KEGG   PATHWAY: btax05146
Entry
btax05146                   Pathway                                
Name
Amoebiasis - Budorcas taxicolor (takin)
Description
Entamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis of amoebiasis begins with parasite attachment and disruption of the intestinal mucus layer, followed by apoptosis of host epithelial cells. Intestinal tissue destruction causes severe dysentery and ulcerations in amoebic colitis. Several amoebic proteins such as lectins, cysteine proteineases, and amoebapores are associated with the invasion process. The parasite can cause extraintestinal infection like amoebic liver abscess by evading immune response.
Class
Human Diseases; Infectious disease: parasitic
Pathway map
btax05146  Amoebiasis
btax05146

Organism
Budorcas taxicolor (takin) [GN:btax]
Gene
128056569  IL1B; interleukin-1 beta [KO:K04519]
128056062  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
128056702  IL1R2; interleukin-1 receptor type 2 [KO:K04387]
128049417  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
128068546  RELA; transcription factor p65 [KO:K04735]
128064766  HSPB1; heat shock protein beta-1 [KO:K04455]
128068935  MUC2; mucin-2 [KO:K10955]
128065257  COL1A1; collagen alpha-1(I) chain [KO:K06236]
128046458  COL1A2; collagen alpha-2(I) chain [KO:K06236]
128069713  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
128070154  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
128070152  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
128057793  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
128057845  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
128071532  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
128071425  fibronectin-like [KO:K05717]
128068063  FN1; fibronectin isoform X1 [KO:K05717]
128053075  LAMA2; laminin subunit alpha-2 [KO:K05637]
128067370  LAMA1; laminin subunit alpha-1 [KO:K05637]
128058740  LAMA5; laminin subunit alpha-5 [KO:K06240]
128067291  LAMA3; laminin subunit alpha-3 [KO:K06240]
128053220  LAMA4; laminin subunit alpha-4 [KO:K06241]
128046398  LAMB1; laminin subunit beta-1 [KO:K05636]
128045013  LOW QUALITY PROTEIN: laminin subunit beta-2-like [KO:K06243]
128053060  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
128061642  LAMB3; laminin subunit beta-3 [KO:K06244]
128046270  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
128061859  LAMC1; laminin subunit gamma-1 [KO:K05635]
128061574  LAMC2; laminin subunit gamma-2 [KO:K06246]
128056135  LAMC3; laminin subunit gamma-3 [KO:K06247]
128068336  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
128052307  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
128050674  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
128052310  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
128051393  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
128058011  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
128058303  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
128054050  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
128068545  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
128065393  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
128066420  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
128063096  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
128058250  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas [KO:K04632]
128058829  neuroendocrine secretory protein 55 [KO:K04632]
128067338  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
128046764  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
128050339  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
128044465  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
128060293  RAB5A; ras-related protein Rab-5A [KO:K07887]
128045062  ras-related protein Rab-5B-like [KO:K07888]
128047345  RAB5B; ras-related protein Rab-5B [KO:K07888]
128064681  RAB5C; ras-related protein Rab-5C [KO:K07889]
128044528  RAB7A; ras-related protein Rab-7a [KO:K07897]
128061795  RAB7B; ras-related protein Rab-7b [KO:K07898]
128062410  TLR2; toll-like receptor 2 [KO:K10159]
128052396  TLR4; toll-like receptor 4 [KO:K10160]
128050920  CD14; monocyte differentiation antigen CD14 [KO:K04391]
128046952  IL6; interleukin-6 [KO:K05405]
128049546  growth-regulated alpha protein [KO:K05505]
128049610  growth-regulated protein homolog gamma-like [KO:K05505]
128049611  growth-regulated alpha protein-like [KO:K05505]
