KEGG   PATHWAY: lja04141
Entry
lja04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Lotus japonicus
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
lja04141  Protein processing in endoplasmic reticulum
lja04141

Other DBs
GO: 0030433 0034976
Organism
Lotus japonicus [GN:lja]
Gene
130710297  uncharacterized protein LOC130710297 [KO:K10956]
130724209  preprotein translocase subunit SECY, chloroplastic [KO:K10956]
130749251  protein transport protein Sec61 subunit beta-like [KO:K09481]
130733920  protein transport protein Sec61 subunit beta-like [KO:K09481]
130740432  protein transport protein Sec61 subunit beta [KO:K09481]
130715710  protein transport protein Sec61 subunit gamma-like [KO:K07342]
130733523  protein transport protein Sec61 subunit gamma [KO:K07342]
130723962  uncharacterized protein LOC130723962 [KO:K12275]
130722401  dnaJ protein ERDJ2A-like [KO:K09540]
130717804  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1B [KO:K12666]
130729169  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1A [KO:K12666]
130717813  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [KO:K12667]
130715930  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1-like [KO:K12668]
130740176  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
130747445  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
130738617  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
130739010  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
130718183  probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3B [KO:K19478]
130723063  uncharacterized protein LOC130723063 [KO:K26501]
130710987  uncharacterized protein LOC130710987 [KO:K26502]
130711264  mannosyl-oligosaccharide glucosidase GCS1 [KO:K01228] [EC:3.2.1.106]
130723049  heat shock 70 kDa protein 17 [KO:K09486]
130710682  luminal-binding protein 5 [KO:K09490] [EC:3.6.4.10]
130731172  luminal-binding protein 4-like [KO:K09490] [EC:3.6.4.10]
130731063  dnaJ protein ERDJ3B [KO:K09517]
130730366  dnaJ protein P58IPK homolog [KO:K09523]
130732913  heat shock protein 90-6, mitochondrial [KO:K09487]
130732914  heat shock protein 90-6, mitochondrial-like isoform X1 [KO:K09487]
130717090  endoplasmin homolog [KO:K09487]
130739689  heat shock protein 90-5, chloroplastic [KO:K09487]
130713981  probable glucan 1,3-alpha-glucosidase [KO:K05546] [EC:3.2.1.207]
130711536  glucosidase 2 subunit beta isoform X1 [KO:K08288]
130710741  calnexin homolog [KO:K08054]
130715997  calnexin homolog [KO:K08054]
130717132  calreticulin [KO:K08057]
130728365  calreticulin-3-like [KO:K08057]
130747387  calreticulin-3 [KO:K08057]
130715612  mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS1-like [KO:K01230] [EC:3.2.1.113]
130745689  mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS1 [KO:K01230] [EC:3.2.1.113]
130722204  mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS3 [KO:K23741] [EC:3.2.1.209]
130716107  SEC12-like protein 2 [KO:K14003]
130717935  SEC12-like protein 1 [KO:K14003]
130718463  SEC12-like protein 2 isoform X1 [KO:K14003]
130710112  GTP-binding protein SAR1A-like [KO:K07953] [EC:3.6.5.-]
130717136  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
130730917  GTP-binding protein SAR1A-like [KO:K07953] [EC:3.6.5.-]
130723848  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
130733073  protein transport protein SEC13 homolog B [KO:K14004]
130724041  protein transport protein SEC13 homolog B-like [KO:K14004]
130747888  protein transport protein SEC31 homolog B [KO:K14005]
130710601  protein transport protein SEC23 E isoform X1 [KO:K14006]
130743253  protein transport protein SEC23 C [KO:K14006]
130722642  protein transport protein SEC23 E-like [KO:K14006]
130723417  protein transport protein SEC23 G [KO:K14006]
130716857  protein transport protein SEC24 C-like isoform X1 [KO:K14007]
130730939  protein transport protein SEC24 A [KO:K14007]
