KEGG   PATHWAY: elk00230
Entry
elk00230                    Pathway                                
Name
Purine metabolism - Enhydra lutris kenyoni (northern sea otter)
Class
Metabolism; Nucleotide metabolism
Pathway map
elk00230  Purine metabolism
elk00230

Module
elk_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:elk00230]
elk_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:elk00230]
elk_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:elk00230]
elk_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:elk00230]
elk_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:elk00230]
elk_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:elk00230]
elk_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:elk00230]
Other DBs
GO: 0006163 0042278
Organism
Enhydra lutris kenyoni (northern sea otter) [GN:elk]
Gene
111157604  ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
111161136  manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
111155612  ADP-sugar pyrophosphatase isoform X1 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
111143383  phosphoglucomutase-1 isoform X1 [KO:K01835] [EC:5.4.2.2]
111148982  phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
111157154  ribose-phosphate pyrophosphokinase 2 isoform X1 [KO:K00948] [EC:2.7.6.1]
111147375  ribose-phosphate pyrophosphokinase 3 [KO:K00948] [EC:2.7.6.1]
111161303  ribose-phosphate pyrophosphokinase 1 isoform X1 [KO:K00948] [EC:2.7.6.1]
111149361  amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
111155699  trifunctional purine biosynthetic protein adenosine-3 isoform X1 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
111161131  phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
111149362  multifunctional protein ADE2 isoform X1 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
111157626  adenylosuccinate lyase isoform X1 [KO:K01756] [EC:4.3.2.2]
111141217  bifunctional purine biosynthesis protein PURH isoform X1 [KO:K00602] [EC:2.1.2.3 3.5.4.10]
111152805  adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
111160332  5'(3')-deoxyribonucleotidase, cytosolic type isoform X1 [KO:K01081] [EC:3.1.3.5]
111143569  cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
111144716  cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
111154161  cytosolic 5'-nucleotidase 1B isoform X1 [KO:K01081] [EC:3.1.3.5]
111139273  5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
111147462  5'-nucleotidase isoform X1 [KO:K19970] [EC:3.1.3.5]
111140568  purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
111147147  laccase domain-containing protein 1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
111162128  hypoxanthine-guanine phosphoribosyltransferase isoform X1 [KO:K00760] [EC:2.4.2.8]
111152011  inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
111143842  inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
111156030  nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
111156044  nucleoside diphosphate kinase, mitochondrial isoform X1 [KO:K00940] [EC:2.7.4.6]
111149129  nucleoside diphosphate kinase A-like [KO:K00940] [EC:2.7.4.6]
111150876  nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
111144125  nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
111151310  nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
111151311  nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
111158237  LOW QUALITY PROTEIN: adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
111159131  ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
111146334  ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
111145332  ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
111160259  soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
111156836  ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
111156630  ectonucleoside triphosphate diphosphohydrolase 6 isoform X1 [KO:K01511] [EC:3.6.1.6]
111148573  LOW QUALITY PROTEIN: ectonucleoside triphosphate diphosphohydrolase 5 [KO:K01511] [EC:3.6.1.6]
111155082  U8 snoRNA-decapping enzyme [KO:K16855] [EC:3.6.1.62 3.6.1.64]
111141752  inosine triphosphate pyrophosphatase isoform X1 [KO:K01519] [EC:3.6.1.66]
111154104  xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
111146086  bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
111149383  GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
111140465  GMP reductase 2 isoform X1 [KO:K00364] [EC:1.7.1.7]
111156646  GMP reductase 1 isoform X1 [KO:K00364] [EC:1.7.1.7]
111153586  guanine deaminase [KO:K01487] [EC:3.5.4.3]
111139422  guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
111159434  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
111146568  ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
111154179  ribonucleoside-diphosphate reductase subunit M2 isoform X1 [KO:K10808] [EC:1.17.4.1]
111147645  HD domain-containing protein 2 [KO:K07023] [EC:3.1.3.89]
111148172  deoxyguanosine kinase, mitochondrial isoform X1 [KO:K00904] [EC:2.7.1.113]
111149150  deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
111152620  guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform X1 [KO:K21138] [EC:3.1.7.2]
111162028  exopolyphosphatase PRUNE1 isoform X1 [KO:K01514] [EC:3.6.1.11]
111157054  adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
111153427  adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
111154044  adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
111162403  adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
111155044  adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
