KEGG   PATHWAY: efo04068
Entry
efo04068                    Pathway                                
Name
FoxO signaling pathway - Epinephelus fuscoguttatus (brown-marbled grouper)
Description
The forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative stress resistance, and longevity. A central regulatory mechanism of FOXO proteins is phosphorylation by the serine-threonine kinase Akt/protein kinase B (Akt/PKB), downstream of phosphatidylinositol 3-kinase (PI3K), in response to insulin or several growth factors. Phosphorylation at three conserved residues results in the export of FOXO proteins from the nucleus to the cytoplasm, thereby decreasing expression of FOXO target genes. In contrast, the stress-activated c-Jun N-terminal kinase (JNK) and the energy sensing AMP-activated protein kinase (AMPK), upon oxidative and nutrient stress stimuli phosphorylate and activate FoxOs. Aside from PKB, JNK and AMPK, FOXOs are regulated by multiple players through several post-translational modifications, including phosphorylation, but also acetylation, methylation and ubiquitylation.
Class
Environmental Information Processing; Signal transduction
Pathway map
efo04068  FoxO signaling pathway
efo04068

Other DBs
GO: 0009267
Organism
Epinephelus fuscoguttatus (brown-marbled grouper) [GN:efo]
Gene
125888922  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
125892868  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
125894017  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
125896682  transforming growth factor beta-3 proprotein-like [KO:K13377]
125901481  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
125881987  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
125904247  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
125892854  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
125899788  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
125889774  mothers against decapentaplegic homolog 4-like [KO:K04501]
125904836  smad10a; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
125905617  smad4a; mothers against decapentaplegic homolog 4a [KO:K04501]
125880698  mothers against decapentaplegic homolog 3 [KO:K23605]
125887698  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
125902413  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
125895929  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
125905972  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
125901835  prkab2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
125889962  prkab1b; 5'-AMP-activated protein kinase subunit beta-1b [KO:K07199]
125905525  prkab1a; 5'-AMP-activated protein kinase subunit beta-1a [KO:K07199]
125901833  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
125884947  prkag3a; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
125900205  prkag3b; 5'-AMP-activated protein kinase subunit gamma-3b isoform X1 [KO:K07200]
125888481  5'-AMP-activated protein kinase subunit gamma-1-like [KO:K07200]
125889086  nlk2; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
125879604  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
125905915  skp2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
125882633  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
125894079  setd7; histone-lysine N-methyltransferase SETD7 [KO:K11431] [EC:2.1.1.364]
125883731  crebbpa; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
125878921  ep300b; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
125878941  crebbpb; CREB binding protein b isoform X1 [KO:K04498] [EC:2.3.1.48]
125880439  ep300a; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
125903879  sirt1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
125878771  usp7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
125883674  solute carrier family 2, facilitated glucose transporter member 4-like [KO:K07191]
125903016  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
125905962  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
125880486  mapk8b; LOW QUALITY PROTEIN: mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
125894559  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
125887195  serine/threonine-protein kinase 4-like [KO:K04411]
125882923  igf1; insulin-like growth factor I [KO:K05459]
125892050  igf3; insulin-like growth factor 3 isoform X1 [KO:K05459]
125887452  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
125901306  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
125898795  ins; insulin [KO:K04526]
125894470  insb; preproinsulin b [KO:K04526]
125901820  insra; insulin receptor a [KO:K04527] [EC:2.7.10.1]
125895265  insrb; insulin receptor b [KO:K04527] [EC:2.7.10.1]
125883633  si:ch73-335l21.1; insulin receptor substrate 1-B [KO:K16172]
125898921  si:ch211-284e13.4; insulin receptor substrate 1-B [KO:K16172]
125884378  insulin receptor substrate 2-B [KO:K07187]
125884695  insulin receptor substrate 2-like isoform X1 [KO:K07187]
125899435  irs2b; insulin receptor substrate 2 [KO:K07187]
125895453  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
125901864  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
