KEGG   PATHWAY: mmyo05224
Entry
mmyo05224                   Pathway                                
Name
Breast cancer - Myotis myotis (greater mouse-eared bat)
Description
Breast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gland. The molecular subtypes of breast cancer, which are based on the presence or absence of hormone receptors (estrogen and progesterone subtypes) and human epidermal growth factor receptor-2 (HER2), include: hormone receptor positive and HER2 negative (luminal A subtype), hormone receptor positive and HER2 positive (luminal B subtype), hormone receptor negative and HER2 positive (HER2 positive), and hormone receptor negative and HER2 negative (basal-like or triple-negative breast cancers (TNBCs)). Hormone receptor positive breast cancers are largely driven by the estrogen/ER pathway. In HER2 positive breast tumours, HER2 activates the PI3K/AKT and the RAS/RAF/MAPK pathways, and stimulate cell growth, survival and differentiation. In patients suffering from TNBC, the deregulation of various signalling pathways (Notch and Wnt/beta-catenin), EGFR protein have been confirmed. In the case of breast cancer only 8% of all cancers are hereditary, a phenomenon linked to genetic changes in BRCA1 or BRCA2. Somatic mutations in only three genes (TP53, PIK3CA and GATA3) occurred at >10% incidence across all breast cancers.
Class
Human Diseases; Cancer: specific types
Pathway map
mmyo05224  Breast cancer
mmyo05224

Organism
Myotis myotis (greater mouse-eared bat) [GN:mmyo]
Gene
118660409  ESR1; estrogen receptor [KO:K08550]
118664766  ESR2; estrogen receptor beta [KO:K08551]
118669224  NCOA1; nuclear receptor coactivator 1 isoform X1 [KO:K09101] [EC:2.3.1.48]
118662730  NCOA3; nuclear receptor coactivator 3 isoform X1 [KO:K11256] [EC:2.3.1.48]
118658230  FOS; proto-oncogene c-Fos [KO:K04379]
118676104  JUN; transcription factor AP-1 [KO:K04448]
118650196  SP1; transcription factor Sp1 [KO:K04684]
118665181  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
118670599  MYC; myc proto-oncogene protein [KO:K04377]
118664480  PGR; progesterone receptor [KO:K08556]
118650977  WNT1; proto-oncogene Wnt-1 [KO:K03209]
118676694  WNT4; protein Wnt-4 [KO:K00408]
118651542  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
118671218  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
118658742  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
118657980  FGF2; fibroblast growth factor 2 [KO:K18497]
118651638  FGF7; fibroblast growth factor 7 [KO:K04358]
118649770  FGF6; fibroblast growth factor 6 [KO:K04358]
118651170  FGF20; fibroblast growth factor 20 [KO:K04358]
118657925  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
118657946  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
118658335  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
118651945  FGF9; fibroblast growth factor 9 isoform X1 [KO:K04358]
118653962  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
118654722  FGF16; fibroblast growth factor 16 [KO:K04358]
118670266  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
118664022  FGF3; fibroblast growth factor 3 [KO:K04358]
118664023  FGF4; fibroblast growth factor 4 [KO:K04358]
118656661  FGF10; fibroblast growth factor 10 [KO:K04358]
118664060  FGF19; fibroblast growth factor 19 [KO:K22603]
118655446  FGF21; fibroblast growth factor 21 [KO:K22429]
118651326  FGF23; fibroblast growth factor 23 [KO:K22428]
118649562  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
118651145  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
118679204  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
118672981  EGF; pro-epidermal growth factor [KO:K04357]
118665909  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
118668862  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
118669819  LOW QUALITY PROTEIN: SHC-transforming protein 1-like [KO:K06279]
118672782  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
118659254  SHC2; SHC-transforming protein 2 [KO:K17447]
118652528  SHC3; SHC-transforming protein 3 isoform X1 [KO:K17448]
118651538  SHC4; SHC-transforming protein 4 [KO:K17449]
118671153  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
118669078  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
118654741  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
