KEGG   PATHWAY: cro03070
Entry
cro03070                    Pathway                                
Name
Bacterial secretion system - Citrobacter rodentium
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
cro03070  Bacterial secretion system
cro03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Citrobacter rodentium [GN:cro]
Gene
ROD_35821  tolC; outer membrane protein TolC [KO:K12340]
ROD_03721  mchD; putative microcin secretion protein [KO:K12340]
ROD_29721  escF; T3SS structural protein EscF [KO:K03221]
ROD_30001  escC; T3SS structural protein EscC [KO:K03219]
ROD_29981  escJ; T3SS structural protein EscJ [KO:K03222]
ROD_30101  escR; T3SS structural protein EscR [KO:K03226]
ROD_30092  escS; T3SS structural protein EscS [KO:K03227]
ROD_30091  escT; T3SS structural protein EscT [KO:K03228]
ROD_30081  escU; T3SS structural protein EscU [KO:K03229]
ROD_29941  escV; T3SS structural protein EscV [KO:K03230]
ROD_29931  escN; T3SS translocator EscN [KO:K03224] [EC:7.4.2.8]
ROD_29901  sepQ; T3SS structural protein SepQ [KO:K03225]
ROD_44971  gspD; putative T2SS protein D [KO:K02453]
ROD_44981  gspC; putative T2SS protein C [KO:K02452]
ROD_44951  gspF; putative T2SS protein F [KO:K02455]
ROD_44941  gspG; putative T2SS protein G [KO:K02456]
ROD_44931  gspH; putative T2SS protein H [KO:K02457]
ROD_44921  gspI; putative T2SS protein I [KO:K02458]
ROD_44911  gspJ; putative T2SS protein J [KO:K02459]
ROD_44901  gspK; putative T2SS protein K [KO:K02460]
ROD_44891  gspL; putative T2SS protein L [KO:K02461]
ROD_44881  gspM; putative T2SS protein M [KO:K02462]
ROD_44961  gspE; putative T2SS protein E [KO:K02454] [EC:7.4.2.8]
ROD_04561  secD; protein-export protein [KO:K03072]
ROD_04571  secF; protein-export protein [KO:K03074]
ROD_37711  secE; preprotein translocase SecE subunit [KO:K03073]
ROD_46581  secG; protein-export membrane protein [KO:K03075]
ROD_45221  secY; preprotein translocase subunit SecY [KO:K03076]
ROD_04551  putative preprotein translocase subunit [KO:K03210]
ROD_40241  oxaA; inner membrane protein [KO:K03217]
ROD_01041  secA; preprotein translocase SecA subunit [KO:K03070] [EC:7.4.2.8]
ROD_01031  secM; secretion monitor precursor [KO:K13301]
ROD_43571  ftsY; cell division protein [KO:K03110]
ROD_42071  secB; protein-export protein SecB [KO:K03071]
ROD_25601  ffh; signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
ROD_39181  tatA; Sec-independent protein translocase protein [KO:K03116]
ROD_39171  tatB; Sec-independent protein translocase protein [KO:K03117]
ROD_39161  tatC; Sec-independent protein translocase protein [KO:K03118]
ROD_06411  tatE; Sec-independent protein translocase protein [KO:K03425]
ROD_p2501  triA; putative conjugal transfer protein TriA [KO:K03194]
ROD_p2491  triB; putative conjugal transfer protein TriB [KO:K03197]
ROD_p2421  triH; putative conjugal transfer protein TriH [KO:K03204]
ROD_p2451  triE; putative conjugal transfer protein TriE [KO:K03201]
ROD_p2431  triG; putative conjugal transfer protein TriG [KO:K03203]
ROD_p2411  triI; putative conjugal transfer protein TriI [KO:K03195]
ROD_p2481  triC; putative conjugal transfer protein TriC [KO:K03199] [EC:7.4.2.8]
ROD_p2401  triJ; putative conjugal transfer protein TriJ [KO:K03196] [EC:7.4.2.8]
ROD_p2391  taxB; putative conjugal transfer coupling protein TaxB [KO:K03205] [EC:7.4.2.8]
ROD_27671  cts1G; VgrG family T6SS protein Cts1G [KO:K11904]
ROD_34241  cts2G; VgrG family T6SS protein Cts2G [KO:K11904]
ROD_28191  putative Rhs protein [KO:K11904]
ROD_34191  cts2H; Hcp family T6SS protein Cts2H [KO:K11903]
ROD_38091  ctsH1; Hcp family T6SS protein CtsH1 [KO:K11903]
ROD_27741  cts1H; Hcp family T6SS protein Cts1H [KO:K11903]
ROD_27731  cts1N; T6SS protein Cts1N [KO:K11906]
ROD_34141  cts2U; T6SS protein Cts2U [KO:K11892]
ROD_27711  cts1U; T6SS protein Cts1U [KO:K11892]
ROD_34231  cts2V; T6SS protein Cts2V [KO:K11907]
ROD_27811  cts1V; T6SS protein Cts1V [KO:K11907]
Compound
C00002  ATP
Reference
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
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