125885349  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
125891486  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
125888244  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
125902071  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
125896428  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
125890643  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
125905500  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
125895325  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
125901675  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
125880414  pdpk1b; 3-phosphoinositide dependent protein kinase 1b [KO:K06276] [EC:2.7.11.1]
125903733  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
125880386  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
125889921  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
125903275  ptena; phosphatase and tensin homolog A isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
125880474  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
125903284  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125885562  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125898179  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
125900668  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125888855  akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125896538  sgk1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
125904954  si:ch211-195b13.1; STKc_SGK domain-containing protein isoform X1 [KO:K13302] [EC:2.7.11.1]
125892643  sgk2b; serine/threonine-protein kinase Sgk2b [KO:K13302] [EC:2.7.11.1]
125891544  sgk2a; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
125881732  sgk3; serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
125898818  forkhead box protein O1-A-like [KO:K07201]
125888651  foxo1a; forkhead box protein O1-A [KO:K07201]
125896773  foxo3b; forkhead box protein O3B [KO:K09408]
125905282  foxo6b; forkhead box protein O6b [KO:K09408]
125901310  foxo3a; forkhead box protein O3a [KO:K09408]
125894062  foxo4; forkhead box protein O6 [KO:K12358]
125893840  forkhead box protein O3-like [KO:K17847]
125896647  grm1a; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
125900357  grm1b; metabotropic glutamate receptor 1b isoform X1 [KO:K04603]
125902187  homer protein homolog 3 isoform X1 [KO:K15010]
125890052  homer1b; homer protein homolog 1b isoform X1 [KO:K15010]
125896213  LOW QUALITY PROTEIN: homer protein homolog 3-like [KO:K15010]
125903170  homer2; homer protein homolog 2 [KO:K15010]
125906339  homer protein homolog 1-like [KO:K15010]
125891159  agap2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
125895361  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1-like [KO:K17848]
125879914  casein kinase I [KO:K08960] [EC:2.7.11.1]
125880489  csnk1e; casein kinase I [KO:K08960] [EC:2.7.11.1]
125905248  interleukin-6-like [KO:K05405]
125891411  il10; interleukin-10 [KO:K05443]
125879355  stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
125894020  egf; pro-epidermal growth factor [KO:K04357]
125882095  melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
125902260  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
125885663  grb2a; growth factor receptor-bound protein 2a [KO:K04364]
125879149  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
125885879  son of sevenless homolog 1-like isoform X1 [KO:K03099]
125900475  sos2; son of sevenless homolog 2 [KO:K03099]
125887517  GTPase HRas [KO:K02833]
125880010  zgc:55558; GTPase KRas [KO:K07827]
125887085  kras; GTPase KRas isoform X1 [KO:K07827]
125882719  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
125891335  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
125890244  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
125888135  map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
125895747  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
125902384  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b isoform X1 [KO:K04369] [EC:2.7.12.2]
125890125  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
125878991  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
125882572  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
125882761  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
125891336  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
125897587  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
125891457  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
125891603  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
125886996  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
125895279  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
125878854  prmt1; protein arginine N-methyltransferase 1 isoform X1 [KO:K11434] [EC:2.1.1.319]
125904063  foxg1b; forkhead box protein G1b [KO:K09385]
125900863  foxg1a; forkhead box protein G1 [KO:K09385]
125888950  foxg1c; forkhead box protein G1c [KO:K09385]
125905887  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
125889518  cyclin N-terminal domain-containing protein 2 isoform X1 [KO:K21770]