118648965  HRAS; GTPase HRas isoform X1 [KO:K02833]
118649554  KRAS; GTPase KRas isoform X1 [KO:K07827]
118672986  NRAS; GTPase NRas [KO:K07828]
118653778  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
118666337  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
118668076  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
118654213  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
118657986  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
118678650  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
118656605  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
118677590  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118668125  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118675045  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118675217  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
118656203  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
118657573  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
118677363  LOW QUALITY PROTEIN: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
118670001  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
118678909  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118655031  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118674834  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118675322  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
118649569  LOW QUALITY PROTEIN: ribosomal protein S6 kinase beta-2-like [KO:K04688] [EC:2.7.11.1]
118649570  ribosomal protein S6 kinase beta-2-like [KO:K04688] [EC:2.7.11.1]
118671643  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
118665219  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
118663641  JAG1; protein jagged-1 isoform X1 [KO:K06052]
118655026  JAG2; protein jagged-2 isoform X1 [KO:K21635]
118650012  DLL4; delta-like protein 4 [KO:K06051]
118674078  DLL3; delta-like protein 3 [KO:K06051]
118660373  DLL1; delta-like protein 1 isoform X1 [KO:K06051]
118655240  NOTCH1; neurogenic locus notch homolog protein 1 isoform X1 [KO:K02599]
118673433  NOTCH2; neurogenic locus notch homolog protein 2 isoform X1 [KO:K20994]
118652571  NOTCH3; neurogenic locus notch homolog protein 3 isoform X1 [KO:K20995]
118679629  NOTCH4; neurogenic locus notch homolog protein 4 [KO:K20996]
118676420  HES1; transcription factor HES-1 [KO:K06054]
118655604  HES5; transcription factor HES-5 [KO:K06055]
118660302  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
118671024  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 [KO:K09091]
118677027  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein isoform X1 [KO:K09091]
118658880  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
118659964  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
118669805  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
118672911  WNT2B; protein Wnt-2b [KO:K00182]
118666478  WNT2; protein Wnt-2 [KO:K00182]
118658755  WNT3A; protein Wnt-3a isoform X1 [KO:K00312]
118672219  WNT3; proto-oncogene Wnt-3 isoform X1 [KO:K00312]
118650248  WNT5B; protein Wnt-5b [KO:K00444]
118667971  WNT5A; protein Wnt-5a [KO:K00444]
118662211  WNT6; protein Wnt-6 [KO:K00445]
118650243  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
118677354  WNT7A; protein Wnt-7a [KO:K00572]
118658912  WNT8A; protein Wnt-8a [KO:K00714]
118669850  WNT8B; protein Wnt-8b [KO:K00714]
118658374  WNT9A; protein Wnt-9a [KO:K01064]
118671436  WNT9B; protein Wnt-9b [KO:K01064]
118651671  WNT10B; protein Wnt-10b [KO:K01357]
118661959  WNT10A; protein Wnt-10a isoform X1 [KO:K01357]
118664619  WNT11; protein Wnt-11 [KO:K01384]
118666468  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
118666245  FZD1; frizzled-1 [KO:K02432]
118661773  FZD7; frizzled-7 [KO:K02432]
118672294  FZD2; frizzled-2 [KO:K02235]
118658774  FZD3; frizzled-3 isoform X1 [KO:K02329]
118664546  FZD4; frizzled-4 [KO:K02354]
118661425  FZD5; frizzled-5 [KO:K02375]
118676314  FZD8; frizzled-8 [KO:K02375]
118670703  FZD6; frizzled-6 [KO:K02376]
118653033  FZD10; LOW QUALITY PROTEIN: frizzled-10 [KO:K02842]
118656623  FZD9; frizzled-9 [KO:K02842]
118649950  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
118665196  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
