KEGG   PATHWAY: mdo00230
Entry
mdo00230                    Pathway                                
Name
Purine metabolism - Monodelphis domestica (gray short-tailed opossum)
Class
Metabolism; Nucleotide metabolism
Pathway map
mdo00230  Purine metabolism
mdo00230

Module
mdo_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:mdo00230]
mdo_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:mdo00230]
mdo_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:mdo00230]
mdo_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:mdo00230]
mdo_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:mdo00230]
mdo_M00546  Purine degradation, xanthine => urea [PATH:mdo00230]
mdo_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:mdo00230]
mdo_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:mdo00230]
Other DBs
GO: 0006163 0042278
Organism
Monodelphis domestica (gray short-tailed opossum) [GN:mdo]
Gene
100016868  NUDT9; nudix hydrolase 9 [KO:K13988] [EC:3.6.1.13]
100031391  ADPRM; ADP-ribose/CDP-alcohol diphosphatase, manganese dependent [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
100013664  NUDT5; nudix hydrolase 5 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
100031421  PGM1; phosphoglucomutase-1 [KO:K01835] [EC:5.4.2.2]
100027227  phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
100022672  PGM2; phosphoglucomutase 2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
100017982  PRPS2; phosphoribosyl pyrophosphate synthetase 2 [KO:K00948] [EC:2.7.6.1]
100014432  ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
107649340  PPAT; phosphoribosyl pyrophosphate amidotransferase [KO:K00764] [EC:2.4.2.14]
100026350  GART; phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
100013885  PFAS; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
100012535  PAICS; phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase [KO:K01587] [EC:4.1.1.21 6.3.2.6]
100027748  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
100012538  ATIC; 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
100019032  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
100027156  NT5C1A; 5'-nucleotidase, cytosolic IA [KO:K01081] [EC:3.1.3.5]
100022628  NT5C2; 5'-nucleotidase, cytosolic II [KO:K01081] [EC:3.1.3.5]
100009896  NT5M; 5',3'-nucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
100029956  NT5C1B; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
100027605  NT5C; 5', 3'-nucleotidase, cytosolic [KO:K01081] [EC:3.1.3.5]
100032364  5'-nucleotidase-like [KO:K01081] [EC:3.1.3.5]
100025946  NT5DC4; 5'-nucleotidase domain containing 4 [KO:K01081] [EC:3.1.3.5]
100024945  NT5E; 5'-nucleotidase ecto [KO:K19970] [EC:3.1.3.5]
100014324  purine nucleoside phosphorylase-like [KO:K03783] [EC:2.4.2.1]
100029558  PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
100011850  LACC1; laccase domain containing 1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
554237  HPRT1; hypoxanthine phosphoribosyltransferase 1 [KO:K00760] [EC:2.4.2.8]
103092060  hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
100019123  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 [KO:K00088] [EC:1.1.1.205]
100020776  IMPDH2; inosine monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
100010534  NME3; NME/NM23 nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
100019176  NME7; NME/NM23 family member 7 [KO:K00940] [EC:2.7.4.6]
100012826  NME2; NME/NM23 nucleoside diphosphate kinase 2 [KO:K00940] [EC:2.7.4.6]
100012868  NME1; NME/NM23 nucleoside diphosphate kinase 1 [KO:K00940] [EC:2.7.4.6]
100010263  NME6; NME/NM23 nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
103101146  NME4; NME/NM23 nucleoside diphosphate kinase 4 [KO:K00940] [EC:2.7.4.6]
