KEGG   PATHWAY: mmur04144
Entry
mmur04144                   Pathway                                
Name
Endocytosis - Microcebus murinus (gray mouse lemur)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
mmur04144  Endocytosis
mmur04144

Other DBs
GO: 0006897
Organism
Microcebus murinus (gray mouse lemur) [GN:mmur]
Gene
105867717  ARF6; ADP-ribosylation factor 6 [KO:K07941]
105873950  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
105855772  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
105873022  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
105875235  PIP5KL1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 [KO:K13712] [EC:2.7.1.68]
105855425  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
105879268  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
105875245  DNM1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
105871673  DNM3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
105885577  DNM2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
105874288  CLTA; clathrin light chain A isoform X1 [KO:K04644]
105880464  CLTB; clathrin light chain B isoform X1 [KO:K04645]
105874345  CLTC; clathrin heavy chain 1 isoform X1 [KO:K04646]
105874056  AP2A2; AP-2 complex subunit alpha-2 [KO:K11824]
105865668  AP2A1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
105883206  AP2B1; AP-2 complex subunit beta isoform X1 [KO:K11825]
105855773  AP2M1; AP-2 complex subunit mu isoform X1 [KO:K11826]
105869576  AP2S1; AP-2 complex subunit sigma [KO:K11827]
105869597  EHD2; EH domain-containing protein 2 [KO:K12469]
105873781  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
105883482  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
105877555  ZFYVE9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
105872635  ZFYVE16; zinc finger FYVE domain-containing protein 16 [KO:K04679]
105862152  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
105860538  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
105857966  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
105879830  TFRC; transferrin receptor protein 1 isoform X1 [KO:K06503]
105877217  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
105867837  PDGFRA; LOW QUALITY PROTEIN: platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105870804  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
105856032  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
105883822  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
105871266  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
105876096  CBL; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
105878030  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
105869505  CBLC; E3 ubiquitin-protein ligase CBL-C [KO:K22518] [EC:2.3.2.27]
105882372  SH3KBP1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
105873927  SH3GL1; endophilin-A2 isoform X1 [KO:K11247]
105874121  SH3GL2; endophilin-A1 isoform X1 [KO:K11247]
105870621  SH3GL3; endophilin-A3 [KO:K11247]
105861773  SH3GLB1; endophilin-B1 isoform X1 [KO:K11248]
105875273  SH3GLB2; endophilin-B2 isoform X1 [KO:K21269]
105878258  amphiphysin [KO:K12562]
105879180  BIN1; myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
105861951  EPN2; epsin-2 isoform X1 [KO:K12471]
105885122  EPN3; epsin-3 isoform X1 [KO:K12471]
105863308  EPN1; epsin-1 isoform X1 [KO:K12471]
105867944  EPS15L1; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
105877541  EPS15; epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472]
105862088  SPG20; spartin [KO:K19366]
105881413  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
105860598  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
105884627  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
105856828  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
105865182  RNF41; E3 ubiquitin-protein ligase NRDP1 isoform X1 [KO:K11981] [EC:2.3.2.27]
105865825  ITCH; E3 ubiquitin-protein ligase Itchy homolog isoform X1 [KO:K05632] [EC:2.3.2.26]
105868303  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
105861697  SMURF2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
105876567  WWP1; LOW QUALITY PROTEIN: NEDD4-like E3 ubiquitin-protein ligase WWP1 [KO:K05633] [EC:2.3.2.26]
105885441  LDLR; LOW QUALITY PROTEIN: low-density lipoprotein receptor [KO:K12473]
105863548  LDLRAP1; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
105881516  DAB2; disabled homolog 2 isoform X1 [KO:K12475]
105855442  disabled homolog 2 [KO:K12475]