125881056  G2/mitotic-specific cyclin-B2-like [KO:K21770]
125881064  G2/mitotic-specific cyclin-B2-like [KO:K21770]
125884393  ccnb3; G2/mitotic-specific cyclin-B3 isoform X1 [KO:K21771]
125902738  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
125887563  G1/S-specific cyclin-D1-like [KO:K04503]
125882679  G1/S-specific cyclin-D2-like [KO:K10151]
125879559  ccndx; cyclin Dx [KO:K10151]
125886786  ccnd2a; G1/S-specific cyclin-D2a isoform X1 [KO:K10151]
125890681  cyclin-G2-like [KO:K10146]
125905994  ccng2; cyclin-G2 [KO:K10146]
125885949  cdkn2a/b; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
125886232  cdkn2d; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
125882802  cdkn1d; cyclin-dependent kinase inhibitor 1D isoform X1 [KO:K06625]
125896012  cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
125887499  cdkn1bb; cyclin-dependent kinase inhibitor 1Bb [KO:K06624]
125882862  cdkn1ba; cyclin-dependent kinase inhibitor 1Ba [KO:K06624]
125887114  rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
125886396  plk1; serine/threonine-protein kinase PLK1 isoform X1 [KO:K06631] [EC:2.7.11.21]
125889842  plk2b; serine/threonine-protein kinase PLK2b [KO:K08861] [EC:2.7.11.21]
125902087  plk3; serine/threonine-protein kinase PLK3 [KO:K08862] [EC:2.7.11.21]
125900462  plk4; serine/threonine-protein kinase PLK4 [KO:K08863] [EC:2.7.11.21]
125895583  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
125889997  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
125896336  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
125902599  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
125905924  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
125905933  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
125901069  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
125895955  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
125894361  cd40lg; CD40 ligand [KO:K04389]
125903298  bcl2l11; bcl-2-like protein 11 [KO:K16341]
125881938  tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
125901463  tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
125902365  bcl6ab; BCL6A transcription repressor b [KO:K15618]
125895295  bcl6aa; BCL6A transcription repressor a isoform X1 [KO:K15618]
125903631  bnip4; BCL2 interacting protein 4 [KO:K15464]
125905914  zgc:73226; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
125893656  atg12; ubiquitin-like protein ATG12 [KO:K08336]
125883899  gabarapa; GABA(A) receptor-associated protein a [KO:K08341]
125893176  zgc:92606; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
125887819  gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
125881233  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
125886639  uncharacterized protein LOC125886639 [KO:K27679]
125887057  cat; catalase [KO:K03781] [EC:1.11.1.6]
125896581  sod2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
125888531  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
125882212  pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
125896920  pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
125878857  glucose-6-phosphatase catalytic subunit 1-like [KO:K01084] [EC:3.1.3.9]
125899216  glucose-6-phosphatase 2-like [KO:K01084] [EC:3.1.3.9]
125880315  g6pc3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
125881339  g6pc1a.2; glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
125881340  g6pc1a.1; glucose-6-phosphatase a, catalytic subunit, tandem duplicate 1 [KO:K01084] [EC:3.1.3.9]
125905939  il7r; interleukin-7 receptor subunit alpha [KO:K05072]
125895887  Krueppel-like factor 2 [KO:K17845]
125901696  Krueppel-like factor 2 [KO:K17845]
125896307  s1pr1; sphingosine 1-phosphate receptor 1 [KO:K04288]
125896368  s1pr4; sphingosine 1-phosphate receptor 4 [KO:K04293]
125888099  rag1; V(D)J recombination-activating protein 1 [KO:K10628] [EC:2.3.2.27]
125887447  rag2; V(D)J recombination-activating protein 2 [KO:K10988]
125897320  fbxo25; F-box only protein 25 isoform X1 [KO:K10305]
125893671  fbxo32; F-box only protein 32 [KO:K10305]
Compound
C00008  ADP
C00020  AMP
C00025  L-Glutamate
C00031  D-Glucose
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17470511
  Authors
Glauser DA, Schlegel W
  Title
The emerging role of FOXO transcription factors in pancreatic beta cells.
  Journal
J Endocrinol 193:195-207 (2007)
DOI:10.1677/JOE-06-0191
Reference
PMID:17522590
  Authors
van der Horst A, Burgering BM
  Title
Stressing the role of FoxO proteins in lifespan and disease.
  Journal
Nat Rev Mol Cell Biol 8:440-50 (2007)
DOI:10.1038/nrm2190
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:23325358
  Authors
Eijkelenboom A, Burgering BM
  Title
FOXOs: signalling integrators for homeostasis maintenance.
  Journal
Nat Rev Mol Cell Biol 14:83-97 (2013)
DOI:10.1038/nrm3507
Reference
PMID:17569704
  Authors
Daitoku H, Fukamizu A
  Title
FOXO transcription factors in the regulatory networks of longevity.
  Journal
J Biochem 141:769-74 (2007)
DOI:10.1093/jb/mvm104
Reference
PMID:19701188
  Authors
Hedrick SM
  Title
The cunning little vixen: Foxo and the cycle of life and death.
