KEGG   PATHWAY: mdo04625
Entry
mdo04625                    Pathway                                
Name
C-type lectin receptor signaling pathway - Monodelphis domestica (gray short-tailed opossum)
Description
C-type lectin receptors (CLRs) are a large superfamily of proteins characterized by the presence of one or more C-type lectin-like domains (CTLDs). CLRs function as pattern-recognition receptors (PRRs) for pathogen-derived ligands in dendric cells, macrophages, neutrophils, etc., such as Dectin-1 and Dectin-2 for recognition of fungi-derived B-glucan and high mannose-type carbohydrates. Upon ligand binding, CLRs stimulate intracellular signaling cascades that induce the production of inflammatory cytokines and chemokines, consequently triggering innate and adaptive immunity to pathogens.
Class
Organismal Systems; Immune system
Pathway map
mdo04625  C-type lectin receptor signaling pathway
mdo04625

Organism
Monodelphis domestica (gray short-tailed opossum) [GN:mdo]
Gene
100032921  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
554186  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
554197  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
100022523  GTPase NRas-like [KO:K07828]
100017121  MRAS; muscle RAS oncogene homolog [KO:K07831]
100030293  RRAS; related RAS viral (r-ras) oncogene homolog [KO:K07829]
100020614  RRAS2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
100015410  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
100030053  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
100618518  RELB; RELB proto-oncogene, NF-kB subunit [KO:K09253]
100018516  IL12A; interleukin 12A [KO:K05406]
100030276  IL12B; interleukin 12B [KO:K05425]
100026024  IL1B; interleukin 1 beta [KO:K04519]
100028356  tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
100028991  PTPN11; protein tyrosine phosphatase, non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
100023824  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
100020668  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
100027952  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
100029209  NFKB2; nuclear factor kappa B subunit 2 [KO:K04469]
100027579  PLCG2; phospholipase C gamma 2 [KO:K05859] [EC:3.1.4.11]
100013305  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
100010212  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
100025596  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
100021688  CALM3; calmodulin 3 [KO:K02183]
100018191  CALM1; calmodulin 1 [KO:K02183]
100032171  CALM2; calmodulin 2 [KO:K02183]
100025795  CALML4; calmodulin like 4 [KO:K02183]
100015722  calmodulin-alpha-like [KO:K02183]
100022649  calmodulin-alpha-like [KO:K02183]
100014900  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
100011077  PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
100033104  PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
100033302  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
100023153  NFATC1; nuclear factor of activated T-cells 1 [KO:K04446]
100028435  NFATC2; nuclear factor of activated T-cells 2 [KO:K17332]
100021991  NFATC3; nuclear factor of activated T-cells 3 [KO:K17333]
100025432  NFATC4; nuclear factor of activated T-cells 4 [KO:K17334]
100619184  IL2; interleukin 2 [KO:K05429]
100616748  IL10; interleukin 10 [KO:K05443]
100017006  EGR2; early growth response 2 [KO:K12496]
100033116  EGR3; early growth response 3 [KO:K12497]
100024802  PTGS2; prostaglandin-endoperoxide synthase 2 [KO:K11987] [EC:1.14.99.1]
100030722  PRKCD; protein kinase C delta [KO:K06068] [EC:2.7.11.13]
100028096  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100012916  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100016983  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
100032596  caspase-1-like [KO:K01370] [EC:3.4.22.36]
100032610  caspase-1-like [KO:K01370] [EC:3.4.22.36]
100032592  caspase-1-like [KO:K01370] [EC:3.4.22.36]
100020522  CARD9; caspase recruitment domain family member 9 [KO:K12794]
100011950  BCL10; B-cell CLL/lymphoma 10 [KO:K07368]
100016169  MALT1; MALT1 paracaspase [KO:K07369] [EC:3.4.22.-]
100017025  CASP18; caspase-18 [KO:K04398] [EC:3.4.22.61]
100617599  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