100029154  AK9; adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
100022843  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
100025436  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
100022899  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
100023686  ectonucleoside triphosphate diphosphohydrolase 8-like [KO:K01510] [EC:3.6.1.5]
100026552  CANT1; calcium activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
100021277  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 [KO:K12305] [EC:3.6.1.6]
100033226  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 (putative) [KO:K01511] [EC:3.6.1.6]
100024118  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 [KO:K01511] [EC:3.6.1.6]
100029401  NUDT16; nudix hydrolase 16 [KO:K16855] [EC:3.6.1.62 3.6.1.64]
100026846  ITPA; inosine triphosphatase [KO:K01519] [EC:3.6.1.66]
100031481  XDH; xanthine dehydrogenase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
100021241  NUDT2; nudix hydrolase 2 [KO:K01518] [EC:3.6.1.17]
100019487  GMPS; guanine monophosphate synthase [KO:K01951] [EC:6.3.5.2]
100025714  GMPR; guanosine monophosphate reductase [KO:K00364] [EC:1.7.1.7]
100030802  GMPR2; guanosine monophosphate reductase 2 [KO:K00364] [EC:1.7.1.7]
100014959  GDA; guanine deaminase [KO:K01487] [EC:3.5.4.3]
100026017  GUK1; guanylate kinase 1 [KO:K00942] [EC:2.7.4.8]
100013713  RRM1; ribonucleotide reductase catalytic subunit M1 [KO:K10807] [EC:1.17.4.1]
100030856  RRM2B; ribonucleotide reductase regulatory TP53 inducible subunit M2B [KO:K10808] [EC:1.17.4.1]
100031990  RRM2; ribonucleotide reductase regulatory subunit M2 [KO:K10808] [EC:1.17.4.1]
100030656  HDDC2; HD domain containing 2 [KO:K07023] [EC:3.1.3.89]
100023732  DGUOK; deoxyguanosine kinase [KO:K00904] [EC:2.7.1.113]
100014536  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
100014823  HDDC3; HD domain containing 3 [KO:K21138] [EC:3.1.7.2]
100017806  PRUNE1; prune exopolyphosphatase [KO:K01514] [EC:3.6.1.11]
100030463  ADCY1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1]
100013164  ADCY2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1]
100025332  ADCY3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
100030872  ADCY4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
100019274  ADCY5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
100013823  ADCY7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
100026554  ADCY8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
100013831  ADCY9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
100018346  ADCY10; adenylate cyclase 10, soluble [KO:K11265] [EC:4.6.1.1]
100017038  GUCY1A3; guanylate cyclase 1 soluble subunit alpha [KO:K12318] [EC:4.6.1.2]
100027037  GUCY1A2; guanylate cyclase 1 soluble subunit alpha 2 [KO:K12318] [EC:4.6.1.2]
100028289  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
100024008  GUCY1B3; guanylate cyclase 1 soluble subunit beta [KO:K12319] [EC:4.6.1.2]
100016988  GUCY2C; guanylate cyclase 2C [KO:K12320] [EC:4.6.1.2]
100014788  GUCY2D; guanylate cyclase 2D, retinal [KO:K12321] [EC:4.6.1.2]
100028110  olfactory guanylyl cyclase GC-D-like [KO:K12321] [EC:4.6.1.2]
100027754  guanylate cyclase 2G-like [KO:K22600] [EC:4.6.1.2]
100019736  NPR1; natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
100020156  NPR2; natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
100024379  atrial natriuretic peptide receptor 1-like [KO:K12324] [EC:4.6.1.2]
100027573  PDE1A; phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
100019026  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
100014975  PDE2A; phosphodiesterase 2A [KO:K18283] [EC:3.1.4.17]
100011746  PDE3A; phosphodiesterase 3A [KO:K19021] [EC:3.1.4.17]
100029160  PDE3B; phosphodiesterase 3B [KO:K13296] [EC:3.1.4.17]