130723579  UDP-glucose:glycoprotein glucosyltransferase isoform X1 [KO:K11718] [EC:2.4.1.-]
130714471  alpha-mannosidase I MNS5 [KO:K10084]
130717584  alpha-mannosidase I MNS4 isoform X1 [KO:K10085]
130748534  protein disulfide isomerase-like 1-6 [KO:K09580] [EC:5.3.4.1]
130738127  protein disulfide-isomerase-like [KO:K09580] [EC:5.3.4.1]
130740410  protein disulfide isomerase-like 1-4 [KO:K09580] [EC:5.3.4.1]
130746745  protein disulfide isomerase-like 1-4 [KO:K09580] [EC:5.3.4.1]
130718416  protein disulfide-isomerase 5-2 [KO:K09580] [EC:5.3.4.1]
130717079  probable protein disulfide-isomerase A6 [KO:K09584] [EC:5.3.4.1]
130730915  probable protein disulfide-isomerase A6 [KO:K09584] [EC:5.3.4.1]
130733507  protein disulfide isomerase-like 2-3 [KO:K09584] [EC:5.3.4.1]
130723396  endoplasmic reticulum oxidoreductin-1-like isoform X1 [KO:K10950] [EC:1.8.4.-]
130724327  endoplasmic reticulum oxidoreductin-1-like [KO:K10950] [EC:1.8.4.-]
130726048  protein OS-9 homolog [KO:K10088]
130747715  translocon-associated protein subunit alpha [KO:K13249]
130729760  uncharacterized protein LOC130729760 [KO:K13250]
130748467  uncharacterized protein LOC130748467 [KO:K14009]
130724659  uncharacterized protein LOC130724659 [KO:K14009]
130729371  uncharacterized protein LOC130729371 [KO:K14009]
130747043  uncharacterized protein LOC130747043 [KO:K14009]
130726213  derlin-2.2 [KO:K13989]
130710325  derlin-1 [KO:K13989]
130714407  plant UBX domain-containing protein 2 [KO:K14011]
130714375  plant UBX domain-containing protein 4-like [KO:K14012]
130724344  plant UBX domain-containing protein 4 [KO:K14012]
130734485  cell division cycle protein 48 homolog [KO:K13525]
130717047  cell division control protein 48 homolog E-like [KO:K13525]
130730332  cell division cycle protein 48 homolog [KO:K13525]
130747244  cell division cycle protein 48 homolog isoform X1 [KO:K13525]
130730877  NPL4-like protein 2 [KO:K14015]
130715664  uncharacterized protein LOC130715664 [KO:K14016]
130740573  uncharacterized protein LOC130740573 [KO:K14016]
130722048  uncharacterized protein LOC130722048 [KO:K14016]
130725755  heat shock cognate 70 kDa protein 2-like [KO:K03283]
130726153  heat shock 70 kDa protein-like [KO:K03283]
130736529  heat shock cognate 70 kDa protein-like [KO:K03283]
130710575  heat shock 70 kDa protein [KO:K03283]
130739136  heat shock cognate 70 kDa protein-like isoform X1 [KO:K03283]
130739137  heat shock cognate 70 kDa protein-like [KO:K03283]
130739758  heat shock cognate 70 kDa protein-like [KO:K03283]
130740529  heat shock cognate 70 kDa protein 2 [KO:K03283]
130717461  heat shock 70 kDa protein 18-like [KO:K03283]
130728050  heat shock cognate 70 kDa protein-like [KO:K03283]
130728731  heat shock cognate 70 kDa protein-like [KO:K03283]
130728736  heat shock cognate 70 kDa protein-like [KO:K03283]
130728739  heat shock cognate 70 kDa protein-like isoform X1 [KO:K03283]
130728744  heat shock 70 kDa protein 18-like [KO:K03283]
130728746  heat shock cognate 70 kDa protein-like [KO:K03283]
130728750  heat shock cognate 70 kDa protein-like [KO:K03283]
130728752  heat shock cognate 70 kDa protein-like [KO:K03283]
130728756  heat shock cognate 70 kDa protein-like [KO:K03283]
130728758  heat shock cognate 70 kDa protein-like [KO:K03283]
130728759  heat shock cognate 70 kDa protein-like [KO:K03283]
130728760  heat shock cognate 70 kDa protein-like [KO:K03283]
130728782  heat shock 70 kDa protein 18-like [KO:K03283]
130728785  heat shock 70 kDa protein 18-like [KO:K03283]
130728826  heat shock cognate 70 kDa protein 2-like [KO:K03283]
130728832  heat shock 70 kDa protein 18-like [KO:K03283]
130728833  heat shock cognate 70 kDa protein 2-like isoform X1 [KO:K03283]
130728834  heat shock cognate 70 kDa protein 2-like isoform X1 [KO:K03283]
130728838  heat shock cognate 70 kDa protein 2-like [KO:K03283]
130728841  heat shock cognate 70 kDa protein-like [KO:K03283]
130728842  heat shock cognate 70 kDa protein 2-like [KO:K03283]