100022918  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
100033031  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
100011769  NFKBIA; NFKB inhibitor alpha [KO:K04734]
100014446  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
100023069  TNF; tumor necrosis factor [KO:K03156]
103104339  IL6; interleukin 6 [KO:K05405]
100010279  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100010891  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
100026324  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
100028821  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100028089  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
100618895  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
100018774  JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
100011932  CBLB; Cbl proto-oncogene B [KO:K22517] [EC:2.3.2.27]
100032759  FCER1G; Fc fragment of IgE receptor Ig [KO:K07983]
100026844  CD209; CD209 molecule [KO:K06563]
100026862  CD209 antigen-like protein C [KO:K06563]
100030904  ARHGEF12; Rho guanine nucleotide exchange factor 12 [KO:K07532]
100021110  RHOA; ras homolog family member A [KO:K04513]
100018336  PAK1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
100024166  KSR1; kinase suppressor of ras 1 [KO:K14958]
100024987  PLK3; polo like kinase 3 [KO:K08862] [EC:2.7.11.21]
100029391  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
100019578  IKBKE; inhibitor of nuclear factor kappa B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
100028917  STAT1; signal transducer and activator of transcription 1 [KO:K11220]
100030758  IRF9; interferon regulatory factor 9 [KO:K04693]
100023643  IL17D; interleukin 17D [KO:K05492]
100014031  CYLD; CYLD lysine 63 deubiquitinase [KO:K08601] [EC:3.4.19.12]
100023638  BCL3; B-cell CLL/lymphoma 3 [KO:K09258]
100021471  CCL17; C-C motif chemokine 17 [KO:K21083]
100021382  CCL22; C-C motif chemokine ligand 22 [KO:K21095]
100014871  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
100021730  CLEC4E; C-type lectin domain family 4 member E [KO:K10059]
100010412  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
100017332  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
100024769  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
100019317  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
100032726  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
100616957  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
100014564  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
100019947  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
100027373  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
100021398  MDM2; MDM2 proto-oncogene [KO:K06643] [EC:2.3.2.27]
103092862  E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
100018712  IRF1; interferon regulatory factor 1 [KO:K09444]
100019250  C-type lectin domain family 1 member B-like [KO:K10070]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00159  D-Mannose
C00165  Diacylglycerol
C00584  Prostaglandin E2
C00965  1,3-beta-D-Glucan
C01019  L-Fucose
C01245  D-myo-Inositol 1,4,5-trisphosphate
C16844  Hydroxyl radical
C21790  Mycobacterial trehalose dimycolate
C21791  Rhodocytin
G13115  Mannose-capped lipoarabinomannan
Reference
PMID:27291962
  Authors
Geijtenbeek TB, Gringhuis SI
  Title
C-type lectin receptors in the control of T helper cell differentiation.
  Journal
Nat Rev Immunol 16:433-48 (2016)
DOI:10.1038/nri.2016.55
Reference
PMID:21350579
  Authors
Hajishengallis G, Lambris JD
  Title
Microbial manipulation of receptor crosstalk in innate immunity.
  Journal
Nat Rev Immunol 11:187-200 (2011)
DOI:10.1038/nri2918
Reference
PMID:28604735
  Authors
Iliev ID, Leonardi I
  Title
Fungal dysbiosis: immunity and interactions at mucosal barriers.
  Journal
Nat Rev Immunol 17:635-646 (2017)
DOI:10.1038/nri.2017.55
Reference
PMID:25002863
  Authors
Richardson MB, Williams SJ
  Title
MCL and Mincle: C-Type Lectin Receptors That Sense Damaged Self and Pathogen-Associated Molecular Patterns.
  Journal
Front Immunol 5:288 (2014)
DOI:10.3389/fimmu.2014.00288
Reference
PMID:21924922
  Authors
Vautier S, MacCallum DM, Brown GD
  Title
C-type lectin receptors and cytokines in fungal immunity.