118677642  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
118655561  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
118672041  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
118669908  FRAT1; proto-oncogene FRAT1 [KO:K03069]
118669907  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
118675932  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
118652848  AXIN1; axin-1 isoform X1 [KO:K02157]
118654322  LOW QUALITY PROTEIN: axin-1-like [KO:K02157]
118671617  AXIN2; axin-2 isoform X1 [KO:K04385]
118658707  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
118655759  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
118668371  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
118657973  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
118665504  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
118653594  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
118654184  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
118662055  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
118657631  TCF7; transcription factor 7 isoform X1 [KO:K02620]
118668800  TCF7L1; transcription factor 7-like 1 isoform X1 [KO:K04490]
118669739  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
118673131  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
118672084  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
118658909  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
118652529  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma isoform X1 [KO:K04402]
118676452  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
118655437  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
118679638  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
118665064  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
118656304  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
118651037  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
118666224  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
118651068  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
118663841  E2F1; transcription factor E2F1 [KO:K17454]
118676426  E2F2; transcription factor E2F2 [KO:K09389]
118676306  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
118671456  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
118651699  BRCA2; breast cancer type 2 susceptibility protein [KO:K08775]
Compound
C00410  Progesterone
C00951  Estradiol-17beta
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:24649067
  Authors
Zhang MH, Man HT, Zhao XD, Dong N, Ma SL
  Title
Estrogen receptor-positive breast cancer molecular signatures and therapeutic potentials (Review).
  Journal
Biomed Rep 2:41-52 (2014)
DOI:10.3892/br.2013.187
Reference
PMID:27390604
  Authors
Dai X, Xiang L, Li T, Bai Z
  Title
Cancer Hallmarks, Biomarkers and Breast Cancer Molecular Subtypes.
  Journal
J Cancer 7:1281-94 (2016)
DOI:10.7150/jca.13141
Reference
PMID:20436504
  Authors
Schnitt SJ
  Title
Classification and prognosis of invasive breast cancer: from morphology to molecular taxonomy.
  Journal
Mod Pathol 23 Suppl 2:S60-4 (2010)
DOI:10.1038/modpathol.2010.33
Reference
PMID:23000897
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  Title
Comprehensive molecular portraits of human breast tumours.
  Journal
Nature 490:61-70 (2012)
DOI:10.1038/nature11412
Reference
PMID:22178455
  Authors
Eroles P, Bosch A, Perez-Fidalgo JA, Lluch A
  Title
Molecular biology in breast cancer: intrinsic subtypes and signaling pathways.
  Journal
Cancer Treat Rev 38:698-707 (2012)
DOI:10.1016/j.ctrv.2011.11.005
Reference
  Authors
Karamouzis MV, Papavassiliou KA, Adamopoulos C, Papavassiliou AG.
  Title
Targeting androgen/estrogen receptors crosstalk in cancer
  Journal
Trends Cancer 2:35-48 (2016)
DOI:10.1016/j.trecan.2015.12.001
Reference
  Authors
Sharp A, Harper-Wynne C.
  Title
Treatment of advanced breast cancer (ABC): the expanding landscape of targeted therapies
  Journal
J Cancer Biol Res 2:1036 (2014)
Reference
PMID:24596345
  Authors
Byler S, Goldgar S, Heerboth S, Leary M, Housman G, Moulton K, Sarkar S
  Title
Genetic and epigenetic aspects of breast cancer progression and therapy.
  Journal
Anticancer Res 34:1071-7 (2014)
Reference
PMID:23988612
  Authors
Mohamed A, Krajewski K, Cakar B, Ma CX
  Title
Targeted therapy for breast cancer.