105857710  CXCR1; C-X-C chemokine receptor type 1 [KO:K04175]
105857650  C-X-C chemokine receptor type 2-like [KO:K05050]
105857653  C-X-C chemokine receptor type 2-like [KO:K05050]
105857711  C-X-C chemokine receptor type 2-like [KO:K05050]
105857712  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
105857645  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
105870048  GRK7; rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
105871942  GRK1; rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
105866915  GRK3; beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
105867521  GRK2; beta-adrenergic receptor kinase 1 isoform X1 [KO:K00910] [EC:2.7.11.15]
105883855  GRK6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
105856035  GRK4; G protein-coupled receptor kinase 4 [KO:K08291] [EC:2.7.11.16]
105857047  GRK5; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
105860366  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
105879284  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
105869918  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
105871538  ACTR2; actin-related protein 2 isoform X2 [KO:K17260]
105883205  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
105857249  ACTR3; actin-related protein 3 [KO:K18584]
105868321  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
105868322  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
105857684  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
105880920  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
105869040  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
105875184  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
105855226  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
105876482  formin-like protein 5 [KO:K19475]
105855119  WIPF3; WAS/WASL-interacting protein family member 3 isoform X1 [KO:K19475]
105865055  WIPF1; WAS/WASL-interacting protein family member 1 [KO:K19475]
105872084  WIPF2; WAS/WASL-interacting protein family member 2 [KO:K19475]
105854849  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
105885170  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
105858167  heat shock 70 kDa protein 1 [KO:K03283]
105858168  heat shock 70 kDa protein 1-like [KO:K03283]
105873559  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
105872828  DNAJC6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
105875598  WASHC4; WASH complex subunit SWIP isoform X1 [KO:K18465]
105875601  WASH complex subunit SWIP-like [KO:K18465]
105882736  WASHC5; WASH complex subunit strumpellin [KO:K18464]
105860123  WASHC2C; WASH complex subunit FAM21C isoform X1 [KO:K18462]
105879290  WASHC1; WAS protein family homolog 1 [KO:K18461]
105875564  WASHC3; WASH complex subunit CCDC53 isoform X1 [KO:K18463]
105882822  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
105869361  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
105878755  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
105884014  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
105880924  VPS29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
105862888  vacuolar protein sorting-associated protein 26A [KO:K18466]
105870325  VPS26A; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 26A [KO:K18466]
105857308  VPS26B; vacuolar protein sorting-associated protein 26B [KO:K18466]
105876218  VPS35; vacuolar protein sorting-associated protein 35 isoform X1 [KO:K18468]
105855323  SNX12; sorting nexin-12 [KO:K17918]
105864930  SNX3; sorting nexin-3 isoform X1 [KO:K17918]
105870713  USP8; ubiquitin carboxyl-terminal hydrolase 8 isoform X1 [KO:K11839] [EC:3.4.19.12]
105884607  STAMBP; STAM-binding protein isoform X1 [KO:K11866] [EC:3.4.19.12]
105882988  RAB7A; ras-related protein Rab-7a [KO:K07897]
105883796  ras-related protein Rab-7a-like [KO:K07897]
105884958  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]
105862393  STAM; signal transducing adapter molecule 1 isoform X1 [KO:K04705]
105879598  STAM2; signal transducing adapter molecule 2 [KO:K04705]
105879953  TSG101; tumor susceptibility gene 101 protein isoform X1 [KO:K12183]
105875202  MVB12B; multivesicular body subunit 12B isoform X3 [KO:K12186]
105855033  MVB12A; multivesicular body subunit 12A isoform X1 [KO:K12186]
105868882  VPS28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
105882527  VPS37A; vacuolar protein sorting-associated protein 37A isoform X1 [KO:K12185]
105878642  VPS37C; vacuolar protein sorting-associated protein 37C isoform X1 [KO:K12185]