  Journal
Cytokine 58:89-99 (2012)
DOI:10.1016/j.cyto.2011.08.031
Reference
PMID:22170181
  Authors
Gauglitz GG, Callenberg H, Weindl G, Korting HC
  Title
Host defence against Candida albicans and the role of pattern-recognition receptors.
  Journal
Acta Derm Venereol 92:291-8 (2012)
DOI:10.2340/00015555-1250
Reference
PMID:22973279
  Authors
Cunha C, Carvalho A, Esposito A, Bistoni F, Romani L
  Title
DAMP signaling in fungal infections and diseases.
  Journal
Front Immunol 3:286 (2012)
DOI:10.3389/fimmu.2012.00286
Reference
PMID:29449845
  Authors
Tang J, Lin G, Langdon WY, Tao L, Zhang J
  Title
Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity.
  Journal
Front Immunol 9:123 (2018)
DOI:10.3389/fimmu.2018.00123
Reference
PMID:27999992
  Authors
Mayer S, Raulf MK, Lepenies B
  Title
C-type lectins: their network and roles in pathogen recognition and immunity.
  Journal
Histochem Cell Biol 147:223-237 (2017)
DOI:10.1007/s00418-016-1523-7
Reference
PMID:23570314
  Authors
Plato A, Willment JA, Brown GD
  Title
C-type lectin-like receptors of the dectin-1 cluster: ligands and signaling pathways.
  Journal
Int Rev Immunol 32:134-56 (2013)
DOI:10.3109/08830185.2013.777065
Reference
PMID:22344277
  Authors
Dupaul-Chicoine J, Saleh M
  Title
A new path to IL-1beta production controlled by caspase-8.
  Journal
Nat Immunol 13:211-2 (2012)
DOI:10.1038/ni.2241
Reference
PMID:24009832
  Authors
Batbayar S, Lee DH, Kim HW
  Title
Immunomodulation of Fungal beta-Glucan in Host Defense Signaling by Dectin-1.
  Journal
Biomol Ther (Seoul) 20:433-45 (2012)
DOI:10.4062/biomolther.2012.20.5.433
Reference
PMID:28606994
  Authors
Bendickova K, Tidu F, Fric J
  Title
Calcineurin-NFAT signalling in myeloid leucocytes: new prospects and pitfalls in immunosuppressive therapy.
  Journal
EMBO Mol Med 9:990-999 (2017)
DOI:10.15252/emmm.201707698
Reference
PMID:18998127
  Authors
den Dunnen J, Gringhuis SI, Geijtenbeek TB
  Title
Innate signaling by the C-type lectin DC-SIGN dictates immune responses.
  Journal
Cancer Immunol Immunother 58:1149-57 (2009)
DOI:10.1007/s00262-008-0615-1
Reference
PMID:28640912
  Authors
Marakalala MJ, Ndlovu H
  Title
Signaling C-type lectin receptors in antimycobacterial immunity.
  Journal
PLoS Pathog 13:e1006333 (2017)
DOI:10.1371/journal.ppat.1006333
Reference
PMID:24867235
  Authors
Gringhuis SI, Kaptein TM, Wevers BA, Mesman AW, Geijtenbeek TB
  Title
Fucose-specific DC-SIGN signalling directs T helper cell type-2 responses via IKKepsilon- and CYLD-dependent Bcl3 activation.
  Journal
Nat Commun 5:3898 (2014)
DOI:10.1038/ncomms4898
Reference
PMID:19521399
  Authors
Geijtenbeek TB, Gringhuis SI
  Title
Signalling through C-type lectin receptors: shaping immune responses.
  Journal
Nat Rev Immunol 9:465-79 (2009)
DOI:10.1038/nri2569
Reference
PMID:19122653
  Authors
Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Wevers B, Bruijns SC, Geijtenbeek TB
  Title
Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk.
  Journal
Nat Immunol 10:203-13 (2009)
DOI:10.1038/ni.1692
Related
pathway
mdo04658  Th1 and Th2 cell differentiation
mdo04659  Th17 cell differentiation
KO pathway
ko04625   
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