KEGG   PATHWAY: btax04623
Entry
btax04623                   Pathway                                
Name
Cytosolic DNA-sensing pathway - Budorcas taxicolor (takin)
Description
Specific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified sensor of cytosolic DNA which activates the IRF and NF-{kappa}B transcription factors, leading to production of type I interferon and other cytokines. The second type of cytoplasmic DNA sensor is AIM2. Upon sensing DNA, AIM2 triggers the assembly of the inflammasome, culminating in interleukin maturation. In addition to these receptors, there is a mechanism to sense foreign DNA, with the host RNA polymerase III converting the DNA into RNA for recognition by the RNA sensor RIG-I. These pathways provide various means to alert the cell.
Class
Organismal Systems; Immune system
Pathway map
btax04623  Cytosolic DNA-sensing pathway
btax04623

Organism
Budorcas taxicolor (takin) [GN:btax]
Gene
128047321  POLR3A; DNA-directed RNA polymerase III subunit RPC1 isoform X1 [KO:K03018] [EC:2.7.7.6]
128047251  POLR3B; DNA-directed RNA polymerase III subunit RPC2 [KO:K03021] [EC:2.7.7.6]
128044901  POLR3C; DNA-directed RNA polymerase III subunit RPC3 [KO:K03023]
128052364  POLR3D; LOW QUALITY PROTEIN: DNA-directed RNA polymerase III subunit RPC4 [KO:K03026]
128064049  POLR3E; DNA-directed RNA polymerase III subunit RPC5 [KO:K14721]
128055841  POLR1C; DNA-directed RNA polymerases I and III subunit RPAC1 [KO:K03027]
128071509  POLR3K; DNA-directed RNA polymerase III subunit RPC10 [KO:K03019]
128061774  DNA-directed RNA polymerase III subunit RPC10-like [KO:K03019]
128057560  POLR1D; DNA-directed RNA polymerases I and III subunit RPAC2 isoform X1 [KO:K03020]
128048438  POLR3H; DNA-directed RNA polymerase III subunit RPC8 isoform X1 [KO:K03022]
128044685  POLR3GL; DNA-directed RNA polymerase III subunit RPC7-like isoform X1 [KO:K03024]
128051480  POLR3G; DNA-directed RNA polymerase III subunit RPC7 [KO:K03024]
128058368  POLR3F; DNA-directed RNA polymerase III subunit RPC6 isoform X1 [KO:K03025]
128050676  POLR2E; DNA-directed RNA polymerases I, II, and III subunit RPABC1 [KO:K03013]
128047808  POLR2F; DNA-directed RNA polymerases I, II, and III subunit RPABC2 isoform X1 [KO:K03014]
128060267  POLR2H; DNA-directed RNA polymerases I, II, and III subunit RPABC3 [KO:K03016]
128052481  RIGI; antiviral innate immune response receptor RIG-I [KO:K12646] [EC:5.6.2.6]
128057999  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
128049417  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
128068546  RELA; transcription factor p65 [KO:K04735]
128046952  IL6; interleukin-6 [KO:K05405]
128055150  PCBP1; poly(rC)-binding protein 1 [KO:K12889]
128050307  G3BP1; ras GTPase-activating protein-binding protein 1 [KO:K17265] [EC:5.6.2.5 5.6.2.3]
128058594  ZCCHC3; zinc finger CCHC domain-containing protein 3 [KO:K27162]
128053541  CGAS; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
128050274  STING1; stimulator of interferon genes protein [KO:K12654]
128063007  ZDHHC1; palmitoyltransferase ZDHHC1 isoform X1 [KO:K20027] [EC:2.3.1.225]
128050794  DDX41; probable ATP-dependent RNA helicase DDX41 [KO:K13116] [EC:5.6.2.7]
128044847  interferon-activable protein 203-like [KO:K20914]
128047841  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
128061603  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
128062922  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
128068703  IRF7; interferon regulatory factor 7 [KO:K09447]
128052429  interferon alpha-H-like [KO:K05414]
128052430  interferon alpha-H-like [KO:K05414]
128052431  interferon alpha-H [KO:K05414]
128052432  interferon alpha-1-like [KO:K05414]
128052433  interferon alpha-H-like [KO:K05414]
128052459  interferon alpha-H-like [KO:K05414]
128052476  interferon alpha-H-like [KO:K05414]
128052682  LOW QUALITY PROTEIN: interferon alpha-3-like [KO:K05414]
128052694  interferon alpha-H-like [KO:K05414]
128052696  interferon alpha-H-like [KO:K05414]