105858862  VPS37D; vacuolar protein sorting-associated protein 37D isoform X1 [KO:K12185]
105880879  VPS37B; vacuolar protein sorting-associated protein 37B [KO:K12185]
105885083  SNF8; vacuolar-sorting protein SNF8 isoform X1 [KO:K12188]
105881151  VPS36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
105859445  VPS25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
105884978  CHMP6; charged multivesicular body protein 6 [KO:K12195]
105865920  CHMP4B; charged multivesicular body protein 4b [KO:K12194]
105866598  CHMP4A; charged multivesicular body protein 4a [KO:K12194]
105857573  CHMP4C; charged multivesicular body protein 4c [KO:K24782]
105864497  CHMP2A; charged multivesicular body protein 2a isoform X1 [KO:K12191]
105859315  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
105857166  CHMP7; charged multivesicular body protein 7 isoform X1 [KO:K15053]
105876726  VPS4B; vacuolar protein sorting-associated protein 4B [KO:K12196]
105858965  VPS4A; vacuolar protein sorting-associated protein 4A isoform X1 [KO:K12196]
105859464  VTA1; vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
105860952  CHMP1B; charged multivesicular body protein 1b [KO:K12197]
105855943  CHMP1A; charged multivesicular body protein 1a [KO:K12197]
105874369  CHMP5; charged multivesicular body protein 5 [KO:K12198]
105871638  LOW QUALITY PROTEIN: charged multivesicular body protein 5-like [KO:K12198]
105858961  IST1; IST1 homolog isoform X1 [KO:K19476]
105873893  PDCD6IP; programmed cell death 6-interacting protein isoform X1 [KO:K12200]
105868121  SPG21; maspardin [KO:K19367]
105868590  IGF2R; LOW QUALITY PROTEIN: cation-independent mannose-6-phosphate receptor [KO:K06564]
105868110  SNX1; sorting nexin-1 isoform X3 [KO:K17917]
105884555  SNX2; sorting nexin-2 isoform X1 [KO:K17917]
105855485  SNX6; sorting nexin-6 [KO:K17920]
105878546  SNX32; sorting nexin-32 isoform X3 [KO:K17920]
105879710  sorting nexin-5 [KO:K17920]
105866030  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
105874032  HRAS; GTPase HRas [KO:K02833]
105858205  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
105883739  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
105855320  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
105874961  RHOA; transforming protein RhoA [KO:K04513]
105881031  transforming protein RhoA-like isoform X1 [KO:K04513]
105855949  HLA class I histocompatibility antigen, B-81 alpha chain-like [KO:K06751]
105855951  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-37 alpha chain-like [KO:K06751]
105870762  LOW QUALITY PROTEIN: saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
105870764  HLA class I histocompatibility antigen, B-37 alpha chain-like isoform X1 [KO:K06751]
105870765  HLA class I histocompatibility antigen, B-48 alpha chain-like [KO:K06751]
105870766  HLA class I histocompatibility antigen, B-44 alpha chain-like [KO:K06751]
105870767  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
105858107  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-OKO alpha chain [KO:K06751]
105860275  LOW QUALITY PROTEIN: folate receptor gamma-like [KO:K13649]
105860321  FOLR2; folate receptor beta isoform X1 [KO:K13649]
105860322  folate receptor alpha [KO:K13649]
105869367  CAV1; caveolin-1 isoform X1 [KO:K06278]
105869365  CAV2; caveolin-2 [KO:K12958]
105869098  CAV3; caveolin-3 [KO:K12959]
105884460  EHD3; EH domain-containing protein 3 [KO:K12476]
105872492  EHD4; EH domain-containing protein 4 [KO:K12477]
105877060  EEA1; early endosome antigen 1 isoform X1 [KO:K12478]
105881575  RAB5A; ras-related protein Rab-5A [KO:K07887]
105864957  RAB5B; ras-related protein Rab-5B [KO:K07888]
105859435  RAB5C; ras-related protein Rab-5C [KO:K07889]
105879247  RABEP1; rab GTPase-binding effector protein 1 [KO:K12480]
105862334  RBSN; rabenosyn-5 [KO:K12481]
105871141  RAB4A; ras-related protein Rab-4A isoform X1 [KO:K07879]
105870327  RUFY2; LOW QUALITY PROTEIN: RUN and FYVE domain-containing protein 2 [KO:K12482]
105885206  RUFY1; RUN and FYVE domain-containing protein 1 isoform X2 [KO:K12482]
105878493  EHD1; EH domain-containing protein 1 [KO:K12483]
105865507  VPS45; vacuolar protein sorting-associated protein 45 [KO:K12479]
105879848  SNX4; LOW QUALITY PROTEIN: sorting nexin-4 [KO:K17919]
105874529  RAB22A; ras-related protein Rab-22A isoform X1 [KO:K07891]
105860983  RAB31; ras-related protein Rab-31 [KO:K07891]
105884362  RAB10; ras-related protein Rab-10 [KO:K07903]
105867954  ras-related protein Rab-8A [KO:K07901]