128051607  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
128049958  CXCL8; interleukin-8 [KO:K10030]
128056772  TNF; tumor necrosis factor [KO:K03156]
128050368  IL12A; interleukin-12 subunit alpha isoform X1 [KO:K05406]
128051514  IL12B; interleukin-12 subunit beta [KO:K05425]
128044627  antigen-presenting glycoprotein CD1d [KO:K06448]
128044710  T-cell surface glycoprotein CD1e, membrane-associated-like [KO:K06448]
128044726  T-cell surface glycoprotein CD1b-2-like [KO:K06448]
128044727  T-cell surface glycoprotein CD1b-2-like [KO:K06448]
128044754  T-cell surface glycoprotein CD1b-1 [KO:K06448]
128044865  LOW QUALITY PROTEIN: T-cell surface glycoprotein CD1c-like [KO:K06448]
128044876  T-cell surface glycoprotein CD1b-3 [KO:K06448]
128044976  T-cell surface glycoprotein CD1a-like [KO:K06448]
128045026  T-cell surface glycoprotein CD1a-like [KO:K06448]
128045473  LOW QUALITY PROTEIN: T-cell surface glycoprotein CD1b-2-like [KO:K06448]
128048506  IFNG; interferon gamma [KO:K04687]
128043774  COL3A1; collagen alpha-1(III) chain [KO:K19720]
128059235  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
128047281  VCL; vinculin isoform X1 [KO:K05700]
128063664  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
128053759  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
128053449  ARG1; arginase-1 [KO:K01476] [EC:3.5.3.1]
128053943  ARG2; arginase-2, mitochondrial [KO:K01476] [EC:3.5.3.1]
128065005  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
128047159  ITGB2; integrin beta-2 [KO:K06464]
128066359  integrin alpha-M-like [KO:K06461]
128050540  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
128044474  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
128066235  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
128045803  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
128061813  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
128068699  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
128050093  peroxiredoxin-1-like [KO:K13279] [EC:1.11.1.24]
128044517  PRDX1; peroxiredoxin-1 [KO:K13279] [EC:1.11.1.24]
128056904  serpin B9-like [KO:K13963]
128056903  serpin B6-like [KO:K13963]
128067331  serpin B4-like [KO:K13963]
128067509  SERPINB13; serpin B13 [KO:K13963]
128055994  serpin B6-like [KO:K13963]
128067561  SERPINB10; serpin B10 [KO:K13963]
128067330  serpin B4-like [KO:K13963]
128055995  serpin B6 [KO:K13963]
128066749  cathepsin G-like [KO:K01319] [EC:3.4.21.20]
128061792  IL10; interleukin-10 [KO:K05443]
128063320  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
128061503  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
128053888  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
128045666  C8A; complement component C8 alpha chain [KO:K03997]
128045434  C8B; complement component C8 beta chain [KO:K03998]
128056557  C8G; complement component C8 gamma chain isoform X1 [KO:K03999]
128066230  C9; complement component C9 [KO:K04000]
Compound
C00027  Hydrogen peroxide
C00062  L-Arginine
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C01074  N-Acetylgalactosamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01498  Gelatine
C02737  Phosphatidylserine
C18287  Monocyte locomotion inhibitory factor
Reference
PMID:11378035
  Authors
Stanley SL
  Title
Pathophysiology of amoebiasis.
  Journal
Trends Parasitol 17:280-5 (2001)
DOI:10.1016/S1471-4922(01)01903-1
Reference
PMID:10756002
  Authors
Espinosa-Cantellano M, Martinez-Palomo A
  Title
Pathogenesis of intestinal amebiasis: from molecules to disease.
  Journal
Clin Microbiol Rev 13:318-31 (2000)
DOI:10.1128/CMR.13.2.318-331.2000
Reference
PMID:9832261
  Authors
Huston CD, Petri WA Jr
  Title
Host-pathogen interaction in amebiasis and progress in vaccine development.
  Journal
Eur J Clin Microbiol Infect Dis 17:601-14 (1998)
DOI:10.1007/BF01708342
Reference
PMID:14700586
  Authors
Huston CD
  Title
Parasite and host contributions to the pathogenesis of amebic colitis.
  Journal
Trends Parasitol 20:23-6 (2004)
DOI:10.1016/j.pt.2003.10.013
Reference
PMID:15813717
  Authors
Campos-Rodriguezp R, Jarillo-Luna A
  Title
The pathogenicity of Entamoeba histolytica is related to the capacity of evading innate immunity.
  Journal
Parasite Immunol 27:1-8 (2005)
DOI:10.1111/j.1365-3024.2005.00743.x
Reference
PMID:19207103
  Authors
Lejeune M, Rybicka JM, Chadee K
  Title
Recent discoveries in the pathogenesis and immune response toward Entamoeba histolytica.