  Journal
Am J Pathol 183:1096-112 (2013)
DOI:10.1016/j.ajpath.2013.07.005
Reference
PMID:22722193
  Authors
Ellis MJ, Ding L, Shen D, Luo J, Suman VJ, Wallis JW, Van Tine BA, Hoog J, Goiffon RJ, Goldstein TC, Ng S, Lin L, Crowder R, Snider J, Ballman K, Weber J, Chen K, Koboldt DC, Kandoth C, Schierding WS, McMichael JF, Miller CA, Lu C, Harris CC, McLellan MD, Wendl MC, DeSchryver K, Allred DC, Esserman L, Unzeitig G, Margenthaler J, Babiera GV, Marcom PK, Guenther JM, Leitch M, Hunt K, Olson J, Tao Y, Maher CA, Fulton LL, Fulton RS, Harrison M, Oberkfell B, Du F, Demeter R, Vickery TL, Elhammali A, Piwnica-Worms H, McDonald S, Watson M, Dooling DJ, Ota D, Chang LW, Bose R, Ley TJ, Piwnica-Worms D, Stuart JM, Wilson RK, Mardis ER
  Title
Whole-genome analysis informs breast cancer response to aromatase inhibition.
  Journal
Nature 486:353-60 (2012)
DOI:10.1038/nature11143
Reference
PMID:25907219
  Authors
Ma CX, Reinert T, Chmielewska I, Ellis MJ
  Title
Mechanisms of aromatase inhibitor resistance.
  Journal
Nat Rev Cancer 15:261-75 (2015)
DOI:10.1038/nrc3920
Reference
PMID:16113099
  Authors
Butt AJ, McNeil CM, Musgrove EA, Sutherland RL
  Title
Downstream targets of growth factor and oestrogen signalling and endocrine resistance: the potential roles of c-Myc, cyclin D1 and cyclin E.
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Endocr Relat Cancer 12 Suppl 1:S47-59 (2005)
DOI:10.1677/erc.1.00993
Reference
PMID:24111892
  Authors
Dasgupta S, Lonard DM, O'Malley BW
  Title
Nuclear receptor coactivators: master regulators of human health and disease.
  Journal
Annu Rev Med 65:279-92 (2014)
DOI:10.1146/annurev-med-051812-145316
Reference
PMID:23702927
  Authors
Brisken C
  Title
Progesterone signalling in breast cancer: a neglected hormone coming into the limelight.
  Journal
Nat Rev Cancer 13:385-96 (2013)
DOI:10.1038/nrc3518
Reference
PMID:20087430
  Authors
Scarpin KM, Graham JD, Mote PA, Clarke CL
  Title
Progesterone action in human tissues: regulation by progesterone receptor (PR) isoform expression, nuclear positioning and coregulator expression.
  Journal
Nucl Recept Signal 7:e009 (2009)
DOI:10.1621/nrs.07009
Reference
PMID:24291072
  Authors
Knutson TP, Lange CA
  Title
Tracking progesterone receptor-mediated actions in breast cancer.
  Journal
Pharmacol Ther 142:114-25 (2014)
DOI:10.1016/j.pharmthera.2013.11.010
Reference
PMID:25544707
  Authors
Dittrich A, Gautrey H, Browell D, Tyson-Capper A
  Title
The HER2 Signaling Network in Breast Cancer--Like a Spider in its Web.
  Journal
J Mammary Gland Biol Neoplasia 19:253-70 (2014)
DOI:10.1007/s10911-014-9329-5
Reference
PMID:21965336
  Authors
Higgins MJ, Baselga J
  Title
Targeted therapies for breast cancer.
  Journal
J Clin Invest 121:3797-803 (2011)
DOI:10.1172/JCI57152
Reference
PMID:26028978
  Authors
Mukohara T
  Title
PI3K mutations in breast cancer: prognostic and therapeutic implications.
  Journal
Breast Cancer (Dove Med Press) 7:111-23 (2015)
DOI:10.2147/BCTT.S60696
Reference
PMID:19088017
  Authors
Schneider BP, Winer EP, Foulkes WD, Garber J, Perou CM, Richardson A, Sledge GW, Carey LA
  Title
Triple-negative breast cancer: risk factors to potential targets.