111157825  adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
111157326  adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
111146667  adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
111156133  adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
111147511  adenylate cyclase type 10-like isoform X1 [KO:K11265] [EC:4.6.1.1]
111150861  adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
111153821  LOW QUALITY PROTEIN: guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
111155838  guanylate cyclase soluble subunit alpha-3 [KO:K12318] [EC:4.6.1.2]
111147095  LOW QUALITY PROTEIN: guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
111154115  guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
111142267  heat-stable enterotoxin receptor isoform X1 [KO:K12320] [EC:4.6.1.2]
111161167  retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
111159348  olfactory guanylyl cyclase GC-D-like [KO:K12321] [EC:4.6.1.2]
111160977  LOW QUALITY PROTEIN: retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
111138909  atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
111146108  atrial natriuretic peptide receptor 2 isoform X1 [KO:K12324] [EC:4.6.1.2]
111147299  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
111143001  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
111157862  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
111159411  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1 [KO:K18283] [EC:3.1.4.17]
111142110  LOW QUALITY PROTEIN: cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
111159494  cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
111153963  cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
111140965  rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha [KO:K08718] [EC:3.1.4.35]
111149075  rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta isoform X1 [KO:K13756] [EC:3.1.4.35]
111144918  cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
111143562  retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform X1 [KO:K13758]
111160255  retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
111142046  retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
111155736  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [KO:K13761] [EC:3.1.4.35]
111158707  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
111142610  dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
111150816  adenylosuccinate synthetase isozyme 2 isoform X1 [KO:K01939] [EC:6.3.4.4]
111148539  adenylosuccinate synthetase isozyme 1 isoform X1 [KO:K01939] [EC:6.3.4.4]
111143295  AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
111159462  AMP deaminase 3 [KO:K01490] [EC:3.5.4.6]
111143131  AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
111144874  adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
111141392  adenosine deaminase [KO:K01488] [EC:3.5.4.4]
111159759  adenosine deaminase 2 isoform X1 [KO:K19572] [EC:3.5.4.4]
111146225  adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
111143296  adenylate kinase 4, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
111143409  adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
111143432  adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
111146144  adenylate kinase isoenzyme 1 isoform X1 [KO:K00939] [EC:2.7.4.3]
111148653  adenylate kinase 7 isoform X1 [KO:K00939] [EC:2.7.4.3]
111161645  adenylate kinase isoenzyme 1-like [KO:K00939] [EC:2.7.4.3]
111155220  adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
111158845  GTP:AMP phosphotransferase AK3, mitochondrial-like [KO:K00944] [EC:2.7.4.10]
111153561  GTP:AMP phosphotransferase AK3, mitochondrial isoform X1 [KO:K00944] [EC:2.7.4.10]
111160507  cancer-related nucleoside-triphosphatase isoform X1 [KO:K06928] [EC:3.6.1.15]
111147804  ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
111147510  ectonucleotide pyrophosphatase/phosphodiesterase family member 3 isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
111143791  cAMP-specific 3',5'-cyclic phosphodiesterase 4C [KO:K13293] [EC:3.1.4.53]
111156885  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
111162526  cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
111143034  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
111155366  high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
111147667  cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
111152625  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
111148266  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
111144098  bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
111147834  bis(5'-adenosyl)-triphosphatase ENPP4 isoform X1 [KO:K18424] [EC:3.6.1.29]
111144951  LOW QUALITY PROTEIN: bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
111153873  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
111143395  uricase [KO:K00365] [EC:1.7.3.3]
111152931  5-hydroxyisourate hydrolase-like [KO:K07127] [EC:3.5.2.17]
111158587  putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
111154112  probable allantoicase [KO:K01477] [EC:3.5.3.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
elk00030  Pentose phosphate pathway
elk00220  Arginine biosynthesis
elk00250  Alanine, aspartate and glutamate metabolism
elk00260  Glycine, serine and threonine metabolism
elk00340  Histidine metabolism
elk00630  Glyoxylate and dicarboxylate metabolism
elk00730  Thiamine metabolism
elk00740  Riboflavin metabolism
elk00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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