KEGG   PATHWAY: dord00230
Entry
dord00230                   Pathway                                
Name
Purine metabolism - Dipodomys ordii (Ord's kangaroo rat)
Class
Metabolism; Nucleotide metabolism
Pathway map
dord00230  Purine metabolism
dord00230

Module
dord_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:dord00230]
dord_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:dord00230]
dord_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:dord00230]
dord_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:dord00230]
dord_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:dord00230]
dord_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:dord00230]
dord_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:dord00230]
Other DBs
GO: 0006163 0042278
Organism
Dipodomys ordii (Ord's kangaroo rat) [GN:dord]
Gene
105995944  Nudt9; ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
105983501  Adprm; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
105984516  Nudt5; ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
105988872  Pgm1; phosphoglucomutase-1 isoform X1 [KO:K01835] [EC:5.4.2.2]
105980162  Pgm2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
105991379  Prps1l1; ribose-phosphate pyrophosphokinase 3 [KO:K00948] [EC:2.7.6.1]
105992816  Prps1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
105997687  Prps2; ribose-phosphate pyrophosphokinase 2 [KO:K00948] [EC:2.7.6.1]
105980193  Ppat; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
105994021  Gart; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
105983279  Pfas; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
105980289  Paics; multifunctional protein ADE2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
105992093  Adsl; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
105982173  Atic; bifunctional purine biosynthesis protein PURH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
105983006  Aprt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
105985710  Nt5m; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
105986098  Nt5c1a; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
105986716  Nt5c2; cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
105992382  5'-nucleotidase-like [KO:K01081] [EC:3.1.3.5]
105983607  cytosolic 5'-nucleotidase 1B-like [KO:K01081] [EC:3.1.3.5]
106002787  Nt5c; LOW QUALITY PROTEIN: 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
105998218  Nt5e; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
106000426  Pnp; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
105982025  Lacc1; laccase domain-containing protein 1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
105986958  Hprt1; hypoxanthine-guanine phosphoribosyltransferase isoform X1 [KO:K00760] [EC:2.4.2.8]
105988415  Impdh1; inosine-5'-monophosphate dehydrogenase 1 [KO:K00088] [EC:1.1.1.205]
105994605  Impdh2; inosine-5'-monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
105985207  Nme7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
105981912  Nme3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
105994541  Nme6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
106003147  nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
106003148  nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
105990050  Ak9; adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
105995640  Entpd8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X1 [KO:K01510] [EC:3.6.1.5]
105996228  Entpd3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
105986747  Entpd1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
105980115  Cant1; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
105999436  Entpd4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
105993696  Entpd6; ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511] [EC:3.6.1.6]
105983604  Entpd5; ectonucleoside triphosphate diphosphohydrolase 5 [KO:K01511] [EC:3.6.1.6]
105981672  Itpa; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
105983773  Xdh; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
105993363  Nudt2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
105985627  Gmps; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
105996381  Gmpr; GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
105992505  Gmpr2; GMP reductase 2 isoform X1 [KO:K00364] [EC:1.7.1.7]
105987236  Gda; guanine deaminase [KO:K01487] [EC:3.5.4.3]
105985290  Guk1; guanylate kinase [KO:K00942] [EC:2.7.4.8]
105984066  Rrm1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
105982864  Rrm2b; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
105983759  Rrm2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
105993499  Hddc2; HD domain-containing protein 2 [KO:K07023] [EC:3.1.3.89]
105999579  Dguok; deoxyguanosine kinase, mitochondrial [KO:K00904] [EC:2.7.1.113]
105988448  Dck; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
105984986  Prune; protein prune homolog [KO:K01514] [EC:3.6.1.11]
105998287  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
105983849  Adcy2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
105983683  Adcy3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
105992475  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
105987907  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
105987548  Adcy6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
105994440  Adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