  Journal
Clin Cancer Res 14:8010-8 (2008)
DOI:10.1158/1078-0432.CCR-08-1208
Reference
PMID:21898546
  Authors
King TD, Suto MJ, Li Y
  Title
The Wnt/beta-catenin signaling pathway: a potential therapeutic target in the treatment of triple negative breast cancer.
  Journal
J Cell Biochem 113:13-8 (2012)
DOI:10.1002/jcb.23350
Reference
PMID:11737884
  Authors
Brown AM
  Title
Wnt signaling in breast cancer: have we come full circle?
  Journal
Breast Cancer Res 3:351-5 (2001)
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Reference
PMID:21076461
  Authors
Geyer FC, Lacroix-Triki M, Savage K, Arnedos M, Lambros MB, MacKay A, Natrajan R, Reis-Filho JS
  Title
beta-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation.
  Journal
Mod Pathol 24:209-31 (2011)
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Reference
PMID:20971825
  Authors
Al-Hussaini H, Subramanyam D, Reedijk M, Sridhar SS
  Title
Notch signaling pathway as a therapeutic target in breast cancer.
  Journal
Mol Cancer Ther 10:9-15 (2011)
DOI:10.1158/1535-7163.MCT-10-0677
Reference
PMID:26968398
  Authors
Rangel MC, Bertolette D, Castro NP, Klauzinska M, Cuttitta F, Salomon DS
  Title
Developmental signaling pathways regulating mammary stem cells and contributing to the etiology of triple-negative breast cancer.
  Journal
Breast Cancer Res Treat 156:211-26 (2016)
DOI:10.1007/s10549-016-3746-7
Reference
PMID:26040571
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Jamdade VS, Sethi N, Mundhe NA, Kumar P, Lahkar M, Sinha N
  Title
Therapeutic targets of triple-negative breast cancer: a review.
  Journal
Br J Pharmacol 172:4228-37 (2015)
DOI:10.1111/bph.13211
Reference
PMID:23196196
  Authors
Karamboulas C, Ailles L
  Title
Developmental signaling pathways in cancer stem cells of solid tumors.
  Journal
Biochim Biophys Acta 1830:2481-95 (2013)
DOI:10.1016/j.bbagen.2012.11.008
Reference
PMID:23881035
  Authors
Ignatiadis M, Sotiriou C
  Title
Luminal breast cancer: from biology to treatment.
  Journal
Nat Rev Clin Oncol 10:494-506 (2013)
DOI:10.1038/nrclinonc.2013.124
Reference
PMID:25013431
  Authors
Shin SJ, Gong G, Lee HJ, Kang J, Bae YK, Lee A, Cho EY, Lee JS, Suh KS, Lee DW, Jung WH
  Title
Positive expression of insulin-like growth factor-1 receptor is associated with a positive hormone receptor status and a favorable prognosis in breast cancer.
  Journal
J Breast Cancer 17:113-20 (2014)
DOI:10.4048/jbc.2014.17.2.113
Reference
PMID:11879567
  Authors
Gasco M, Shami S, Crook T
  Title
The p53 pathway in breast cancer.
  Journal
Breast Cancer Res 4:70-6 (2002)
DOI:10.1186/bcr426
Reference
PMID:15343273
  Authors
Narod SA, Foulkes WD
  Title
BRCA1 and BRCA2: 1994 and beyond.
  Journal
Nat Rev Cancer 4:665-76 (2004)
DOI:10.1038/nrc1431
Related
pathway
mmyo03440  Homologous recombination
mmyo04010  MAPK signaling pathway
mmyo04110  Cell cycle
mmyo04115  p53 signaling pathway
mmyo04151  PI3K-Akt signaling pathway
mmyo04310  Wnt signaling pathway
mmyo04330  Notch signaling pathway
mmyo04915  Estrogen signaling pathway
KO pathway
ko05224   
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