100018314  PDE5A; phosphodiesterase 5A [KO:K13762] [EC:3.1.4.35]
100028818  PDE6A; phosphodiesterase 6A [KO:K08718] [EC:3.1.4.35]
100018608  PDE6B; phosphodiesterase 6B [KO:K13756] [EC:3.1.4.35]
100023714  PDE6C; phosphodiesterase 6C [KO:K13757] [EC:3.1.4.35]
100021852  PDE6D; phosphodiesterase 6D [KO:K13758]
100025770  PDE6G; phosphodiesterase 6G [KO:K13759]
100011684  PDE6H; phosphodiesterase 6H [KO:K13760]
100024005  PDE9A; phosphodiesterase 9A [KO:K13761] [EC:3.1.4.35]
100032566  PDE10A; phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
100026785  PDE11A; phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
100016321  ADSSL1; adenylosuccinate synthase like 1 [KO:K01939] [EC:6.3.4.4]
100027228  ADSS; adenylosuccinate synthase [KO:K01939] [EC:6.3.4.4]
100033068  AMPD2; adenosine monophosphate deaminase 2 [KO:K01490] [EC:3.5.4.6]
100029814  AMPD3; adenosine monophosphate deaminase 3 [KO:K01490] [EC:3.5.4.6]
100009726  AMPD1; adenosine monophosphate deaminase 1 [KO:K01490] [EC:3.5.4.6]
100011774  ADK; adenosine kinase [KO:K00856] [EC:2.7.1.20]
100619873  ADA; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
100021637  CECR1; cat eye syndrome chromosome region, candidate 1 [KO:K19572] [EC:3.5.4.4]
100011946  AK1; adenylate kinase 1 [KO:K00939] [EC:2.7.4.3]
100017433  AK4; adenylate kinase 4 [KO:K00939] [EC:2.7.4.3]
100023866  AK7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
100026105  AK2; adenylate kinase 2 [KO:K00939] [EC:2.7.4.3]
100025761  adenylate kinase isoenzyme 1 [KO:K00939] [EC:2.7.4.3]
100017521  AK8; adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
103098847  adenylate kinase isoenzyme 5-like [KO:K00939] [EC:2.7.4.3]
100015977  AK6; adenylate kinase 6 [KO:K18532] [EC:2.7.4.3]
100014818  AK3; adenylate kinase 3 [KO:K00944] [EC:2.7.4.10]
100022598  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
100021763  NTPCR; nucleoside-triphosphatase, cancer-related [KO:K06928] [EC:3.6.1.15]
100031043  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
100031034  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
100012755  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A [KO:K13293] [EC:3.1.4.53]
100014218  PDE4C; phosphodiesterase 4C [KO:K13293] [EC:3.1.4.53]
100032166  PDE4D; phosphodiesterase 4D [KO:K13293] [EC:3.1.4.53]
100030953  PDE4B; phosphodiesterase 4B [KO:K13293] [EC:3.1.4.53]
100029397  PDE7A; phosphodiesterase 7A [KO:K18436] [EC:3.1.4.53]
100031447  PDE7B; phosphodiesterase 7B [KO:K18436] [EC:3.1.4.53]
100020085  PDE8B; phosphodiesterase 8B [KO:K18437] [EC:3.1.4.53]
100010222  PDE8A; phosphodiesterase 8A [KO:K18437] [EC:3.1.4.53]
100016692  FHIT; fragile histidine triad [KO:K01522] [EC:3.6.1.29]
100012154  ENPP4; ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) [KO:K18424] [EC:3.6.1.29]
100022288  PAPSS2; 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
100012218  PAPSS1; 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
100012925  uricase-like [KO:K00365] [EC:1.7.3.3]
100027752  5-hydroxyisourate hydrolase-like [KO:K07127] [EC:3.5.2.17]
100025244  URAD; ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase [KO:K13485] [EC:4.1.1.97]
100021695  allantoinase, mitochondrial-like [KO:K01466] [EC:3.5.2.5]
100032281  ALLC; allantoicase [KO:K01477] [EC:3.5.3.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
mdo00030  Pentose phosphate pathway
mdo00220  Arginine biosynthesis
mdo00250  Alanine, aspartate and glutamate metabolism
mdo00260  Glycine, serine and threonine metabolism
mdo00340  Histidine metabolism
mdo00630  Glyoxylate and dicarboxylate metabolism
mdo00730  Thiamine metabolism
mdo00740  Riboflavin metabolism
mdo00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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