  Journal
Future Microbiol 4:105-18 (2009)
DOI:10.2217/17460913.4.1.105
Reference
PMID:17576362
  Authors
Carrero JC, Cervantes-Rebolledo C, Aguilar-Diaz H, Diaz-Gallardo MY, Laclette JP, Morales-Montor J
  Title
The role of the secretory immune response in the infection by Entamoeba histolytica.
  Journal
Parasite Immunol 29:331-8 (2007)
DOI:10.1111/j.1365-3024.2007.00955.x
Reference
PMID:12660071
  Authors
Stanley SL Jr
  Title
Amoebiasis.
  Journal
Lancet 361:1025-34 (2003)
DOI:10.1016/S0140-6736(03)12830-9
Reference
PMID:14502002
  Authors
Stauffer W, Ravdin JI
  Title
Entamoeba histolytica: an update.
  Journal
Curr Opin Infect Dis 16:479-85 (2003)
DOI:10.1097/01.qco.0000092821.42392.ca
Reference
PMID:12142490
  Authors
Petri WA Jr, Haque R, Mann BJ
  Title
The bittersweet interface of parasite and host: lectin-carbohydrate interactions during human invasion by the parasite Entamoeba histolytica.
  Journal
Annu Rev Microbiol 56:39-64 (2002)
DOI:10.1146/annurev.micro.56.012302.160959
Reference
PMID:18725798
  Authors
Baxt LA, Singh U
  Title
New insights into Entamoeba histolytica pathogenesis.
  Journal
Curr Opin Infect Dis 21:489-94 (2008)
DOI:10.1097/QCO.0b013e32830ce75f
Reference
PMID:12160867
  Authors
Petri WA Jr
  Title
Pathogenesis of amebiasis.
  Journal
Curr Opin Microbiol 5:443-7 (2002)
DOI:10.1016/S1369-5274(02)00335-1
Reference
PMID:17702556
  Authors
Guo X, Houpt E, Petri WA Jr
  Title
Crosstalk at the initial encounter: interplay between host defense and ameba survival strategies.
  Journal
Curr Opin Immunol 19:376-84 (2007)
DOI:10.1016/j.coi.2007.07.005
Reference
PMID:20303955
  Authors
Mortimer L, Chadee K
  Title
The immunopathogenesis of Entamoeba histolytica.
  Journal
Exp Parasitol 126:366-80 (2010)
DOI:10.1016/j.exppara.2010.03.005
Reference
PMID:16380324
  Authors
Meza I, Talamas-Rohana P, Vargas MA
  Title
The cytoskeleton of Entamoeba histolytica: structure, function, and regulation by signaling pathways.
  Journal
Arch Med Res 37:234-43 (2006)
DOI:10.1016/j.arcmed.2005.09.008
Reference
PMID:10637584
  Authors
Meza I
  Title
Extracellular matrix-induced signaling in Entamoeba histolytica: its role in invasiveness.
  Journal
Parasitol Today 16:23-8 (2000)
DOI:10.1016/S0169-4758(99)01586-0
Reference
PMID:11352795
  Authors
Stanley SL Jr, Reed SL
  Title
Microbes and microbial toxins: paradigms for microbial-mucosal interactions. VI. Entamoeba histolytica: parasite-host interactions.
  Journal
Am J Physiol Gastrointest Liver Physiol 280:G1049-54 (2001)
DOI:10.1152/ajpgi.2001.280.6.G1049
Reference
PMID:20145703
  Authors
Wong-Baeza I, Alcantara-Hernandez M, Mancilla-Herrera I, Ramirez-Saldivar I, Arriaga-Pizano L, Ferat-Osorio E, Lopez-Macias C, Isibasi A
  Title
The role of lipopeptidophosphoglycan in the immune response to Entamoeba histolytica.
  Journal
J Biomed Biotechnol 2010:254521 (2010)
DOI:10.1155/2010/254521
Related
pathway
btax00330  Arginine and proline metabolism
btax00590  Arachidonic acid metabolism
btax04144  Endocytosis
btax04210  Apoptosis
btax04510  Focal adhesion
btax04610  Complement and coagulation cascades
btax04612  Antigen processing and presentation
btax04620  Toll-like receptor signaling pathway
btax04672  Intestinal immune network for IgA production
btax04810  Regulation of actin cytoskeleton
KO pathway
ko05146   
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