; heterogeneous nuclear ribonucleoprotein A1 [KO:K12741]
785761  heterogeneous nuclear ribonucleoprotein A1 [KO:K12741]
101902301  heterogeneous nuclear ribonucleoprotein A3-like [KO:K12741]
100848353  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
614922  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
785445  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
112445996  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
101902221  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A3-like [KO:K12741]
781499  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A3-like [KO:K12741]
615271  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A3-like [KO:K12741]
510852  HNRNPC; heterogeneous nuclear ribonucleoproteins C1/C2 [KO:K12884]
509591  RBMX; RNA-binding motif protein, X chromosome [KO:K12885]
528135  HNRNPK; heterogeneous nuclear ribonucleoprotein K [KO:K12886]
786726  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein K-like [KO:K12886]
515290  HNRNPM; heterogeneous nuclear ribonucleoprotein M [KO:K12887]
539950  HNRNPU; heterogeneous nuclear ribonucleoprotein U [KO:K12888]
509917  PCBP1; poly(rC)-binding protein 1 [KO:K12889]
615796  SRSF1; serine/arginine-rich splicing factor 1 [KO:K12890]
508312  SRSF2; serine/arginine-rich splicing factor 2 [KO:K12891]
100847359  serine/arginine-rich splicing factor 2-like [KO:K12891]
540276  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
614310  SRSF4; serine/arginine-rich splicing factor 4 [KO:K12893]
510474  SRSF5; serine/arginine-rich splicing factor 5 [KO:K12893]
507828  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
507066  SRSF7; serine/arginine-rich splicing factor 7 [KO:K12896]
509905  SRSF9; serine/arginine-rich splicing factor 9 [KO:K21123]
101903900  serine/arginine-rich splicing factor 9-like [KO:K21123]
534586  TRA2A; transformer-2 protein homolog alpha [KO:K12897]
615156  TRA2B; transformer-2 protein homolog beta [KO:K12897]
768310  SRSF10; serine/arginine-rich splicing factor 10 [KO:K12900]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

DBGET integrated database retrieval system