128052697  interferon alpha-1-like [KO:K05414]
128052706  LOW QUALITY PROTEIN: interferon alpha-2-like [KO:K05414]
128052625  interferon beta-2-like [KO:K05415]
128052626  interferon beta-2-like [KO:K05415]
128052627  interferon beta-2-like [KO:K05415]
128052628  interferon beta-2 [KO:K05415]
128052635  interferon beta-2-like [KO:K05415]
128052636  interferon beta-2-like [KO:K05415]
128052637  interferon beta-2-like [KO:K05415]
128052638  interferon beta-2-like [KO:K05415]
128052639  interferon beta-2-like [KO:K05415]
128052640  interferon beta-2-like [KO:K05415]
128052652  interferon beta-2-like [KO:K05415]
128058752  ZBP1; Z-DNA-binding protein 1 [KO:K12965]
128055992  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
128054462  RIPK3; receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
128069947  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
128067677  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
128068238  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
128063416  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
128066643  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
128064808  C-C motif chemokine 4 [KO:K12964]
128064805  C-C motif chemokine 5 [KO:K12499]
128050033  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
128051444  NLRP3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800]
128066501  MEFV; pyrin [KO:K12803]
128068641  FADD; FAS-associated death domain protein [KO:K02373]
128064775  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
128043606  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
128060592  CASP1; caspase-1 [KO:K01370] [EC:3.4.22.36]
128063711  MLKL; mixed lineage kinase domain-like protein [KO:K08849] [EC:2.7.11.1]
128068336  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
128067718  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
128046676  GSDME; gasdermin-E [KO:K22146]
128059451  GSDMD; gasdermin-D isoform X1 [KO:K20917]
128056569  IL1B; interleukin-1 beta [KO:K04519]
128060832  IL18; interleukin-18 [KO:K05482]
128052701  IL33; interleukin-33 [KO:K12967]
128044728  ADAR; double-stranded RNA-specific adenosine deaminase isoform X1 [KO:K12968] [EC:3.5.4.37]
128058346  SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1 [KO:K22544] [EC:3.1.5.-]
128050426  TREX1; three-prime repair exonuclease 1 [KO:K10790] [EC:3.1.11.2]
128045111  DNASE2B; deoxyribonuclease-2-beta [KO:K01158] [EC:3.1.22.1]
128051394  DNASE2; deoxyribonuclease-2-alpha isoform X1 [KO:K01158] [EC:3.1.22.1]
Compound
C00039  DNA
C20640  Cyclic GMP-AMP
Reference
PMID:19362700
  Authors
Yanai H, Savitsky D, Tamura T, Taniguchi T
  Title
Regulation of the cytosolic DNA-sensing system in innate immunity: a current view.
  Journal
Curr Opin Immunol 21:17-22 (2009)
DOI:10.1016/j.coi.2009.01.005
Reference
PMID:19497760
  Authors
Vilaysane A, Muruve DA
  Title
The innate immune response to DNA.
  Journal
Semin Immunol 21:208-14 (2009)
DOI:10.1016/j.smim.2009.05.006
Reference
PMID:18573338
  Authors
Takeshita F, Ishii KJ
  Title
Intracellular DNA sensors in immunity.
  Journal
Curr Opin Immunol 20:383-8 (2008)
DOI:10.1016/j.coi.2008.05.009
Reference
PMID:19122387
  Authors
Takaoka A, Shinohara S
  Title
DNA sensors in innate immune system.
  Journal
Uirusu 58:37-46 (2008)
DOI:10.2222/jsv.58.37
Reference
PMID:18280611
  Authors
Takaoka A, Taniguchi T
  Title
Cytosolic DNA recognition for triggering innate immune responses.
  Journal
Adv Drug Deliv Rev 60:847-57 (2008)
DOI:10.1016/j.addr.2007.12.002
Reference
PMID:18941233
  Authors
Kaiser WJ, Upton JW, Mocarski ES
  Title
Receptor-interacting protein homotypic interaction motif-dependent control of NF-kappa B activation via the DNA-dependent activator of IFN regulatory factors.
  Journal
J Immunol 181:6427-34 (2008)
DOI:10.4049/jimmunol.181.9.6427
Reference
PMID:19590578
  Authors
Rebsamen M, Heinz LX, Meylan E, Michallet MC, Schroder K, Hofmann K, Vazquez J, Benedict CA, Tschopp J
  Title
DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB.