105861454  ras-related protein Rab-44-like [KO:K07901]
105866868  ras-related protein Rab-35 isoform X1 [KO:K07876]
105868094  RAB11A; ras-related protein Rab-11A [KO:K07904]
105885668  RAB11B; ras-related protein Rab-11B isoform X1 [KO:K07905]
105870378  RAB11FIP1; rab11 family-interacting protein 1 isoform X1 [KO:K12484]
105863241  RAB11FIP5; rab11 family-interacting protein 5 isoform X1 [KO:K12484]
105872293  RAB11FIP2; rab11 family-interacting protein 2 isoform X1 [KO:K12484]
105873164  ZFYVE27; protrudin isoform X1 [KO:K19368]
105881706  KIF5B; kinesin-1 heavy chain [KO:K10396]
105877979  KIF5A; kinesin heavy chain isoform X1 [KO:K10396]
105857620  KIF5C; kinesin heavy chain [KO:K10396]
105856271  RAB11FIP3; rab11 family-interacting protein 3 isoform X1 [KO:K12485]
105857036  RAB11FIP4; rab11 family-interacting protein 4 isoform X1 [KO:K12485]
105871976  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
105884737  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
105872272  PARD6B; partitioning defective 6 homolog beta isoform X1 [KO:K06093]
105859026  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
105877684  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
105879189  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
105873610  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
105855073  SMAP2; stromal membrane-associated protein 2 isoform X1 [KO:K12486]
105863336  SMAP1; stromal membrane-associated protein 1 isoform X1 [KO:K12486]
105857941  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
105866936  GIT2; ARF GTPase-activating protein GIT2 isoform X1 [KO:K12487]
105882755  ASAP1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
105882939  ASAP2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
105863550  ASAP3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12488]
105877640  ACAP3; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12489]
105877802  ACAP1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 [KO:K12489]
105879791  ACAP2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12489]
105860301  ARAP1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
105874835  ARAP2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K18440]
105862632  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
105883180  AGAP3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12491]
105865694  AGAP1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X7 [KO:K12491]
105877993  AGAP2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
105875735  ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
105855138  LOW QUALITY PROTEIN: ADP-ribosylation factor GTPase-activating protein 2-like [KO:K12493]
105858529  ARFGAP3; ADP-ribosylation factor GTPase-activating protein 3 [KO:K12493]
105874186  PSD; PH and SEC7 domain-containing protein 1 [KO:K12494]
105882546  PSD3; PH and SEC7 domain-containing protein 3 isoform X1 [KO:K12494]
105862556  PSD2; PH and SEC7 domain-containing protein 2 isoform X1 [KO:K12494]
105859195  PSD4; PH and SEC7 domain-containing protein 4 isoform X1 [KO:K12494]
105882646  IQSEC1; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
105861234  IQSEC2; IQ motif and SEC7 domain-containing protein 2 isoform X3 [KO:K12495]
105862192  IQSEC3; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
105866721  CYTH1; cytohesin-1 isoform X1 [KO:K18441]
105868248  CYTH3; cytohesin-3 [KO:K18441]
105883745  CYTH4; cytohesin-4 isoform X1 [KO:K18441]
105865640  CYTH2; cytohesin-2 isoform X1 [KO:K18441]
105860152  ARFGEF1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 [KO:K18442]
105868923  ARFGEF2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1 [KO:K18442]
105874158  GBF1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
105863667  ADP-ribosylation factor 2-like isoform X1 [KO:K07937]
105878829  ARF1; ADP-ribosylation factor 1 [KO:K07937]
105868443  ARF3; ADP-ribosylation factor 3 [KO:K07938]
105860010  ADP-ribosylation factor 4-like [KO:K07939]
105884910  ARF4; ADP-ribosylation factor 4 isoform X1 [KO:K07939]
109731320  ADP-ribosylation factor 4-like [KO:K07939]
105884830  ARF5; ADP-ribosylation factor 5 [KO:K07940]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
mmur04060  Cytokine-cytokine receptor interaction
mmur04070  Phosphatidylinositol signaling system
mmur04130  SNARE interactions in vesicular transport
mmur04142  Lysosome
mmur04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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