130728843  heat shock cognate 70 kDa protein 2-like [KO:K03283]
130728844  heat shock cognate 70 kDa protein-like [KO:K03283]
130728845  heat shock 70 kDa protein 4-like [KO:K03283]
130728847  heat shock 70 kDa protein 4-like [KO:K03283]
130728848  heat shock cognate 70 kDa protein-like [KO:K03283]
130728849  heat shock cognate 70 kDa protein-like [KO:K03283]
130728850  heat shock 70 kDa protein 4-like [KO:K03283]
130728851  heat shock cognate 70 kDa protein-like [KO:K03283]
130728853  heat shock cognate 70 kDa protein 2-like [KO:K03283]
130728885  heat shock cognate 70 kDa protein 2-like [KO:K03283]
130728886  heat shock cognate 70 kDa protein 2-like [KO:K03283]
130745710  heat shock 70 kDa protein 4-like [KO:K03283]
130729291  heat shock cognate 70 kDa protein 2-like [KO:K03283]
130722248  stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283]
130722546  heat shock cognate 70 kDa protein-like [KO:K03283]
130730450  heat shock cognate 70 kDa protein 2-like [KO:K03283]
130731075  stromal 70 kDa heat shock-related protein, chloroplastic-like [KO:K03283]
130718780  heat shock cognate 70 kDa protein 2-like [KO:K03283]
130745153  dnaJ protein homolog 2-like [KO:K09503]
130747079  dnaJ protein homolog [KO:K09503]
130748362  dnaJ protein homolog ANJ1 [KO:K09503]
130723132  chaperone protein dnaJ 49 [KO:K09518]
130732970  heat shock protein 90-2 [KO:K04079]
130738108  heat shock protein 83 [KO:K04079]
130721522  heat shock protein 83-like [KO:K04079]
130723112  heat shock cognate protein 80 [KO:K04079]
130726259  uncharacterized protein LOC130726259 [KO:K09562]
130749753  hsp70 nucleotide exchange factor fes1 isoform X1 [KO:K09562]
130732145  17.6 kDa class II heat shock protein-like [KO:K13993]
130725019  17.1 kDa class II heat shock protein [KO:K13993]
130733644  18.2 kDa class I heat shock protein-like [KO:K13993]
130733646  17.8 kDa class I heat shock protein-like [KO:K13993]
130734168  18.2 kDa class I heat shock protein-like [KO:K13993]
130736692  15.7 kDa heat shock protein, peroxisomal-like [KO:K13993]
130737042  18.1 kDa class I heat shock protein-like [KO:K13993]
130714701  18.5 kDa class I heat shock protein [KO:K13993]
130716628  22.0 kDa class IV heat shock protein [KO:K13993]
130718151  17.9 kDa class II heat shock protein [KO:K13993]
130718372  17.9 kDa class II heat shock protein-like [KO:K13993]
130729229  18.1 kDa class I heat shock protein-like [KO:K13993]
130745810  26.5 kDa heat shock protein, mitochondrial [KO:K13993]
130720976  17.9 kDa class II heat shock protein-like [KO:K13993]
130729922  16.9 kDa class I heat shock protein 1-like [KO:K13993]
130745991  small heat shock protein, chloroplastic [KO:K13993]
130746412  17.4 kDa class III heat shock protein [KO:K13993]
130721527  17.9 kDa class II heat shock protein-like [KO:K13993]
130722538  small heat shock protein, chloroplastic-like [KO:K13993]
130747294  17.5 kDa class I heat shock protein-like [KO:K13993]
130723343  15.4 kDa class V heat shock protein [KO:K13993]
130747856  heat shock 22 kDa protein, mitochondrial-like isoform X1 [KO:K13993]
130748295  17.8 kDa class I heat shock protein-like [KO:K13993]
130723990  small heat shock protein, chloroplastic-like [KO:K13993]
130715521  18.5 kDa class I heat shock protein-like [KO:K13993]
130733763  15.7 kDa heat shock protein, peroxisomal [KO:K13993]
130733116  OVARIAN TUMOR DOMAIN-containing deubiquitinating enzyme 2 isoform X1 [KO:K13719] [EC:3.1.2.-]
130747441  uncharacterized protein LOC130747441 [KO:K14018]
130748497  ubiquitin receptor RAD23b-like [KO:K10839]
130739553  ubiquitin receptor RAD23c-like [KO:K10839]
130717176  ubiquitin receptor RAD23d-like isoform X1 [KO:K10839]
130728990  ubiquitin receptor RAD23d-like [KO:K10839]
130710480  ubiquitin domain-containing protein DSK2a-like [KO:K04523]
130740369  ubiquitin domain-containing protein DSK2b-like [KO:K04523]