  Journal
Nat Immunol 10:1057-63 (2009)
DOI:10.1038/ni.1784
Reference
PMID:15516968
  Authors
Coffer PJ, Burgering BM
  Title
Forkhead-box transcription factors and their role in the immune system.
  Journal
Nat Rev Immunol 4:889-99 (2004)
DOI:10.1038/nri1488
Reference
PMID:22902436
  Authors
Ro SH, Liu D, Yeo H, Paik JH
  Title
FoxOs in neural stem cell fate decision.
  Journal
Arch Biochem Biophys 534:55-63 (2013)
DOI:10.1016/j.abb.2012.07.017
Reference
PMID:18403263
  Authors
Maiese K, Chong ZZ, Shang YC
  Title
OutFOXOing disease and disability: the therapeutic potential of targeting FoxO proteins.
  Journal
Trends Mol Med 14:219-27 (2008)
DOI:10.1016/j.molmed.2008.03.002
Reference
PMID:23801966
  Authors
Hagenbuchner J, Ausserlechner MJ
  Title
Mitochondria and FOXO3: breath or die.
  Journal
Front Physiol 4:147 (2013)
DOI:10.3389/fphys.2013.00147
Reference
PMID:18045156
  Authors
Maiese K, Chong ZZ, Shang YC
  Title
"Sly as a FOXO": new paths with Forkhead signaling in the brain.
  Journal
Curr Neurovasc Res 4:295-302 (2007)
DOI:10.2174/156720207782446306
Reference
PMID:22761423
  Authors
Oh HM, Yu CR, Dambuza I, Marrero B, Egwuagu CE
  Title
STAT3 protein interacts with Class O Forkhead transcription factors in the cytoplasm and regulates nuclear/cytoplasmic localization of FoxO1 and FoxO3a proteins in CD4(+) T cells.
  Journal
J Biol Chem 287:30436-43 (2012)
DOI:10.1074/jbc.M112.359661
Reference
PMID:21238503
  Authors
Huang H, Tindall DJ
  Title
Regulation of FOXO protein stability via ubiquitination and proteasome degradation.
  Journal
Biochim Biophys Acta 1813:1961-4 (2011)
DOI:10.1016/j.bbamcr.2011.01.007
Reference
PMID:16288288
  Authors
Greer EL, Brunet A
  Title
FOXO transcription factors at the interface between longevity and tumor suppression.
  Journal
Oncogene 24:7410-25 (2005)
DOI:10.1038/sj.onc.1209086
Reference
PMID:15084259
  Authors
Seoane J, Le HV, Shen L, Anderson SA, Massague J
  Title
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.
  Journal
Cell 117:211-23 (2004)
DOI:10.1016/S0092-8674(04)00298-3
Reference
PMID:18951090
  Authors
Yamagata K, Daitoku H, Takahashi Y, Namiki K, Hisatake K, Kako K, Mukai H, Kasuya Y, Fukamizu A
  Title
Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.
  Journal
Mol Cell 32:221-31 (2008)
DOI:10.1016/j.molcel.2008.09.013
Reference
PMID:16964248
  Authors
van der Horst A, de Vries-Smits AM, Brenkman AB, van Triest MH, van den Broek N, Colland F, Maurice MM, Burgering BM
  Title
FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP.
  Journal
Nat Cell Biol 8:1064-73 (2006)
DOI:10.1038/ncb1469
Reference
PMID:21613825
  Authors
Zhang Y, Gan B, Liu D, Paik JH
  Title
FoxO family members in cancer.
  Journal
Cancer Biol Ther 12:253-9 (2011)
DOI:10.4161/cbt.12.4.15954
Reference
PMID:15005655
  Authors
Van Der Heide LP, Hoekman MF, Smidt MP
  Title
The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation.
  Journal
Biochem J 380:297-309 (2004)
DOI:10.1042/BJ20040167
Related
pathway
efo00010  Glycolysis / Gluconeogenesis
efo00020  Citrate cycle (TCA cycle)
efo00190  Oxidative phosphorylation
efo04010  MAPK signaling pathway
efo04110  Cell cycle
efo04120  Ubiquitin mediated proteolysis
efo04140  Autophagy - animal
efo04210  Apoptosis
efo04350  TGF-beta signaling pathway
efo04910  Insulin signaling pathway
KO pathway
ko04068   
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