105992323  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
105981874  Adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
105987747  adenylate cyclase type 10-like [KO:K11265] [EC:4.6.1.1]
105989633  Adcy10; adenylate cyclase type 10 isoform X1 [KO:K11265] [EC:4.6.1.1]
105980723  Gucy1a2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
105995912  Gucy1a3; guanylate cyclase soluble subunit alpha-3 [KO:K12318] [EC:4.6.1.2]
105995942  Gucy1b3; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
105999722  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
105992222  Gucy2c; heat-stable enterotoxin receptor [KO:K12320] [EC:4.6.1.2]
105983282  Gucy2d; retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
105983940  olfactory guanylyl cyclase GC-D-like [KO:K12321] [EC:4.6.1.2]
105992794  Gucy2f; retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
105986609  guanylate cyclase 2G-like [KO:K22600] [EC:4.6.1.2]
105984966  Npr1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
105993342  Npr2; atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
105996524  Pde1a; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
105997936  Pde1b; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
105999983  Pde1c; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
105984057  Pde2a; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1 [KO:K18283] [EC:3.1.4.17]
105999173  Pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
105991235  Pde5a; cGMP-specific 3',5'-cyclic phosphodiesterase [KO:K13762] [EC:3.1.4.35]
105992590  Pde6a; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha isoform X1 [KO:K08718] [EC:3.1.4.35]
105991300  Pde6b; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
105999388  Pde6c; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' isoform X1 [KO:K13757] [EC:3.1.4.35]
105993082  Pde6d; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform X1 [KO:K13758]
105998440  Pde6g; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
105992277  Pde6h; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
105993989  Pde9a; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
105991796  Pde10a; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
105994507  Pde11a; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
105986393  Adss; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
105983064  Adssl1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
105991915  Ampd1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
105995052  Ampd3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
105997472  Ampd2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
105992643  Adk; adenosine kinase [KO:K00856] [EC:2.7.1.20]
105981431  Ada; adenosine deaminase isoform X1 [KO:K01488] [EC:3.5.4.4]
105990307  adenylate kinase isoenzyme 1 [KO:K00939] [EC:2.7.4.3]
105987108  adenylate kinase isoenzyme 5-like [KO:K00939] [EC:2.7.4.3]
105983330  Ak7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
105988805  Ak2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
105988864  Ak4; adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
105989349  Ak1; adenylate kinase isoenzyme 1 [KO:K00939] [EC:2.7.4.3]
105989355  Ak8; adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
106000594  Ak5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
106001206  LOW QUALITY PROTEIN: adenylate kinase 2, mitochondrial-like [KO:K00939] [EC:2.7.4.3]
105985373  Ak6; adenylate kinase isoenzyme 6 isoform X1 [KO:K18532] [EC:2.7.4.3]
105987264  Ak3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
105995576  Entpd2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
105984444  Ntpcr; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
105993494  Enpp3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
105993508  Enpp1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
105992411  Pde4d; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
105988855  Pde4b; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
105999068  Pde4a; cAMP-specific 3',5'-cyclic phosphodiesterase 4A [KO:K13293] [EC:3.1.4.53]
105993529  Pde7b; cAMP-specific 3',5'-cyclic phosphodiesterase 7B [KO:K18436] [EC:3.1.4.53]
105999464  Pde7a; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
105985398  Pde8b; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B [KO:K18437] [EC:3.1.4.53]
105982288  Pde8a; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A [KO:K18437] [EC:3.1.4.53]
105981219  Fhit; bis(5'-adenosyl)-triphosphatase isoform X1 [KO:K01522] [EC:3.6.1.29]
105987755  Enpp4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
105991221  Papss1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
105986358  Papss2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
105987044  uricase [KO:K00365] [EC:1.7.3.3]
105999037  5-hydroxyisourate hydrolase-like [KO:K07127] [EC:3.5.2.17]
105993913  Urad; putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
105995182  Allc; probable allantoicase [KO:K01477] [EC:3.5.3.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
dord00030  Pentose phosphate pathway
dord00220  Arginine biosynthesis
dord00250  Alanine, aspartate and glutamate metabolism
dord00260  Glycine, serine and threonine metabolism
dord00340  Histidine metabolism
dord00630  Glyoxylate and dicarboxylate metabolism
dord00730  Thiamine metabolism
dord00740  Riboflavin metabolism
dord00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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