130731260  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase [KO:K01456] [EC:3.5.1.52]
130749378  ataxin-3 homolog [KO:K11863] [EC:3.4.22.-]
130739415  probable ubiquitin conjugation factor E4 [KO:K10597] [EC:2.3.2.27]
130727690  eukaryotic translation initiation factor 2 subunit alpha homolog [KO:K03237]
130738969  subtilisin-like protease SBT6.1 [KO:K08653] [EC:3.4.21.112]
130711547  membrane-bound transcription factor site-2 protease homolog [KO:K07765] [EC:3.4.24.85]
130710778  serine/threonine-protein kinase/endoribonuclease IRE1a-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
130713405  serine/threonine-protein kinase/endoribonuclease IRE1-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
130740347  serine/threonine-protein kinase/endoribonuclease IRE1a [KO:K08852] [EC:2.7.11.1 3.1.26.-]
130710100  probable E3 ubiquitin ligase SUD1 isoform X1 [KO:K10661] [EC:2.3.2.27]
130714450  ubiquitin-conjugating enzyme E2 32-like [KO:K10578] [EC:2.3.2.23]
130723216  ubiquitin-conjugating enzyme E2 32-like [KO:K10578] [EC:2.3.2.23]
130746389  ubiquitin-conjugating enzyme E2 34-like [KO:K04554] [EC:2.3.2.23]
130740524  ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:2.3.2.23]
130743380  ubiquitin-conjugating enzyme E2 7-like [KO:K10575] [EC:2.3.2.23]
130741329  ERAD-associated E3 ubiquitin-protein ligase HRD1B-like [KO:K10601] [EC:2.3.2.27]
130722103  ERAD-associated E3 ubiquitin-protein ligase HRD1B-like [KO:K10601] [EC:2.3.2.27]
130748841  E3 ubiquitin-protein ligase RMA3-like [KO:K10666] [EC:2.3.2.27]
130746790  E3 ubiquitin-protein ligase RMA1H1-like [KO:K10666] [EC:2.3.2.27]
130723851  E3 ubiquitin-protein ligase RMA1H1-like [KO:K10666] [EC:2.3.2.27]
130718303  uncharacterized protein LOC130718303 isoform X1 [KO:K10666] [EC:2.3.2.27]
130730712  uncharacterized protein LOC130730712 [KO:K10666] [EC:2.3.2.27]
130740762  uncharacterized protein LOC130740762 [KO:K10666] [EC:2.3.2.27]
130716119  ERAD-associated E3 ubiquitin-protein ligase component HRD3A [KO:K14026]
130744641  E3 ubiquitin protein ligase RIN2-like [KO:K10636] [EC:2.3.2.36]
130743281  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
130733856  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
130714385  ubiquitin-conjugating enzyme E2 28-like [KO:K06689] [EC:2.3.2.23]
130715210  ubiquitin-conjugating enzyme E2 28-like [KO:K06689] [EC:2.3.2.23]
130741503  ubiquitin-conjugating enzyme E2 10 [KO:K06689] [EC:2.3.2.23]
130742439  ubiquitin-conjugating enzyme E2-17 kDa-like [KO:K06689] [EC:2.3.2.23]
130728101  ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:2.3.2.23]
130728809  ubiquitin-conjugating enzyme E2-17 kDa-like [KO:K06689] [EC:2.3.2.23]
130731801  ubiquitin-conjugating enzyme E2 28-like isoform X1 [KO:K06689] [EC:2.3.2.23]
130747593  ubiquitin-conjugating enzyme E2 28-like [KO:K06689] [EC:2.3.2.23]
130723619  ubiquitin-conjugating enzyme E2-17 kDa-like [KO:K06689] [EC:2.3.2.23]
130749032  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
130749219  RING-box protein 1a-like [KO:K03868] [EC:2.3.2.32]
130747013  RING-box protein 1a-like [KO:K03868] [EC:2.3.2.32]
130711350  cullin-1-like [KO:K03347]
130722612  cullin-1 [KO:K03347]
130735704  SKP1-like protein 1A [KO:K03094]
130735857  SKP1-like protein 1A [KO:K03094]
130714098  SKP1-like protein 1A [KO:K03094]
130714204  SKP1-like protein 1A [KO:K03094]
130740605  SKP1-like protein 1A [KO:K03094]
130742514  SKP1-like protein 1A [KO:K03094]
130718174  SKP1-like protein 1B [KO:K03094]
130744661  SKP1-like protein 11 [KO:K03094]
130744663  SKP1-like protein 14 [KO:K03094]
130720020  SKP1-like protein 1A [KO:K03094]
130745678  SKP1-like protein 14 [KO:K03094]
130721021  SKP1-like protein 1A [KO:K03094]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
lja00510  N-Glycan biosynthesis
lja03050  Proteasome
lja03060  Protein export
KO pathway
ko04141   
LinkDB

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