  Journal
EMBO Rep 10:916-22 (2009)
DOI:10.1038/embor.2009.109
Reference
PMID:18375758
  Authors
Wang Z, Choi MK, Ban T, Yanai H, Negishi H, Lu Y, Tamura T, Takaoka A, Nishikura K, Taniguchi T
  Title
Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules.
  Journal
Proc Natl Acad Sci U S A 105:5477-82 (2008)
DOI:10.1073/pnas.0801295105
Reference
PMID:18724932
  Authors
Stetson DB, Ko JS, Heidmann T, Medzhitov R
  Title
Trex1 prevents cell-intrinsic initiation of autoimmunity.
  Journal
Cell 134:587-98 (2008)
DOI:10.1016/j.cell.2008.06.032
Reference
PMID:19321146
  Authors
Schroder K, Muruve DA, Tschopp J
  Title
Innate immunity: cytoplasmic DNA sensing by the AIM2 inflammasome.
  Journal
Curr Biol 19:R262-5 (2009)
DOI:10.1016/j.cub.2009.02.011
Reference
PMID:19567913
  Authors
Krieg AM
  Title
AIMing 2 detect foreign DNA.
  Journal
Sci Signal 2:pe39 (2009)
DOI:10.1126/scisignal.277pe39
Reference
PMID:19665965
  Authors
O'Neill LA
  Title
DNA makes RNA makes innate immunity.
  Journal
Cell 138:428-30 (2009)
DOI:10.1016/j.cell.2009.07.021
Reference
PMID:16286919
  Authors
Ishii KJ, Coban C, Kato H, Takahashi K, Torii Y, Takeshita F, Ludwig H, Sutter G, Suzuki K, Hemmi H, Sato S, Yamamoto M, Uematsu S, Kawai T, Takeuchi O, Akira S
  Title
A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.
  Journal
Nat Immunol 7:40-8 (2006)
DOI:10.1038/ni1282
Reference
PMID:19767723
  Authors
Cao X
  Title
New DNA-sensing pathway feeds RIG-I with RNA.
  Journal
Nat Immunol 10:1049-51 (2009)
DOI:10.1038/ni1009-1049
Reference
PMID:23258413
  Authors
Sun L, Wu J, Du F, Chen X, Chen ZJ
  Title
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.
  Journal
Science 339:786-91 (2013)
DOI:10.1126/science.1232458
Reference
PMID:35006429
  Authors
Gao M, He Y, Tang H, Chen X, Liu S, Tao Y
  Title
cGAS/STING: novel perspectives of the classic pathway.
  Journal
Mol Biomed 1:7 (2020)
DOI:10.1186/s43556-020-00006-z
Reference
PMID:34949589
  Authors
Benjamin P, Sudhakar S, D'Arco F, Lobel U, Carney O, Roux CJ, Boddaert N, Hemingway C, Eleftheriou D, Mankad K
  Title
Spectrum of Neuroradiologic Findings Associated with Monogenic Interferonopathies.
  Journal
AJNR Am J Neuroradiol 43:2-10 (2022)
DOI:10.3174/ajnr.A7362
Reference
PMID:32829024
  Authors
Place DE, Lee S, Kanneganti TD
  Title
PANoptosis in microbial infection.
  Journal
Curr Opin Microbiol 59:42-49 (2021)
DOI:10.1016/j.mib.2020.07.012
Reference
PMID:34970269
  Authors
Jiang W, Deng Z, Dai X, Zhao W
  Title
PANoptosis: A New Insight Into Oral Infectious Diseases.
  Journal
Front Immunol 12:789610 (2021)
DOI:10.3389/fimmu.2021.789610
Reference
PMID:34504660
  Authors
Wang Y, Kanneganti TD
  Title
From pyroptosis, apoptosis and necroptosis to PANoptosis: A mechanistic compendium of programmed cell death pathways.
  Journal
Comput Struct Biotechnol J 19:4641-4657 (2021)
DOI:10.1016/j.csbj.2021.07.038
Related
pathway
btax04064  NF-kappa B signaling pathway
btax04120  Ubiquitin mediated proteolysis
btax04210  Apoptosis
btax04217  Necroptosis
btax04621  NOD-like receptor signaling pathway
btax04622  RIG-I-like receptor signaling pathway
KO pathway
ko04623   
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